{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:39:30Z","timestamp":1793741970064,"version":"4.6.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["gimjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.gim.2022.03.019","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T05:01:22Z","timestamp":1653368482000},"page":"1379-1391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["Systematic evidence-based review: The application of noninvasive prenatal screening using cell-free DNA in general-risk pregnancies"],"prefix":"10.1016","volume":"24","author":[{"given":"Nancy C.","family":"Rose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Barrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Malinowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle P.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica R.","family":"McClain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"LaGrave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco L.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.gim.2022.03.019_bib1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/GIM.0b013e3182368a0e","article-title":"DNA sequencing of maternal plasma to detect Down syndrome: an international clinical validation study","volume":"13","author":"Palomaki","year":"2011","journal-title":"Genet Med"},{"issue":"4","key":"10.1016\/j.gim.2022.03.019_bib2","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1373\/clinchem.2014.233312","article-title":"Detection of fetal subchromosomal abnormalities by sequencing circulating cell-free DNA from maternal plasma","volume":"61","author":"Zhao","year":"2015","journal-title":"Clin Chem"},{"issue":"10","key":"10.1016\/j.gim.2022.03.019_bib3","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/gim.2016.97","article-title":"Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics","volume":"18","author":"Gregg","year":"2016","journal-title":"Genet Med"},{"issue":"3","key":"10.1016\/j.gim.2022.03.019_bib4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/uog.17484","article-title":"Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis","volume":"50","author":"Gil","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.gim.2022.03.019_bib5","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/AOG.0b013e31824fb482","article-title":"Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing","volume":"119","author":"Bianchi","year":"2012","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.gim.2022.03.019_bib6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/uog.14792","article-title":"Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146,958 pregnancies","volume":"45","author":"Zhang","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.gim.2022.03.019_bib7","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1311037","article-title":"DNA sequencing versus standard prenatal aneuploidy screening","volume":"370","author":"Bianchi","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.gim.2022.03.019_bib8","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1097\/AOG.0000000000004084","article-title":"Committee on Genetics, Society for Maternal-Fetal Medicine. Screening for fetal chromosomal abnormalities: ACOG Practice Bulletin, Number 226","volume":"136","year":"2020","journal-title":"Obstet Gynecol"},{"issue":"10","key":"10.1016\/j.gim.2022.03.019_bib9","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/pd.5832","article-title":"International Society for Prenatal Diagnosis Position Statement: cell free (cf)DNA screening for Down syndrome in multiple pregnancies","volume":"41","author":"Palomaki","year":"2021","journal-title":"Prenat Diagn"},{"issue":"2","key":"10.1016\/j.gim.2022.03.019_bib10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/uog.23648","article-title":"Cell-free DNA testing of maternal blood in screening for trisomies in twin pregnancy: updated cohort study at 10-14 weeks and meta-analysis","volume":"58","author":"Judah","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.gim.2022.03.019_bib11","doi-asserted-by":"crossref","first-page":"906","DOI":"10.11124\/JBIES-21-00112","article-title":"PRISMA 2020: a reporting guideline for the next generation of systematic reviews","volume":"19","author":"Brennan","year":"2021","journal-title":"JBI Evid Synth"},{"key":"10.1016\/j.gim.2022.03.019_bib12","doi-asserted-by":"crossref","first-page":"f1049","DOI":"10.1136\/bmj.f1049","article-title":"Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement","volume":"346","author":"Husereau","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.gim.2022.03.019_bib13","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.gim.2022.03.019_bib14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.gim.2022.03.019_bib15","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1001\/jama.295.6.676","article-title":"Comparison of two methods to detect publication bias in meta-analysis","volume":"295","author":"Peters","year":"2006","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.gim.2022.03.019_bib16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/1471-0528.16464","article-title":"Secondary non-invasive prenatal screening for fetal trisomy: an effectiveness study in a public health setting","volume":"128","author":"Guy","year":"2021","journal-title":"BJOG"},{"key":"10.1016\/j.gim.2022.03.019_bib17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13039-019-0446-0","article-title":"Non-invasive prenatal testing of fetal chromosomal aneuploidies: validation and clinical performance of the veracity test","volume":"12","author":"Kypri","year":"2019","journal-title":"Mol