{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:02:54Z","timestamp":1790791374554,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e9cologie Obst\u00e9trique & Fertilit\u00e9"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.gyobfe.2011.10.009","type":"journal-article","created":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T15:01:54Z","timestamp":1326380514000},"page":"109-115","source":"Crossref","is-referenced-by-count":12,"title":["Contraception orale estro-progestative\u00a0: quelle diff\u00e9rence entre \u00e9thinylestradiol et estradiol\u00a0?"],"prefix":"10.1016","volume":"40","author":[{"given":"F.","family":"Tr\u00e9mollieres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gyobfe.2011.10.009_bib0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/09513599609041268","article-title":"A three-year clinical investigation into efficacy, cycle control and tolerability of a new low-dose monophasic oral contraceptive containing gestodene","volume":"10","author":"Dusterberg","year":"1996","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/13625180008500375","article-title":"Efficacy and tolerability of a monophasic oral contraceptive containing ethinylestradiol and drospirenone","volume":"5","author":"Huber","year":"2000","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0010-7824(97)00123-6","article-title":"Modulation of ovarian function by an oral contraceptive containing 30\u00a0micrograms ethinyl estradiol in combination with 2.00mg dienogest","volume":"56","author":"Spona","year":"1997","journal-title":"Contraception"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/humupd\/dmi046","article-title":"New progestagens for contraceptive use","volume":"12","author":"Sitruk-Ware","year":"2006","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0025","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.steroids.2011.02.002","article-title":"Nomegestrol acetate: a novel progestogen for oral contraception","volume":"76","author":"Mueck","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/bmj.2.5703.203","article-title":"Thromboembolic disease and the steroidal content of oral contraceptives. A report to the committee on safety of drugs","volume":"2","author":"Inman","year":"1970","journal-title":"Br Med J"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0035","first-page":"CD003989","article-title":"20\u00a0mcg versus>20\u00a0mcg estrogen combined oral contraceptives for contraception","author":"Gallo","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1055\/s-0038-1646528","article-title":"A comparison between effects of estradiol valerate and low dose ethinyl estradiol on haemostasis parameters","volume":"61","author":"Lindberg","year":"1989","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0045","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0940-2993(98)80034-1","article-title":"Approaches to the replacement of ethinylestradiol by natural 17beta-estradiol in combined oral contraceptives","volume":"50","author":"Hoffman","year":"1998","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0050","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0010-7824(96)00136-9","article-title":"Bioavailability of orally administered sex steroids used in oral contraception and hormone replacement therapy","volume":"54","author":"Fotherby","year":"1996","journal-title":"Contraception"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13697130500148875","article-title":"Pharmacology of estrogens and progestogens: influence of different routes of administration","volume":"8","author":"Kuhl","year":"2005","journal-title":"Climacteric"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0060","first-page":"966","article-title":"Pharmacokinetics of estradiol, free and total estrone, in young women following single intravenous and oral administration of 17\u00a0beta-estradiol","volume":"43","author":"Kuhnz","year":"1993","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0065","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0378-5122(82)90064-0","article-title":"Pharmacokinetic and pharmacological features of estradiol valerate","volume":"4","author":"D\u00fcrstenberg","year":"1982","journal-title":"Maturitas"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/carcin\/19.1.1","article-title":"Functional role of estrogen metabolism in target cells: review and perspectives","volume":"19","author":"Zhu","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0075","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1210\/me.2004-0050","article-title":"Dissecting physiological roles of estrogen receptor \u03b1 and \u03b2 with potent selective ligands from structure-based design","volume":"18","author":"Hillisch","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0080","doi-asserted-by":"crossref","first-page":"12971","DOI":"10.1074\/jbc.M110.205112","article-title":"Exploration of dimensions of estrogen potency: parsing ligand binding and coactivator binding affinities","volume":"286","author":"Jeyakumar","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0085","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0002-9378(82)90218-6","article-title":"Comparison of pharmacodynamic properties of various estrogen formulations","volume":"144","author":"Mashchak","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0090","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000298914","article-title":"Estrogen induction of liver proteins and high-density lipoprotein cholesterol: comparison between estradiol valerate and ethinyl estradiol","volume":"22","author":"Ottosson","year":"1986","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0095","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0378-5122(88)90069-2","article-title":"A comparison of the effects of ethinyl estradiol and estradiol valerate on serum and lipoprotein lipids","volume":"10","author":"Lindberg","year":"1988","journal-title":"Maturitas."