{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:23:44Z","timestamp":1789503824805,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["09\/114(0217)2019-EMR-I"],"award-info":[{"award-number":["09\/114(0217)2019-EMR-I"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone & IGF Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ghir.2025.101638","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T16:31:45Z","timestamp":1740069105000},"page":"101638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Picropodophyllotoxin alters EMT in neuroblastoma via inhibition of surface receptors IGF1R and ALK"],"prefix":"10.1016","volume":"80","author":[{"given":"Poonam","family":"Bhagriya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afridi","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hetal","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2025.101638_bb0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.14715\/cmb\/2022.68.6.19","article-title":"Regulations of LINC0196\/miR-584-5p\/miR-34a-5p\/TRIM59 on progression of pediatric neuroblastoma","volume":"68","author":"Xie","year":"2022","journal-title":"Cell. Mol. Biol. (Noisy-Le-Grand)"},{"key":"10.1016\/j.ghir.2025.101638_bb0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejca.2019.09.025","article-title":"Neuroblastoma between 1990 and 2014 in the Netherlands: increased incidence and improved survival of high-risk neuroblastoma","volume":"124","author":"Tas","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ghir.2025.101638_bb0015","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3892\/mmr.2014.2258","article-title":"Insulin-like growth factors in embryonic and fetal growth and skeletal development (review)","volume":"10","author":"Agrogiannis","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ghir.2025.101638_bb0020","first-page":"3","article-title":"Insulin-like growth factors and their binding proteins: biological actions","volume":"16","author":"Jones","year":"1995","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ghir.2025.101638_bb0025","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1158\/0008-5472.CAN-05-1448","article-title":"Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to bone","volume":"66","author":"Van Golen","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.ghir.2025.101638_bb0030","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/1471-2407-9-314","article-title":"Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605","volume":"9","author":"Pappano","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ghir.2025.101638_bb0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10555-021-10001-7","article-title":"Systematic review of the receptor tyrosine kinase superfamily in neuroblastoma pathophysiology","volume":"41","author":"Rozen","year":"2022","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.ghir.2025.101638_bb0040","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.2147\/CMAR.S196862","article-title":"IGF1R facilitates epithelial-mesenchymal transition and cancer stem cell properties in neuroblastoma via the STAT3\/AKT axis","volume":"11","author":"Wang","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.ghir.2025.101638_bb0045","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/sj.onc.1206924","article-title":"Insulin-like growth factor-I signaling in human neuroblastoma cells","volume":"23","author":"Kim","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ghir.2025.101638_bb0050","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/apm.12940","article-title":"Targeting anaplastic lymphoma kinase in neuroblastoma","volume":"127","author":"Umapathy","year":"2019","journal-title":"APMIS"},{"key":"10.1016\/j.ghir.2025.101638_bb0055","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature07398","article-title":"Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma","volume":"455","author":"Janoueix-Lerosey","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ghir.2025.101638_bb0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/BJ20081834","article-title":"High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours","volume":"416","author":"Car\u00e9n","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.ghir.2025.101638_bb0065","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nature07261","article-title":"Identification of ALK as a major familial neuroblastoma predisposition gene","volume":"455","author":"Moss\u00e9","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ghir.2025.101638_bb0070","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nature07397","article-title":"Activating mutations in ALK provide a therapeutic target in neuroblastoma","volume":"455","author":"George","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ghir.2025.101638_bb0075","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nature07399","article-title":"Oncogenic mutations of ALK kinase in neuroblastoma","volume":"455","author":"Chen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ghir.2025.101638_bb0080","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/med.21750","article-title":"Molecular targeting therapies for neuroblastoma: Progress and challenges","volume":"41","author":"Zafar","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ghir.2025.101638_bb0085","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10637-018-0574-0","article-title":"A phase 2 study of OSI-906 (linsitinib, an insulin-like growth factor receptor-1 inhibitor) in patients with asymptomatic or