{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:43:06Z","timestamp":1778312586058,"version":"3.51.4"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.ghir.2022.101496","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T11:53:27Z","timestamp":1658922807000},"page":"101496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Do neurosteroids have impact on depression and cognitive functions in cases with acromegaly?"],"prefix":"10.1016","volume":"66","author":[{"given":"Esra","family":"Hatipoglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalcin","family":"Hacioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeliz","family":"Polat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilmi Furkan","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sena","family":"Oner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem Balci","family":"Ekmekci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutlu","family":"Niyazoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ghir.2022.101496_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11102-020-01091-7","article-title":"A pituitary society update to acromegaly management guidelines","volume":"24","author":"Fleseriu","year":"2021","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2022.101496_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ghir.2021.101439","article-title":"Personality traits in acromegalic patients: comparison with patients with non-functioning adenomas and healthy controls","volume":"62","author":"Kan","year":"2022","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2022.101496_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1100\/tsw.2006.22","article-title":"Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain","volume":"6","author":"Aberg","year":"2006","journal-title":"TheScientificWorldJournal"},{"key":"10.1016\/j.ghir.2022.101496_bb0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2147\/PRBM.S183950","article-title":"Executive functioning and quality of life in acromegaly","volume":"12","author":"Solomon","year":"2019","journal-title":"Psychol. Res. Behav. Manag."},{"issue":"1","key":"10.1016\/j.ghir.2022.101496_bb0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ghir.2008.05.002","article-title":"Evaluation of cognitive performance by using P300 auditory event related potentials (ERPs) in patients with growth hormone (GH) deficiency and acromegaly","volume":"19","author":"Tanriverdi","year":"2009","journal-title":"Growth Hormon. IGF Res."},{"issue":"3","key":"10.1016\/j.ghir.2022.101496_bb0030","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s11102-011-0326-z","article-title":"Cognitive function in acromegaly: description and brain volumetric correlates","volume":"15","author":"Sievers","year":"2012","journal-title":"Pituitary"},{"issue":"9","key":"10.1016\/j.ghir.2022.101496_bb0035","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1210\/jc.2010-0394","article-title":"Evidence of cognitive and neurophysiological impairment in patients with untreated naive acromegaly","volume":"95","author":"Leon-Carrion","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2022.101496_bb0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pneurobio.2013.09.003","article-title":"The role of allopregnanolone in depression and anxiety","volume":"113","author":"Sch\u00fcle","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ghir.2022.101496_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105682","article-title":"Allopregnanolone in mood disorders: mechanism and therapeutic development","volume":"169","author":"Chen","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ghir.2022.101496_bb0050","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pneurobio.2013.08.004","article-title":"Allopregnanolone as regenerative therapeutic for Alzheimer\u2019s disease: translational development and clinical promise","volume":"113","author":"Irwin","year":"2014","journal-title":"Prog. Neurobiol."},{"issue":"4","key":"10.1016\/j.ghir.2022.101496_bb0055","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0091-3057(94)90197-X","article-title":"Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze","volume":"48","author":"Melchior","year":"1994","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"5","key":"10.1016\/j.ghir.2022.101496_bb0060","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1073\/pnas.89.5.1567","article-title":"Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it","volume":"89","author":"Flood","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ghir.2022.101496_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.619916","article-title":"Increased plasma level of 24S-Hydroxycholesterol and polymorphism of CYP46A1 SNP (rs754203) are associated with mild cognitive impairment in patients with type 2 