Cytogenet"},{"issue":"11","key":"10.1016\/j.gim.2022.03.019_bib18","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/gim.2018.4","article-title":"Cell-free fetal DNA versus maternal serum screening for trisomy 21 in pregnant women with and without assisted reproduction technology: a prospective interventional study","volume":"20","author":"Costa","year":"2018","journal-title":"Genet Med"},{"issue":"4","key":"10.1016\/j.gim.2022.03.019_bib19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3390\/genes12040478","article-title":"Performance of cell-free DNA screening for fetal common aneuploidies and sex chromosomal abnormalities: a prospective study from a less developed autonomous region in Mainland China","volume":"12","author":"Lai","year":"2021","journal-title":"Genes (Basel)"},{"issue":"6","key":"10.1016\/j.gim.2022.03.019_bib20","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/s41436-021-01101-4","article-title":"Outcome of publicly funded nationwide first-tier noninvasive prenatal screening","volume":"23","author":"Van Den Bogaert","year":"2021","journal-title":"Genet Med"},{"issue":"2","key":"10.1016\/j.gim.2022.03.019_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/a-0651-0459","article-title":"Follow-up studies of cf-DNA testing from 101 consecutive fetuses and related ultrasound findings","volume":"41","author":"Basaran","year":"2020","journal-title":"Ultraschall Med"},{"issue":"6","key":"10.1016\/j.gim.2022.03.019_bib22","doi-asserted-by":"crossref","first-page":"691.e1","DOI":"10.1016\/j.ajog.2017.10.005","article-title":"Positive predictive value estimates for cell-free noninvasive prenatal screening from data of a large referral genetic diagnostic laboratory","volume":"217","author":"Petersen","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.gim.2022.03.019_bib23","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s12884-019-2434-0","article-title":"Clinical application of a contingent screening strategy for trisomies with cell-free DNA: a pilot study","volume":"19","author":"S\u00e1nchez-Dur\u00e1n","year":"2019","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"10.1016\/j.gim.2022.03.019_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1055\/a-1226-6538","article-title":"Cell-free DNA testing in routine practice: characterisation of a cohort with positive results for trisomies, sex chromosome anomalies and microdeletions","volume":"81","author":"Tekesin","year":"2021","journal-title":"Geburtshilfe Frauenheilkd"},{"issue":"4","key":"10.1016\/j.gim.2022.03.019_bib25","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/uog.18905","article-title":"First-trimester risk assessment based on ultrasound and cell-free DNA vs combined screening: a randomized controlled trial","volume":"51","author":"Kagan","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.gim.2022.03.019_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40246-019-0250-2","article-title":"Noninvasive prenatal testing for chromosome aneuploidies and subchromosomal microdeletions\/microduplications in a cohort of 42,910 single pregnancies with different clinical features","volume":"13","author":"Chen","year":"2019","journal-title":"Hum Genomics"},{"issue":"4","key":"10.1016\/j.gim.2022.03.019_bib27","doi-asserted-by":"crossref","first-page":"e1185","DOI":"10.1002\/mgg3.1185","article-title":"Analyzing false-negative results detected in low-risk non-invasive prenatal screening cases","volume":"8","author":"Lin","year":"2020","journal-title":"Mol Genet Genomic Med"},{"issue":"9","key":"10.1016\/j.gim.2022.03.019_bib28","doi-asserted-by":"crossref","first-page":"104001","DOI":"10.1016\/j.ejmg.2020.104001","article-title":"A\u00a0retrospective analysis the clinic data and follow-up of non-invasive prenatal test in detection of fetal chromosomal aneuploidy in more than 40,000 cases in a single prenatal diagnosis center","volume":"63","author":"Luo","year":"2020","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.gim.2022.03.019_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejogrb.2020.05.070","article-title":"Genome-wide non-invasive prenatal testing in single- and multiple-pregnancies at any risk: identification of maternal polymorphisms to reduce the number of unnecessary invasive confirmation testing","volume":"252","author":"Oneda","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"10.1016\/j.gim.2022.03.019_bib30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11427-017-9344-7","article-title":"Genome-wide detection of additional fetal chromosomal abnormalities by cell-free DNA testing of 15,626 consecutive pregnant women","volume":"62","author":"Yao","year":"2019","journal-title":"Sci China Life Sci"},{"issue":"13","key":"10.1016\/j.gim.2022.03.019_bib31","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/pd.5597","article-title":"Validation of fetal DNA fraction estimation and its application in noninvasive prenatal testing for aneuploidy detection in multiple pregnancies","volume":"39","author":"Chen","year":"2019","journal-title":"Prenat Diagn"},{"issue":"8","key":"10.1016\/j.gim.2022.03.019_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220979","article-title":"A\u00a0new era in aneuploidy screening: cfDNA testing in >30,000 multifetal gestations: experience at one clinical laboratory","volume":"14","author":"Dyr","year":"2019","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.gim.2022.03.019_bib33","first-page":"937","article-title":"Validation of a single-nucleotide polymorphism-based non-invasive prenatal test in twin gestations: determination of zygosity, individual fetal sex, and