{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:00:49Z","timestamp":1785344449940,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902398"],"award-info":[{"award-number":["81902398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2021YJ0203"],"award-info":[{"award-number":["2021YJ0203"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","giejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastrointestinal Endoscopy"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.gie.2022.12.015","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T19:46:02Z","timestamp":1671824762000},"page":"952-961.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["A novel ultra-low-volume regimen combining 1 L polyethylene glycol and linaclotide versus 2 L polyethylene glycol for colonoscopy cleansing in low-risk individuals: a randomized controlled trial"],"prefix":"10.1016","volume":"97","author":[{"given":"Chen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoshuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gie.2022.12.015_bib1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.14309\/ajg.0000000000001020","article-title":"A\u00a0safety and efficacy comparison of a new sulfate-based tablet bowel preparation versus a PEG and ascorbate comparator in adult subjects undergoing colonoscopy","volume":"116","author":"Di Palma","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2022.12.015_bib2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/ajg.2018.25","article-title":"Same-day single dose of 2 liter polyethylene glycol is not inferior to the standard bowel preparation regimen in low-risk patients: a randomized, controlled trial","volume":"113","author":"Kang","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2022.12.015_bib3","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1055\/a-0959-0505","article-title":"Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline\u2013Update 2019","volume":"51","author":"Hassan","year":"2019","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2022.12.015_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1055\/a-0639-5070","article-title":"Colon cleansing efficacy and safety with 1 L NER1006 versus sodium picosulfate with magnesium citrate: a randomized phase 3 trial","volume":"51","author":"Schreiber","year":"2019","journal-title":"Endoscopy"},{"key":"10.1016\/j.gie.2022.12.015_bib5","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.dld.2015.06.008","article-title":"2-Litre polyethylene glycol-citrate-simethicone plus bisacodyl versus 4-litre polyethylene glycol as preparation for colonoscopy in chronic constipation","volume":"47","author":"Parente","year":"2015","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.gie.2022.12.015_bib6","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.cgh.2019.10.044","article-title":"Efficacy and tolerability of high- vs low-volume split-dose bowel cleansing regimens for colonoscopy: a systematic review and meta-analysis","volume":"18","author":"Spadaccini","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.gie.2022.12.015_bib7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.dld.2017.01.167","article-title":"Evaluation of Clensia, a new low-volume PEG bowel preparation in colonoscopy: multicentre randomized controlled trial versus 4L PEG","volume":"49","author":"Spada","year":"2017","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.gie.2022.12.015_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.dld.2012.07.011","article-title":"A\u00a0new low-volume isosmotic polyethylene glycol solution plus bisacodyl versus split-dose 4 L polyethylene glycol for bowel cleansing prior to colonoscopy: a randomised controlled trial","volume":"45","author":"Cesaro","year":"2013","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.gie.2022.12.015_bib9","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/ajg.2014.272","article-title":"Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US Multi-Society Task Force on Colorectal Cancer","volume":"109","author":"Johnson","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2022.12.015_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cgh.2017.08.016","article-title":"Patient characteristics associated with quality of colonoscopy preparation: a systematic review and meta-analysis","volume":"16","author":"Gandhi","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.gie.2022.12.015_bib11","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1007\/s10620-019-05847-5","article-title":"Risk factors associated with inadequate bowel preparation in patients with functional constipation","volume":"65","author":"Guo","year":"2020","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.gie.2022.12.015_bib12","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ajg.2017.53","article-title":"Comparison of two intensive bowel cleansing regimens in patients with previous poor bowel preparation: a randomized controlled study","volume":"112","author":"Gimeno-Garc\u00eda","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2022.12.015_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/00365521.2021.1977842","article-title":"Low-volume regimen without additional liquids or adjunctive agents versus standard bowel preparation in non-constipated patients: a propensity score matching analysis","volume":"57","author":"Li","year":"2022","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.gie.2022.12.015_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/den.14015","article-title":"Efficacy of ultra-low volume (\u22641 L) bowel preparation fluids: systematic review and meta-analysis","volume":"34","author":"van Riswijk","year":"2022","journal-title":"Dig Endosc"},{"key":"10.1016\/j.gie.2022.12.015_bib15","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1038\/ajg.2012.254","article-title":"Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety","volume":"107","author":"Chey","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2022.12.015_bib16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000496350","article-title":"Single-dose