{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:57:13Z","timestamp":1760954233232},"reference-count":117,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Clinics of North America"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.gtc.2007.08.003","type":"journal-article","created":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T02:50:57Z","timestamp":1196823057000},"page":"901-926","source":"Crossref","is-referenced-by-count":12,"title":["Neoplastic Precursor Lesions Related to the Development of Cancer in Inflammatory Bowel Disease"],"prefix":"10.1016","volume":"36","author":[{"given":"Noam","family":"Harpaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.48.4.526","article-title":"The risk of colorectal cancer in ulcerative colitis: a meta-analysis","volume":"48","author":"Eaden","year":"2001","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.gtc.2007.08.003_bib2","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1111\/j.1572-0241.2000.02297.x","article-title":"Colorectal cancer complicating ulcerative colitis: a review","volume":"95","author":"Eaden","year":"2000","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.gtc.2007.08.003_bib3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/gut.25.3.228","article-title":"Survival of patients with colorectal cancer complicating ulcerative colitis","volume":"25","author":"Gyde","year":"1984","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib4","first-page":"339","article-title":"Colorectal cancer in idiopathic inflammatory bowel disease","volume":"13","author":"Harpaz","year":"1996","journal-title":"Semin Diagn Pathol"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib5","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1053\/j.gastro.2004.03.025","article-title":"Diagnosis and management of dysplasia in patients with inflammatory bowel diseases","volume":"126","author":"Itzkowitz","year":"2004","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib6","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1053\/j.gastro.2005.12.035","article-title":"Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis","volume":"130","author":"Rutter","year":"2006","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0016-5085(79)90279-8","article-title":"Cancer in universal and left-sided ulcerative colitis: factors determining risk","volume":"77","author":"Greenstein","year":"1979","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.gtc.2007.08.003_bib8","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.gtc.2006.07.002","article-title":"Molecular biology of dysplasia and cancer in inflammatory bowel disease","volume":"35","author":"Itzkowitz","year":"2006","journal-title":"Gastroenterol Clin North Am"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib9","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00384-002-0476-6","article-title":"Chemoprevention of colorectal cancer in ulcerative colitis","volume":"18","author":"Croog","year":"2003","journal-title":"Int J Colorectal Dis"},{"issue":"11","key":"10.1016\/j.gtc.2007.08.003_bib10","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.cgh.2006.08.014","article-title":"Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitis","volume":"4","author":"Rubin","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4 Suppl 2","key":"10.1016\/j.gtc.2007.08.003_bib11","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1097\/01.mcg.0000155554.01336.ff","article-title":"Preventing neoplastic progression in ulcerative colitis","volume":"39","author":"Ullman","year":"2005","journal-title":"J Clin Gastroenterol"},{"issue":"Suppl 4","key":"10.1016\/j.gtc.2007.08.003_bib12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1365-2036.2004.02046.x","article-title":"Review article: colorectal carcinoma and inflammatory bowel disease","volume":"20","author":"Eaden","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib13","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z","article-title":"Cancer risk in patients with inflammatory bowel disease: a population-based study","volume":"91","author":"Bernstein","year":"2001","journal-title":"Cancer 15"},{"issue":"7","key":"10.1016\/j.gtc.2007.08.003_bib14","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1136\/gut.35.7.950","article-title":"Similarity of colorectal cancer in Crohn's disease and ulcerative colitis: implications for carcinogenesis and prevention","volume":"35","author":"Choi","year":"1994","journal-title":"Gut"},{"issue":"8711","key":"10.1016\/j.gtc.2007.08.003_bib15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0140-6736(90)91889-I","article-title":"Increased risk of large-bowel cancer in Crohn's disease with colonic involvement","volume":"336","author":"Ekbom","year":"1990","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/gut.35.5.651","article-title":"Crohn's disease and colorectal cancer","volume":"35","author":"Gillen","year":"1994","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.gtc.2007.08.003_bib17","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1111\/j.1572-0241.2005.00287.x","article-title":"Increased