fetal aneuploidy","volume":"8","author":"Norwitz","year":"2019","journal-title":"J\u00a0Clin Med"},{"issue":"9","key":"10.1016\/j.gim.2022.03.019_bib34","first-page":"1311","article-title":"Quality assurance of non-invasive prenatal screening (NIPS) for fetal aneuploidy using positive predictive values as outcome measures","volume":"8","author":"DiNonno","year":"2019","journal-title":"J\u00a0Clin Med"},{"issue":"3","key":"10.1016\/j.gim.2022.03.019_bib35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/pd.4778","article-title":"Follow-up of multiple aneuploidies and single monosomies detected by noninvasive prenatal testing: implications for management and counseling","volume":"36","author":"Snyder","year":"2016","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.gim.2022.03.019_bib36","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3389\/fgene.2020.00624","article-title":"The clinical utility of non-invasive prenatal testing for pregnant women with different diagnostic indications","volume":"11","author":"Zheng","year":"2020","journal-title":"Front Genet"},{"key":"10.1016\/j.gim.2022.03.019_bib37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13039-020-00508-z","article-title":"Application value of NIPT for uncommon fetal chromosomal abnormalities","volume":"13","author":"Yin","year":"2020","journal-title":"Mol Cytogenet"},{"issue":"11","key":"10.1016\/j.gim.2022.03.019_bib38","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1159\/000510069","article-title":"First trimester screening for common trisomies and microdeletion 22q11.2 syndrome using cell-free DNA: a prospective clinical study","volume":"47","author":"Kagan","year":"2020","journal-title":"Fetal Diagn Ther"},{"issue":"6","key":"10.1016\/j.gim.2022.03.019_bib39","doi-asserted-by":"crossref","first-page":"e674","DOI":"10.1002\/mgg3.674","article-title":"Noninvasive prenatal testing for fetal subchromosomal copy number variations and chromosomal aneuploidy by low-pass whole-genome sequencing","volume":"7","author":"Yu","year":"2019","journal-title":"Mol Genet Genomic Med"},{"key":"10.1016\/j.gim.2022.03.019_bib40","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ejogrb.2020.11.026","article-title":"Identification of copy number variants by NGS-based NIPT at low sequencing depth","volume":"256","author":"Ye","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"9","key":"10.1016\/j.gim.2022.03.019_bib41","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1038\/s41436-019-0467-4","article-title":"Clinical utility of noninvasive prenatal screening for expanded chromosome disease syndromes","volume":"21","author":"Liang","year":"2019","journal-title":"Genet Med"},{"issue":"3","key":"10.1016\/j.gim.2022.03.019_bib42","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/pd.5217","article-title":"Clinical experience of laboratory follow-up with noninvasive prenatal testing using cell-free DNA and positive microdeletion results in 349 cases","volume":"38","author":"Schwartz","year":"2018","journal-title":"Prenat Diagn"},{"issue":"2","key":"10.1016\/j.gim.2022.03.019_bib43","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/cge.13098","article-title":"Clinical experience with a single-nucleotide polymorphism-based non-invasive prenatal test for five clinically significant microdeletions","volume":"93","author":"Martin","year":"2018","journal-title":"Clin Genet"},{"issue":"8","key":"10.1016\/j.gim.2022.03.019_bib44","first-page":"1412","article-title":"Decisional regret in women receiving high risk or inconclusive prenatal cell-free DNA screening results","volume":"33","author":"Gammon","year":"2020","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"14","key":"10.1016\/j.gim.2022.03.019_bib45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.21037\/atm.2019.06.57","article-title":"Clinical features and pregnancy outcomes of women with abnormal cell-free fetal DNA test results","volume":"7","author":"Zhou","year":"2019","journal-title":"Ann Transl Med"},{"issue":"2","key":"10.1016\/j.gim.2022.03.019_bib46","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1001\/jama.2015.7120","article-title":"Noninvasive prenatal testing and incidental detection of occult maternal malignancies","volume":"314","author":"Bianchi","year":"2015","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.gim.2022.03.019_bib47","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/gim.2016.113","article-title":"Accuracy and clinical value of maternal incidental findings during noninvasive prenatal testing for fetal aneuploidies","volume":"19","author":"Brison","year":"2017","journal-title":"Genet Med"},{"issue":"3","key":"10.1016\/j.gim.2022.03.019_bib48","doi-asserted-by":"crossref","first-page":"100152","DOI":"10.1016\/j.ajogmf.2020.100152","article-title":"Detection of maternal X chromosome abnormalities using single nucleotide polymorphism-based noninvasive prenatal testing","volume":"2","author":"Martin","year":"2020","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"19","key":"10.1016\/j.gim.2022.03.019_bib49","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1080\/14767058.2016.1247800","article-title":"QUAD versus cfDNA in an urban population in the second trimester for detection of trisomy 21: a cost sensitivity analysis","volume":"30","author":"Crimmins","year":"2017","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"1","key":"10.1016\/j.gim.2022.03.019_bib50","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40246-019-0201-y","article-title":"The significance of trisomy 7 mosaicism in noninvasive prenatal screening","volume":"13","author":"Qi","year":"2019","journal-title":"Hum