diabetes","volume":"13","author":"Shi","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ghir.2022.101496_bb0070","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/1745017901612010024","article-title":"Dehydroepiandrosterone, its sulfate and cognitive functions","volume":"12","author":"de Menezes","year":"2016","journal-title":"Clin. Pract. Epidemiol. Ment. Health: CP & EMH"},{"issue":"8","key":"10.1016\/j.ghir.2022.101496_bb0075","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0306-4530(98)00071-7","article-title":"Neurosteroids: a novel function of the brain","volume":"23","author":"Baulieu","year":"1998","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ghir.2022.101496_bb0080","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.pharmthera.2018.06.011","article-title":"Neurosteroids: non-genomic pathways in neuroplasticity and involvement in neurological diseases","volume":"191","author":"Schverer","year":"2018","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.ghir.2022.101496_bb0085","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1042\/EBC20200043","article-title":"Biosynthesis and signalling functions of central and peripheral nervous system neurosteroids in health and disease","volume":"64","author":"Lloyd-Evans","year":"2020","journal-title":"Essays Biochem."},{"key":"10.1016\/j.ghir.2022.101496_bb0090","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1749-6632.2009.04981.x","article-title":"Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy","volume":"1179","author":"Brown","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10.1016\/j.ghir.2022.101496_bb0095","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0006-8993(02)02414-9","article-title":"Allopregnanolone inhibits learning in the Morris water maze","volume":"934","author":"Johansson","year":"2002","journal-title":"Brain Res."},{"issue":"10","key":"10.1016\/j.ghir.2022.101496_bb0100","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1258\/ebm.2010.009334","article-title":"Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome","volume":"235","author":"Rasmusson","year":"2010","journal-title":"Exp. Biol. Med. (Maywood, N.J.)"},{"issue":"9","key":"10.1016\/j.ghir.2022.101496_bb0105","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2174\/1389450115666140717111116","article-title":"The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: a systematic review","volume":"15","author":"Peixoto","year":"2014","journal-title":"Curr. Drug Targets"},{"issue":"9","key":"10.1016\/j.ghir.2022.101496_bb0110","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/brain\/awr200","article-title":"Impaired neurosteroid synthesis in multiple sclerosis","volume":"134","author":"Noorbakhsh","year":"2011","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.ghir.2022.101496_bb0115","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/glia.23179","article-title":"Suppressed oligodendrocyte steroidogenesis in multiple sclerosis: implications for regulation of neuroinflammation","volume":"65","author":"Boghozian","year":"2017","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.ghir.2022.101496_bb0120","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00213-005-0186-1","article-title":"3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer\u2019s disease and perhaps non-Alzheimer\u2019s dementia","volume":"186","author":"Smith","year":"2006","journal-title":"Psychopharmacology"},{"issue":"12","key":"10.1016\/j.ghir.2022.101496_bb0125","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.biopsych.2006.06.017","article-title":"The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer\u2019s disease","volume":"60","author":"Marx","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.ghir.2022.101496_bb0130","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1210\/jc.2007-1229","article-title":"Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer\u2019s disease, and related to neuropathological disease stage","volume":"93","author":"Naylor","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2022.101496_bb0135","series-title":"Handbook of Psychiatric Measures","first-page":"504","article-title":"Beck depression inventory (BDI)","author":"Beck","year":"2008"},{"key":"10.1016\/j.ghir.2022.101496_bb0140","first-page":"118","article-title":"Beck Depresyon Envanterinin gecerliligi uzerine bit calisma (a study on the validity of Beck depression inventory.)","volume":"6","author":"Hisli","year":"1988","journal-title":"Psikoloji Dergisi."