{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:32:42Z","timestamp":1786692762962,"version":"build-2736575974"},"reference-count":20,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100018584","name":"Down Syndrome Education International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018584","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["gimjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.gim.2025.101422","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T19:30:13Z","timestamp":1743967813000},"page":"101422","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Estimation of the number of people with Down syndrome living in Canada"],"prefix":"10.1016","volume":"27","author":[{"given":"Gert","family":"de Graaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"LaChance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-9882","authenticated-orcid":false,"given":"Brian G.","family":"Skotko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.gim.2025.101422_bib4","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1002\/ajmg.a.38402","article-title":"Estimation of live birth and population prevalence of Down syndrome in nine U.S. states","volume":"173","author":"de Graaf","year":"2017","journal-title":"Am J Med Genet A"},{"issue":"4","key":"10.1016\/j.gim.2025.101422_bib5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/gim.2016.127","article-title":"Estimation of the number of people with Down syndrome in the United States","volume":"19","author":"de Graaf","year":"2017","journal-title":"Genet Med"},{"issue":"3","key":"10.1016\/j.gim.2025.101422_bib6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41431-020-00748-y","article-title":"Estimation of the number of people with Down syndrome in Europe","volume":"29","author":"de Graaf","year":"2021","journal-title":"Eur J Hum Genet"},{"issue":"12","key":"10.1016\/j.gim.2025.101422_bib7","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1016\/j.gim.2022.08.029","article-title":"Estimation of the number of people with Down syndrome in Australia and New Zealand","volume":"24","author":"de Graaf","year":"2022","journal-title":"Genet Med"},{"issue":"5","key":"10.1016\/j.gim.2025.101422_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/gim.2016.15","article-title":"Live births, natural losses, and elective terminations with Down syndrome in Massachusetts","volume":"18","author":"de Graaf","year":"2016","journal-title":"Genet Med"},{"issue":"5","key":"10.1016\/j.gim.2025.101422_bib9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41431-023-01330-y","article-title":"Down syndrome screening and diagnosis practices in Europe, United States, Australia, and New Zealand from 1990-2021","volume":"31","author":"Wilmot","year":"2023","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.gim.2025.101422_bib10","author":"de Graaf"},{"issue":"1","key":"10.1016\/j.gim.2025.101422_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/jms.9.1.2","article-title":"Revised estimates of the maternal age specific live birth prevalence of Down\u2019s syndrome","volume":"9","author":"Morris","year":"2002","journal-title":"J Med Screen"},{"issue":"4","key":"10.1016\/j.gim.2025.101422_bib14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1258\/096914105775220679","article-title":"Corrections to maternal age-specific live birth prevalence of Down\u2019s syndrome","volume":"12","author":"Morris","year":"2005","journal-title":"J Med Screen"},{"key":"10.1016\/j.gim.2025.101422_bib22","series-title":"Canadian Perinatal Health Report","year":"2008"},{"key":"10.1016\/j.gim.2025.101422_bib23","series-title":"Congenital anomalies in Canada: a perinatal health report, 2002","author":"Kohut","year":"2002"},{"issue":"8","key":"10.1016\/j.gim.2025.101422_bib24","first-page":"739","article-title":"Prenatal diagnosis of genetic disease in Canada: report of a collaborative study","volume":"115","author":"Simpson","year":"1976","journal-title":"Can Med Assoc J"},{"issue":"400","key":"10.1016\/j.gim.2025.101422_bib25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1192\/bjp.95.400.685","article-title":"The incidence of mongolism in the general population","volume":"95","author":"Penrose","year":"1949","journal-title":"J Ment Sci"},{"key":"10.1016\/j.gim.2025.101422_bib29","series-title":"Deaths from Congenital Anomalies in Canada, 1974 to 2012","author":"Navaneelan","year":"2016"},{"issue":"4","key":"10.1016\/j.gim.2025.101422_bib30","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/ajmg.a.37001","article-title":"Estimates of the live births, natural losses, and elective terminations with Down syndrome in the United States","volume":"167A","author":"de Graaf","year":"2015","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.gim.2025.101422_bib32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1186\/1472-6963-14-437","article-title":"Explaining variation in Down\u2019s syndrome screening uptake: comparing the Netherlands with England and Denmark using documentary analysis and expert stakeholder interviews","volume":"14","author":"Crombag","year":"2014","journal-title":"BMC Health Serv Res"},{"issue":"3","key":"10.1016\/j.gim.2025.101422_bib33","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/pd.6329","article-title":"A cross-country comparison of pregnant women\u2019s decision-making and perspectives when opting for non-invasive prenatal testing in the Netherlands and Belgium","volume":"43","author":"Lannoo","year":"2023","journal-title":"Prenat Diagn"},{"issue":"6","key":"10.1016\/j.gim.2025.101422_bib37","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0022-3476(87)80395-5","article-title":"Life expectancy in Down syndrome","volume":"110","author":"Baird","year":"1987","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.gim.2025.101422_bib38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/tera.1420140105","article-title":"Down syndrome in British Columbia, 1952-73: incidence and mean maternal age","volume":"14","author":"Lowry","year":"1976","journal-title":"Teratology"},{"issue":"4","key":"10.1016\/j.gim.2025.101422_bib40","doi-asserted-by":"crossref","first-page":"572","DOI":"10.7326\/M20-4986","article-title":"COVID-19 mortality risk in Down syndrome: results from a cohort study of 8 million adults","volume":"174","author":"Clift","year":"2021","journal-title":"Ann Intern Med"}],"container-title":["Genetics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360025000693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360025000693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:14:05Z","timestamp":1786691645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098360025000693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S1098360025000693"],"URL":"https:\/\/doi.org\/10.1016\/j.gim.2025.101422","relation":{},"ISSN":["1098-3600"],"issn-type":[{"value":"1098-3600","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estimation of the number of people with Down syndrome living in Canada","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gim.2025.101422","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American College of Medical Genetics and Genomics. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101422"}}