{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:46:03Z","timestamp":1791755163044,"version":"4.3.4"},"reference-count":97,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K23692"],"award-info":[{"award-number":["JP24K23692"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["gimjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.gim.2026.102714","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:03:06Z","timestamp":1788879786000},"page":"102714","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection rate of pathogenic variants by postmortem genetic testing for sudden cardiac death among children and young adults: Systematic review and meta-analysis"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5882-1333","authenticated-orcid":false,"given":"Kanako Koike","family":"Fukushima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0560-8686","authenticated-orcid":false,"given":"Takahiro","family":"Itaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kamiakito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1209-8896","authenticated-orcid":false,"given":"Seiko","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8798-1304","authenticated-orcid":false,"given":"Hirokazu","family":"Kotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-5686","authenticated-orcid":false,"given":"Shoji","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7589-6487","authenticated-orcid":false,"given":"Masakazu","family":"Nishigaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.gim.2026.102714_bib1","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.jacc.2022.02.041","article-title":"Incidence of sudden cardiac death in the European Union","volume":"79","author":"Empana","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.gim.2026.102714_bib2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/eurheartj\/ehq428","article-title":"Nationwide study of sudden cardiac death in persons aged 1-35 years","volume":"32","author":"Winkel","year":"2011","journal-title":"Eur Heart J"},{"issue":"25","key":"10.1016\/j.gim.2026.102714_bib3","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMoa1510687","article-title":"A prospective study of sudden cardiac death among children and young adults","volume":"374","author":"Bagnall","year":"2016","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00428-007-0505-5","article-title":"Guidelines for autopsy investigation of sudden cardiac death","volume":"452","author":"Basso","year":"2008","journal-title":"Virchows Arch"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1253\/circj.CJ-22-0265","article-title":"Implementation of molecular autopsy for sudden cardiac death in Japan\u2014focus group study of stakeholders","volume":"87","author":"Koike","year":"2022","journal-title":"Circ J"},{"issue":"4","key":"10.1016\/j.gim.2026.102714_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-0038-1668079","article-title":"A systematic review of molecular autopsy studies in sudden infant death cases","volume":"7","author":"Heathfield","year":"2018","journal-title":"J Pediatr Genet"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012264","article-title":"Systematic review of the genetics of sudden unexpected death in epilepsy: potential overlap with sudden cardiac death and arrhythmia-related genes","volume":"9","author":"Chahal","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"7","key":"10.1016\/j.gim.2026.102714_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2024.101159","article-title":"A systematic review to assess the utility of genomic autopsy using exome or genome sequencing in cases of congenital anomalies and perinatal death","volume":"26","author":"Schubert","year":"2024","journal-title":"Genet Med"},{"key":"10.1016\/j.gim.2026.102714_bib9","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.gim.2026.102714_bib10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"issue":"6","key":"10.1016\/j.gim.2026.102714_bib80","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ajhg.2017.04.015","article-title":"Evaluating the clinical validity of gene-disease associations: an evidence-based framework developed by the clinical genome resource","volume":"100","author":"Strande","year":"2017","journal-title":"Am J Hum Genet"},{"issue":"3","key":"10.1016\/j.gim.2026.102714_bib11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/XEB.0000000000000054","article-title":"Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data","volume":"13","author":"Munn","year":"2015","journal-title":"Int J Evid-Based Healthc"},{"issue":"9","key":"10.1016\/j.gim.2026.102714_bib12","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.jacc.2003.11.052","article-title":"Postmortem