{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:56:35Z","timestamp":1763765795009},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Clinics of North America"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.gtc.2009.03.004","type":"journal-article","created":{"date-parts":[[2009,5,14]],"date-time":"2009-05-14T05:21:48Z","timestamp":1242278508000},"page":"353-361","source":"Crossref","is-referenced-by-count":29,"title":["Helicobacter pylori-Negative Nonsteroidal Anti-Inflammatory Drug-Negative Ulcer"],"prefix":"10.1016","volume":"38","author":[{"given":"Kenneth E.L.","family":"McColl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gtc.2009.03.004_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000201350","article-title":"Helicobacter pylori-negative duodenal and pyloric ulcer: role of NSAIDs","volume":"57","author":"Hyvarinen","year":"1996","journal-title":"Digestion"},{"issue":"11","key":"10.1016\/j.gtc.2009.03.004_bib2","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1023\/A:1026669123593","article-title":"H pylori-negative duodenal ulcer prevalence and causes in 774 patients","volume":"44","author":"Gisbert","year":"1999","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.gtc.2009.03.004_bib3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s005350050296","article-title":"Helicobacter pylori-negative gastric and duodenal ulcers","volume":"34","author":"Tsuji","year":"1999","journal-title":"J Gastroenterol"},{"issue":"3","key":"10.1016\/j.gtc.2009.03.004_bib4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1046\/j.1523-5378.2001.00034.x","article-title":"Non-Helicobacter pylori related duodenal ulcer disease in children","volume":"6","author":"Elitsur","year":"2001","journal-title":"Helicobacter"},{"key":"10.1016\/j.gtc.2009.03.004_bib5","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/gut.34.6.762","article-title":"A study of the pathogenesis of Helicobacter pylori negative chronic duodenal ulceration","volume":"34","author":"McColl","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.gtc.2009.03.004_bib6","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/j.1572-0241.1999.01214.x","article-title":"Helicobacter pylori infection rates in duodenal patients in the United States may be lower than previously estimated","volume":"94","author":"Ciociola","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gtc.2009.03.004_bib7","first-page":"1926","article-title":"The prevalence of Helicobacter pylori in duodenal ulcer disease \u2013 a community based study","volume":"91","author":"Sprung","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gtc.2009.03.004_bib8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1572-0241.1998.167_b.x","article-title":"Prevalence of Helicobacter pylori in peptic ulcer patients in Great Rochester, NY: is empirical triple therapy justified?","volume":"93","author":"Jyotheeswaran","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gtc.2009.03.004_bib9","first-page":"33","article-title":"Helicobacter pylori negative peptic ulcer in Japan: which contributes most to peptic ulcer development, Helicobacter pylori, NSAIDs or stress?","volume":"35","author":"Aoyama","year":"2000","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.gtc.2009.03.004_bib10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1083-4389.2004.00219.x","article-title":"The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drugs is negligible in Southern Europe","volume":"9","author":"Arroyo","year":"2004","journal-title":"Helicobacter"},{"key":"10.1016\/j.gtc.2009.03.004_bib11","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/oxfordjournals.eurheartj.a015436","article-title":"Helicobacter pylori infection and coronary heart disease in the north Glasgow MONICA population","volume":"18","author":"McDonagh","year":"1997","journal-title":"Eur Heart J"},{"key":"10.1016\/j.gtc.2009.03.004_bib12","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/0016-5085(91)90644-Z","article-title":"Epidemiology of Helicobacter pylori infection in an asymptomatic population in the United States","volume":"100","author":"Graham","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gtc.2009.03.004_bib13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1053\/gast.1996.v110.pm8613015","article-title":"Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: A review","volume":"110","author":"Hopkins","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gtc.2009.03.004_bib14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1046\/j.1365-2036.1996.40182000.x","article-title":"Review article: Clinical aspects of Helicobacter pylori eradication therapy in peptic ulcer disease","volume":"10","author":"Penston","year":"1996","journal-title":"Aliment