{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:13:30Z","timestamp":1778937210521,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":201,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSAINVJun21-0003"],"award-info":[{"award-number":["NMRC\/CSAINVJun21-0003"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["SingHealth-2023-12-00347"],"award-info":[{"award-number":["SingHealth-2023-12-00347"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["2024\/2090"],"award-info":[{"award-number":["2024\/2090"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["CG21APR1006"],"award-info":[{"award-number":["CG21APR1006"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001350","name":"Ministry of Health -Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gimopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine Open"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.gimo.2024.101877","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T16:54:24Z","timestamp":1721840064000},"page":"101877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Advancing precision medicine through the integration of clinical cardiovascular genetics - An Asian perspective"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1339-434X","authenticated-orcid":false,"given":"Iswaree D.","family":"Balakrishnan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Bylstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikki","family":"Fong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nellie B.S.","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Kam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Yuan","family":"Khoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.H.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela S.","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hak Chiaw","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Le","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weng Khong","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee Jian","family":"Pua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart A.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ee Shien","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khung Keong","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-8349","authenticated-orcid":false,"given":"Saumya S.","family":"Jamuar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.gimo.2024.101877_bib1","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1161\/CIR.0000000000001106","article-title":"2022 ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association\/American College of Cardiology joint committee on clinical practice guidelines","volume":"146","author":"Isselbacher","year":"2022","journal-title":"Circulation"},{"issue":"40","key":"10.1016\/j.gimo.2024.101877_bib2","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.gimo.2024.101877_bib3","first-page":"1","article-title":"2023 ESC Guidelines for the management of cardiomyopathies. Developed by the task force on the management of cardiomyopathies of the European Society of Cardiology (ESC) (United Kingdom)","author":"Arbelo","year":"2023","journal-title":"Pablo Garcia-Pav"},{"issue":"17","key":"10.1016\/j.gimo.2024.101877_bib4","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.gimo.2024.101877_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/HCG.0000000000000067","article-title":"Genetic testing for inherited cardiovascular diseases: a scientific statement from the American Heart Association","volume":"13","author":"Musunuru","year":"2020","journal-title":"Circ Genom Precis Med"},{"issue":"10","key":"10.1016\/j.gimo.2024.101877_bib6","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/s41436-018-0135-0","article-title":"Medical genetics in developing countries in the Asia-Pacific region: challenges and opportunities","volume":"20","author":"Thong","year":"2018","journal-title":"Genet Med"},{"issue":"3","key":"10.1016\/j.gimo.2024.101877_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007537","article-title":"Clinical profile and health disparities in a multiethnic cohort of patients with hypertrophic cardiomyopathy","volume":"14","author":"Butters","year":"2021","journal-title":"Circ Heart Fail"},{"issue":"4","key":"10.1016\/j.gimo.2024.101877_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1001\/jamacardio.2017.5382","article-title":"Reducing racial\/ethnic disparities in cardiovascular genetic testing","volume":"3","author":"Dellefave-Castillo","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"1","key":"10.1016\/j.gimo.2024.101877_bib9","doi-asserted-by":"crossref","DOI":"10.1080\/10872981.2022.2143920","article-title":"Physician perception of the importance of medical genetics and genomics in medical education and clinical practice","volume":"28","author":"French","year":"2023","journal-title":"Med Educ Online"},{"key":"10.1016\/j.gimo.2024.101877_bib10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev-genom-082509-141740","article-title":"Public attitudes and beliefs about genetics","volume":"11","author":"Condit","year":"2010","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"7","key":"10.1016\/j.gimo.2024.101877_bib11","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/gim.2017.77","article-title":"Medical genetics and genomics education: how do we define success? Where do we focus our resources?","volume":"19","author":"Bennett","year":"2017","journal-title":"Genet Med"},{"issue":"June","key":"10.1016\/j.gimo.2024.101877_bib12","article-title":"Evolving cardiovascular genetic counseling needs in the era of precision medicine","volume":"10","author":"Morales","year":"2023","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.gimo.2024.101877_bib13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/jmedgenet-2016-104302","article-title":"Impact of subsidies on cancer genetic testing uptake in Singapore","volume":"54","author":"Li","year":"2017","journal-title":"J\u00a0Med Genet"},{"issue":"1","key":"10.1016\/j.gimo.2024.101877_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41525-019-0085-8","article-title":"Implementation of genomics in medical practice to deliver precision medicine for an Asian population","volume":"4","author":"Bylstra","year":"2019","journal-title":"npj Genom Med"},{"issue":"3","key":"10.1016\/j.gimo.2024.101877_bib17","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.cell.2019.09.019","article-title":"Large-scale whole-genome sequencing of three diverse Asian populations in Singapore","volume":"179","author":"Wu","year":"2019","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.gimo.2024.101877_bib18","doi-asserted-by":"crossref","first-page":"E2403","DOI":"10.1002\/humu.22619","article-title":"Online registry for mutations in hereditary amyloidosis including nomenclature recommendations","volume":"35","author":"Rowczenio","year":"2014","journal-title":"Hum Mutat"},{"issue":"4","key":"10.1016\/j.gimo.2024.101877_bib19","first-page":"723","article-title":"Hereditary transthyretin amyloidosis- clinical and genetic characteristics of a multiracial South-East Asian cohort in Singapore","volume":"8","author":"Chen","year":"2021","journal-title":"J\u00a0Neuromuscul Dis"},{"issue":"5","key":"10.1016\/j.gimo.2024.101877_bib20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1161\/CIRCGEN.119.002823","article-title":"Genetic studies of hypertrophic cardiomyopathy in Singaporeans identify variants in TNNI3 and TNNT2 that are common in Chinese patients","volume":"13","author":"Pua","year":"2020","journal-title":"Circ Genom Precis Med"},{"issue":"1","key":"10.1016\/j.gimo.2024.101877_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12910-022-00744-5","article-title":"Who\u2019s afraid of genetic tests?: an assessment of Singapore\u2019s public attitudes and changes in attitudes after taking a genetic test","volume":"23","author":"Cheung","year":"2022","journal-title":"BMC Med Ethics"},{"issue":"5","key":"10.1016\/j.gimo.2024.101877_bib22","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/HCG.0000000000000031","article-title":"Enhancing literacy in cardiovascular genetics: a scientific statement from the American Heart Association","volume":"9","author":"Mital","year":"2016","journal-title":"Circ Cardiovasc Genet"},{"issue":"9","key":"10.1016\/j.gimo.2024.101877_bib23","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1002\/ajmg.a.62779","article-title":"Systematic use of phenotype evidence in clinical genetic testing reduces the frequency of variants of uncertain significance","volume":"188","author":"Johnson","year":"2022","journal-title":"Am J Med Genet A"},{"issue":"6","key":"10.1016\/j.gimo.2024.101877_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/HCG.0000000000000054","article-title":"Establishment of specialized clinical cardiovascular genetics programs: recognizing the need and meeting standards: a scientific statement from the American Heart Association","volume":"12","author":"Ahmad","year":"2019","journal-title":"Circ Genom Precis Med"},{"issue":"23","key":"10.1016\/j.gimo.2024.101877_bib25","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1016\/j.jacc.2009.12.063","article-title":"Active cascade screening in primary inherited arrhythmia syndromes: does it lead to prophylactic treatment?","volume":"55","author":"Hofman","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"April","key":"10.1016\/j.gimo.2024.101877_bib26","first-page":"11","article-title":"Cardiovascular cascade genetic testing: exploring the role of direct contact and technology","volume":"3","author":"Sturm","year":"2016","journal-title":"Front Cardiovasc Med"},{"issue":"20","key":"10.1016\/j.gimo.2024.101877_bib27","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/j.jacc.2020.12.071","article-title":"Precision medicine in cardiovascular disease: genetics and impact on