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Here, we applied single-cell multi-omics sequencing for seven infants with blastula chromosomal mosaicism detected by TE biopsy. The chromosome ploidy was examined by single-cell genome analysis, with the cellular identity being identified by single-cell transcriptome analysis. A total of 1616 peripheral leukocytes from seven infants with embryonic chromosomal mosaicism and three control ones with euploid TE biopsy were analyzed. A small number of blood cells showed copy number alterations (CNAs) on seemingly random locations at a frequency of 0%\u22122.5% per infant. However, none of the cells showed CNAs that were the same as those of the corresponding TE biopsies. The blastula chromosomal mosaicism may be fully self-corrected, probably through the selective loss of the aneuploid cells during development, and the transferred embryos can be born as euploid infants without mosaic CNAs corresponding to the TE biopsies. The results provide a new reference for the evaluations of transferring chromosomal mosaic embryos in certain situations.<\/jats:p>","DOI":"10.1016\/j.gpb.2022.07.004","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T13:04:31Z","timestamp":1659791071000},"page":"1224-1231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Single-Cell Sequencing Reveals Clearance of Blastula Chromosomal Mosaicism in\n                    <i>In Vitro<\/i>\n                    Fertilization Babies"],"prefix":"10.1093","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9254-8863","authenticated-orcid":false,"given":"Yuan","family":"Gao","sequence":"first","affiliation":[{"name":"Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University , Beijing 100871 , China"},{"name":"Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, 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Diagnosis Center, The University of Hong Kong\u2013Shenzhen Hospital , Shenzhen 518053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-5994","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, The First Medical Center of PLA General Hospital , Beijing 100853 , China"},{"name":"Reproductive Medicine and Prenatal Diagnosis Center, The University of Hong Kong\u2013Shenzhen Hospital , Shenzhen 518053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-9066","authenticated-orcid":false,"given":"Yanfei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, The First Medical Center of PLA General Hospital , Beijing 100853 , China"},{"name":"Reproductive Medicine and Prenatal Diagnosis Center, The University of Hong Kong\u2013Shenzhen Hospital , Shenzhen 518053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-5651","authenticated-orcid":false,"given":"Shuang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, The First Medical Center of PLA General Hospital , Beijing 100853 , China"},{"name":"Reproductive Medicine and Prenatal Diagnosis Center, The University of Hong Kong\u2013Shenzhen Hospital , Shenzhen 518053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5184-7741","authenticated-orcid":false,"given":"Minyue","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, The First Medical Center of PLA General Hospital , Beijing 100853 , China"},{"name":"Reproductive Medicine and Prenatal Diagnosis Center, The University of Hong Kong\u2013Shenzhen Hospital , Shenzhen 518053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7214-5995","authenticated-orcid":false,"given":"Hongmei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, The First Medical Center of PLA General Hospital , Beijing 100853 , China"},{"name":"Reproductive Medicine and Prenatal Diagnosis Center, The University of Hong Kong\u2013Shenzhen Hospital , Shenzhen 518053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-1876","authenticated-orcid":false,"given":"Lu","family":"Wen","sequence":"additional","affiliation":[{"name":"Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University , Beijing 100871 , China"},{"name":"Beijing Advanced Innovation Center for Genomics, MOE Key Laboratory of Cell Proliferation and Differentiation , Beijing 100871 , 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Published by Elsevier B.V. and Science Press on behalf of Beijing Institute of Genomics, Chinese Academy of Sciences \/ China National Center for Bioinformation and Genetics Society of China.","name":"copyright","label":"Copyright"}]}}