},{"key":"10.1016\/j.ghir.2022.101496_bb0145","author":"Wechsler"},{"issue":"1","key":"10.1016\/j.ghir.2022.101496_bb0150","first-page":"451","article-title":"Wechsler Yeti\u015fkinler \u0130\u00e7in Zek\u00e2 \u00d6l\u00e7e\u011fi G\u00f6zden Ge\u00e7irilmi\u015f Formu WAIS-R T\u00fcrkiye Standardizasyonu: \u00d6n \u00c7al\u0131\u015fma, Ankara \u00dcniversitesi Dil ve Tarih-Co\u011frafya Fak\u00fcltesi Dergisi","volume":"54","author":"Sezgin","year":"2014"},{"key":"10.1016\/j.ghir.2022.101496_bb0155","series-title":"Manual for the Wechsler adult intelligence scale","author":"Wechsler","year":"1955"},{"key":"10.1016\/j.ghir.2022.101496_bb0160","series-title":"Neuropsychological Assessment","author":"Lezak","year":"1995"},{"key":"10.1016\/j.ghir.2022.101496_bb0165","series-title":"Normal Deneklerde Frontal Hasarlara Duyarli Bazi Testlerde Performansa Ya\u015f ve E\u011fitimin Etkisi","author":"Tumac","year":"1997"},{"key":"10.1016\/j.ghir.2022.101496_bb0170","series-title":"Higher Cortical Functions in Man","author":"Luria","year":"2012"},{"issue":"6","key":"10.1016\/j.ghir.2022.101496_bb0175","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/(SICI)1099-1166(199706)12:6<619::AID-GPS554>3.0.CO;2-H","article-title":"The clock drawing test for dementia of the Alzheimer\u2019s type: a comparison of three scoring methods in a memory disorders clinic","volume":"12","author":"Brodaty","year":"1997","journal-title":"Int. J. Geriatr. Psych."},{"key":"10.1016\/j.ghir.2022.101496_bb0180","series-title":"Gunes T\u0131p Kitabevler, Bolum 11","first-page":"343","article-title":"Klinik n\u00f6ropsikoloji ve n\u00f6ropsikiyatrik hastal\u0131klar","author":"Kumral","year":"2014"},{"issue":"6","key":"10.1016\/j.ghir.2022.101496_bb0185","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1001\/archneur.1978.00500300038006","article-title":"Visuospatial judgment: a clinical test","volume":"35","author":"Benton","year":"1978","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ghir.2022.101496_bb0190","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1017\/S0317167100039317","article-title":"Contributions to neuropsychological assessment. 2nd Edition. 1994. By Arthur L. Benton, Abigail B. Sivan, Kerry deS. Hamsher, Nils R. Varney and Otfried Spreen. Published by Oxford university press. 159 pages. $C34.95","volume":"23","author":"Kirk","year":"1996","journal-title":"Can. J. Neurol. Sci. J. Canad. Sci. Neurol."},{"key":"10.1016\/j.ghir.2022.101496_bb0195","series-title":"B\u0130LNOT bataryas\u0131 el kitab\u0131: N\u00f6ropsikolojik testler i\u00e7in ara\u015ft\u0131rma ve geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131","author":"Karaka\u015f","year":"2004"},{"key":"10.1016\/j.ghir.2022.101496_bb0200","series-title":"Neuropsychological Assessment","author":"Lezak","year":"2004"},{"issue":"3","key":"10.1016\/j.ghir.2022.101496_bb0205","first-page":"179","article-title":"Benton y\u00fcz tan\u0131ma testi\u2019nin \u201cT\u00fcrkiye toplumu normal yeti\u015fkin denekler \u00fczerindeki standardizasyonu\u201d","volume":"14","author":"Keskinkili\u00e7","year":"2008","journal-title":"T\u00fcrk N\u00f6roloji Dergisi"},{"key":"10.1016\/j.ghir.2022.101496_bb0210","series-title":"2nd Philadelphia: Lea & Febiger.[Google Scholar]","article-title":"The Boston naming test","author":"Kaplan","year":"1983"},{"issue":"1","key":"10.1016\/j.ghir.2022.101496_bb0215","first-page":"6","article-title":"Boston Adland\u0131rma Testi T\u00fcrk Formu \u0130\u00e7in Ara\u015ft\u0131rma-Geli\u015ftirme \u00c7al\u0131\u015fmas\u0131","volume":"54","author":"Kurt","year":"2016","journal-title":"Yeni Sympos."},{"issue":"7","key":"10.1016\/j.ghir.2022.101496_bb0220","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1080\/13803390490510716","article-title":"Boston naming test short forms: a comparison of previous forms with new item response theory based forms","volume":"26","author":"Graves","year":"2004","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.ghir.2022.101496_bb0225","first-page":"196","article-title":"A verbal test of memory processes","volume":"29","author":"\u00d6ktem","year":"1992","journal-title":"Arch Neuropsych."},{"issue":"4","key":"10.1016\/j.ghir.2022.101496_bb0230","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s11154-020-09588-z","article-title":"Multidisciplinary management of acromegaly: a consensus","volume":"21","author":"Giustina","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.ghir.2022.101496_bb0235","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exger.2014.10.002","article-title":"Growth hormone, insulin-like growth factor-1 and the aging brain","volume":"68","author":"Ashpole","year":"2015","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.ghir.2022.101496_bb0240","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000090123","article-title":"Growth hormone deficiency and memory functioning in adults visualized by functional magnetic resonance imaging","volume":"82","author":"Arwert","year":"2005","journal-title":"Neuroendocrinology"},{"issue":"1","key":"10.1016\/j.ghir.2022.101496_bb0245","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000093337","article-title":"Effects of growth hormone substitution therapy on cognitive functioning in growth hormone deficient patients: a functional MRI