{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:30:18Z","timestamp":1790105418368,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","giejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastrointestinal Endoscopy"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.gie.2020.11.027","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T16:48:27Z","timestamp":1607618907000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Safety of endoscopist-directed nurse-administered balanced propofol sedation in patients with severe systemic disease (ASA class III)"],"prefix":"10.1016","volume":"94","author":[{"given":"Patrick","family":"McKenzie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas G.","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8968-6998","authenticated-orcid":false,"given":"Andrew J.","family":"Gawron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gie.2020.11.027_bib1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ajg.2016.266","article-title":"Anesthesia service use during outpatient gastroenterology procedures continued to increase from 2010 to 2013 and potentially discretionary spending remained high","volume":"112","author":"Predmore","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2020.11.027_bib2","first-page":"259","article-title":"Endoscopist-administered propofol sedation is safe - a prospective evaluation of 10,000 patients in an outpatient practice","volume":"21","author":"Friedrich","year":"2012","journal-title":"J\u00a0Gastrointestin Liver Dis"},{"key":"10.1016\/j.gie.2020.11.027_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1572-0241.2003.04022.x","article-title":"Technical performance of colonoscopy in patients sedated with nurse-administered propofol","volume":"99","author":"Hansen","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2020.11.027_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/MEG.0b013e328353fcbc","article-title":"Nonanesthesiologist-administered propofol sedation for colonoscopy is safe and effective: a prospective Spanish study over 1000 consecutive exams","volume":"24","author":"Lucendo","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.gie.2020.11.027_bib5","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.3109\/00365521.2013.837951","article-title":"No increased risk of perforation during colonoscopy in patients undergoing Nurse Administered Propofol Sedation","volume":"48","author":"Okholm","year":"2013","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.gie.2020.11.027_bib6","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1053\/j.gastro.2009.06.042","article-title":"Endoscopist-directed administration of propofol: a worldwide safety experience","volume":"137","author":"Rex","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gie.2020.11.027_bib7","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1053\/j.gastro.2005.08.014","article-title":"Trained registered nurses\/endoscopy teams can administer propofol safely for endoscopy","volume":"129","author":"Rex","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gie.2020.11.027_bib8","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/j.1572-0241.2002.05683.x","article-title":"Safety of propofol administered by registered nurses with gastroenterologist supervision in 2000 endoscopic cases","volume":"97","author":"Rex","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2020.11.027_bib9","first-page":"25","article-title":"Quality of sedation with propofol administered by non-anesthetists in a digestive endoscopy unit: the results of a one year experience","volume":"98","author":"S\u00e1enz-L\u00f3pez","year":"2006","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.gie.2020.11.027_bib10","doi-asserted-by":"crossref","first-page":"E110","DOI":"10.1055\/s-0042-121667","article-title":"Assessing the safety of physician-directed nurse-administered propofol sedation in low-risk patients undergoing endoscopy and colonoscopy","volume":"05","author":"Sathananthan","year":"2017","journal-title":"Endosc. Int Open"},{"key":"10.1016\/j.gie.2020.11.027_bib11","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.cgh.2018.06.025","article-title":"Safety and effectiveness of nurse-administered propofol sedation in outpatients undergoing gastrointestinal endoscopy","volume":"17","author":"Sato","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.gie.2020.11.027_bib12","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1067\/mge.2002.124636","article-title":"Propofol versus midazolam\/meperidine for outpatient colonoscopy: administration by nurses supervised by endoscopists","volume":"55","author":"Sipe","year":"2002","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2020.11.027_bib13","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.3109\/00365521.2011.619274","article-title":"Nurse-administered propofol sedation for gastrointestinal endoscopic procedures: first Nordic results from implementation of a structured training program","volume":"46","author":"Slagelse","year":"2011","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.gie.2020.11.027_bib14","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1067\/mge.2003.191","article-title":"Risk stratification and safe administration of propofol by registered nurses supervised by the gastroenterologist: a prospective observational study of more than 2000 cases","volume":"57","author":"Heuss","year":"2003","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2020.11.027_bib15","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1055\/s-2005-921192","article-title":"Propofol sedation during endoscopic procedures: Safe and effective administration by registered nurses supervised by