{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:08:39Z","timestamp":1787238519543,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","giejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastrointestinal Endoscopy"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.gie.2017.01.025","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T04:15:22Z","timestamp":1485836122000},"page":"1133-1143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Exploring endoscopic therapy for the treatment of Crohn\u2019s\u00a0disease\u2013related fistula and abscess"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6409-0736","authenticated-orcid":false,"given":"Bo","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gie.2017.01.025_bib1","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1056\/NEJM199905063401804","article-title":"Infliximab for the treatment of fistulas in patients with Crohn's disease","volume":"340","author":"Present","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.gie.2017.01.025_bib2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1365-2036.2010.04466.x","article-title":"The CHOICE trial: adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn's disease who failed prior infliximab therapy","volume":"32","author":"Lichtiger","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"issue":"Suppl 1","key":"10.1016\/j.gie.2017.01.025_bib3","first-page":"E261","article-title":"Endoscopic needle knife fistulotomy technique for ileal pouch-to-pouch fistula","volume":"47","author":"Chidi","year":"2015","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2017.01.025_bib4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1463-1318.2009.01811.x","article-title":"Seton drainage and fibrin glue injection for complex anal fistulas","volume":"12","author":"Parades","year":"2010","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.gie.2017.01.025_bib5","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1007\/s10350-004-7247-0","article-title":"A\u00a0randomized, controlled trial of fibrin glue vs. conventional treatment for anal fistula","volume":"45","author":"Lindsey","year":"2002","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2017.01.025_bib6","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1111\/j.1365-2036.2005.02456.x","article-title":"Long-term healing of Crohn's anal fistulas with fibrin glue injection","volume":"21","author":"Vitton","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.gie.2017.01.025_bib7","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s10350-003-0076-8","article-title":"Fibrin glue treatment of complex anal fistulas has low success rate","volume":"47","author":"Loungnarath","year":"2004","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2017.01.025_bib8","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1053\/j.gastro.2010.02.013","article-title":"Fibrin glue is effective healing perianal fistulas in patients with Crohn's disease","volume":"138","author":"Grimaud","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gie.2017.01.025_bib9","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1007\/s10350-006-0718-8","article-title":"Fibrin glue as an adjunct to flap repair of anal fistulas: a randomized, controlled study","volume":"49","author":"Ellis","year":"2006","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2017.01.025_bib10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00384-015-2281-z","article-title":"Healing of a chronic anal stump sinus after administration of combined high-concentration dextrose and doxycycline solution","volume":"31","author":"Nyabanga","year":"2016","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.gie.2017.01.025_bib11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10350-005-0288-1","article-title":"Efficacy of anal fistula plug vs. fibrin glue in closure of anorectal fistulas","volume":"49","author":"Johnson","year":"2006","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2017.01.025_bib12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/DCR.0000000000000288","article-title":"Prospective multicenter study of a synthetic bioabsorbable anal fistula plug to treat cryptoglandular transsphincteric anal fistulas","volume":"58","author":"Stamos","year":"2015","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2017.01.025_bib13","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s10350-006-0695-y","article-title":"Efficacy of anal fistula plug in closure of Crohn's anorectal fistulas","volume":"49","author":"O'Connor","year":"2006","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2017.01.025_bib14","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.jvir.2011.01.453","article-title":"Percutaneous embolization of persistent biliary and enteric fistulas with Histoacryl","volume":"22","author":"Bae","year":"2011","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.gie.2017.01.025_bib15","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1053\/j.gastro.2015.06.014","article-title":"Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn's disease","volume":"149","author":"Molendijk","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gie.2017.01.025_bib16","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0140-6736(16)31203-X","article-title":"Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial","volume":"388","author":"Pan\u00e9s","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.gie.2017.01.025_bib17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/codi.13311","article-title":"Treatment of perianal fistula in Crohn's disease: a systematic review and meta-analysis comparing seton drainage and anti-tumour necrosis factor treatment","volume":"18","author":"de Groof","year":"2016","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.gie.2017.01.025_bib18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.gie.2015.04.020","article-title":"Endoscopically placed guidewire-assisted seton for an ileal pouch-pouch fistula","volume":"82","author":"Sinh","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2017.01.025_bib19","first-page":"1833","article-title":"Endoscopic stent drainage of peripouch abscess","volume":"108","author":"Shen","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2017.01.025_bib20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10151-011-0719-z","article-title":"Endoanal ultrasonography may distinguish Crohn's anal fistulae from cryptoglandular fistulae in patients with Crohn's disease: a cross-sectional study","volume":"15","author":"Blom","year":"2011","journal-title":"Tech Coloproctol"},{"key":"10.1016\/j.gie.2017.01.025_bib21","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1097\/MIB.0000000000000409","article-title":"Use