{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:03:42Z","timestamp":1790496222051,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","gastro.theclinics.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology Clinics of North America"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.gtc.2017.05.002","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T19:46:48Z","timestamp":1500493608000},"page":"449-461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Crohn's Disease"],"prefix":"10.1016","volume":"46","author":[{"given":"Ming-Hsi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Picco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.gtc.2017.05.002_bib1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.gtc.2017.05.002_bib2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1053\/j.gastro.2013.04.007","article-title":"Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study","volume":"145","author":"Ng","year":"2013","journal-title":"Gastroenterology"},{"issue":"6837","key":"10.1016\/j.gtc.2017.05.002_bib3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"issue":"6837","key":"10.1016\/j.gtc.2017.05.002_bib4","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A\u00a0frameshift mutation in NOD2 associated with susceptibility to Crohn's disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.gtc.2017.05.002_bib5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1572-0241.2006.00926.x","article-title":"A\u00a0population-based case-control study of CARD15 and other risk factors in Crohn's disease and ulcerative colitis","volume":"102","author":"Brant","year":"2007","journal-title":"Am J Gastroenterol"},{"issue":"22","key":"10.1016\/j.gtc.2017.05.002_bib6","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1093\/hmg\/ddi379","article-title":"Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease","volume":"14","author":"Yamazaki","year":"2005","journal-title":"Hum Mol Genet"},{"issue":"7422","key":"10.1016\/j.gtc.2017.05.002_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.gtc.2017.05.002_bib8","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat Genet"},{"issue":"10014","key":"10.1016\/j.gtc.2017.05.002_bib9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0140-6736(15)00465-1","article-title":"Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study","volume":"387","author":"Cleynen","year":"2016","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.gtc.2017.05.002_bib10","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/01.MIB.0000225332.83861.5f","article-title":"Functional consequences of NOD2 (CARD15) mutations","volume":"12","author":"Abraham","year":"2006","journal-title":"Inflamm Bowel Dis"},{"issue":"12","key":"10.1016\/j.gtc.2017.05.002_bib11","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1111\/j.1572-0241.2004.40304.x","article-title":"Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis","volume":"99","author":"Economou","year":"2004","journal-title":"Am J Gastroenterol"},{"issue":"5804","key":"10.1016\/j.gtc.2017.05.002_bib12","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.1135245","article-title":"A\u00a0genome-wide association study identifies IL23R as an inflammatory bowel disease gene","volume":"314","author":"Duerr","year":"2006","journal-title":"Science"},{"issue":"20","key":"10.1016\/j.gtc.2017.05.002_bib13","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1056\/NEJMoa1602773","article-title":"Ustekinumab as induction and maintenance therapy for Crohn's disease","volume":"375","author":"Feagan","year":"2016","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.gtc.2017.05.002_bib14","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/gut.45.3.395","article-title":"HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis","volume":"45","author":"Stokkers","year":"1999","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.gtc.2017.05.002_bib15","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/ng2032","article-title":"Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis","volume":"39","author":"Rioux","year":"2007","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.gtc.2017.05.002_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ng1954","article-title":"A\u00a0genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1","volume":"39","author":"Hampe","year":"2007","journal-title":"Nat Genet"},{"issue":"7219","key":"10.1016\/j.gtc.2017.05.002_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature07416","article-title":"A\u00a0key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells","volume":"456","author":"Cadwell","year":"2008","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.gtc.2017.05.002_bib18","doi-asserted-by":"crossref","first-page":"e3391","DOI":"10.1371\/journal.pone.0003391","article-title":"Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant","volume":"3","author":"Kuballa","year":"2008","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.gtc.2017.05.002_bib19","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/ng2061","article-title":"Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility","volume":"39","author":"Parkes","year":"2007","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.gtc.2017.05.002_bib20","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ng.215","article-title":"Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease","volume":"40","author":"McCarroll","year":"2008","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.gtc.2017.05.002_bib21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1136\/gut.2007.134254","article-title":"Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis","volume":"57","author":"Xavier","year":"2008","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.gtc.2017.05.002_bib22","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng.175","article-title":"Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease","volume":"40","author":"Barrett","year":"2008","journal-title":"Nat