{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:54:18Z","timestamp":1771505658622,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone & IGF Research"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ghir.2024.101605","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T14:46:29Z","timestamp":1722005189000},"page":"101605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Adult patients with Laron syndrome tend to develop the metabolic syndrome"],"prefix":"10.1016","volume":"78","author":[{"given":"Zvi","family":"Laron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivka","family":"Kauli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avivah","family":"Silbergeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2024.101605_bb0005","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1172\/JCI111776","article-title":"Hyperinsulinemia. A link between hypertension obesity and glucose intolerance","volume":"75","author":"Modan","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ghir.2024.101605_bb0010","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","article-title":"Banting lecture 1988. Role of insulin resistance in human disease","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes"},{"key":"10.1016\/j.ghir.2024.101605_bb0015","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1053\/j.gastro.2007.03.052","article-title":"The epidemiology of obesity","volume":"132","author":"Ogden","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ghir.2024.101605_bb0020","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","article-title":"Metabolic syndrome-a new world-wide definition, a consensus statement from the international diabetes federation","volume":"23","author":"Alberti","year":"2006","journal-title":"Diabet. Med."},{"key":"10.1016\/j.ghir.2024.101605_bb0025","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ecl.2004.03.005","article-title":"The metabolic syndrome: prevalence in worldwide populations","volume":"33","author":"Cameron","year":"2004","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"10.1016\/j.ghir.2024.101605_bb0030","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1464-5491.1999.00059.x","article-title":"Comment on the provisional report from the WHO consultation, European Group for the Study of insulin resistance (EGIR)","volume":"16","author":"Balkau","year":"1999","journal-title":"Diabet. Med."},{"key":"10.1016\/j.ghir.2024.101605_bb0035","first-page":"237","article-title":"American College of Endocrinology position statement on the insulin resistance syndrome","volume":"2","author":"Einhorn","year":"2003","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.ghir.2024.101605_bb0040","first-page":"41","article-title":"Growth hormone and the metabolic syndrome","volume":"22","author":"Johannsson","year":"1999","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.ghir.2024.101605_bb0045","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11102-020-01048-w","article-title":"Metabolic syndrome and its components in adult hypopituitary patients","volume":"23","author":"Abe","year":"2020","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2024.101605_bb0050","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1530\/EJE-06-0699","article-title":"The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH","volume":"156","author":"van der Klaauw","year":"2007","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2024.101605_bb0055","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1530\/EC-18-0096","article-title":"The prevalence of the metabolic syndrome and associated cardiovascular complications in adult-onset GHD during GH replacement: a KIMS analysis","volume":"7","author":"Verhelst","year":"2018","journal-title":"Endocrol. Connect."},{"key":"10.1016\/j.ghir.2024.101605_bb0060","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1210\/jc.2003-031033","article-title":"Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958-2003","volume":"89","author":"Laron","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2024.101605_bb0065","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1073\/pnas.86.20.8083","article-title":"Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism","volume":"86","author":"Godowski","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ghir.2024.101605_bb0070","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJM198910123211501","article-title":"Laron dwarfism and mutations of the growth hormone-receptor gene","volume":"321","author":"Amselem","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2024.101605_bb0075","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000183762","article-title":"Body fat in Laron syndrome patients: effect of insulin-like growth factor I treatment","volume":"40","author":"Laron","year":"1993","journal-title":"Horm. Res."},{"key":"10.1016\/j.ghir.2024.101605_bb0080","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ghir.2015.08.004","article-title":"Fifty seven years of follow-up of the Israeli cohort of Laron syndrome patients \u2013 from discovery to treatment","volume":"28","author":"Laron","year":"2016","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2024.101605_bb0085","series-title":"Review of Methods for Body Composition Assessment in Children","first-page":"461","author":"Wells","year":"2007"},{"key":"10.1016\/j.ghir.2024.101605_bb0090","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/adc.50.2.142","article-title":"Revised standards for triceps and subscapular skinfolds in British children","volume":"50","author":"Tanner","year":"1975","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ghir.2024.101605_bb0095","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1016\/j.orcp.2012.11.001","article-title":"Biphasic response of subscapular skinfold thickness to hGH or IGF-1 administration to patients with congenital IGHD, congenital MPHD and Laron syndrome","volume":"8","author":"Bisker-Kassif","year":"2014","journal-title":"Obes. Res. Clin. Pract."