study","volume":"83","author":"Arwert","year":"2006","journal-title":"Neuroendocrinology"},{"issue":"3","key":"10.1016\/j.ghir.2022.101496_bb0250","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s12020-015-0634-6","article-title":"Impaired decision making and delayed memory are related with anxiety and depressive symptoms in acromegaly","volume":"50","author":"Crespo","year":"2015","journal-title":"Endocrine"},{"issue":"12","key":"10.1016\/j.ghir.2022.101496_bb0255","doi-asserted-by":"crossref","first-page":"E392","DOI":"10.1210\/jc.2010-1253","article-title":"Increased psychopathology and maladaptive personality traits, but normal cognitive functioning, in patients after long-term cure of acromegaly","volume":"95","author":"Tiemensma","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.ghir.2022.101496_bb0260","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1590\/1980-57642015dn93000008","article-title":"Use of a modified version of the switching verbal fluency test for the assessment of cognitive flexibility","volume":"9","author":"de Paula","year":"2015","journal-title":"Dement. Neuropsychol."},{"key":"10.1016\/j.ghir.2022.101496_bb0265","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2307\/2785779","article-title":"Cognitive complexity and cognitive flexibility","author":"Scott","year":"1962","journal-title":"Sociometry"},{"issue":"6","key":"10.1016\/j.ghir.2022.101496_bb0270","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1037\/a0012919","article-title":"Semantic error patterns on the Boston naming test in normal aging, amnestic mild cognitive impairment, and mild Alzheimer\u2019s disease: is there semantic disruption?","volume":"22","author":"Balthazar","year":"2008","journal-title":"Neuropsychology"},{"issue":"4","key":"10.1016\/j.ghir.2022.101496_bb0275","first-page":"501","article-title":"Standard form of the Boston naming test: normative data for the Latin American Spanish speaking adult population","volume":"37","author":"Olabarrieta-Landa","year":"2015","journal-title":"NeuroRehabilitation"},{"issue":"6","key":"10.1016\/j.ghir.2022.101496_bb0280","first-page":"255","article-title":"Cognitive impairment and psychopathology in patients with pituitary diseases","volume":"70","author":"Pereira","year":"2012","journal-title":"Neth. J. Med."},{"issue":"1","key":"10.1016\/j.ghir.2022.101496_bb0285","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1530\/EJE-15-0888","article-title":"Morphometric changes correlate with poor psychological outcomes in patients with acromegaly","volume":"174","author":"Imran","year":"2016","journal-title":"Eur. J. Endocrinol."},{"issue":"5","key":"10.1016\/j.ghir.2022.101496_bb0290","first-page":"524","article-title":"Is there any difference in acromegaly and other chronic disease in quality of life and psychiatric morbidity?","volume":"68","author":"Szcze\u015bniak","year":"2017","journal-title":"Endokrynol. Polska"},{"issue":"3","key":"10.1016\/j.ghir.2022.101496_bb0295","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1530\/JOE-18-0226","article-title":"Corticosteroids and the brain","volume":"238","author":"Jo\u00ebls","year":"2018","journal-title":"J. Endocrinol."},{"issue":"3","key":"10.1016\/j.ghir.2022.101496_bb0300","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/j.2040-4603.2016.tb00710.x","article-title":"Sex hormones and cognition: neuroendocrine influences on memory and learning","volume":"6","author":"Hamson","year":"2016","journal-title":"Comprehens. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.ghir.2022.101496_bb0305","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jnr.23809","article-title":"Understanding the broad influence of sex hormones and sex differences in the brain","volume":"95","author":"McEwen","year":"2017","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.ghir.2022.101496_bb0310","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/ilar.45.2.189","article-title":"Cognition, mood disorders, and sex hormones","volume":"45","author":"Shively","year":"2004","journal-title":"ILAR J."},{"key":"10.1016\/j.ghir.2022.101496_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2019.100206","article-title":"GABA-A receptor modulating steroids in acute and chronic stress; relevance for cognition and dementia?","volume":"12","author":"Bengtsson","year":"2020","journal-title":"Neurobiol. Stress"},{"issue":"1","key":"10.1016\/j.ghir.2022.101496_bb0320","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1038\/s41467-021-23133-9","article-title":"NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95","volume":"12","author":"Compans","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ghir.2022.101496_bb0325","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jsbmb.2015.09.030","article-title":"Neurosteroids and potential therapeutics: focus on pregnenolone","volume":"160","author":"Vall\u00e9e","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"33","key":"10.1016\/j.ghir.2022.101496_bb0330","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.2174\/138161208786848838","article-title":"Neuroactive