mildly symptomatic (non-opioid requiring) metastatic castrate resistant prostate cancer (CRPC)","volume":"36","author":"Barata","year":"2018","journal-title":"Investig. New Drugs"},{"key":"10.1016\/j.ghir.2025.101638_bb0090","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1634\/theoncologist.2018-0380","article-title":"Clinical Management of Adverse Events Associated with Lorlatinib","volume":"24","author":"Bauer","year":"2019","journal-title":"Oncologist"},{"key":"10.1016\/j.ghir.2025.101638_bb0095","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/S1470-2045(21)00536-2","article-title":"Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study","volume":"22","author":"Fischer","year":"2021","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ghir.2025.101638_bb0100","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.18632\/oncotarget.2292","article-title":"Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via insulin-like growth factor-1 receptor-independent mechanism","volume":"5","author":"Waraky","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.ghir.2025.101638_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-017-3495-y","article-title":"Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo","volume":"17","author":"Tarnowski","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ghir.2025.101638_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033581","article-title":"Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment","volume":"7","author":"Mazot","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ghir.2025.101638_bb0125","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.3389\/fendo.2020.620013","article-title":"Controlled signaling\u2014insulin-like growth factor receptor endocytosis and presence at intracellular compartments","volume":"11","author":"Rieger","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ghir.2025.101638_bb0130","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a001115","article-title":"ALK: a tyrosine kinase target for cancer therapy","volume":"3","author":"Holla","year":"2017","journal-title":"Mol. Case Stud."},{"key":"10.1016\/j.ghir.2025.101638_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161158","article-title":"IGF1R derived PI3K\/AKT signaling maintains growth in a subset of human T-cell acute lymphoblastic leukemias","volume":"11","author":"Gusscott","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ghir.2025.101638_bb0140","first-page":"3951","article-title":"Bioinformatics analysis of the CDK2 functions in neuroblastoma","volume":"17","author":"Bo","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ghir.2025.101638_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22062935","article-title":"Cyclin-dependent kinases (CDK) and their role in diseases development\u2013review","volume":"22","author":"\u0141ukasik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ghir.2025.101638_bb0150","first-page":"1","article-title":"A review on the role of cyclin dependent kinases in cancers","volume":"22","author":"Ghafouri-Fard","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ghir.2025.101638_bb0155","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1021\/acs.jmedchem.7b00901","article-title":"Cyclin-dependent kinase 8: a new hope in targeted cancer therapy?","volume":"61","author":"Philip","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ghir.2025.101638_bb0160","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.3892\/mmr.2020.11585","article-title":"Capsaicin suppresses breast cancer cell viability by regulating the CDK8\/PI3K\/Akt\/Wnt\/\u03b2-catenin signaling pathway","volume":"22","author":"Wu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ghir.2025.101638_bb0165","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.molonc.2015.11.005","article-title":"Novel pharmacodynamic biomarkers for MYCN protein and PI3K\/AKT\/mTOR pathway signaling in children with neuroblastoma","volume":"10","author":"Smith","year":"2016","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.ghir.2025.101638_bb0170","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jcp.10352","article-title":"Urokinase type plasminogen activator receptor is involved in insulin-like growth factor-induced migration of rhabdomyosarcoma cells in vitro","volume":"197","author":"Gallicchio","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ghir.2025.101638_bb0175","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.3892\/ijo.2015.2906","article-title":"5-Azacytidine inhibits human rhabdomyosarcoma cell growth by downregulating insulin-like growth factor 2 expression and reactivating the H19 gene product miR-675, which negatively affects insulin-like growth factors and insulin signaling","volume":"46","author":"Tarnowski","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ghir.2025.101638_bb0180","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-016-0576-5","article-title":"IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights","volume":"16","author":"Li","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ghir.2025.101638_bb0185","first-page":"1","article-title":"Role of IGF-1R in ameliorating apoptosis of GNE deficient cells","volume":"8","author":"Singh","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ghir.2025.101638_bb0190","article-title":"Co-targeting IGF-1R and autophagy enhances the effects of cell growth suppression and apoptosis induced by the IGF-1R inhibitor NVP-AEW541 in triple-negative breast cancer cells","volume":"12","author":"Wu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ghir.2025.101638_bb0195","first-page":"44","article-title":"PQ401, an IGF-1R inhibitor, induces apoptosis and inhibits growth, proliferation and migration of glioma cells","volume":"28","author":"Zhou","year":"2016"},{"key":"10.1016\/j.ghir.2025.101638_bb0200","first-page":"9","article-title":"Chemoprevention of neuroblastoma: progress and promise beyond uncertainties","volume":"9","author":"Aravindan","year":"2023","journal-title":"J. Cancer Metastasis Treat."