Genet"},{"issue":"21","key":"10.1016\/j.gtc.2017.05.002_bib23","doi-asserted-by":"crossref","first-page":"9879","DOI":"10.1073\/pnas.1004676107","article-title":"Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice","volume":"107","author":"Tong","year":"2010","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"6","key":"10.1016\/j.gtc.2017.05.002_bib24","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1086\/302913","article-title":"Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci","volume":"66","author":"Rioux","year":"2000","journal-title":"Am J Hum Genet"},{"issue":"11","key":"10.1016\/j.gtc.2017.05.002_bib25","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/ibd.20512","article-title":"Contributions of IBD5, IL23R, ATG16L1, and NOD2 to Crohn's disease risk in a population-based case-control study: evidence of gene-gene interactions","volume":"14","author":"Okazaki","year":"2008","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"10.1016\/j.gtc.2017.05.002_bib26","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cgh.2008.03.014","article-title":"Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: meta-analysis of placebo-controlled trials","volume":"6","author":"Peyrin-Biroulet","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.gtc.2017.05.002_bib27","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1053\/j.gastro.2014.07.023","article-title":"The diagnostic approach to monogenic very early onset inflammatory bowel disease","volume":"147","author":"Uhlig","year":"2014","journal-title":"Gastroenterology"},{"issue":"21","key":"10.1016\/j.gtc.2017.05.002_bib28","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1056\/NEJMoa0907206","article-title":"Inflammatory bowel disease and mutations affecting the interleukin-10 receptor","volume":"361","author":"Glocker","year":"2009","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.gtc.2017.05.002_bib29","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/ibd.20171","article-title":"Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease","volume":"13","author":"de Ridder","year":"2007","journal-title":"Inflamm Bowel Dis"},{"issue":"12","key":"10.1016\/j.gtc.2017.05.002_bib30","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1097\/01.mib.0000235836.32176.5e","article-title":"Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study","volume":"12","author":"Seiderer","year":"2006","journal-title":"Inflamm Bowel Dis"},{"issue":"11","key":"10.1016\/j.gtc.2017.05.002_bib31","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1136\/gutjnl-2011-300777","article-title":"Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project","volume":"62","author":"Cleynen","year":"2013","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.gtc.2017.05.002_bib32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ajg.2011.19","article-title":"The prognostic power of the NOD2 genotype for complicated Crohn's disease: a meta-analysis","volume":"106","author":"Adler","year":"2011","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"10.1016\/j.gtc.2017.05.002_bib33","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1056\/NEJMoa1112168","article-title":"Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis","volume":"367","author":"Sandborn","year":"2012","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.gtc.2017.05.002_bib34","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.cgh.2014.01.029","article-title":"A\u00a0phase 2 study of tofacitinib, an oral Janus kinase inhibitor, in patients with Crohn's disease","volume":"12","author":"Sandborn","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.gtc.2017.05.002_bib35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00054725-200309000-00001","article-title":"Defining complex contributions of NOD2\/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes","volume":"9","author":"Brant","year":"2003","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"10.1016\/j.gtc.2017.05.002_bib36","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1053\/gast.2002.35396","article-title":"Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes","volume":"123","author":"Orchard","year":"2002","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.gtc.2017.05.002_bib37","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0016-5085(00)70209-5","article-title":"Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease","volume":"118","author":"Orchard","year":"2000","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.gtc.2017.05.002_bib38","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1046\/j.1365-2249.2001.01662.x","article-title":"MHC class I chain-like gene A (MICA) and its associations with inflammatory bowel disease and peripheral arthropathy","volume":"126","author":"Orchard","year":"2001","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1016\/j.gtc.2017.05.002_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1001\/archopht.1997.01100150063010","article-title":"Uveitis associated with inflammatory bowel disease compared with uveitis associated with spondyloarthropathy","volume":"115","author":"Lyons","year":"1997","journal-title":"Arch Ophthalmol"},{"issue":"11","key":"10.1016\/j.gtc.2017.05.002_bib40","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ng.689","article-title":"Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2","volume":"42","author":"Ellinghaus","year":"2010","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.gtc.2017.05.002_bib41","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00439-013-1395-z","article-title":"Gene-gene and gene-environment interactions in ulcerative colitis","volume":"133","author":"Wang","year":"2014","journal-title":"Hum Genet"},{"issue":"4","key":"10.1016\/j.gtc.2017.05.002_bib42","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s10620-011-1977-3","article-title":"NOD2 polymorphism