{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:03:32Z","timestamp":1776405812031,"version":"3.51.2"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone & IGF Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.ghir.2024.101572","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T19:35:52Z","timestamp":1706124952000},"page":"101572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Growth hormone directly stimulates GATA2 expression"],"prefix":"10.1016","volume":"74","author":[{"given":"Mana","family":"Mitsutani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Hano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Fujikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Tagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2024.101572_bb0005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1267\/ahc.09004","article-title":"Pathology, pathogenesis and therapy of growth hormone (GH)-producing pituitary adenomas: technical advances in Histochemistry and their contribution","volume":"29","author":"Osamura","year":"2009","journal-title":"Acta Histochem. Cytochem."},{"key":"10.1016\/j.ghir.2024.101572_bb0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1126\/science.290.5489.134","article-title":"Function of GATA transcription factors in preadipocyte-adipocyte transition","volume":"290","author":"Tong","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ghir.2024.101572_bb0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/modpathol.3880484","article-title":"Expression of GATA-2 in human pituitary adenomas","volume":"15","author":"Umeoka","year":"2002","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.ghir.2024.101572_bb0020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.alit.2016.01.006","article-title":"Regulation of basophil and mast cell development by transcription factors","volume":"65","author":"Sasaki","year":"2016","journal-title":"Allergol. Int."},{"key":"10.1016\/j.ghir.2024.101572_bb0025","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.4049\/jimmunol.1700556","article-title":"The Neurobeachin-like 2 protein regulates mast cell homeostasis","volume":"15","author":"Drube","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.ghir.2024.101572_bb0030","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1128\/MCB.06699-11","article-title":"UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice","volume":"32","author":"Ainoya","year":"2021","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ghir.2024.101572_bb0035","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.celrep.2018.09.049","article-title":"Complementary Wnt sources regulate lymphatic vascular development via PROX1-dependent Wnt\/\u03b2-catenin signaling","volume":"16","author":"Cha","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.ghir.2024.101572_bb0040","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1620\/tjem.255.143","article-title":"Combined mutation of the GATA2 gene and STAT5B gene in patient with hypogammaglobulinemia and autoimmunity","volume":"255","author":"Liu","year":"2021","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.ghir.2024.101572_bb0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ghir.2016.04.005","article-title":"Growth hormone regulates the expression of UCP2 in myocytes","volume":"29","author":"Futawaka","year":"2016","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2024.101572_bb0055","first-page":"C374","article-title":"Energy-sensitive regulation of Na+\/K+-ATPase by Janus kinase 2","volume":"15","author":"Bhavsar","year":"2014","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.ghir.2024.101572_bb0060","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1128\/MCB.18.7.3871","article-title":"Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation","volume":"18","author":"Onishi","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ghir.2024.101572_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137079","article-title":"High-throughput siRNA screening to reveal GATA-2 upstream transcriptional mechanisms in hematopoietic cells","volume":"10","author":"Saito","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ghir.2024.101572_bb0070","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1210\/endo.138.10.5445","article-title":"Regulation of K+ channels by cell contact in a cloned folliculo-stellate cell (TtT\/GF)","volume":"138","author":"Yamasaki","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.ghir.2024.101572_bb0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ghir.2018.01.002","article-title":"GH directly stimulates UCP3 expression","volume":"40","author":"Hayashi","year":"2018","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2024.101572_bb0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ghir.2017.10.006","article-title":"Effects of growth hormone on uncoupling protein 1 in white adipose tissues in obese mice","volume":"37","author":"Hayashi","year":"2017","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2024.101572_bb0085","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1210\/endo.140.8.6878","article-title":"Growth hormone regulation of SOCS-2, SOCS-3, and CIS messenger ribonucleic acid expression in the rat","volume":"140","author":"Tollet-Egnell","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.ghir.2024.101572_bb0090","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/iub.2169","article-title":"GATA factor transcriptional activity: insights from genome-wide binding profiles","volume":"72","author":"Romano","year":"2020","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ghir.2024.101572_bb0100","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/j.2040-4603.2017.tb00782.x","article-title":"Hormonal regulation of adipogenesis","volume":"7","author":"Lee","year":"2017","journal-title":"Compreh. Physiol."