risk of intestinal cancer in Crohn's disease: a meta-analysis of population-based cohort studies","volume":"100","author":"Jess","year":"2005","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1053\/j.gastro.2003.11.010","article-title":"Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis","volume":"126","author":"Rutter","year":"2004","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib19","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1053\/j.gastro.2007.08.001","article-title":"Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study","volume":"133","author":"Bansal Gupta","year":"2007","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.gtc.2007.08.003_bib20","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/00054725-200608000-00001","article-title":"Incidence and prognosis of colorectal dysplasia in inflammatory bowel disease: a population-based study from Olmsted County, Minnesota","volume":"12","author":"Jess","year":"2006","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib21","first-page":"1404","article-title":"Primary sclerosing cholangitis and ulcerative colitis: evidence for increased neoplastic potential","volume":"22","author":"Broome","year":"1995","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3109\/00365528709011139","article-title":"Primary sclerosing cholangitis: a long-term follow-up study","volume":"22","author":"Aadland","year":"1987","journal-title":"Scand J Gastroenterol"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1053\/gast.1996.v110.pm8566577","article-title":"Risk and natural history of colonic neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis","volume":"110","author":"Brentnall","year":"1996","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib24","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/0016-5085(92)90308-L","article-title":"Primary sclerosing cholangitis in ulcerative colitis\u2014a risk factor for the development of dysplasia and DNA aneuploidy?","volume":"102","author":"Broome","year":"1992","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/gut.41.4.522","article-title":"Is there an excess risk for colorectal cancer in patients with ulcerative colitis and concomitant primary sclerosing cholangitis? A population based study","volume":"41","author":"Kornfeld","year":"1997","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib26","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1111\/j.1572-0241.1999.01156.x","article-title":"The risk for cancer or dysplasia in ulcerative colitis patients with primary sclerosing cholangitis","volume":"94","author":"Shetty","year":"1999","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1136\/gut.2004.051771","article-title":"Risk of haematopoietic cancer in patients with inflammatory bowel disease","volume":"54","author":"Askling","year":"2005","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib28","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0016-5085(98)70077-0","article-title":"Familial predisposition for colorectal cancer in chronic ulcerative colitis: a case-control study","volume":"115","author":"Nuako","year":"1998","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/1097-0142(19800715)46:2<403::AID-CNCR2820460232>3.0.CO;2-6","article-title":"Patterns of neoplasia in Crohn's disease and ulcerative colitis","volume":"46","author":"Greenstein","year":"1980","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0016-5085(85)90343-9","article-title":"Colorectal carcinoma in patients with Crohn's disease","volume":"89","author":"Hamilton","year":"1985","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00000658-198602000-00002","article-title":"A comparison of multiple synchronous colorectal cancer in ulcerative colitis, familial polyposis coli, and de novo cancer","volume":"203","author":"Greenstein","year":"1986","journal-title":"Ann Surg"},{"issue":"7","key":"10.1016\/j.gtc.2007.08.003_bib32","first-page":"382","article-title":"Cancer and dysplasia in ulcerative colitis: a histologic study of 301 surgical specimen","volume":"32","author":"von Herbay","year":"1994","journal-title":"Z Gastroenterol"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00054725-200311000-00002","article-title":"Gross versus microscopic pancolitis and the occurrence of neoplasia in ulcerative colitis","volume":"9","author":"Mathy","year":"2003","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.gtc.2007.08.003_bib34","first-page":"657","article-title":"Pathogenesis of ulcerative colitis","volume":"25","author":"Warren","year":"1949","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib35","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/gut.8.5.423","article-title":"Rectal biopsy as an aid to cancer control in ulcerative colitis","volume":"8","author":"Morson","year":"1967","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.gtc.2007.08.003_bib36","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1136\/gut.35.10.1419","article-title":"Clinicopathological characteristics of colorectal carcinoma complicating ulcerative colitis","volume":"35","author":"Connell","year":"1994","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.gtc.2007.08.003_bib37","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/gut.31.7.800","article-title":"Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years","volume":"31","author":"Lennard-Jones","year":"1990","journal-title":"Gut"},{"issue":"18","key":"10.1016\/j.gtc.2007.08.003_bib38","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1056\/NEJM199011013231802","article-title":"Ulcerative colitis and colorectal cancer. A population-based study","volume":"323","author":"Ekbom","year":"1990","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib39","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/0016-5085(87)90260-5","article-title":"Crohn's disease and intestinal carcinoma. A report of 11 cases with emphasis on associated epithelial dysplasia","volume":"93","author":"Petras","year":"1987","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib40","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/00000658-198906000-00014","article-title":"Crohn's disease\u2013associated carcinoma. A poorly recognized complication of inflammatory bowel disease","volume":"209","author":"Richards","year":"1989","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib41","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/00000478-199906000-00003","article-title":"Intestinal adenocarcinoma in Crohn's disease: a report of 30 cases with a focus on coexisting dysplasia","volume":"23","author":"Sigel","year":"1999","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"10.1016\/j.gtc.2007.08.003_bib42","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1007\/BF02047872","article-title":"Crohn's disease and carcinoma: increasing justification for surveillance?","volume":"35","author":"Stahl","year":"1992","journal-title":"Dis Colon Rectum"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib43","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1365-2036.2007.03241.x","article-title":"Meta-analysis: cancer risk of low-grade dysplasia in chronic ulcerative colitis","volume":"25","author":"Thomas","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"issue":"8889","key":"10.1016\/j.gtc.2007.08.003_bib44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0140-6736(94)90813-3","article-title":"Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis?","volume":"343","author":"Bernstein","year":"1994","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib45","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/0016-5085(94)90216-X","article-title":"Factors affecting the outcome of endoscopic surveillance for cancer in ulcerative colitis","volume":"107","author":"Connell","year":"1994","journal-title":"Gastroenterology"},{"issue":"8342","key":"10.1016\/j.gtc.2007.08.003_bib46","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(83)90129-0","article-title":"Cancer surveillance in ulcerative colitis. Experience over 15 years","volume":"2","author":"Lennard-Jones","year":"1983","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib47","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1055\/s-2005-861421","article-title":"Endoscopic surveillance of chronic inflammatory bowel disease","volume":"37","author":"Barthet","year":"2005","journal-title":"Endoscopy"},{"issue":"Suppl 5","key":"10.1016\/j.gtc.2007.08.003_bib48","doi-asserted-by":"crossref","first-page":"V10","DOI":"10.1136\/gut.51.suppl_5.v10","article-title":"Guidelines for screening and surveillance of asymptomatic colorectal cancer in patients with inflammatory bowel disease","volume":"51","author":"Eaden","year":"2002","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.gtc.2007.08.003_bib49","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/01.MIB.0000160811.76729.d5","article-title":"Consensus conference: Colorectal cancer screening and surveillance in inflammatory bowel disease","volume":"11","author":"Itzkowitz","year":"2005","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib50","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1053\/gast.2001.22449","article-title":"Screening and surveillance colonoscopy in chronic Crohn's colitis","volume":"120","author":"Friedman","year":"2001","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib51","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000279.pub3","article-title":"Strategies for detecting colon cancer and\/or dysplasia in patients with inflammatory bowel disease","author":"Collins","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"10.1016\/j.gtc.2007.08.003_bib52","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0046-8177(83)80175-0","article-title":"Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications","volume":"14","author":"Riddell","year":"1983","journal-title":"Hum Pathol"},{"key":"10.1016\/j.gtc.2007.08.003_bib53","volume":"Vol 2","author":"Hamilton","year":"2000"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib54","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/gut.47.2.251","article-title":"The