},{"key":"10.1016\/j.ghir.2025.101638_bb0205","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.4014\/jmb.2109.09012","article-title":"Picropodophyllotoxin induces G1 cell cycle arrest and apoptosis in human colorectal cancer cells via ROS generation and activation of p38 MAPK signaling pathway","volume":"31","author":"Lee","year":"2021","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.ghir.2025.101638_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-017-3495-y","article-title":"Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo","volume":"17","author":"Tarnowski","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ghir.2025.101638_bb0215","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.3109\/10428194.2013.862241","article-title":"Inhibition of type I insulin-like growth factor receptor tyrosine kinase by picropodophyllin induces apoptosis and cell cycle arrest in T lymphoblastic leukemia\/lymphoma","volume":"55","author":"Huang","year":"2014","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.ghir.2025.101638_bb0120","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1182\/blood-2005-01-0293","article-title":"Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model","volume":"107","author":"Menu","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ghir.2025.101638_bb0220","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-017-3495-y","article-title":"Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo","volume":"17","author":"Tarnowski","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ghir.2025.101638_bb0225","first-page":"916","article-title":"Emerging roles of Cdk8 in cell cycle control","volume":"2013","author":"Szilagyi","year":"1829","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ghir.2025.101638_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/cells5020016","article-title":"The NF-\u03baB pathway and cancer stem cells","volume":"5","author":"Rinkenbaugh","year":"2016","journal-title":"Cells"},{"key":"10.1016\/j.ghir.2025.101638_bb0235","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ccell.2016.01.002","article-title":"Exploitation of the apoptosis-primed state of MYCN-amplified neuroblastoma to develop a potent and specific targeted therapy combination","volume":"29","author":"Ham","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ghir.2025.101638_bb0240","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1038\/s41388-022-02376-w","article-title":"IGF1R acts as a cancer-promoting factor in the tumor microenvironment facilitating lung metastasis implantation and progression","volume":"41","author":"Alfaro-Arnedo","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.ghir.2025.101638_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020448","article-title":"Apoptosis: a target for anticancer therapy","volume":"19","author":"Pfeffer","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ghir.2025.101638_bb0250","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026104","article-title":"The cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression","volume":"6","author":"Chen","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ghir.2025.101638_bb0255","series-title":"BAX Gene, Definitions","author":"Carpenter","year":"2023"},{"issue":"1","key":"10.1016\/j.ghir.2025.101638_bb0260","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/cdd.2017.186","article-title":"BCL-2 family proteins: changing partners in the dance towards death","volume":"25","author":"Kale","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ghir.2025.101638_bb0265","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot4493","article-title":"Acridine orange\/ethidium bromide (AO\/EB) staining to detect apoptosis","author":"Kasibhatla","year":"2006","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1016\/j.ghir.2025.101638_bb0270","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-015-0578-y","article-title":"A phase I pilot study of the insulin-like growth factor 1 receptor pathway modulator AXL1717 in combination with gemcitabine HCl and carboplatin in previously untreated, locally advanced, or metastatic non-small cell lung cancer","volume":"32","author":"Holgersson","year":"2015","journal-title":"Med. Oncol."}],"container-title":["Growth Hormone & IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637425000024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637425000024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T07:50:36Z","timestamp":1741593036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637425000024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":53,"alternative-id":["S1096637425000024"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2025.101638","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Picropodophyllotoxin alters EMT in neuroblastoma via inhibition of surface receptors IGF1R and ALK","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2025.101638","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101638"}}