},{"key":"10.1016\/j.ghir.2024.101572_bb0105","first-page":"635","article-title":"Transcriptional regulation of adipogenesis","volume":"16","author":"Mota de S\u00e1","year":"2017","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.ghir.2024.101572_bb0110","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nrendo.2013.64","article-title":"The GH\/IGF-1 axis in obesity: pathophysiology and therapeutic considerations","volume":"9","author":"Berryman","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ghir.2024.101572_bb0115","article-title":"GATA transcription factors in development and disease","volume":"22","author":"Tremblay","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.ghir.2024.101572_bb0120","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1677\/JME-08-0099","article-title":"Functions of PIT1 in GATA2-dependent transactivation of the thyrotropin beta promoter","volume":"42","author":"Kashiwabara","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ghir.2024.101572_bb0125","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1210\/endo.131.6.1446645","article-title":"Establishment of a folliculo-stellate-like cell line from a murine thyrotropic pituitary tumor","volume":"131","author":"Inoue","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.ghir.2024.101572_bb0130","doi-asserted-by":"crossref","first-page":"24339","DOI":"10.1074\/jbc.272.39.24339","article-title":"Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter","volume":"26","author":"Gordon","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ghir.2024.101572_bb0135","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1210\/me.2005-0378","article-title":"Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function","volume":"20","author":"Charles","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ghir.2024.101572_bb0140","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1210\/me.2007-0513","article-title":"Role of the GATA family of transcription factors in endocrine development, function, and disease","volume":"22","author":"Viger","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ghir.2024.101572_bb0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/iub.2178","article-title":"The roles and controls of GATA factors in blood and cardiac development","volume":"72","author":"Dobrzycki","year":"2020","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ghir.2024.101572_bb0150","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.1073\/pnas.1610615114","article-title":"Dissecting BMP signaling input into the gene regulatory networks driving specification of the blood stem cell lineage","volume":"114","author":"Kirmizitas","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ghir.2024.101572_bb0155","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/15216540410001703956","article-title":"New insights into the regulation of erythroid cells","volume":"56","author":"Ingley","year":"2004","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ghir.2024.101572_bb0160","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0076-6879(07)35010-6","article-title":"Control of erythropoietin gene expression and its use in medicine","volume":"435","author":"Jelkmann","year":"2007","journal-title":"Methods Enzymol."},{"issue":"8","key":"10.1016\/j.ghir.2024.101572_bb0165","first-page":"100","article-title":"Erythropoiesis in vertebrates: from ontogeny to clinical relevance","volume":"1","author":"Nogueira-Pedro","year":"2016","journal-title":"Front. Biosci. (Elite Ed.)"},{"key":"10.1016\/j.ghir.2024.101572_bb0170","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s12020-015-0591-0","article-title":"Effects of growth hormone therapeutic supplementation on hematopoietic stem\/progenitor cells in children with growth hormone deficiency: focus on proliferation and differentiation capabilities","volume":"50","author":"Kawa","year":"2015","journal-title":"Endocrine"},{"key":"10.1016\/j.ghir.2024.101572_bb0175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ghir.2018.07.005","article-title":"Growth hormone and hematopoiesis: a retrospective analysis on a large cohort of children with growth hormone deficiency","volume":"42-43","author":"Ciresi","year":"2018","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2024.101572_bb0180","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12020-015-0781-9","article-title":"Long-term effects of growth hormone (GH) replacement therapy on hematopoiesis in a large cohort of children with GH deficiency","volume":"53","author":"Esposito","year":"2016","journal-title":"Endocrine."}],"container-title":["Growth Hormone & IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637424000029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637424000029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:53:12Z","timestamp":1761087192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637424000029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":34,"alternative-id":["S1096637424000029"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2024.101572","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth hormone directly stimulates GATA2 expression","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2024.101572","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101572"}}