{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:26:38Z","timestamp":1771651598021,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gynecologic Oncology Reports"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.gore.2025.101966","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T04:15:45Z","timestamp":1759551345000},"page":"101966","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Insights from plastic and reconstructive surgery wound specialists in managing complex vaginal and vulvar toxicities following radiation therapy"],"prefix":"10.1016","volume":"61","author":[{"given":"Ovya","family":"Ganesan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1130-2004","authenticated-orcid":false,"given":"Stephanie M.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Aiven","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Cain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen M.","family":"Feltmate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-7310","authenticated-orcid":false,"given":"Dennis P.","family":"Orgill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gore.2025.101966_b0005","doi-asserted-by":"crossref","unstructured":"G. Varyt\u0117 D. Bartkevi\u010dien\u0117 (2021). Pelvic radiation therapy induced vaginal stenosis: a review of current modalities and recent treatment advances. Medicina (Kaunas) 57. Doi: 10.3390\/medicina57040336.","DOI":"10.3390\/medicina57040336"},{"issue":"2","key":"10.1016\/j.gore.2025.101966_b0010","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ygyno.2020.11.025","article-title":"Vaginal necrosis: a rare late toxicity after radiation therapy","volume":"160","author":"Jia","year":"2021","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.gore.2025.101966_b0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.22462\/01.01.2023.16","article-title":"Successful treatment of radiation-induced vaginal soft tissue radionecrosis with HBO2","volume":"50","author":"McGlynn","year":"2023","journal-title":"Undersea Hyperb. Med."},{"issue":"3","key":"10.1016\/j.gore.2025.101966_b0020","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brachy.2011.05.005","article-title":"Three-dimensional image-based high-dose-rate interstitial brachytherapy for vaginal cancer","volume":"11","author":"Beriwal","year":"2012","journal-title":"Brachytherapy"},{"key":"10.1016\/j.gore.2025.101966_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.680038","article-title":"Changes in the vaginal microbiome and associated toxicities following radiation therapy for gynecologic cancers","volume":"11","author":"Tsementzi","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.gore.2025.101966_b0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clon.2021.07.014","article-title":"Lichen sclerosis is associated with a high rate of local failure after radio(chemo)therapy for vulvar cancer","volume":"34","author":"Fokdal","year":"2022","journal-title":"Clin. Oncol. (R. Coll. Radiol.)"},{"issue":"1","key":"10.1016\/j.gore.2025.101966_b0035","article-title":"Effect of diluted dakin's solution versus standard care on diabetic foot ulcer management: a randomized controlled trial","volume":"112","author":"Jaber","year":"2022","journal-title":"J. Am. Podiatr. Med. Assoc."},{"issue":"Sup10a","key":"10.1016\/j.gore.2025.101966_b0040","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.12968\/jowc.2020.29.Sup10a.S4","article-title":"Wound cleansing: benefits of hypochlorous acid","volume":"29","author":"Joachim","year":"2020","journal-title":"J. Wound Care"},{"issue":"6","key":"10.1016\/j.gore.2025.101966_b0045","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/iwj.12428","article-title":"Efficacy of 1% acetic acid in the treatment of chronic wounds infected with Pseudomonas aeruginosa: prospective randomised controlled clinical trial","volume":"13","author":"Madhusudhan","year":"2016","journal-title":"Int. Wound J."},{"key":"10.1016\/j.gore.2025.101966_b0050","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ijsu.2017.06.073","article-title":"Povidone iodine in wound healing: a review of current concepts and practices","volume":"44","author":"Bigliardi","year":"2017","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.gore.2025.101966_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2025.103214","article-title":"Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): long-term follow-up of a randomised controlled, phase 2\u20133 trial","volume":"83","author":"Oscarsson","year":"2025","journal-title":"eClinicalMedicine"},{"issue":"5","key":"10.1016\/j.gore.2025.101966_b0060","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3747\/co.v18i5.767","article-title":"Hyperbaric oxygen therapy for late radiation tissue injury in gynecologic malignancies","volume":"18","author":"Craighead","year":"2011","journal-title":"Curr. Oncol."},{"issue":"3","key":"10.1016\/j.gore.2025.101966_b0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11547-022-01455-y","article-title":"EROS 2.0 study: evaluation of two interventional radiotherapy (brachytherapy) schedules for endometrial cancer: a comparison of late vaginal toxicity rates","volume":"127","author":"Lancellotta","year":"2022","journal-title":"Radiol. Med."