{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:13:55Z","timestamp":1783505635605,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":120,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022736","name":"Hospital Moinhos de Vento","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gimopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine Open"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.gimo.2026.104403","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:02:58Z","timestamp":1779206578000},"page":"104403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The distinct molecular profile of metastatic prostate cancer in the mixed Brazilian population"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-9577","authenticated-orcid":false,"given":"Gabriel S.","family":"Macedo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline Bohrer","family":"Schuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan Araujo","family":"Cadore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Cerveira de Baumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana Dallaio","family":"Curzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bordignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahira Lopes","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Silveira da Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Lacerda","family":"Costa Louzeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Arruda do Rego Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Notari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Bobato","family":"Lara Gongora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor","family":"Fiorin de Vasconcellos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Williams Fernandes","family":"Barra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Guesser","family":"Ascenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"D'Almeida Preto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Janoski de Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilmar","family":"de Moura Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Knackfuss","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Emanuel","family":"Rubini Liedke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00e1ucio Ant\u00f4nio","family":"Bertollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Kowalski","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Luiz","family":"Campos Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Hehn de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Liane","family":"Neubarth Estivallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Finger","family":"Andreis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Caroline Fonseca","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Vasconcelos","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Moura","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Ventura","family":"Castiglioni Dornela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millene Arruda","family":"Bechara Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleyton Santos de","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Fernandes de","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Tortato","family":"Meneguete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian Lucchesi Fernandes de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Colombo","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia Valente","family":"Gon\u00e7alves Schuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Bessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Dornelles","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.gimo.2026.104403_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"10437","key":"10.1016\/j.gimo.2026.104403_bib2","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0140-6736(24)00651-2","article-title":"The Lancet Commission on prostate cancer: planning for the surge in cases","volume":"403","author":"James","year":"2024","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.gimo.2026.104403_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.eururo.2023.04.021","article-title":"2022 Update on prostate cancer epidemiology and risk factors-a systematic review","volume":"84","author":"Bergengren","year":"2023","journal-title":"Eur Urol"},{"issue":"6","key":"10.1016\/j.gimo.2026.104403_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41585-022-00580-7","article-title":"Germline testing and genetic counselling in prostate cancer","volume":"19","author":"Russo","year":"2022","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.gimo.2026.104403_bib5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ejca.2023.02.018","article-title":"Management of patients with advanced prostate cancer-metastatic and\/or castration-resistant prostate cancer: report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022","volume":"185","author":"Gillessen","year":"2023","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.gimo.2026.104403_bib6","unstructured":"National Comprehensive Cancer Network. Genetic\/familial high-risk assessment: breast, ovarian, pancreatic, and prostate. version 1.2025. In: NCCN Clinical Practice Guidelines in Oncology."