linaclotide is equal in efficacy to polyethylene glycol for bowel preparation prior to capsule endoscopy","volume":"37","author":"Stein","year":"2019","journal-title":"Dig Dis"},{"key":"10.1016\/j.gie.2022.12.015_bib17","doi-asserted-by":"crossref","first-page":"e625","DOI":"10.1097\/MEG.0000000000002184","article-title":"Polyethylene glycol combined with linaclotide is an effective and well-tolerated bowel preparation regimen for colonoscopy: an endoscopist-blinded, randomized, controlled trial","volume":"33","author":"Zhang","year":"2021","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.gie.2022.12.015_bib18","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1007\/s10620-012-2266-5","article-title":"Colonoscopy preparation: polyethylene glycol with Gatorade is as safe and efficacious as four liters of polyethylene glycol with balanced electrolytes","volume":"57","author":"McKenna","year":"2012","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.gie.2022.12.015_bib19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.gie.2011.09.029","article-title":"Optimal preparation-to-colonoscopy interval in split-dose PEG bowel preparation determines satisfactory bowel preparation quality: an observational prospective study","volume":"75","author":"Seo","year":"2012","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2022.12.015_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1443-1661.2012.01356.x","article-title":"Pilot validation of the Boston Bowel Preparation Scale in China","volume":"25","author":"Gao","year":"2013","journal-title":"Dig Endosc"},{"key":"10.1016\/j.gie.2022.12.015_bib21","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1056\/NEJMoa055498","article-title":"Colonoscopic withdrawal times and adenoma detection during screening colonoscopy","volume":"355","author":"Barclay","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.gie.2022.12.015_bib22","doi-asserted-by":"crossref","first-page":"654847","DOI":"10.3389\/fmed.2021.654847","article-title":"An enhanced high-volume preparation for colonoscopy is not better than a conventional low-volume one in patients at risk of poor bowel cleansing: a randomized controlled trial","volume":"8","author":"Gimeno-Garc\u00eda","year":"2021","journal-title":"Front Med"},{"key":"10.1016\/j.gie.2022.12.015_bib23","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/ajg.2012.255","article-title":"A\u00a012-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation","volume":"107","author":"Rao","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gie.2022.12.015_bib24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10620-016-4343-7","article-title":"Predictors of suboptimal bowel preparation using 3-L of polyethylene glycol for an outpatient colonoscopy: a prospective observational study","volume":"62","author":"Cheng","year":"2017","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.gie.2022.12.015_bib25","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cgh.2009.02.014","article-title":"Impact of obesity on bowel preparation for colonoscopy","volume":"7","author":"Borg","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.gie.2022.12.015_bib26","first-page":"2740","article-title":"Risk factors of inadequate bowel preparation for screening colonoscopy","volume":"10","author":"Amitay","year":"2021","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.gie.2022.12.015_bib27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.cgh.2011.12.037","article-title":"A\u00a0predictive model identifies patients most likely to have inadequate bowel preparation for colonoscopy","volume":"10","author":"Hassan","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.gie.2022.12.015_bib28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/MCG.0000000000000284","article-title":"Neostigmine administered with MoviPrep improves bowel preparation for elective colonoscopy in patients with spinal cord injury: a randomized study","volume":"49","author":"Korsten","year":"2015","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.gie.2022.12.015_bib29","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1007\/s00464-011-2068-4","article-title":"Impact of previous gastric or colonic resection on polyethylene glycol bowel preparation for colonoscopy","volume":"26","author":"Lim","year":"2012","journal-title":"Surg Endosc"},{"key":"10.1016\/j.gie.2022.12.015_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.gie.2014.07.058","article-title":"Quality indicators for colonoscopy","volume":"81","author":"Rex","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gie.2022.12.015_bib31","article-title":"Factors predicting the colorectal adenoma detection rate in colonoscopic screening of a Chinese population: a prospective study","volume":"98","author":"Wang","year":"2019","journal-title":"Medicine (Baltimore)"}],"container-title":["Gastrointestinal Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016510722022258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016510722022258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:24:21Z","timestamp":1758043461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016510722022258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0016510722022258"],"URL":"https:\/\/doi.org\/10.1016\/j.gie.2022.12.015","relation":{},"ISSN":["0016-5107"],"issn-type":[{"value":"0016-5107","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel ultra-low-volume regimen combining 1 L polyethylene glycol and linaclotide versus 2 L polyethylene glycol for colonoscopy cleansing in low-risk individuals: a randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Gastrointestinal Endoscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gie.2022.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Society for Gastrointestinal Endoscopy","name":"copyright","label":"Copyright"}]}}