},{"key":"10.1016\/j.gore.2025.101966_b0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ygyno.2025.04.003","article-title":"Reduced symptoms of late radiation tissue injury of the vagina after treatment with hyperbaric oxygen therapy: a retrospective analysis of 19 patients","volume":"197","author":"M\u00f6ring","year":"2025","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.gore.2025.101966_b0075","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1186\/s12885-022-09695-x","volume":"22","author":"Hwang","year":"2022","journal-title":"BMC Cancer"},{"issue":"12","key":"10.1016\/j.gore.2025.101966_b0080","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1007\/s00066-017-1178-x","article-title":"Increased genitourinary fistula rate after bevacizumab in recurrent cervical cancer patients initially treated with definitive radiochemotherapy and image-guided adaptive brachytherapy","volume":"193","author":"Sturdza","year":"2017","journal-title":"Strahlenther. Onkol."},{"issue":"9","key":"10.1016\/j.gore.2025.101966_b0085","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s10147-022-02196-8","article-title":"Incidence of fistula occurrence in patients with cervical cancer treated with bevacizumab: data from real-world clinical practice","volume":"27","author":"Sugiyama","year":"2022","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.gore.2025.101966_b0090","article-title":"Organ perforation and fistula formation as adverse events in patients receiving tyrosine kinase inhibitors: a post-market analysis","volume":"43(5_suppl):528-","author":"Myint","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.gore.2025.101966_b0095","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.radonc.2021.01.019","article-title":"Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: an EMBRACE analysis","volume":"158","author":"Spampinato","year":"2021","journal-title":"Radiother. Oncol."},{"issue":"2","key":"10.1016\/j.gore.2025.101966_b0100","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ygyno.2014.02.005","article-title":"Impact of post-radiation biopsies on development of fistulae in patients with cervical cancer","volume":"133","author":"Feddock","year":"2014","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.gore.2025.101966_b0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3892\/ol.2023.14139","article-title":"Rectal ulcer associated with lenvatinib 15years after definitive radiotherapy for prostate cancer: a case report","volume":"27","author":"Kawata","year":"2024","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.gore.2025.101966_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1009884","article-title":"Human amniotic membrane for myocutaneous dehiscence after a radical surgical treatment of vulvar cancer: a case report","volume":"12","author":"Restaino","year":"2022","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.gore.2025.101966_b0115","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.ygyno.2007.08.063","article-title":"Reconstruction of the pelvic floor and perineum with human acellular dermal matrix and thigh flaps following pelvic exenteration","volume":"107","author":"Said","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.gore.2025.101966_b0120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gore.2016.01.002","article-title":"Restoration of vaginal anatomy after extensive posterior wall resection utilizing human acellular dermal matrix","volume":"16","author":"Bhavsar","year":"2016","journal-title":"Gynecol Oncol Rep."},{"issue":"2","key":"10.1016\/j.gore.2025.101966_b0125","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1080\/08941939.2017.1399177","article-title":"Vaginoplasty with acellular dermal matrix after radical resection for carcinoma of the uterine cervix","volume":"32","author":"Wang","year":"2019","journal-title":"J. Invest. Surg."},{"issue":"6","key":"10.1016\/j.gore.2025.101966_b0130","article-title":"Deconstructing fat to reverse radiation induced soft tissue fibrosis","volume":"10","author":"Prescher","year":"2023","journal-title":"Bioengineering (basel)"},{"issue":"7","key":"10.1016\/j.gore.2025.101966_b0135","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/aogs.14621","article-title":"Prospects for use of bioengineered tissue from stem cells in gynecology","volume":"102","author":"Br\u00e4nnstr\u00f6m","year":"2023","journal-title":"Acta Obstet. Gynecol. Scand."}],"container-title":["Gynecologic Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352578925002917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352578925002917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T02:10:55Z","timestamp":1761185455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352578925002917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":27,"alternative-id":["S2352578925002917"],"URL":"https:\/\/doi.org\/10.1016\/j.gore.2025.101966","relation":{},"ISSN":["2352-5789"],"issn-type":[{"value":"2352-5789","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights from plastic and reconstructive surgery wound specialists in managing complex vaginal and vulvar toxicities following radiation therapy","name":"articletitle","label":"Article Title"},{"value":"Gynecologic Oncology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gore.2025.101966","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101966"}}