molecular screening in unexplained sudden death","volume":"43","author":"Chugh","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.gim.2026.102714_bib13","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00414-011-0572-7","article-title":"Prevalence of HCM and long QT syndrome mutations in young sudden cardiac death-related cases","volume":"125","author":"Allegue","year":"2011","journal-title":"Int J Legal Med"},{"issue":"6","key":"10.1016\/j.gim.2026.102714_bib14","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.mayocp.2012.02.017","article-title":"Cardiac channel molecular autopsy: insights from 173 consecutive cases of autopsy-negative sudden unexplained death referred for postmortem genetic testing","volume":"87","author":"Tester","year":"2012","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.gim.2026.102714_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.forsciint.2014.01.014","article-title":"Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths","volume":"237","author":"Wang","year":"2014","journal-title":"Forensic Sci Int"},{"issue":"4","key":"10.1016\/j.gim.2026.102714_bib16","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.hrthm.2014.01.017","article-title":"Exome analysis-based molecular autopsy in cases of sudden unexplained death in the young","volume":"11","author":"Bagnall","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.gim.2026.102714_bib17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.forsciint.2014.10.004","article-title":"Post-mortem genetic analysis in juvenile cases of sudden cardiac death","volume":"245","author":"Campuzano","year":"2014","journal-title":"Forensic Sci Int"},{"issue":"10","key":"10.1016\/j.gim.2026.102714_bib18","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1136\/archdischild-2015-308200","article-title":"Broad-based molecular autopsy: a potential tool to investigate the involvement of subtle cardiac conditions in sudden unexpected death in infancy and early childhood","volume":"100","author":"Santori","year":"2015","journal-title":"Arch Dis Child"},{"issue":"4","key":"10.1016\/j.gim.2026.102714_bib19","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00414-014-1105-y","article-title":"Next-generation sequencing of 34 genes in sudden unexplained death victims in forensics and in patients with channelopathic cardiac diseases","volume":"129","author":"Hertz","year":"2015","journal-title":"Int J Legal Med"},{"issue":"4","key":"10.1016\/j.gim.2026.102714_bib20","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s00246-014-1082-4","article-title":"Post-mortem Whole exome sequencing with gene-specific analysis for autopsy-negative sudden unexplained death in the young: a case series","volume":"36","author":"Narula","year":"2015","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.gim.2026.102714_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.forsciint.2015.06.023","article-title":"Targeted next generation sequencing application in cardiac channelopathies: analysis of a cohort of autopsy-negative sudden unexplained deaths","volume":"254","author":"Farrugia","year":"2015","journal-title":"Forensic Sci Int"},{"issue":"6","key":"10.1016\/j.gim.2026.102714_bib22","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/europace\/euv285","article-title":"Diagnostic yield of molecular autopsy in patients with sudden arrhythmic death syndrome using targeted exome sequencing","volume":"18","author":"Nunn","year":"2016","journal-title":"Europace"},{"issue":"11","key":"10.1016\/j.gim.2026.102714_bib23","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.mayocp.2016.06.031","article-title":"Does sudden unexplained nocturnal death syndrome remain the autopsy-negative disorder: a gross, microscopic, and molecular autopsy investigation in southern China","volume":"91","author":"Zhang","year":"2016","journal-title":"Mayo Clin Proc"},{"issue":"12","key":"10.1016\/j.gim.2026.102714_bib24","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1038\/ejhg.2016.118","article-title":"Genetic investigation of 100 heart genes in sudden unexplained death victims in a forensic setting","volume":"24","author":"Christiansen","year":"2016","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00414-015-1237-8","article-title":"Genetic screening in sudden cardiac death in the young can save future lives","volume":"130","author":"Stattin","year":"2016","journal-title":"Int J Legal Med"},{"issue":"12","key":"10.1016\/j.gim.2026.102714_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167358","article-title":"Natural and undetermined sudden death: value of post-mortem genetic