{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:01:34Z","timestamp":1784808094647,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","giejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastrointestinal Endoscopy"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.gie.2010.04.001","type":"journal-article","created":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T04:23:48Z","timestamp":1278044628000},"page":"406-412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Split dosing of bowel preparations for colonoscopy: an analysis of its efficacy, safety, and tolerability"],"prefix":"10.1016","volume":"72","author":[{"given":"Lawrence B.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gie.2010.04.001_bib1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1067\/mge.2003.294","article-title":"Impact of colonoscopy preparation quality on detection of suspected colonic neoplasia","volume":"58","author":"Harewood","year":"2003","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0016-5107(04)02776-2","article-title":"Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European Panel of Appropriateness of Gastrointestinal Endoscopy European multicenter study","volume":"61","author":"Froehlich","year":"2005","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/01.SGA.0000310933.54551.ca","article-title":"Key safety issues of bowel preparations for colonoscopy and importance of adequate hydration","volume":"31","author":"Dykes","year":"2008","journal-title":"Gastroenterol Nurs"},{"key":"10.1016\/j.gie.2010.04.001_bib4","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0016-5085(80)90781-7","article-title":"Development of a lavage solution associated with minimal water and electrolyte absorption or secretion","volume":"78","author":"Davis","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gie.2010.04.001_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0016-5085(90)91284-D","article-title":"A low-sodium solution for gastrointestinal lavage","volume":"98","author":"Fordtran","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gie.2010.04.001_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0016-5107(98)70351-7","article-title":"Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation","volume":"47","author":"Sharma","year":"1998","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF02048160","article-title":"Bisacodyl reduces the volume of polyethylene glycol solution required for bowel preparation","volume":"37","author":"Adams","year":"1994","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2010.04.001_bib8","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1572-0241.2007.01708.x","article-title":"Randomized trial of low-volume PEG solution versus standard PEG + electrolytes for bowel cleansing before colonoscopy","volume":"103","author":"Ell","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2010.04.001_bib9","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/j.1365-2036.2006.03167.x","article-title":"Results of a prospective randomised multicentre controlled trial comparing a new 2-L ascorbic acid plus polyethylene glycol and electrolyte solution vs. sodium phosphate solution in patients undergoing elective colonoscopy","volume":"24","author":"Bitoun","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.gie.2010.04.001_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1463-1318.2006.00970.x","article-title":"Which is the optimal bowel preparation for colonoscopy\u2014a meta-analysis","volume":"8","author":"Tan","year":"2006","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.gie.2010.04.001_bib11","first-page":"422","article-title":"A randomized prospective trial comparing oral sodium phosphate with standard polyethylene glycol-based lavage solution (Golytely) in the preparation of patients for colonoscopy","volume":"85","author":"Vanner","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2010.04.001_bib12","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1055\/s-2002-33207","article-title":"Two liters of polyethylene glycol-electrolyte lavage solution versus sodium phosphate as bowel cleansing regimen for colonoscopy: a prospective randomized controlled trial","volume":"34","author":"Poon","year":"2002","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2010.04.001_bib13","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/BF02054413","article-title":"Prospective, randomized, endoscopic-blinded trial comparing precolonoscopy bowel cleansing methods","volume":"37","author":"Cohen","year":"1994","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2010.04.001_bib14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0016-5107(95)70098-6","article-title":"Single-day, divided-dose oral sodium phosphate laxative versus intestinal lavage as preparation for colonoscopy: efficacy and patient tolerance","volume":"42","author":"Henderson","year":"1995","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib15","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1007\/BF02236740","article-title":"Oral sodium phosphate solution is a superior colonoscopy preparation to polyethylene glycol with bisacodyl","volume":"43","author":"Young","year":"2000","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2010.04.001_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0016-5107(91)70668-8","article-title":"Prospective blinded trial of the colonoscopic miss-rate of large colorectal polyps","volume":"37","author":"Hixson","year":"1991","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0016-5085(97)70214-2","article-title":"Colonoscopic