},{"issue":"4","key":"10.1016\/j.gimo.2026.104403_bib7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/jamaoncol.2018.6760","article-title":"Prevalence of germline variants in prostate cancer and implications for current genetic testing guidelines","volume":"5","author":"Nicolosi","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.gimo.2026.104403_bib8","article-title":"Personalized screening strategies for TP53 R337H carriers: a retrospective cohort study of tumor spectrum in Li-Fraumeni syndrome adult carriers","volume":"42","author":"Galante","year":"2025","journal-title":"Lancet Reg Health Am"},{"issue":"22","key":"10.1016\/j.gimo.2026.104403_bib9","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa1911440","article-title":"Olaparib for metastatic castration-resistant prostate cancer","volume":"382","author":"de Bono","year":"2020","journal-title":"N Engl J Med"},{"issue":"10398","key":"10.1016\/j.gimo.2026.104403_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0140-6736(23)01055-3","article-title":"Talazoparib plus enzalutamide in men with first-line metastatic castration-resistant prostate cancer (TALAPRO-2): a randomised, placebo-controlled, phase 3 trial","volume":"402","author":"Agarwal","year":"2023","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.gimo.2026.104403_bib11","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1200\/JCO.22.01649","article-title":"Niraparib and abiraterone acetate for metastatic castration-resistant prostate cancer","volume":"41","author":"Chi","year":"2023","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1016\/j.gimo.2026.104403_bib12","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1158\/1078-0432.CCR-21-3940","article-title":"Tumor genomic testing for >4,000 men with metastatic castration-resistant prostate cancer in the phase III trial PROfound (olaparib)","volume":"28","author":"Hussain","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10.1016\/j.gimo.2026.104403_bib13","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1158\/1078-0432.CCR-21-2577","article-title":"Differences in prostate cancer genomes by self-reported race: contributions of genetic ancestry, modifiable cancer risk factors, and clinical factors","volume":"28","author":"Stopsack","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"8","key":"10.1016\/j.gimo.2026.104403_bib14","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1158\/1078-0432.CCR-22-2598","article-title":"CHIP happens: clonal hematopoiesis of indeterminate potential and its relationship to solid tumors","volume":"29","author":"Reed","year":"2023","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.gimo.2026.104403_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1001\/jamaoncol.2020.5161","article-title":"Association of clonal hematopoiesis in DNA repair genes with prostate cancer plasma cell-free DNA testing interference","volume":"7","author":"Jensen","year":"2021","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.gimo.2026.104403_bib16","doi-asserted-by":"crossref","first-page":"1350162","DOI":"10.3389\/fonc.2024.1350162","article-title":"Mapping breast and prostate cancer in the Brazilian public health system: study protocol of the Onco-Genomas Brasil","volume":"14","author":"Schuch","year":"2024","journal-title":"Front Oncol"},{"issue":"5","key":"10.1016\/j.gimo.2026.104403_bib17","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.gimo.2026.104403_bib18","article-title":"OncoKB: a precision oncology knowledge base","volume":"2017","author":"Chakravarty","year":"2017","journal-title":"JCO Precis Oncol"},{"issue":"1","key":"10.1016\/j.gimo.2026.104403_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1158\/2159-8290.CD-23-0467","article-title":"Quantifying the expanding landscape of clinical actionability for patients with cancer","volume":"14","author":"Suehnholz","year":"2024","journal-title":"Cancer Discov"},{"issue":"1","key":"10.1016\/j.gimo.2026.104403_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2015-03-631747","article-title":"Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes","volume":"126","author":"Steensma","year":"2015","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.gimo.2026.104403_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.eururo.2019.08.005","article-title":"Recent global patterns in prostate cancer incidence and mortality rates","volume":"77","author":"Culp","year":"2020","journal-title":"Eur Urol"},{"issue":"2","key":"10.1016\/j.gimo.2026.104403_bib22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/cncr.26191","article-title":"Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and pancreatic cancer","volume":"118","author":"Stadler","year":"2012","journal-title":"Cancer"},{"issue":"7","key":"10.1016\/j.gimo.2026.104403_bib23","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41431-022-01098-7","article-title":"The genetics of hereditary cancer risk syndromes in Brazil: a comprehensive analysis of 1682 patients","volume":"30","author":"de Oliveira","year":"2022","journal-title":"Eur J Hum Genet"},{"issue":"5","key":"10.1016\/j.gimo.2026.104403_bib24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa1603144","article-title":"Inherited DNA-repair gene mutations in men with metastatic prostate cancer","volume":"375","author":"Pritchard","year":"2016","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.gimo.2026.104403_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s44276-023-00024-8","article-title":"Germline sequencing in men with metastatic castration-resistant prostate cancer from the BARCODE2 study reveals a