Pharmacol Ther"},{"issue":"9","key":"10.1016\/j.gtc.2009.03.004_bib15","first-page":"1409","article-title":"Has the impact of Helicobacter pylori therapy on ulcer recurrence in the United States been overstated? A meta-analysis of rigorously designed trials","volume":"93","author":"Laine","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gtc.2009.03.004_bib16","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/00042737-199809000-00006","article-title":"Current or recent proton pump inhibitor therapy markedly impairs the accuracy of the [14C] urea breath test","volume":"10","author":"El-Nujumi","year":"1998","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.gtc.2009.03.004_bib17","first-page":"89","article-title":"Prolonged effect of omeprazole on the 14C-urea breath test","volume":"91","author":"Chey","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gtc.2009.03.004_bib18","first-page":"446","article-title":"Lansoprazole and ranitidine affect the accuracy of the 14C-urea breath test by a pH-dependent mechanism","volume":"92","author":"Chey","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gtc.2009.03.004_bib19","first-page":"2120","article-title":"Helicobacter pylori does not migrate from the antrum to the corpus in response to omeprazole","volume":"91","author":"Graham","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gtc.2009.03.004_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.0953-0673.1996.00289.x","article-title":"Effect of proton pump inhibitors on the detection of Helicobacter pylori in gastric biopsies","volume":"10","author":"Dicket","year":"1996","journal-title":"Aliment Pharmacol Ther"},{"issue":"7483","key":"10.1016\/j.gtc.2009.03.004_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/bmj.330.7483.105","article-title":"Test and treat for dyspepsia \u2013 but which test? Urea breath test and stool antigen test are better than serological tests","volume":"330","author":"McNulty","year":"2005","journal-title":"Br Med J"},{"key":"10.1016\/j.gtc.2009.03.004_bib22","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1067\/mge.2001.112840","article-title":"Is non-Helicobacter pylori, non-NSAID peptic ulcer a common cause of upper GI bleeding? A prospective study of 977 patients","volume":"53","author":"Chan","year":"2001","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gtc.2009.03.004_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1572-0241.2007.01506.x","article-title":"Isolated H pylori duodenal colonization and idiopathic duodenal ulcers","volume":"103","author":"Pietroiusti","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gtc.2009.03.004_bib24","first-page":"A962","article-title":"Intractable peptic ulceration due to aspirin abuse in patients who have not had gastric surgery","volume":"112","author":"Hirschowitz","year":"1997","journal-title":"Gastroenterology"},{"issue":"Pt 2","key":"10.1016\/j.gtc.2009.03.004_bib25","first-page":"A23","article-title":"How common are duodenal ulcers negative for Helicobacter pylori?","volume":"98","author":"Borody","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gtc.2009.03.004_bib26","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/S0140-6736(05)61696-0","article-title":"Healing of duodenal ulcer after eradication of Helicobacter heilmannii","volume":"349","author":"Goddard","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.gtc.2009.03.004_bib27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1443-1661.2001.00090.x","article-title":"Cytomegalovirus-associated gastric ulcers in immunocompromised patients","volume":"13","author":"Fukami","year":"2001","journal-title":"Dig Endosc"},{"issue":"2","key":"10.1016\/j.gtc.2009.03.004_bib28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1046\/j.1365-2230.2001.00787.x","article-title":"Cytomegalovirus-associated gastric ulcer in an immunosuppressed patient with pemphigus vulgaris","volume":"26","author":"Orton","year":"2001","journal-title":"Clin Exp Dermatol"},{"issue":"42","key":"10.1016\/j.gtc.2009.03.004_bib29","doi-asserted-by":"crossref","first-page":"6644","DOI":"10.3748\/wjg.v11.i42.6644","article-title":"Herpes simplex virus type 1 in peptic ulcer disease: an inverse association with Helicobacter pylori","volume":"11","author":"Tsamakidis","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.gtc.2009.03.004_bib30","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0016-5085(86)90566-4","article-title":"Linear gastric erosion","volume":"91","author":"Cameron","year":"1986","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.gtc.2009.03.004_bib31","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.ijrobp.2006.02.052","article-title":"In Vivo assessment of the gastric mucosal tolerance dose after