miss rates of adenomas determined by back-to-back colonoscopies","volume":"112","author":"Rex","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gie.2010.04.001_bib18","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1056\/NEJMoa031618","article-title":"Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults","volume":"349","author":"Pickhardt","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gie.2010.04.001_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.gastro.2004.03.055","article-title":"Computed tomographic colonography compared with colonoscopy in patients at increased risk for colorectal cancer","volume":"127","author":"Van Gelder","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gie.2010.04.001_bib20","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa0800996","article-title":"Accuracy of CT colonography for detection of large adenomas and cancers","volume":"359","author":"Johnson","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gie.2010.04.001_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1136\/gut.2007.128926","article-title":"Narrow band imaging for colonoscopic surveillance in hereditary non-polyposis colorectal cancer","volume":"57","author":"East","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.gie.2010.04.001_bib22","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.gie.2007.07.036","article-title":"Narrow-band imaging colonoscopy\u2014a pilot feasibility study for the detection of polyps and correlation of surface patterns with polyp histologic diagnosis","volume":"67","author":"Rastogi","year":"2008","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib23","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJM200004203421601","article-title":"Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas","volume":"342","author":"Schatzkin","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gie.2010.04.001_bib24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1053\/j.gastro.2005.05.012","article-title":"Colorectal cancer in patients under close colonoscopic surveillance","volume":"129","author":"Robertson","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gie.2010.04.001_bib25","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1056\/NEJM199312303292701","article-title":"Prevention of colorectal cancer by colonoscopic polypectomy","volume":"329","author":"Winawer","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gie.2010.04.001_bib26","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1001\/jama.295.20.2366","article-title":"Risk of developing colorectal cancer following a negative colonoscopy examination: evidence for a 10-year interval between colonoscopies","volume":"295","author":"Singh","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.gie.2010.04.001_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-150-1-200901060-00306","article-title":"Association of colonoscopy and death from colorectal cancer","volume":"150","author":"Baxter","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.gie.2010.04.001_bib28","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/ajg.2009.104","article-title":"American College of Gastroenterology guidelines for colorectal cancer screening 2009","volume":"104","author":"Rex","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2010.04.001_bib29","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1572-0241.2006.00673.x","article-title":"Quality indicators for colonoscopy","volume":"101","author":"Rex","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2010.04.001_bib30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF02055690","article-title":"Cleansing ability and tolerance of three bowel preparations for colonoscopy","volume":"40","author":"Frommer","year":"1997","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2010.04.001_bib31","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/BF02258217","article-title":"Effectiveness of polyethylene glycol antegrade gut lavage bowel preparation for colonoscopy\u2014timing is the key!","volume":"41","author":"Church","year":"1998","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2010.04.001_bib32","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.gie.2005.09.030","article-title":"A randomized prospective trial comparing different regimens of oral sodium phosphate and polyethylene glycol\u2013based lavage solution in the preparation of patients for colonoscopy","volume":"64","author":"Rostom","year":"2006","journal-title":"Gastrointest Endosc"},{"issue":"suppl 3","key":"10.1016\/j.gie.2010.04.001_bib33","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.gie.2008.09.047","article-title":"Duration of the interval between the completion of bowel preparation and the start of colonoscopy predicts bowel-preparation quality","volume":"69","author":"Siddiqui","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib34","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1111\/j.1572-0241.2006.00868.x","article-title":"The impact of colon preparation timing on colonoscopic detection of colorectal neoplasms\u2014a prospective endoscopist-blinded randomized trial","volume":"101","author":"Chiu","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2010.04.001_bib35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1067\/mge.2003.318","article-title":"A randomized single-blind trial of whole versus split-dose polyethylene glycol-electrolyte solution for colonoscopy preparation","volume":"58","author":"El