investigation","volume":"11","author":"Sanchez","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00414-015-1261-8","article-title":"Next-generation sequencing of 100 candidate genes in young victims of suspected sudden cardiac death with structural abnormalities of the heart","volume":"130","author":"Hertz","year":"2016","journal-title":"Int J Legal Med"},{"issue":"7","key":"10.1016\/j.gim.2026.102714_bib28","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.hrthm.2016.03.038","article-title":"Postmortem genetic analysis of sudden unexplained death syndrome under 50 years of age: a next-generation sequencing study","volume":"13","author":"Hata","year":"2016","journal-title":"Heart Rhythm"},{"issue":"3","key":"10.1016\/j.gim.2026.102714_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1161\/CIRCGENETICS.115.001370","article-title":"Whole-exome molecular autopsy after exertion-related sudden unexplained death in the young","volume":"9","author":"Anderson","year":"2016","journal-title":"Circ Cardiovasc Genet"},{"issue":"9","key":"10.1016\/j.gim.2026.102714_bib30","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1101\/gr.195800.115","article-title":"Postmortem genetic screening for the identification, verification, and reporting of genetic variants contributing to the sudden death of the young","volume":"26","author":"Methner","year":"2016","journal-title":"Genome Res"},{"issue":"6","key":"10.1016\/j.gim.2026.102714_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.117.001839","article-title":"Applying high-resolution variant classification to cardiac arrhythmogenic gene testing in a demographically diverse cohort of sudden unexplained deaths","volume":"10","author":"Lin","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"issue":"10","key":"10.1016\/j.gim.2026.102714_bib32","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.recesp.2017.01.010","article-title":"Clinical and genetic diagnosis of nonischemic sudden cardiac death","volume":"70","author":"Jim\u00e9nez-J\u00e1imez","year":"2017","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.gim.2026.102714_bib33","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.forsciint.2016.12.035","article-title":"Genetic analysis in post-mortem samples with micro-ischemic alterations","volume":"271","author":"Campuzano","year":"2017","journal-title":"Forensic Sci Int"},{"issue":"5","key":"10.1016\/j.gim.2026.102714_bib34","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.117.001828","article-title":"Genomic triangulation and coverage analysis in whole-exome sequencing\u2013based molecular autopsies","volume":"10","author":"Shanks","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"issue":"4","key":"10.1016\/j.gim.2026.102714_bib35","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.116.001738","article-title":"Investigating the genetic causes of sudden unexpected death in children through targeted next-generation sequencing analysis","volume":"10","author":"Dewar","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.gim.2026.102714_bib36","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fcvm.2017.00072","article-title":"Molecular autopsy for sudden death in the young: is data aggregation the key?","volume":"4","author":"Rueda","year":"2017","journal-title":"Front Cardiovasc Med"},{"issue":"11","key":"10.1016\/j.gim.2026.102714_bib37","first-page":"1881","article-title":"Molecular autopsy of sudden unexplained deaths reveals genetic predispositions for cardiac diseases among young forensic cases","volume":"19","author":"Hellenthal","year":"2017","journal-title":"Europace"},{"issue":"7","key":"10.1016\/j.gim.2026.102714_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180056","article-title":"Molecular investigation by whole exome sequencing revealed a high proportion of pathogenic variants among Thai victims of sudden unexpected death syndrome","volume":"12","author":"Suktitipat","year":"2017","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.gim.2026.102714_bib39","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1007\/s40279-017-0705-3","article-title":"Sudden arrhythmic death during exercise: a post-mortem genetic analysis","volume":"47","author":"Campuzano","year":"2017","journal-title":"Sports Med"},{"issue":"17","key":"10.1016\/j.gim.2026.102714_bib40","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.jacc.2017.02.046","article-title":"Utility of post-mortem genetic testing in cases of sudden arrhythmic death syndrome","volume":"69","author":"Lahrouchi","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.gim.2026.102714_bib41","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00414-018-1775-y","article-title":"Exome analysis in 34 sudden unexplained death (SUD) victims mainly identified variants in channelopathy-associated genes","volume":"132","author":"Neubauer","year":"2018","journal-title":"Int J Legal Med"},{"issue":"25","key":"10.1016\/j.gim.2026.102714_bib42","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1161\/CIRCULATIONAHA.117.031053","article-title":"Importance of variant interpretation in whole-exome molecular autopsy: population-based case series","volume":"137","author":"Shanks","year":"2018","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.gim.2026.102714_bib43","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1161\/CIRCULATIONAHA.117.032175","article-title":"Primary myocardial fibrosis as an alternative phenotype pathway of inherited cardiac structural disorders","volume":"137","author":"Junttila","year":"2018","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.gim.2026.102714_bib44","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41431-018-0119-1","article-title":"Role of copy number variants in sudden cardiac death and related diseases: genetic analysis and translation into clinical practice","volume":"26","author":"Mates","year":"2018","journal-title":"Eur J Hum Genet"},{"issue":"21","key":"10.1016\/j.gim.2026.102714_bib45","first-page":"9135","article-title":"Post-mortem toxicology in the diagnosis of sudden death in young and middle-aged victims","volume":"23","author":"Ripoll","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib46","first-page":"21","article-title":"Sudden arrhythmia death syndrome in young victims: a five-year retrospective review and two-year prospective molecular autopsy study by next-generation sequencing and clinical evaluation of their first-degree relatives","volume":"25","author":"Mak","year":"2019","journal-title":"Hong Kong Med J"},{"issue":"9","key":"10.1016\/j.gim.2026.102714_bib47","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41379-019-0274-0","article-title":"Minimal inflammatory foci of unknown etiology may be a tentative sign of early stage inherited cardiomyopathy","volume":"32","author":"Hata","year":"2019","journal-title":"Mod Pathol"},{"issue":"6","key":"10.1016\/j.gim.2026.102714_bib48","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1007\/s00414-019-02127-9","article-title":"Whole genome and transcriptome sequencing of post-mortem cardiac tissues from sudden cardiac death victims identifies a gene regulatory variant in NEXN","volume":"133","author":"Andersen","year":"2019","journal-title":"Int J Legal Med"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib49","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00414-019-02179-x","article-title":"Targeted molecular genetic testing in young sudden cardiac death victims from Western Denmark","volume":"134","author":"Larsen","year":"2020","journal-title":"Int J Legal Med"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41431-019-0500-8","article-title":"The yield of postmortem genetic testing in sudden death cases with structural findings at autopsy","volume":"28","author":"Lahrouchi","year":"2020","journal-title":"Eur J Hum Genet"},{"issue":"9","key":"10.1016\/j.gim.2026.102714_bib51","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.3390\/jcm10091806","article-title":"Diagnostic yield of genetic testing in sudden cardiac death with autopsy findings of uncertain significance","volume":"10","author":"Iglesias","year":"2021","journal-title":"J Clin Med"},{"issue":"9","key":"10.1016\/j.gim.2026.102714_bib54","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1001\/jamacardio.2021.1573","article-title":"Genetic variants associated with unexplained sudden cardiac death in adult White and African American individuals","volume":"6","author":"Guo","year":"2021","journal-title":"JAMA Cardiol"},{"issue":"11","key":"10.1016\/j.gim.2026.102714_bib55","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/jamacardio.2021.2789","article-title":"Genomic autopsy of sudden deaths in young individuals","volume":"6","author":"Webster","year":"2021","journal-title":"JAMA Cardiol"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib56","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12920-021-00946-7","article-title":"HPO-driven virtual gene panel: a new efficient approach in molecular autopsy of sudden unexplained death","volume":"14","author":"Sch\u00f6n","year":"2021","journal-title":"BMC Med Genomics"},{"issue":"5","key":"10.1016\/j.gim.2026.102714_bib57","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.hroo.2021.07.006","article-title":"Prevalence and potential genetic determinants of young sudden unexplained death victims with suspected arrhythmogenic mitral valve prolapse