single fraction, small volume irradiation of liver malignancies by computed tomography-guided, high-dose-rate brachytherapy","volume":"65","author":"Streitparth","year":"2006","journal-title":"Int J Radiat Oncol Boil Phys"},{"issue":"8","key":"10.1016\/j.gtc.2009.03.004_bib32","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1136\/gut.33.8.1044","article-title":"Duodenal ulcer \u2013 a model of impaired mucosal defence","volume":"33","author":"Gompertz","year":"1992","journal-title":"Gut"},{"key":"10.1016\/j.gtc.2009.03.004_bib33","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0016-5085(88)80012-X","article-title":"Gastrointestinal dysfunction in systemic mastocytosis: a prospective study","volume":"95","author":"Cherner","year":"1988","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.gtc.2009.03.004_bib34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/01.md.0000236956.74128.76","article-title":"Prospective study of fasting serum gastrin in 309 patients from the National Institute of Health and comparison with 2229 cases from the literature","volume":"85","author":"Berna","year":"2006","journal-title":"Medicine"},{"key":"10.1016\/j.gtc.2009.03.004_bib35","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1046\/j.1365-2036.2001.00976.x","article-title":"A randomised controlled crossover study comparing synthetic porcine and human secretins with biologically derived porcine secretin to diagnose Zollinger-Ellison syndrome","volume":"15","author":"Metz","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.gtc.2009.03.004_bib36","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/MD.0b013e31802b518c","volume":"85","author":"Berna","year":"2006","journal-title":"Medicine"},{"issue":"11","key":"10.1016\/j.gtc.2009.03.004_bib37","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1210\/jc.2007-0986","article-title":"Secretin-receptor and secretin-receptor-variant expression in gastrinomas: correlation with clinical and tumoral features and secretin and calcium provocative test results","volume":"92","author":"Long","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.gtc.2009.03.004_bib38","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1023\/A:1022808003014","article-title":"Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer","volume":"48","author":"Kamada","year":"2003","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.gtc.2009.03.004_bib39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0016-5085(99)70118-6","article-title":"Rebound hypersecretion after omeprazole and its relation to on-treatment acid suppression and Helicobacter pylori status","volume":"116","author":"Gillen","year":"1999","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.gtc.2009.03.004_bib40","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1053\/j.gastro.2004.01.004","article-title":"Helicobacter pylori eradication releases prolonged increased acid secretion following omeprazole treatment","volume":"126","author":"Gillen","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gtc.2009.03.004_bib41","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/gut.39.5.649","article-title":"Marked increase in gastric acid secretory capacity after omeprazole treatment","volume":"29","author":"Waldum","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.gtc.2009.03.004_bib42","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1053\/gast.1996.v110.pm8608881","article-title":"Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcer","volume":"110","author":"Labenz","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gtc.2009.03.004_bib43","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/gut.36.4.539","article-title":"Effect of Helicobacter pylori status on intragastric pH during treatment with omeprazole","volume":"36","author":"Verdu","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.gtc.2009.03.004_bib44","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1053\/j.gastro.2005.03.026","article-title":"Long-term outcome of Helicobacter pylori-negative idiopathic bleeding ulcers: a prospective cohort study","volume":"128","author":"Hung","year":"2005","journal-title":"Gastroenterology"}],"container-title":["Gastroenterology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889855309000314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889855309000314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T22:18:57Z","timestamp":1558304337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889855309000314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0889855309000314"],"URL":"https:\/\/doi.org\/10.1016\/j.gtc.2009.03.004","relation":{},"ISSN":["0889-8553"],"issn-type":[{"value":"0889-8553","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}