{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:19:46Z","timestamp":1763464786215,"version":"3.45.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ghir.2025.101667","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:41:15Z","timestamp":1761090075000},"page":"101667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The effect of treatment with somatostatin analogs in children with neurofibromatosis type 1 and growth hormone excess"],"prefix":"10.1016","volume":"82","author":[{"given":"Sofie Skov","family":"Koch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan Frederik","family":"Carlsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilie","family":"Ejerskov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Feldt-Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina M.","family":"Main","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Sehested","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Mathiasen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Linea","family":"von Holstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stense","family":"Farholt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke Beck","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ghir.2025.101667_bb0005","first-page":"160","article-title":"An epidemiological, clinical and genetic survey of Neurofibromatosis type 1 in children under sixteen years of age","volume":"77","author":"McKeever","year":"2008","journal-title":"Ulster Med. J."},{"issue":"8","key":"10.1016\/j.ghir.2025.101667_bb0010","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/s41436-021-01170-5","article-title":"Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation","volume":"23","author":"Legius","year":"2021","journal-title":"Genet. Med."},{"key":"10.1016\/j.ghir.2025.101667_bb0015","first-page":"1","article-title":"Neurofibromatosis 1","author":"Friedman","year":"1998","journal-title":"GeneReviews"},{"issue":"1","key":"10.1016\/j.ghir.2025.101667_bb0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/WNO.0000000000000550","article-title":"Optic pathway gliomas in Neurofibromatosis type 1: an update: surveillance, treatment indications, and biomarkers of vision","volume":"37","author":"de Blank","year":"2017","journal-title":"J. Neuroophthalmol."},{"issue":"3","key":"10.1016\/j.ghir.2025.101667_bb0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000458525","article-title":"Endocrine long-term follow-up of children with Neurofibromatosis type 1 and optic pathway glioma","volume":"87","author":"Sani","year":"2017","journal-title":"Horm. Res. Paediatr."},{"issue":"4","key":"10.1016\/j.ghir.2025.101667_bb0030","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3171\/jns.1994.81.4.0595","article-title":"Optic pathway glioma infiltrating into somatostatinergic pathways in a young boy with gigantism","volume":"81","author":"Manski","year":"1994","journal-title":"J. Neurosurg."},{"issue":"6","key":"10.1016\/j.ghir.2025.101667_bb0035","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1542\/peds.103.6.1257","article-title":"Growth, puberty, and endocrine functions in patients with sporadic or familial Neurofibromatosis type 1: a longitudinal study","volume":"103","author":"Carmi","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.ghir.2025.101667_bb0040","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1096-8628(19991203)87:4<317::AID-AJMG7>3.0.CO;2-X","article-title":"Neurofibromatosis type 1 growth charts","volume":"87","author":"Clementi","year":"1999","journal-title":"Am. J. Med. Genet."},{"issue":"3","key":"10.1016\/j.ghir.2025.101667_bb0045","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jpeds.2010.09.013","article-title":"Growth hormone excess in children with neurofibromatosis type 1-associated and sporadic optic pathway tumors","volume":"158","author":"Josefson","year":"2011","journal-title":"J. Pediatr."},{"issue":"3","key":"10.1016\/j.ghir.2025.101667_bb0050","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1469-8749.1983.tb13774.x","article-title":"Optic gliomata affecting twins with neurofibromatosis","volume":"25","author":"Crawford","year":"1983","journal-title":"Dev. Med. Child Neurol."},{"issue":"3","key":"10.1016\/j.ghir.2025.101667_bb0055","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/ana.410150318","article-title":"Hypothalamic mass and gigantism in Neurofibromatosis: treatment with bromocriptine","volume":"15","author":"Duchowny","year":"1984","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ghir.2025.101667_bb0060","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1177\/000992289803701207","article-title":"Growth hormone excess in a child with Neurofibromatosis type 1 and optic pathway tumor: a patient report","volume":"37","author":"Fuqua","year":"1998","journal-title":"Clin. Pediatr. (Phila)"},{"key":"10.1016\/j.ghir.2025.101667_bb0065","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1365-2265.2000.01041.x","article-title":"Case report 535 gigantism due to growth hormone excess in a boy with optic glioma","volume":"53","author":"Drimmie","year":"2000","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2025.101667_bb0070","first-page":"305","article-title":"Case report growth hormone hypersecretion in a girl with Neurofibromatosis type 1 and an optic nerve glioma: resolution following chemotherapy","volume":"53","author":"Drake","year":"2000","journal-title":"Horm. Res."