syndrome","volume":"2","author":"Giudicessi","year":"2021","journal-title":"Heart Rhythm O2"},{"issue":"5","key":"10.1016\/j.gim.2026.102714_bib58","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.recesp.2020.03.001","article-title":"Sudden cardiac death in persons aged 50 years or younger: diagnostic yield of a regional molecular autopsy program using massive sequencing","volume":"74","author":"Ripoll-Vera","year":"2021","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.gim.2026.102714_bib59","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.resuscitation.2021.07.042","article-title":"The emergency medical service has a crucial role to unravel the genetics of sudden cardiac arrest in young, out of hospital resuscitated patients: interim data from the MAP-IT study","volume":"168","author":"Tiesmeier","year":"2021","journal-title":"Resuscitation"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib60","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13073-021-00973-0","article-title":"Lethal variants in humans: lessons learned from a large molecular autopsy cohort","volume":"13","author":"Shamseldin","year":"2021","journal-title":"Genome Med"},{"issue":"4","key":"10.1016\/j.gim.2026.102714_bib61","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00414-021-02580-5","article-title":"Re-evaluation of single nucleotide variants and identification of structural variants in a cohort of 45 sudden unexplained death cases","volume":"135","author":"Neubauer","year":"2021","journal-title":"Int J Legal Med"},{"key":"10.1016\/j.gim.2026.102714_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.forsciint.2022.111240","article-title":"Benefits and outcomes of a new multidisciplinary approach for the management and financing of sudden unexplained death cases in a forensic setting in Switzerland","volume":"334","author":"Neubauer","year":"2022","journal-title":"Forensic Sci Int"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib63","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.121.003497","article-title":"Exome sequencing highlights a potential role for concealed cardiomyopathies in youthful sudden cardiac death","volume":"15","author":"Neves","year":"2022","journal-title":"Circ Genom Precis Med"},{"issue":"2","key":"10.1016\/j.gim.2026.102714_bib64","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00414-021-02765-y","article-title":"Post-mortem genetic investigation in sudden cardiac death victims: complete exon sequencing of forty genes using next-generation sequencing","volume":"136","author":"Fadoni","year":"2022","journal-title":"Int J Legal Med"},{"issue":"2","key":"10.1016\/j.gim.2026.102714_bib65","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00414-021-02764-z","article-title":"Variant interpretation in molecular autopsy: a useful dilemma","volume":"136","author":"Scheiper-Welling","year":"2022","journal-title":"Int J Legal Med"},{"issue":"4","key":"10.1016\/j.gim.2026.102714_bib66","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.gim.2021.12.004","article-title":"Genetic determinants of sudden unexpected death in pediatrics","volume":"24","author":"Koh","year":"2022","journal-title":"Genet Med"},{"issue":"17","key":"10.1016\/j.gim.2026.102714_bib67","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.029100","article-title":"Cardiac genetic investigation of sudden infant and early childhood death: a study from victims to families","volume":"12","author":"Kotta","year":"2023","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib68","article-title":"Copy number variation and structural genomic findings in 116 cases of sudden unexplained death between 1 and 28 months of age","volume":"4","author":"Brownstein","year":"2023","journal-title":"Adv Genet (Hoboken)"},{"issue":"6","key":"10.1016\/j.gim.2026.102714_bib69","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s00414-023-03075-1","article-title":"Post-mortem genetic analysis of sudden unexplained death in a young cohort: a whole-exome sequencing study","volume":"137","author":"Wang","year":"2023","journal-title":"Int J Legal Med"},{"issue":"6","key":"10.1016\/j.gim.2026.102714_bib70","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1111\/1556-4029.15366","article-title":"Postmortem genetic testing in sudden unexplained death: a public health laboratory experience","volume":"68","author":"Rohrer","year":"2023","journal-title":"J Forensic Sci"},{"issue":"2","key":"10.1016\/j.gim.2026.102714_bib71","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00414-023-02951-0","article-title":"Reevaluation of ambiguous genetic variants in sudden unexplained deaths of a young cohort","volume":"137","author":"Martinez-Barrios","year":"2023","journal-title":"Int