Vienna classification of gastrointestinal epithelial neoplasia","volume":"47","author":"Schlemper","year":"2000","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib55","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1136\/gut.45.5.686","article-title":"Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations","volume":"45","author":"Andersen","year":"1999","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib56","first-page":"222","article-title":"Villous epithelial regeneration and dysplasia in ulcerative colitis","volume":"101","author":"Antonioli","year":"1977","journal-title":"Arch Pathol Lab Med"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib57","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF02555626","article-title":"Villous dysplasia. An ominous histologic sign in colitic patients","volume":"27","author":"Rubio","year":"1984","journal-title":"Dis Colon Rectum"},{"issue":"6C","key":"10.1016\/j.gtc.2007.08.003_bib58","first-page":"4761","article-title":"Villous and serrated adenomatous growth bordering carcinomas in inflammatory bowel disease","volume":"20","author":"Rubio","year":"2000","journal-title":"Anticancer Res"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib59","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1463-1318.2002.00392.x","article-title":"Histological changes associated with the use of intravenous cyclosporin in the treatment of severe ulcerative colitis may mimic dysplasia","volume":"4","author":"Hyde","year":"2002","journal-title":"Colorectal Dis"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib60","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0016-5085(81)90727-7","article-title":"Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy","volume":"80","author":"Blackstone","year":"1981","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.gtc.2007.08.003_bib61","first-page":"2094","article-title":"Conservative management of small adenomata in ulcerative colitis","volume":"92","author":"Medlicott","year":"1997","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib62","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0016-5085(99)70278-7","article-title":"Polypectomy may be adequate treatment for adenoma-like dysplastic lesions in chronic ulcerative colitis","volume":"117","author":"Engelsgjerd","year":"1999","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.gtc.2007.08.003_bib63","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S1542-3565(04)00237-X","article-title":"Long-term follow-up after polypectomy treatment for adenoma-like dysplastic lesions in ulcerative colitis","volume":"2","author":"Odze","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib64","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0016-5085(99)70279-9","article-title":"Colonoscopic polypectomy in chronic colitis: conservative management after endoscopic resection of dysplastic polyps","volume":"117","author":"Rubin","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gtc.2007.08.003_bib65","unstructured":"Farraye FA, Waye JD, Heeren TC, et al. Variability in the diagnosis and management of adenoma-like and non-adenoma like DALMs in patients with ulcerative colitis. Gastrointest Endosc, in press."},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib66","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/01.pcr.0000133038.11825.1d","article-title":"Adenoma-like dysplastic polyps in inflammatory bowel disease","volume":"9","author":"Harpaz","year":"2004","journal-title":"Pathol Case Rev"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib67","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/00054725-200307000-00006","article-title":"Management of neoplastic polyps in inflammatory bowel disease","volume":"9","author":"Friedman","year":"2003","journal-title":"Inflamm Bowel Dis"},{"issue":"9","key":"10.1016\/j.gtc.2007.08.003_bib68","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/01.mib.0000233818.81970.bf","article-title":"Polypoid dysplasia in inflammatory bowel disease: removing the bumps in the road","volume":"12","author":"Itzkowitz","year":"2006","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"10.1016\/j.gtc.2007.08.003_bib69","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00000478-199803000-00001","article-title":"Polypoid dysplasia and adenomas in inflammatory bowel disease: a clinical, pathologic, and follow-up study of 89 polyps from 59 patients","volume":"22","author":"Torres","year":"1998","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"10.1016\/j.gtc.2007.08.003_bib70","first-page":"653","article-title":"Differential diagnosis of adenomas and dysplastic lesions in patients with ulcerative colitis","volume":"31","author":"Schneider","year":"1993","journal-title":"Z Gastroenterol"},{"issue":"1","key":"10.1016\/j.gtc.2007.08.003_bib71","first-page":"74A","article-title":"Partial- vs full-thickness mucosal dysplasia in resected colons with ulcerative colitis: implications for distinction between