},{"issue":"1","key":"10.1016\/j.ghir.2025.101667_bb0075","first-page":"1","article-title":"Pegvisomant treatment in a 4-year-old girl with neurofibromatosis type 1","volume":"65","author":"Main","year":"2006","journal-title":"Horm. Res."},{"key":"10.1016\/j.ghir.2025.101667_bb0080","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/ajmg.a.38308","article-title":"Growth hormone excess in children with neurofibromatosis type-1 and optic glioma","volume":"173A","author":"Cambiaso","year":"2017","journal-title":"Am. J. Med. Genet."},{"issue":"6","key":"10.1016\/j.ghir.2025.101667_bb0085","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1159\/000440956","article-title":"Reversible growth hormone excess in two girls with Neurofibromatosis type 1 and optic pathway glioma","volume":"84","author":"Bruzzi","year":"2015","journal-title":"Horm. Res. Paediatr."},{"issue":"8","key":"10.1016\/j.ghir.2025.101667_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11082168","article-title":"Neurofibromatosis type 1 has a wide Spectrum of growth hormone excess","volume":"11","author":"Hannah-Shmouni","year":"2022","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.ghir.2025.101667_bb0095","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000447326","article-title":"Growth hormone excess in children with optic pathway tumors is a transient phenomenon","volume":"86","author":"Josefson","year":"2016","journal-title":"Horm. Res. Paediatr."},{"issue":"5","key":"10.1016\/j.ghir.2025.101667_bb0100","first-page":"575","article-title":"Conference Statement. National Institutes of Health consensus development Conference","volume":"45","author":"Neurofibromatosis","year":"1998","journal-title":"Arch. Neurol."},{"issue":"2","key":"10.1016\/j.ghir.2025.101667_bb0105","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/apa.12468","article-title":"The 2014 Danish references from birth to 20 years for height, weight and body mass index","volume":"103","author":"Tinggaard","year":"2014","journal-title":"Acta Paediatr."},{"issue":"4","key":"10.1016\/j.ghir.2025.101667_bb0110","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.2047-6310.2012.00064.x","article-title":"Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity","volume":"7","author":"Cole","year":"2012","journal-title":"Pediatr. Obes."},{"issue":"3","key":"10.1016\/j.ghir.2025.101667_bb0115","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000497214","article-title":"Growth hormone response to Oral glucose load: from Normal to pathological conditions","volume":"108","author":"Hage","year":"2019","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ghir.2025.101667_bb0120","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1259\/bjr\/65246351","article-title":"Radiological classification of optic pathway gliomas: experience of a modified functional classification system","volume":"81","author":"Taylor","year":"2008","journal-title":"Br. J. Radiol."},{"issue":"4","key":"10.1016\/j.ghir.2025.101667_bb0125","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1542\/peds.100.4.667","article-title":"Endocrinologic disorders and optic pathway gliomas in children with neurofibromatosis type 1","volume":"100","author":"Cnossen","year":"1997","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.ghir.2025.101667_bb0130","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1210\/clinem\/dgaa138","article-title":"Pretreatment endocrine disorders due to optic pathway gliomas in pediatric neurofibromatosis type 1: multicenter study","volume":"105","author":"Santoro","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.ghir.2025.101667_bb0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/S1807-59322008000100008","article-title":"Identification of growth hormone receptor in plexiform neurofibromas of patients with neurofibromatosis type 1","volume":"63","author":"Cunha","year":"2008","journal-title":"Clinics"},{"issue":"3","key":"10.1016\/j.ghir.2025.101667_bb0140","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12672-018-0328-7","article-title":"Type 1 IGF receptor localization in Paediatric gliomas: significant association with WHO grading and clinical outcome","volume":"9","author":"Cl\u00e9ment","year":"2018","journal-title":"Horm Cancer"}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637425000310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637425000310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:16:31Z","timestamp":1763464591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637425000310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":28,"alternative-id":["S1096637425000310"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2025.101667","relation":{},"ISSN":["1096-6374"],"issn-type":[{"type":"print","value":"1096-6374"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of treatment with somatostatin analogs in children with neurofibromatosis type 1 and growth hormone excess","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2025.101667","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101667"}}