Genomics"},{"issue":"4","key":"10.1016\/j.gim.2022.03.019_bib51","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tjog.2019.05.021","article-title":"A\u00a0two-year experience of non-invasive prenatal testing (NIPT) at an urban tertiary medical center in South Korea","volume":"58","author":"Noh","year":"2019","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.gim.2022.03.019_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/mgg3.1062","article-title":"Social and medical need for whole genome high resolution NIPT","volume":"8","author":"Srebniak","year":"2020","journal-title":"Mol Genet Genomic Med"},{"issue":"7","key":"10.1016\/j.gim.2022.03.019_bib53","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jogoh.2019.04.001","article-title":"Cell-free DNA and contingent screening: our first year","volume":"48","author":"Gomes","year":"2019","journal-title":"J\u00a0Gynecol Obstet Hum Reprod"},{"issue":"12","key":"10.1016\/j.gim.2022.03.019_bib54","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/pd.5174","article-title":"Comparison of first-tier cell-free DNA screening for common aneuploidies with conventional publically funded screening","volume":"37","author":"Langlois","year":"2017","journal-title":"Prenat Diagn"},{"issue":"14","key":"10.1016\/j.gim.2022.03.019_bib55","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1055\/s-0037-1603992","article-title":"The impact of cfDNA screening on the frequency of invasive procedures in a geographically diverse private network","volume":"34","author":"Garite","year":"2017","journal-title":"Am J Perinatol"},{"issue":"11","key":"10.1016\/j.gim.2022.03.019_bib56","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1080\/14767058.2019.1647161","article-title":"Cell-free fetal DNA screening for detection of microdeletion syndromes: a cost-effectiveness analysis","volume":"34","author":"Avram","year":"2021","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"7052","key":"10.1016\/j.gim.2022.03.019_bib57","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/bmj.313.7052.275","article-title":"Guidelines for authors and peer reviewers of economic submissions to the BMJ. The BMJ Economic Evaluation Working Party","volume":"313","author":"Drummond","year":"1996","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.gim.2022.03.019_bib58","first-page":"1","article-title":"Noninvasive prenatal testing for trisomies 21, 18, and 13, sex chromosome aneuploidies, and microdeletions: a health technology assessment","volume":"19","year":"2019","journal-title":"Ont Health Technol Assess Ser"},{"issue":"6","key":"10.1016\/j.gim.2022.03.019_bib59","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/uog.20284","article-title":"Screening for trisomies by cfDNA testing of maternal blood in twin pregnancy: update of The Fetal Medicine Foundation results and meta-analysis","volume":"53","author":"Gil","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.gim.2022.03.019_bib60","doi-asserted-by":"crossref","first-page":"79.e1","DOI":"10.1016\/j.ajog.2021.01.005","article-title":"Noninvasive prenatal screening in twin pregnancies with cell-free DNA using the IONA test: a prospective multicenter study","volume":"225","author":"Khalil","year":"2021","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.gim.2022.03.019_bib61","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/aogs.13842","article-title":"Clinical performance of non-invasive prenatal testing for trisomies 21, 18 and 13 in twin pregnancies: a cohort study and a systematic meta-analysis","volume":"99","author":"He","year":"2020","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"1","key":"10.1016\/j.gim.2022.03.019_bib62","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/genes12010011","article-title":"Clinical significance of non-invasive prenatal screening for trisomy 7: Cohort study and literature review","volume":"12","author":"Zhu","year":"2020","journal-title":"Genes (Basel)"},{"issue":"10","key":"10.1016\/j.gim.2022.03.019_bib63","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jclinepi.2005.02.022","article-title":"Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews","volume":"58","author":"Reitsma","year":"2005","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"3","key":"10.1016\/j.gim.2022.03.019_bib64","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41436-020-01009-5","article-title":"High-throughput fetal fraction amplification increases analytical performance of noninvasive prenatal screening","volume":"23","author":"Welker","year":"2021","journal-title":"Genet Med"}],"updated-by":[{"DOI":"10.1016\/j.gim.2022.07.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000}}],"container-title":["Genetics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360022007146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360022007146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T23:44:02Z","timestamp":1688168642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098360022007146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S1098360022007146"],"URL":"https:\/\/doi.org\/10.1016\/j.gim.2022.03.019","relation":{},"ISSN":["1098-3600"],"issn-type":[{"value":"1098-3600","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic evidence-based review: The application of noninvasive prenatal screening using cell-free DNA in general-risk pregnancies","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gim.2022.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American College of Medical Genetics and Genomics. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}