endoscopists","volume":"38","author":"Tohda","year":"2006","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2020.11.027_bib16","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1111\/j.1572-0241.2003.07605.x","article-title":"Nurse-administered propofol sedation without anesthesia specialists in 9152 endoscopic cases in an ambulatory surgery center","volume":"98","author":"Walker","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2020.11.027_bib17","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1111\/j.1572-0241.2003.08668.x","article-title":"Nurse-administered propofol versus midazolam and meperidine for upper endoscopy in cirrhotic patients","volume":"98","author":"Weston","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2020.11.027_bib18","first-page":"1751","article-title":"Safety of propofol for conscious sedation during endoscopic procedures in high-risk patients-a prospective, controlled study","volume":"98","author":"Heuss","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2020.11.027_bib19","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1046\/j.1365-2036.2003.01608.x","article-title":"Conscious sedation with propofol in elderly patients: a prospective evaluation","volume":"17","author":"Heuss","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.gie.2020.11.027_bib20","first-page":"A4467","article-title":"Nurse administered propofol sedation for pulmonary endoscopies requires a specific protocol","volume":"59","author":"Jensen","year":"2012","journal-title":"Dan Med J"},{"key":"10.1016\/j.gie.2020.11.027_bib21","first-page":"A5049","article-title":"Moderate and deep nurse-administered propofol sedation is safe","volume":"62","author":"Jensen","year":"2015","journal-title":"Dan Med J"},{"key":"10.1016\/j.gie.2020.11.027_bib22","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/j.1572-0241.2000.02080.x","article-title":"Propofol versus midazolam and meperidine for conscious sedation in GI endoscopy","volume":"95","author":"Koshy","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2020.11.027_bib23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.gie.2007.01.037","article-title":"Propofol sedation during endoscopic procedures: how much staff and monitoring are necessary?","volume":"66","author":"K\u00fclling","year":"2007","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2020.11.027_bib24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.17235\/reed.2018.5283\/2017","article-title":"Quality of sedation with propofol administered by non-anesthetists in a digestive endoscopy unit: the results of a one year experience","volume":"110","author":"L\u00f3pez Mu\u00f1oz","year":"2018","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.gie.2020.11.027_bib25","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1055\/s-0030-1256515","article-title":"Nurse-administered propofol sedation for endoscopy: a risk analysis during an implementation phase","volume":"43","author":"Jensen","year":"2011","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2020.11.027_bib26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.0269-2813.2004.01833.x","article-title":"Review article: Registered nurse-administered propofol sedation for endoscopy","volume":"19","author":"Chen","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.gie.2020.11.027_bib28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1177\/0884533612443712","article-title":"A\u00a0retrospective study of nurse-assisted propofol sedation in patients with amyotrophic lateral sclerosis undergoing percutaneous endoscopic gastrostomy","volume":"27","author":"Kawa","year":"2012","journal-title":"Nutr Clin Pract"},{"key":"10.1016\/j.gie.2020.11.027_bib29","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1007\/s10620-011-1645-7","article-title":"Nurse-administered propofol sedation is safe for patients with obstructive sleep apnea undergoing routine endoscopy: a pilot study","volume":"56","author":"Adler","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.gie.2020.11.027_bib31","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.gie.2007.12.046","article-title":"A\u00a0systematic review and meta-analysis of randomized, controlled trials of moderate sedation for routine endoscopic procedures","volume":"67","author":"McQuaid","year":"2008","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2020.11.027_bib32","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1055\/s-0034-1393414","article-title":"Non-anesthesiologist administration of propofol for gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates guideline - updated June 2015","volume":"47","author":"Dumonceau","year":"2015","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2020.11.027_bib33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.gie.2017.07.018","article-title":"Guidelines for sedation and anesthesia in GI endoscopy","volume":"87","author":"Early","year":"2018","journal-title":"Gastrointest Endosc"}],"container-title":["Gastrointestinal Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016510720350409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016510720350409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:20:04Z","timestamp":1758043204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016510720350409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0016510720350409"],"URL":"https:\/\/doi.org\/10.1016\/j.gie.2020.11.027","relation":{},"ISSN":["0016-5107"],"issn-type":[{"value":"0016-5107","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of endoscopist-directed nurse-administered balanced propofol sedation in patients with severe systemic disease (ASA class III)","name":"articletitle","label":"Article Title"},{"value":"Gastrointestinal Endoscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gie.2020.11.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American Society for Gastrointestinal Endoscopy","name":"copyright","label":"Copyright"}]}}