wide range of pathogenic variants in DNA repair genes","volume":"2","author":"Benafif","year":"2024","journal-title":"BJC Rep"},{"issue":"1","key":"10.1016\/j.gimo.2026.104403_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/jncics\/pkab097","article-title":"DNA repair pathways and their association with lethal prostate cancer in African American and European American men","volume":"6","author":"Plym","year":"2022","journal-title":"JNCI Cancer Spectr"},{"issue":"3","key":"10.1016\/j.gimo.2026.104403_bib27","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41391-022-00517-6","article-title":"Germline alterations among Hispanic men with prostate cancer","volume":"25","author":"Pan","year":"2022","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.gimo.2026.104403_bib28","article-title":"Prospective study of homologous recombination repair gene mutation prevalence in patients with advanced prostate cancer from Latin America: challenges and future approaches","volume":"8","author":"Manneh","year":"2024","journal-title":"JCO Precis Oncol"},{"issue":"22","key":"10.1016\/j.gimo.2026.104403_bib29","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1001\/jama.2011.743","article-title":"Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome","volume":"305","author":"Bonadona","year":"2011","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.gimo.2026.104403_bib30","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S1470-2045(21)00522-2","article-title":"A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (Impact): initial results from an international prospective study","volume":"22","author":"Bancroft","year":"2021","journal-title":"Lancet Oncol"},{"issue":"7","key":"10.1016\/j.gimo.2026.104403_bib31","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/jnci\/89.7.470","article-title":"Alfred Knudson: two hits times 25 years","volume":"89","author":"Kuska","year":"1997","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"10.1016\/j.gimo.2026.104403_bib32","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41391-023-00676-0","article-title":"Guidelines for genetic testing in prostate cancer: a scoping review","volume":"27","author":"Tuffaha","year":"2024","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"1","key":"10.1016\/j.gimo.2026.104403_bib33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.trecan.2019.11.006","article-title":"Evolving significance of tumor-normal sequencing in cancer care","volume":"6","author":"Mandelker","year":"2020","journal-title":"Trends Cancer"},{"issue":"5","key":"10.1016\/j.gimo.2026.104403_bib34","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41588-018-0078-z","article-title":"The long tail of oncogenic drivers in prostate cancer","volume":"50","author":"Armenia","year":"2018","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.gimo.2026.104403_bib35","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.cell.2015.10.025","article-title":"The molecular taxonomy of primary prostate cancer","volume":"163","year":"2015","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.gimo.2026.104403_bib36","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.cell.2015.05.001","article-title":"Integrative clinical genomics of advanced prostate cancer","volume":"161","author":"Robinson","year":"2015","journal-title":"Cell"},{"issue":"18","key":"10.1016\/j.gimo.2026.104403_bib37","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1056\/NEJMoa1506859","article-title":"DNA-repair defects and olaparib in metastatic prostate cancer","volume":"373","author":"Mateo","year":"2015","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.gimo.2026.104403_bib38","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1056\/NEJMc2000069","article-title":"Racial differences in genomic profiling of prostate cancer","volume":"383","author":"Mahal","year":"2020","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.gimo.2026.104403_bib39","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41585-022-00622-0","article-title":"Race and prostate cancer: genomic landscape","volume":"19","author":"Arenas-Gallo","year":"2022","journal-title":"Nat Rev Urol"},{"issue":"suppl 16","key":"10.1016\/j.gimo.2026.104403_bib40","article-title":"Presence of somatic\/germline homologous recombination repair (HRR) mutations and outcomes in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) receiving first-line (1L) treatment stratified by BRCA status","volume":"41","author":"Olmos","year":"2023","journal-title":"J Clin Oncol"}],"container-title":["Genetics in Medicine Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949774426009131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949774426009131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:18:23Z","timestamp":1783502303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2949774426009131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":40,"alternative-id":["S2949774426009131"],"URL":"https:\/\/doi.org\/10.1016\/j.gimo.2026.104403","relation":{},"ISSN":["2949-7744"],"issn-type":[{"value":"2949-7744","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The distinct molecular profile of metastatic prostate cancer in the mixed Brazilian population","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gimo.2026.104403","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics.","name":"copyright","label":"Copyright"}],"article-number":"104403"}}