of endoscopic ultrasound to guide adalimumab treatment in perianal Crohn's disease results in faster fistula healing","volume":"21","author":"Wiese","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.gie.2017.01.025_bib22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.crohns.2011.09.001","article-title":"Endoscopic ultrasound for perianal Crohn's disease: disease and fistula characteristics, and impact on therapy","volume":"6","author":"Lahat","year":"2012","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.gie.2017.01.025_bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4293\/108680813X13693422521999","article-title":"Healing of complicated gastric leaks in bariatric patients using endoscopic clips","volume":"17","author":"Ritter","year":"2013","journal-title":"JSLS"},{"key":"10.1016\/j.gie.2017.01.025_bib24","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1097\/MIB.0000000000000433","article-title":"Endoscopic therapy in Crohn's disease: principle, preparation, and technique","volume":"21","author":"Chen","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.gie.2017.01.025_bib25","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.gie.2014.03.049","article-title":"International multicenter experience with an over-the-scope clipping device for endoscopic management of GI defects (with video)","volume":"80","author":"Haito-Chavez","year":"2014","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2017.01.025_bib26","first-page":"120","article-title":"Closure of leak at the tip of the \u201cJ\u201d after ileal pouch-anal anastomosis using a novel over-the-scope clipping system","volume":"34","author":"Lian","year":"2014","journal-title":"J\u00a0Coloproctol"},{"key":"10.1016\/j.gie.2017.01.025_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10151-015-1284-7","article-title":"The OTSC(\u00ae) proctology clip system for the closure of refractory anal fistulas","volume":"19","author":"Mennigen","year":"2015","journal-title":"Tech Coloproctol"},{"key":"10.1016\/j.gie.2017.01.025_bib28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/MCG.0000000000000336","article-title":"A\u00a0large multicenter experience with endoscopic suturing for management of gastrointestinal defects and stent anchorage in 122 patients: a retrospective review","volume":"50","author":"Sharaiha","year":"2016","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.gie.2017.01.025_bib29","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1055\/s-0042-114036","article-title":"Safety and efficacy of fistula closure by endoscopic suturing: a multi-center study","volume":"48","author":"Mukewar","year":"2016","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2017.01.025_bib30","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.gie.2013.08.039","article-title":"Treatment of esophageal leaks, fistulae, and perforations with temporary stents: evaluation of efficacy, adverse events, and factors associated with successful outcomes","volume":"79","author":"El Hajj","year":"2014","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2017.01.025_bib31","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/1756283X15610052","article-title":"Fully covered self-expandable metal stent in the treatment of postsurgical colorectal diseases: outcome in 29 patients","volume":"9","author":"Cereatti","year":"2016","journal-title":"Therap Adv Gastroenterol"},{"key":"10.1016\/j.gie.2017.01.025_bib32","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1055\/s-0034-1391403","article-title":"Endoscopic placement of self-expanding stents in patients with symptomatic anastomotic leakage after colorectal resection for cancer: long-term results","volume":"47","author":"Lamazza","year":"2015","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2017.01.025_bib33","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1097\/MIB.0000000000000154","article-title":"Severe adverse outcomes of endoscopic perforations in patients with and without IBD","volume":"20","author":"Mukewar","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.gie.2017.01.025_bib34","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/01.mcg.0000155128.31208.44","article-title":"Efficacy and safety of endoscopic balloon dilation of symptomatic upper and lower gastrointestinal Crohn's disease strictures","volume":"39","author":"Singh","year":"2005","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.gie.2017.01.025_bib35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.crohns.2010.12.005","article-title":"Prevelance and risk factor of colonic perforation in hospitalized inflammatory bowel disease patients","volume":"5","author":"Navaneethan","year":"2011","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.gie.2017.01.025_bib36","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/gut.36.4.577","article-title":"Efficacy and safety of hydrostatic balloon dilatation of ileocolonic Crohn's strictures: a prospective long term analysis","volume":"36","author":"Couckuyt","year":"1995","journal-title":"Gut"},{"issue":"10 Suppl","key":"10.1016\/j.gie.2017.01.025_bib37","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1007\/s10350-006-0685-0","article-title":"Efficacy and safety of endoscopic balloon dilation for Crohn's strictures","volume":"49","author":"Nomura","year":"2006","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gie.2017.01.025_bib38","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.gie.2013.05.021","article-title":"Endoscopic needle-knife therapy for ileal pouch sinus\u2014a novel approach for the surgical adverse event (with video)","volume":"78","author":"Wu","year":"2013","journal-title":"Gastrointest Endosc"}],"container-title":["Gastrointestinal Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001651071730069X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001651071730069X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:09:25Z","timestamp":1758042565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001651071730069X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S001651071730069X"],"URL":"https:\/\/doi.org\/10.1016\/j.gie.2017.01.025","relation":{},"ISSN":["0016-5107"],"issn-type":[{"value":"0016-5107","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring endoscopic therapy for the treatment of Crohn\u2019s\u00a0disease\u2013related fistula and abscess","name":"articletitle","label":"Article Title"},{"value":"Gastrointestinal Endoscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gie.2017.01.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the American Society for Gastrointestinal Endoscopy","name":"copyright","label":"Copyright"}]}}