{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:07:08Z","timestamp":1765609628603},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["theclinics.com","gastro.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology Clinics of North America"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.gtc.2014.11.014","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T08:49:24Z","timestamp":1419065364000},"page":"185-189","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Future Directions in the Treatment of Gastroparesis"],"prefix":"10.1016","volume":"44","author":[{"given":"Pankaj Jay","family":"Pasricha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gtc.2014.11.014_bib1","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1053\/j.gastro.2011.01.046","article-title":"Cellular changes in diabetic and idiopathic gastroparesis","volume":"140","author":"Grover","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gtc.2014.11.014_bib2","doi-asserted-by":"crossref","first-page":"13393","DOI":"10.1074\/jbc.M110.196089","article-title":"Altered expression of Ano1 variants in human diabetic gastroparesis","volume":"286","author":"Mazzone","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.gtc.2014.11.014_bib3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2982.2012.01894.x","article-title":"Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium","volume":"24","author":"Grover","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.gtc.2014.11.014_bib4","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1053\/j.gastro.2005.12.027","article-title":"Reduced stem cell factor links smooth myopathy and loss of interstitial cells of Cajal in murine diabetic gastroparesis","volume":"130","author":"Horvath","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gtc.2014.11.014_bib5","doi-asserted-by":"crossref","first-page":"G725","DOI":"10.1152\/ajpgi.00406.2006","article-title":"Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum","volume":"292","author":"Gangula","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.gtc.2014.11.014_bib6","doi-asserted-by":"crossref","first-page":"G692","DOI":"10.1152\/ajpgi.00450.2009","article-title":"Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats","volume":"298","author":"Gangula","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.gtc.2014.11.014_bib7","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/j.1365-2982.2010.01588.x","article-title":"Sepiapterin reverses the changes in gastric nNOS dimerization and function in diabetic gastroparesis","volume":"22","author":"Gangula","year":"2010","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.gtc.2014.11.014_bib8","first-page":"36","article-title":"Sapropterin improves gastric accommodation and symptoms in women with diabetic gastroparesis","volume":"25","author":"Nguyen","year":"2013","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.gtc.2014.11.014_bib9","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1517\/14656566.2013.795948","article-title":"Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives","volume":"14","author":"Stevens","year":"2013","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.gtc.2014.11.014_bib10","doi-asserted-by":"crossref","first-page":"G612","DOI":"10.1152\/ajpgi.00431.2003","article-title":"Regional gastric contractility alterations in a diabetic gastroparesis mouse model: effects of cholinergic and serotoninergic stimulation","volume":"287","author":"James","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.gtc.2014.11.014_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.autneu.2010.10.006","article-title":"Regional differences in neostigmine-induced contraction and relaxation of stomach from diabetic guinea pig","volume":"160","author":"Cellini","year":"2011","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.gtc.2014.11.014_bib12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1440-1746.2006.04113.x","article-title":"Effect of sildenafil on gastric emptying in healthy adults","volume":"21","author":"Cho","year":"2006","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.gtc.2014.11.014_bib13","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/BF02208676","article-title":"Compliance of the proximal stomach and dyspeptic symptoms in patients with type I diabetes mellitus","volume":"40","author":"Samsom","year":"1995","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.gtc.2014.11.014_bib14","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1001\/jama.2013.282833","article-title":"Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial","volume":"310","author":"Parkman","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.gtc.2014.11.014_bib15","doi-asserted-by":"crossref","first-page":"358-e169","DOI":"10.1111\/j.1365-2982.2011.01874.x","article-title":"Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea","volume":"24","author":"Wong","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.gtc.2014.11.014_bib16","doi-asserted-by":"crossref","first-page":"G796","DOI":"10.1152\/ajpgi.00130.2013","article-title":"Prokinetic effects of mirtazapine on gastrointestinal transit","volume":"306","author":"Yin","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.gtc.2014.11.014_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejphar.2013.08.049","article-title":"Molecular mechanisms of 5-HT(3) and NK(1) receptor antagonists in prevention of emesis","volume":"722","author":"Rojas","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.gtc.2014.11.014_bib18","first-page":"641","article-title":"Therapeutic effect of multiple resiniferatoxin intravesical instillations in patients with refractory detrusor overactivity: a randomized, double-blind, placebo controlled study","volume":"176","author":"Kuo","year":"2006","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.gtc.2014.11.014_bib19","first-page":"A-688","article-title":"Topical intragastric application of the TRPV1 agonist, resiniferatoxin (RTX), attenuates experimental nausea and vomiting","volume":"132","author":"Hawari","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gtc.2014.11.014_bib20","article-title":"Macrophages in diabetic gastroparesis - the missing link?","author":"Neshatian","year":"2014","journal-title":"Neurogastroenterol Motil"}],"container-title":["Gastroenterology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889855314001459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889855314001459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T16:27:12Z","timestamp":1537979232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889855314001459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0889855314001459"],"URL":"https:\/\/doi.org\/10.1016\/j.gtc.2014.11.014","relation":{},"ISSN":["0889-8553"],"issn-type":[{"value":"0889-8553","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Future Directions in the Treatment of Gastroparesis","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gtc.2014.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}