predicts response to treatment in Crohn's disease\u2013first steps to a personalized therapy","volume":"57","author":"Niess","year":"2012","journal-title":"Dig Dis Sci"},{"issue":"3","key":"10.1016\/j.gtc.2017.05.002_bib43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2036.2004.01946.x","article-title":"Tumour necrosis factor-alpha receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab","volume":"20","author":"Pierik","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.gtc.2017.05.002_bib44","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/gutjnl-2012-303557","article-title":"Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease","volume":"63","author":"Gutierrez","year":"2014","journal-title":"Gut"},{"issue":"13","key":"10.1016\/j.gtc.2017.05.002_bib45","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.3748\/wjg.v20.i13.3609","article-title":"Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with Crohn's disease","volume":"20","author":"Thomas","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"8","key":"10.1016\/j.gtc.2017.05.002_bib46","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1038\/ajg.2010.95","article-title":"Disease activity, ANCA, and IL23R genotype status determine early response to infliximab in patients with ulcerative colitis","volume":"105","author":"Jurgens","year":"2010","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.gtc.2017.05.002_bib47","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1053\/gast.2001.23966","article-title":"ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease","volume":"120","author":"Taylor","year":"2001","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.gtc.2017.05.002_bib48","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1080\/gas.37.7.818.824","article-title":"A\u00a0positive response to infliximab in Crohn disease: association with a higher systemic inflammation before treatment but not with -308 TNF gene polymorphism","volume":"37","author":"Louis","year":"2002","journal-title":"Scand J Gastroenterol"},{"issue":"2","key":"10.1016\/j.gtc.2017.05.002_bib49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/sj.tpj.6500091","article-title":"Pharmacogenetic investigation of the TNF\/TNF-receptor system in patients with chronic active Crohn's disease treated with infliximab","volume":"2","author":"Mascheretti","year":"2002","journal-title":"Pharmacogenomics J"},{"issue":"12","key":"10.1016\/j.gtc.2017.05.002_bib50","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.2217\/pgs.15.90","article-title":"Association between TNF-alpha (-308 A\/G, -238 A\/G, -857 C\/T) polymorphisms and responsiveness to TNF-alpha blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis","volume":"16","author":"Song","year":"2015","journal-title":"Pharmacogenomics"},{"issue":"6","key":"10.1016\/j.gtc.2017.05.002_bib51","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1053\/j.gastro.2015.07.065","article-title":"Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans","volume":"149","author":"Huang","year":"2015","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.gtc.2017.05.002_bib52","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1136\/jmg.16.4.263","article-title":"A\u00a0high incidence of chronic inflammatory bowel disease in patients with Turner's syndrome","volume":"16","author":"Price","year":"1979","journal-title":"J\u00a0Med Genet"},{"issue":"12","key":"10.1016\/j.gtc.2017.05.002_bib53","first-page":"2241","article-title":"Differences in risk of Crohn's disease in offspring of mothers and fathers with inflammatory bowel disease","volume":"92","author":"Akolkar","year":"1997","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.gtc.2017.05.002_bib54","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ibd.21027","article-title":"Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naive and treated Crohn's disease","volume":"16","author":"Beltran","year":"2010","journal-title":"Inflamm Bowel Dis"},{"issue":"9","key":"10.1016\/j.gtc.2017.05.002_bib55","first-page":"1799","article-title":"A\u00a0novel approach to detect cumulative genetic effects and genetic interactions in Crohn's disease","volume":"19","author":"Wang","year":"2013","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"10.1016\/j.gtc.2017.05.002_bib56","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/j.1572-0241.2007.01124.x","article-title":"Inflammatory bowel disease in the South Asian pediatric population of British Columbia","volume":"102","author":"Pinsk","year":"2007","journal-title":"Am J Gastroenterol"},{"issue":"Supple 2","key":"10.1016\/j.gtc.2017.05.002_bib57","doi-asserted-by":"crossref","first-page":"S503","DOI":"10.14309\/00000434-201410002-01701","article-title":"Model integrating genetic and environmental factors interactions can predict Crohn\u2019s disease risk","volume":"109","author":"Wang","year":"2014","journal-title":"A Am J Gastroenterol"},{"issue":"4","key":"10.1016\/j.gtc.2017.05.002_bib58","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/MOG.0000000000000081","article-title":"Systems biology in inflammatory bowel diseases: ready for prime time","volume":"30","author":"Polytarchou","year":"2014","journal-title":"Curr Opin Gastroenterol"}],"container-title":["Gastroenterology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889855317300560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889855317300560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T23:50:17Z","timestamp":1602546617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889855317300560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0889855317300560"],"URL":"https:\/\/doi.org\/10.1016\/j.gtc.2017.05.002","relation":{},"ISSN":["0889-8553"],"issn-type":[{"value":"0889-8553","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crohn's Disease","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gtc.2017.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}