colitis-associated and sporadic (adenomatous) dysplasia","volume":"79","author":"Cymes","year":"1999","journal-title":"Lab Invest"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib72","first-page":"477","article-title":"Comparison of p53 immunoexpression with allelic loss of p53 in ulcerative colitis\u2013associated dysplasia and carcinoma","volume":"5","author":"Fogt","year":"1998","journal-title":"Oncol Rep"},{"issue":"9","key":"10.1016\/j.gtc.2007.08.003_bib73","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1097\/00000478-200009000-00003","article-title":"Genetic alterations in chronic ulcerative colitis\u2013associated adenoma-like DALMs are similar to non-colitic sporadic adenomas","volume":"24","author":"Odze","year":"2000","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"10.1016\/j.gtc.2007.08.003_bib74","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/gast.2002.31904","article-title":"Artificial neural networks distinguish among subtypes of neoplastic colorectal lesions","volume":"122","author":"Selaru","year":"2002","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.gtc.2007.08.003_bib75","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/00000478-199908000-00015","article-title":"P53 and beta catenin expression in chronic ulcerative colitis\u2013associated polypoid dysplasia and sporadic adenomas: an immunohistochemical study","volume":"23","author":"Walsh","year":"1999","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"10.1016\/j.gtc.2007.08.003_bib76","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/ibd.20194","article-title":"Chromoendoscopy should be the standard method and more widely used for cancer surveillance colonoscopy in ulcerative colitis\u2014con","volume":"13","author":"Ullman","year":"2007","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"10.1016\/j.gtc.2007.08.003_bib77","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0016-5107(04)01710-9","article-title":"Most dysplasia in ulcerative colitis is visible at colonoscopy","volume":"60","author":"Rutter","year":"2004","journal-title":"Gastrointest Endosc"},{"issue":"7","key":"10.1016\/j.gtc.2007.08.003_bib78","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.gie.2006.09.025","article-title":"Are dysplasia and colorectal cancer endoscopically visible in patients with ulcerative colitis?","volume":"65","author":"Rubin","year":"2007","journal-title":"Gastrointest Endosc"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib79","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/0016-5085(92)91185-7","article-title":"DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis","volume":"103","author":"Rubin","year":"1992","journal-title":"Gastroenterology"},{"issue":"Suppl 3","key":"10.1016\/j.gtc.2007.08.003_bib80","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2036.2006.03062.x","article-title":"Review article: colorectal cancer surveillance in ulcerative colitis\u2014What should we be doing?","volume":"24","author":"Obrador","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib81","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0016-5107(00)70405-6","article-title":"How gastroenterologists screen for colonic cancer in ulcerative colitis: an analysis of performance","volume":"51","author":"Eaden","year":"2000","journal-title":"Gastrointest Endosc"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib82","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.gastro.2003.08.023","article-title":"Progression of flat low-grade dysplasia to advanced neoplasia in patients with ulcerative colitis","volume":"125","author":"Ullman","year":"2003","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.gtc.2007.08.003_bib83","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1136\/jcp.41.11.1180","article-title":"Brush cytology of the colon and rectum in ulcerative colitis: an aid to cancer diagnosis","volume":"41","author":"Melville","year":"1988","journal-title":"J Clin Pathol"},{"issue":"1","key":"10.1016\/j.gtc.2007.08.003_bib84","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1053\/j.gastro.2003.05.021","article-title":"Further validation of high-magnification chromoscopic-colonoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis","volume":"126","author":"Hurlstone","year":"2004","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.gtc.2007.08.003_bib85","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1055\/s-2005-921032","article-title":"Indigo carmine\u2013assisted high-magnification chromoscopic colonoscopy for the detection and characterisation of intraepithelial neoplasia in ulcerative colitis: a prospective evaluation","volume":"37","author":"Hurlstone","year":"2005","journal-title":"Endoscopy"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib86","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/gut.2003.016386","article-title":"Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis","volume":"53","author":"Rutter","year":"2004","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib87","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1053\/gast.2003.50146","article-title":"Methylene