J Legal Med"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib72","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1536\/ihj.23-252","article-title":"Postmortem identification of genetic variations associated with sudden unexpected death in young people","volume":"65","author":"Miura","year":"2024","journal-title":"Int Heart J"},{"issue":"3","key":"10.1016\/j.gim.2026.102714_bib73","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/eurjpc\/zwae389","article-title":"Influence of age and sex on the diagnostic yield of inherited cardiac conditions in sudden arrhythmic death syndrome decedents","volume":"33","author":"Gray","year":"2026","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib74","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s40246-024-00657-x","article-title":"Whole-exome sequencing to identify causative variants in juvenile sudden cardiac death","volume":"18","author":"Modena","year":"2024","journal-title":"Hum Genomics"},{"issue":"11","key":"10.1016\/j.gim.2026.102714_bib75","doi-asserted-by":"crossref","DOI":"10.1002\/ajmg.a.63797","article-title":"Molecular autopsy in Chinese sudden cardiac death in the young","volume":"194","author":"Kwok","year":"2024","journal-title":"Am J Med Genet A"},{"issue":"5","key":"10.1016\/j.gim.2026.102714_bib76","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ihj.2025.06.007","article-title":"Sudden cardiac death in young: a cardiac-focused autopsy and molecular study to identify the cause","volume":"77","author":"Arava","year":"2025","journal-title":"Indian Heart J"},{"issue":"3","key":"10.1016\/j.gim.2026.102714_bib77","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s12024-025-00944-6","article-title":"Next generation sequencing: a possible answer to sudden unexplained deaths in a young South African cohort?","volume":"21","author":"van Deventer","year":"2025","journal-title":"Forensic Sci Med Pathol"},{"issue":"3","key":"10.1016\/j.gim.2026.102714_bib78","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jacep.2024.10.027","article-title":"Heritable burden of community sudden death by autopsy and molecular phenotyping for precision genotype correlation","volume":"11","author":"Tseng","year":"2025","journal-title":"JACC Clin Electrophysiol"},{"issue":"8","key":"10.1016\/j.gim.2026.102714_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2025.101454","article-title":"ACMG SF v3.3 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG)","volume":"27","author":"Lee","year":"2025","journal-title":"Genet Med"},{"issue":"7","key":"10.1016\/j.gim.2026.102714_bib81","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.hrthm.2022.03.1225","article-title":"expert consensus statement on the state of genetic testing for cardiac diseases","volume":"19","author":"Wilde","year":"2022","journal-title":"Heart Rhythm"},{"issue":"2","key":"10.1016\/j.gim.2026.102714_bib82","doi-asserted-by":"crossref","first-page":"228","DOI":"10.5858\/arpa.2012-0012-CP","article-title":"Accounting for the professional work of pathologists performing autopsies","volume":"137","author":"Sinard","year":"2013","journal-title":"Arch Pathol Lab Med"},{"issue":"10","key":"10.1016\/j.gim.2026.102714_bib83","doi-asserted-by":"crossref","first-page":"539","DOI":"10.5694\/j.1326-5377.2008.tb02173.x","article-title":"Reducing sudden death in young people in Australia and New Zealand: the TRAGADY initiative","volume":"189","author":"Skinner","year":"2008","journal-title":"Med J Aust"},{"issue":"5","key":"10.1016\/j.gim.2026.102714_bib84","first-page":"391","article-title":"Guidelines for autopsy investigation of sudden cardiac death","volume":"102","author":"Basso","year":"2010","journal-title":"Pathologica"},{"issue":"6","key":"10.1016\/j.gim.2026.102714_bib86","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00428-017-2221-0","article-title":"Guidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology","volume":"471","author":"Basso","year":"2017","journal-title":"Virchows Arch"},{"issue":"6","key":"10.1016\/j.gim.2026.102714_bib87","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/europace\/eut329","article-title":"The importance of specialist cardiac histopathological examination in the investigation of young sudden cardiac deaths","volume":"16","author":"de Noronha","year":"2014","journal-title":"Europace"},{"issue":"2","key":"10.1016\/j.gim.2026.102714_bib88","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/01.CCM.0000195015.73154.3D","article-title":"Relationship between cardiopulmonary resuscitation and injuries of the cardiac conduction system: pathological features and pathogenesis of such