steroids as endogenous modulators of anxiety","volume":"14","author":"Eser","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ghir.2022.101496_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135771","article-title":"Rapid effects of neurosteroids on neuronal plasticity and their physiological and pathological implications","volume":"750","author":"Kudova","year":"2021","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.ghir.2022.101496_bb0340","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.eurpsy.2008.12.005","article-title":"CYP46A1 variants influence Alzheimer\u2019s disease risk and brain cholesterol metabolism","volume":"24","author":"K\u00f6lsch","year":"2009","journal-title":"Europ. Psych. J. Assoc. Europ. Psychiatr."},{"issue":"28","key":"10.1016\/j.ghir.2022.101496_bb0345","doi-asserted-by":"crossref","first-page":"24666","DOI":"10.1074\/jbc.M111.236273","article-title":"24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis","volume":"286","author":"Yamanaka","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ghir.2022.101496_bb0350","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/bs.vh.2018.01.005","article-title":"Dehydroepiandrosterone and bone","volume":"108","author":"Zhou","year":"2018","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.ghir.2022.101496_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.110949","article-title":"Impact of dehydroepianrosterone (DHEA) supplementation on serum levels of insulin-like growth factor 1 (IGF-1): a dose-response meta-analysis of randomized controlled trials","volume":"136","author":"Xie","year":"2020","journal-title":"Exp. Gerontol."},{"issue":"6","key":"10.1016\/j.ghir.2022.101496_bb0360","first-page":"1360","article-title":"Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age","volume":"78","author":"Morales","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2022.101496_bb0365","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1749-6632.1995.tb17376.x","article-title":"Dehydroepiandrosterone sulfate and aging","volume":"774","author":"Vermeulen","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"8","key":"10.1016\/j.ghir.2022.101496_bb0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024293","article-title":"Allopregnanolone promotes regeneration and reduces \u03b2-amyloid burden in a preclinical model of Alzheimer\u2019s disease","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ghir.2022.101496_bb0375","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0074-7742(01)46066-1","article-title":"Neurosteroids in learning and memory processes","volume":"46","author":"Vall\u00e9e","year":"2001","journal-title":"Int. Rev. Neurobiol."},{"issue":"6","key":"10.1016\/j.ghir.2022.101496_bb0380","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1528-1167.2005.00705.x","article-title":"Anticonvulsant activity of androsterone and etiocholanolone","volume":"46","author":"Kaminski","year":"2005","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.ghir.2022.101496_bb0385","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1001\/archpsyc.63.4.450","article-title":"Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men","volume":"63","author":"Bloch","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"issue":"5","key":"10.1016\/j.ghir.2022.101496_bb0390","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.yhbeh.2008.07.013","article-title":"Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice","volume":"54","author":"Frye","year":"2008","journal-title":"Horm. Behav."},{"issue":"9","key":"10.1016\/j.ghir.2022.101496_bb0395","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.neurobiolaging.2011.09.014","article-title":"Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats","volume":"33","author":"Molina","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.ghir.2022.101496_bb0400","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuroscience.2004.08.001","article-title":"Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning","volume":"129","author":"Ramsey","year":"2004","journal-title":"Neuroscience"}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637422000533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637422000533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:53:19Z","timestamp":1761087199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637422000533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":80,"alternative-id":["S1096637422000533"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2022.101496","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Do neurosteroids have impact on depression and cognitive functions in cases with acromegaly?","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2022.101496","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101496"}}