blue\u2013aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis","volume":"124","author":"Kiesslich","year":"2003","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.gtc.2007.08.003_bib88","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1053\/j.gastro.2007.01.048","article-title":"Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis","volume":"132","author":"Kiesslich","year":"2007","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib89","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10350-004-6255-4","article-title":"Low-grade dysplasia in extensive, long-standing inflammatory bowel disease: a follow-up study","volume":"45","author":"Befrits","year":"2002","journal-title":"Dis Colon Rectum"},{"issue":"8","key":"10.1016\/j.gtc.2007.08.003_bib90","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1136\/gut.52.8.1127","article-title":"Ten year follow up of ulcerative colitis patients with and without low grade dysplasia","volume":"52","author":"Lim","year":"2003","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib91","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0016-5085(92)90831-I","article-title":"Surveillance in the routine management of ulcerative colitis: the predictive value of low-grade dysplasia","volume":"103","author":"Woolrich","year":"1992","journal-title":"Gastroenterology"},{"issue":"5 Pt 1","key":"10.1016\/j.gtc.2007.08.003_bib92","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/0016-5085(91)70010-U","article-title":"Cancer surveillance in ulcerative colitis","volume":"100","author":"Nugent","year":"1991","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.gtc.2007.08.003_bib93","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/00000478-200608000-00014","article-title":"Intestinal low-grade tubuloglandular adenocarcinoma in inflammatory bowel disease","volume":"30","author":"Levi","year":"2006","journal-title":"Am J Surg Pathol"},{"issue":"4 Suppl 1","key":"10.1016\/j.gtc.2007.08.003_bib94","doi-asserted-by":"crossref","first-page":"A649","DOI":"10.1016\/S0016-5085(03)83291-2","article-title":"The fate of indefinite dysplasia in ulcerative colitis","volume":"124","author":"Jani","year":"2003","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib95","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-2559.1988.tb02055.x","article-title":"Observer variation in the assessment of dysplasia in ulcerative colitis","volume":"13","author":"Dixon","year":"1988","journal-title":"Histopathology"},{"issue":"11","key":"10.1016\/j.gtc.2007.08.003_bib96","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1136\/jcp.40.11.1282","article-title":"Can histopathologists reliably assess dysplasia in chronic inflammatory bowel disease?","volume":"40","author":"Dundas","year":"1987","journal-title":"J Clin Pathol"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib97","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/path.876","article-title":"Inter-observer variation between general and specialist gastrointestinal pathologists when grading dysplasia in ulcerative colitis","volume":"194","author":"Eaden","year":"2001","journal-title":"J Pathol"},{"issue":"10","key":"10.1016\/j.gtc.2007.08.003_bib98","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/0046-8177(89)90273-6","article-title":"Observer study of the grading of dysplasia in ulcerative colitis: comparison with clinical outcome","volume":"20","author":"Melville","year":"1989","journal-title":"Hum Pathol"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib99","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/modpathol.3880534","article-title":"Interobserver variability in the diagnosis of ulcerative colitis-associated dysplasia by telepathology","volume":"15","author":"Odze","year":"2002","journal-title":"Mod Pathol"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib100","first-page":"1123","article-title":"Variability in the diagnosis of dysplasia in ulcerative colitis by dynamic telepathology","volume":"16","author":"Odze","year":"2006","journal-title":"Oncol Rep"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib101","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0016-5085(98)70018-6","article-title":"Sialyl-Tn antigen as a marker of colon cancer risk in ulcerative colitis: relation to dysplasia and DNA aneuploidy","volume":"115","author":"Karlen","year":"1998","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.gtc.2007.08.003_bib102","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1053\/gast.1996.v110.pm8608878","article-title":"Sialosyl-Tn antigen is prevalent and precedes dysplasia in ulcerative colitis: a retrospective case-control study","volume":"110","author":"Itzkowitz","year":"1996","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib103","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00022744-200106000-00007","article-title":"Expression of survivin, YB-1, and KI-67 in sporadic adenomas and dysplasia-associated lesions or masses in ulcerative