phenotypes: JACC focus Seminar 1\/5","volume":"77","author":"Semsarian","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.gimo.2024.101877_bib28","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.hrthm.2022.03.1225","article-title":"European Heart Rhythm Association (EHRA)\/Heart Rhythm Society (HRS)\/Asia Pacific Heart Rhythm Society (APHRS)\/Latin American Heart Rhythm Society (LAHRS) expert consensus statement on the state of genetic testing for cardiac diseases","volume":"19","author":"Wilde","year":"2022","journal-title":"Heart Rhythm"},{"issue":"11","key":"10.1016\/j.gimo.2024.101877_bib29","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jacc.2022.11.022","article-title":"2023 ACC Expert Consensus decision pathway on comprehensive multidisciplinary care for the patient with cardiac amyloidosis: a report of the American College of Cardiology Solution Set Oversight Committee","volume":"81","author":"Kittleson","year":"2023","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.gimo.2024.101877_bib30","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.008193","article-title":"Long-term survival with tafamidis in patients with transthyretin amyloid cardiomyopathy","volume":"15","author":"Elliott","year":"2022","journal-title":"Circ Heart Fail"},{"issue":"8","key":"10.1016\/j.gimo.2024.101877_bib31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/heartjnl-2011-300368","article-title":"A\u00a0cost-effectiveness model of genetic testing for the evaluation of families with hypertrophic cardiomyopathy","volume":"98","author":"Ingles","year":"2012","journal-title":"Heart"},{"issue":"12","key":"10.1016\/j.gimo.2024.101877_bib32","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1038\/s41436-019-0582-2","article-title":"A\u00a0cost-effectiveness model of genetic testing and periodical clinical screening for the evaluation of families with dilated cardiomyopathy","volume":"21","author":"Catchpool","year":"2019","journal-title":"Genet Med"},{"issue":"5","key":"10.1016\/j.gimo.2024.101877_bib33","first-page":"464","article-title":"The Cost-effectiveness of genetic screening for familial hypercholesterolemia: a systematic review","volume":"29","author":"Rosso","year":"2017","journal-title":"Ann Ig"},{"issue":"2","key":"10.1016\/j.gimo.2024.101877_bib34","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41588-022-01274-x","article-title":"The Singapore national precision medicine strategy","volume":"55","author":"Wong","year":"2023","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.gimo.2024.101877_bib35","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1377\/hlthaff.2017.1595","article-title":"Lack of diversity in genomic databases is a barrier to translating precision medicine research into practice","volume":"37","author":"Landry","year":"2018","journal-title":"Health Aff (Millwood)"},{"issue":"1","key":"10.1016\/j.gimo.2024.101877_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/CIRCGENETICS.110.957365","article-title":"Psychological issues in genetic testing for inherited cardiovascular diseases","volume":"4","author":"Aatre","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"issue":"7","key":"10.1016\/j.gimo.2024.101877_bib37","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1056\/NEJMsa1507092","article-title":"Genetic misdiagnoses and the potential for health disparities","volume":"375","author":"Manrai","year":"2016","journal-title":"N\u00a0Engl J Med"},{"issue":"8","key":"10.1016\/j.gimo.2024.101877_bib38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41569-021-00586-5","article-title":"A\u00a0call for training programmes in cardiovascular genomics","volume":"18","author":"Safarova","year":"2021","journal-title":"Nat Rev Cardiol"},{"issue":"13","key":"10.1016\/j.gimo.2024.101877_bib39","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.jacc.2017.08.020","article-title":"Preparing fellows for precision cardiology: are we ready?","volume":"70","author":"Vaduganathan","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Genetics in Medicine Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949774424010239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949774424010239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:58:22Z","timestamp":1778936302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2949774424010239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":37,"alternative-id":["S2949774424010239"],"URL":"https:\/\/doi.org\/10.1016\/j.gimo.2024.101877","relation":{},"ISSN":["2949-7744"],"issn-type":[{"value":"2949-7744","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancing precision medicine through the integration of clinical cardiovascular genetics - An Asian perspective","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gimo.2024.101877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics.","name":"copyright","label":"Copyright"}],"article-number":"101877"}}