},{"key":"10.1016\/j.ghir.2024.101605_bb0100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000185429","article-title":"Muscle force and endurance in untreated and human growth hormone or insulin-like growth factor 1 - treated patients with growth hormone deficiency or Laron syndrome","volume":"47","author":"Brat","year":"1997","journal-title":"Horm. Res."},{"key":"10.1016\/j.ghir.2024.101605_bb0105","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1210\/jc.2003-030623","article-title":"Are adult patients with Laron syndrome osteopenic? A comparison between dual-energy X-ray absorptiometry and volumetric bone densities","volume":"88","author":"BenBassat","year":"2003","journal-title":"J. Clin. Endocinol. Metab."},{"key":"10.1016\/j.ghir.2024.101605_bb0110","first-page":"113","article-title":"Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity)","volume":"65","author":"Laron","year":"2006","journal-title":"Clin Edocrinol. A"},{"key":"10.1016\/j.ghir.2024.101605_bb0115","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ghir.2008.03.003","article-title":"Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion \u2013 preliminary report","volume":"18","author":"Laron","year":"2008","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2024.101605_bb0120","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1515\/JPEM.1998.11.5.653","article-title":"Serum leptin in obese patients with Laron syndrome before and during IGF-1 treatment","volume":"11","author":"Laron","year":"1998","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2024.101605_bb0125","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1530\/EJE-09-0419","article-title":"Total and high molecular weight adiponectin are elevated in patients with Laron syndrome despite marked obesity","volume":"161","author":"Kanety","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2024.101605_bb0130","series-title":"Laron Syndrome","first-page":"343","article-title":"IGF-1 treatment of patients with Laron syndrome","author":"Laron","year":"2011"},{"key":"10.1016\/j.ghir.2024.101605_bb0135","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2265.1994.tb01829.x","article-title":"IGF-I treatment of adult patients with Laron syndrome: preliminary results","volume":"41","author":"Laron","year":"1994","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2024.101605_bb0140","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1055\/s-0028-1094068","article-title":"Glucose tolerance and insulin secretion in parents and children with familial dwarfism and high plasma immunoreactive growth hormone (IR-HGH) and familial isolated growth hormone deficiency","volume":"4","author":"Karp","year":"1972","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.ghir.2024.101605_bb0145","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0026-0495(95)90231-7","article-title":"Carbohydrate metabolism in primary GH resistance (Laron syndrome) before and during insulin-like growth factor-1 treatment","volume":"44","author":"Laron","year":"1995","journal-title":"Metabolism"},{"key":"10.1016\/j.ghir.2024.101605_bb0150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1530\/eje.0.1510103","article-title":"Diabetic retinopathy in two patient\u2019s with congenital IGF-1 deficiency (Laron syndrome)","volume":"151","author":"Laron","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2024.101605_bb0155","series-title":"Laron Syndrome Patients \u2013 From Man to Mouse","first-page":"293","article-title":"Cardiovascular Aspects","author":"Scheinowitz","year":"2011"},{"key":"10.1016\/j.ghir.2024.101605_bb0160","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.CIR.0000027563.44593.CC","article-title":"Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study","volume":"106","author":"Juul","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ghir.2024.101605_bb0165","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2337\/dc08-s240","article-title":"Natural history of cardiovascular disease in patients with diabetes: role of hyperglycemia","volume":"31","author":"Milicevic","year":"2008","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.ghir.2024.101605_bb0170","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.medj.2024.03.022","article-title":"Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency","volume":"5","author":"Guevara-Aguirre","year":"2024","journal-title":"Med"},{"key":"10.1016\/j.ghir.2024.101605_bb0175","first-page":"1","article-title":"GLP-1 receptor agonists: an updated review of head-to-head clinical studies, Ther","volume":"12","author":"Trujillo","year":"2021","journal-title":"Adv. Endocrinol. Metab."}],"container-title":["Growth Hormone & IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637424000352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637424000352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:35:05Z","timestamp":1726360505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637424000352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":35,"alternative-id":["S1096637424000352"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2024.101605","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adult patients with Laron syndrome tend to develop the metabolic syndrome","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2024.101605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101605"}}