colitis","volume":"9","author":"Fogt","year":"2001","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib104","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1046\/j.1365-2559.2000.00934.x","article-title":"Immunohistochemical assessment of Ki67 and p53 expression assists the diagnosis and grading of ulcerative colitis\u2013related dysplasia","volume":"37","author":"Wong","year":"2000","journal-title":"Histopathology"},{"issue":"11","key":"10.1016\/j.gtc.2007.08.003_bib105","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/(SICI)1097-0142(19961201)78:11<2307::AID-CNCR6>3.0.CO;2-J","article-title":"The pattern of cell proliferation in neoplastic and nonneoplastic lesions of ulcerative colitis","volume":"78","author":"Noffsinger","year":"1996","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib106","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/gcc.10101","article-title":"Epigenetic control of the E-cadherin gene (CDH1) by CpG methylation in colectomy samples of patients with ulcerative colitis","volume":"35","author":"Azarschab","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"issue":"6","key":"10.1016\/j.gtc.2007.08.003_bib107","first-page":"604","article-title":"Enhanced epithelial cell turnover associated with p53 accumulation and high p21WAF1\/CIP1 expression in ulcerative colitis","volume":"12","author":"Arai","year":"1999","journal-title":"Mod Pathol"},{"issue":"10","key":"10.1016\/j.gtc.2007.08.003_bib108","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0046-8177(94)90067-1","article-title":"P53 protein expression in ulcerative colitis\u2013associated colorectal dysplasia and carcinoma","volume":"25","author":"Harpaz","year":"1994","journal-title":"Hum Pathol"},{"issue":"13","key":"10.1016\/j.gtc.2007.08.003_bib109","first-page":"3333","article-title":"Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease","volume":"60","author":"Hussain","year":"2000","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.gtc.2007.08.003_bib110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0215(19980330)76:1<1::AID-IJC1>3.0.CO;2-4","article-title":"Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis","volume":"76","author":"Holzmann","year":"1998","journal-title":"Int J Cancer"},{"issue":"7","key":"10.1016\/j.gtc.2007.08.003_bib111","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/01.pas.0000213268.30468.b4","article-title":"AMACR immunostaining is useful in detecting dysplastic epithelium in Barrett's esophagus, ulcerative colitis, and Crohn's disease","volume":"30","author":"Dorer","year":"2006","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.gtc.2007.08.003_bib112","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1053\/j.gastro.2005.04.011","article-title":"Molecular phenotype of inflammatory bowel disease\u2013associated neoplasms with microsatellite instability","volume":"129","author":"Schulmann","year":"2005","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.gtc.2007.08.003_bib113","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/0016-5085(92)91184-6","article-title":"Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele","volume":"103","author":"Burmer","year":"1992","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.gtc.2007.08.003_bib114","doi-asserted-by":"crossref","first-page":"G7","DOI":"10.1152\/ajpgi.00079.2004","article-title":"Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation","volume":"287","author":"Itzkowitz","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"10.1016\/j.gtc.2007.08.003_bib115","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/01.mog.0000231812.95525.a7","article-title":"Cancer surveillance in inflammatory bowel disease: new molecular approaches","volume":"22","author":"Risques","year":"2006","journal-title":"Curr Opin Gastroenterol"},{"issue":"2","key":"10.1016\/j.gtc.2007.08.003_bib116","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0002-9440(10)63860-6","article-title":"DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia\/cancer-free","volume":"162","author":"Chen","year":"2003","journal-title":"Am J Pathol"},{"issue":"9","key":"10.1016\/j.gtc.2007.08.003_bib117","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/carcin\/bgi106","article-title":"The initiation of colon cancer in a chronic inflammatory setting","volume":"26","author":"Chen","year":"2005","journal-title":"Carcinogenesis"}],"container-title":["Gastroenterology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889855307000787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889855307000787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,5]],"date-time":"2019-05-05T14:55:41Z","timestamp":1557068141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889855307000787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":117,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0889855307000787"],"URL":"https:\/\/doi.org\/10.1016\/j.gtc.2007.08.003","relation":{},"ISSN":["0889-8553"],"issn-type":[{"value":"0889-8553","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}