Sayed","year":"2003","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib36","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1055\/s-2007-966434","article-title":"Quality and effect of single dose versus split dose of polyethylene glycol bowel preparation for early-morning colonoscopy","volume":"39","author":"Park","year":"2007","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2010.04.001_bib37","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1055\/s-2007-966375","article-title":"Comparison of two schedules (previous evening versus same morning) of bowel preparation for colonoscopy","volume":"39","author":"Gupta","year":"2007","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2010.04.001_bib38","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.gie.2008.01.044","article-title":"A randomized, controlled, double-blind trial of the adjunct use of tegaserod in whole-dose or split-dose polyethylene glycol electrolyte solution for colonoscopy preparation","volume":"68","author":"Abdul-Baki","year":"2008","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib39","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0016-5107(05)00371-8","article-title":"A randomized single-blind trial of split-dose PEG-electrolyte solution without dietary restriction compared with whole dose PEG-electrolyte solution with dietary restriction for colonoscopy preparation","volume":"62","author":"Aoun","year":"2005","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1067\/mge.2002.125361","article-title":"Low-volume oral colonoscopy bowel preparation: sodium phosphate and magnesium citrate","volume":"56","author":"Berkelhammer","year":"2002","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib41","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.3748\/wjg.v12.i38.6161","article-title":"The timing of bowel preparation before colonoscopy determines the quality of cleansing, and is a significant factor contributing to the detection of flat lesions: a randomized study","volume":"12","author":"Parra-Blanco","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.gie.2010.04.001_bib42","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.gie.2006.07.047","article-title":"Residue-free sodium phosphate tablets (OsmoPrep) versus Visicol for colon cleansing: a randomized, investigator-blinded trial","volume":"65","author":"Wruble","year":"2007","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2010.04.001_bib43","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1038\/ajg.2009.389","article-title":"A randomized clinical study evaluating the safety and efficacy of a new, reduced-volume, oral sulfate colon-cleansing preparation for colonoscopy","volume":"104","author":"Di Palma","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2010.04.001_bib44","first-page":"e260","article-title":"The time course and effect on serum electrolytes of oral sodium phosphates solution in healthy male and female volunteers","volume":"14","author":"Caswell","year":"2007","journal-title":"Can J Clin Pharmacol"},{"issue":"suppl","key":"10.1016\/j.gie.2010.04.001_bib45","doi-asserted-by":"crossref","first-page":"AB246","DOI":"10.1016\/j.gie.2008.03.649","article-title":"Patient acceptance, convenience and efficacy of one-day versus two-day colonoscopy bowel preparation","volume":"67","author":"Khan","year":"2008","journal-title":"Gastrointest Endosc"},{"issue":"suppl 20","key":"10.1016\/j.gie.2010.04.001_bib46","first-page":"1","article-title":"Current issues in optimal bowel preparation: excerpts from a roundtable discussion among colon-cleansing experts","volume":"5","author":"Cohen","year":"2009","journal-title":"Gastroenterol and Hepatol"},{"key":"10.1016\/j.gie.2010.04.001_bib47","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/j.gastro.2007.06.002","article-title":"AGA Institute review of endoscopic sedation","volume":"133","author":"Cohen","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gie.2010.04.001_bib48","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/bja\/70.1.6","article-title":"Preoperative drinking does not affect gastric contents","volume":"70","author":"Phillips","year":"1993","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.gie.2010.04.001_bib49","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/00000542-199903000-00034","volume":"90","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.gie.2010.04.001_bib50","doi-asserted-by":"crossref","first-page":"S720","DOI":"10.14309\/00000434-200910003-01515","article-title":"Willingness to undergo split-dose bowel preparation for colonoscopy","volume":"104","author":"Rex","year":"2009","journal-title":"Am J Gastroenterol"}],"container-title":["Gastrointestinal Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016510710015087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016510710015087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:13:30Z","timestamp":1758039210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016510710015087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0016510710015087"],"URL":"https:\/\/doi.org\/10.1016\/j.gie.2010.04.001","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.722765517.793515161","asserted-by":"object"}]},"ISSN":["0016-5107"],"issn-type":[{"value":"0016-5107","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Split dosing of bowel preparations for colonoscopy: an analysis of its efficacy, safety, and tolerability","name":"articletitle","label":"Article Title"},{"value":"Gastrointestinal Endoscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gie.2010.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}