injuries","volume":"34","author":"Nishida","year":"2006","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.gim.2026.102714_bib89","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00414-019-02225-8","article-title":"Second opinion system for sudden cardiac death cases in forensic practice","volume":"134","author":"Sabatasso","year":"2020","journal-title":"Int J Legal Med"},{"issue":"1","key":"10.1016\/j.gim.2026.102714_bib90","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.hrthm.2020.10.010","article-title":"2020 APHRS\/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families","volume":"18","author":"Stiles","year":"2021","journal-title":"Heart Rhythm"},{"issue":"2","key":"10.1016\/j.gim.2026.102714_bib91","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00414-020-02481-z","article-title":"Sudden cardiac death-update","volume":"135","author":"Markwerth","year":"2021","journal-title":"Int J Legal Med"},{"issue":"2","key":"10.1016\/j.gim.2026.102714_bib92","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/1073110516654124","article-title":"Ethical and legal challenges associated with public molecular autopsies","volume":"44","author":"Moore","year":"2016","journal-title":"J Law Med Ethics"},{"issue":"9","key":"10.1016\/j.gim.2026.102714_bib93","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1101\/gr.192401.115","article-title":"The ethics of conducting molecular autopsies in cases of sudden death in the young","volume":"26","author":"McGuire","year":"2016","journal-title":"Genome Res"},{"issue":"5","key":"10.1016\/j.gim.2026.102714_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2023.100017","article-title":"Points to consider in the practice of postmortem genetic testing: a statement of the American College of Medical Genetics and Genomics (ACMG)","volume":"25","author":"Deignan","year":"2023","journal-title":"Genet Med"},{"issue":"6","key":"10.1016\/j.gim.2026.102714_bib95","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/s41436-018-0338-4","article-title":"Psychological adaptation to molecular autopsy findings following sudden cardiac death in the young","volume":"21","author":"Bates","year":"2019","journal-title":"Genet Med"},{"issue":"2","key":"10.1016\/j.gim.2026.102714_bib96","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jgc4.1733","article-title":"Sudden cardiac death in the young: a qualitative study of experiences of family members with cardiogenetic evaluation","volume":"33","author":"van den Heuvel","year":"2024","journal-title":"J Genet Couns"},{"issue":"4","key":"10.1016\/j.gim.2026.102714_bib97","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41569-024-00989-0","article-title":"The role of the molecular autopsy in sudden cardiac death in young individuals","volume":"21","author":"Isbister","year":"2024","journal-title":"Nat Rev Cardiol"},{"issue":"11","key":"10.1016\/j.gim.2026.102714_bib98","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/s44161-024-00558-1","article-title":"Concealed cardiomyopathy as an emerging cause of sudden cardiac arrest and sudden cardiac death","volume":"3","author":"Isbister","year":"2024","journal-title":"Nat Cardiovasc Res"},{"issue":"8","key":"10.1016\/j.gim.2026.102714_bib99","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1177\/1474515120922347","article-title":"A qualitative analysis of psychosocial needs and support impacts in families affected by young sudden cardiac death: the role of community and peer support","volume":"19","author":"Steffen","year":"2020","journal-title":"Eur J Cardiovasc Nurs"},{"issue":"suppl 1","key":"10.1016\/j.gim.2026.102714_bib100","article-title":"European Resuscitation Council Guidelines 2025 epidemiology in resuscitation","volume":"215","author":"Baldi","year":"2025","journal-title":"Resuscitation"}],"container-title":["Genetics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360026010324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360026010324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:10:31Z","timestamp":1791753031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098360026010324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":97,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S1098360026010324"],"URL":"https:\/\/doi.org\/10.1016\/j.gim.2026.102714","relation":{},"ISSN":["1098-3600"],"issn-type":[{"value":"1098-3600","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection rate of pathogenic variants by postmortem genetic testing for sudden cardiac death among children and young adults: Systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gim.2026.102714","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics.","name":"copyright","label":"Copyright"}],"article-number":"102714"}}