},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0100","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1001\/jama.1996.03540170041030","article-title":"The comparative effect on bone density, endometrium and lipids of continuous hormones as replacement therapy (CHART study)","volume":"276","author":"Speroff","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0105","first-page":"173","article-title":"The effects of seven monophasic oral contraceptive regimens on hemostatic variables: conclusions from a large randomised multicenter study","volume":"63","author":"The oral contraceptive and hemostasis study group","year":"2003","journal-title":"Contraception"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0110","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0010-7824(80)90010-4","article-title":"A randomized, double-blind study of two combined oral contraceptives containing the same progestogen, but different estrogens. World Health Organization task force on oral contraception","volume":"21","author":"Koetsawang","year":"1980","journal-title":"Contraception"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-0412.1981.tb00038.x","article-title":"Effectivity and acceptability of oral contraceptives containing natural and artificial estrogens in combination with a gestagen. A controlled double-blind investigation","volume":"60","author":"Serup","year":"1981","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0120","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0015-0282(16)56210-4","article-title":"Ovulation inhibition with a combined oral contraceptive containing 1mg micronized 17\u00a0beta-estradiol","volume":"60","author":"Wenzl","year":"1993","journal-title":"Fertil Steril"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0378-5122(94)00856-3","article-title":"Oral contraceptive containing natural estradiol for premenopausal women","volume":"21","author":"Hirvonen","year":"1995","journal-title":"Maturitas"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0378-5122(88)90023-0","article-title":"New natural oestradiol\/cyproterone acetate oral contraceptive for pre-menopausal women","volume":"10","author":"Hirvonen","year":"1988","journal-title":"Maturitas"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0135","first-page":"517","article-title":"A 19-norprogestin without 17alfa-ethinyl group II\/dienogest from a pharmacodynamic point of view","volume":"31","author":"Oettel","year":"1995","journal-title":"Drugs Today"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0140","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.steroids.2007.10.003","article-title":"Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile","volume":"73","author":"Sasagawa","year":"2008","journal-title":"Steroids"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0145","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.2165\/11206320-000000000-00000","article-title":"Dienogest: a review of its use in the treatment of endometriosis","volume":"70","author":"McCormack","year":"2010","journal-title":"Drugs"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0150","first-page":"105","article-title":"Alternatives for the replacement of ethinylestradiol by natural 17\u03b2-estradiol in dienogest-containing oral contraceptives","volume":"35","author":"Hoffmann","year":"1999","journal-title":"Drugs Today"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0155","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejogrb.2009.11.001","article-title":"Efficacy and safety of a novel oral contraceptive based on oestradiol (oestradiol valerate\/dienogest): a Phase III trial","volume":"149","author":"Palacios","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0160","unstructured":"Qlaira. Dossier d\u2019AMM. Rapport de l\u2019\u00e9tude A39818."},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0165","first-page":"S94","article-title":"Bleeding patterns and cycle control with a novel four-phasic combined oral contraceptive containing estradiol valerate and dienogest","volume":"13","author":"Parke","year":"2008","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0170","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/AOG.0b013e3182118ac3","article-title":"Effective treatment of heavy menstrual bleeding with estradiol valerate and dienogest. A randomized controlled trial","volume":"117","author":"Jensen","year":"2011","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0175","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/13625187.2011.554923","article-title":"Inhibition of ovulation by NOMAC\/E2, a novel monophasic oral contraceptive combining nomegestrol acetate and 17b-oestradiol: A double-blind, randomised, dose-finding pilot study","volume":"16","author":"Chabbert-Buffet","year":"2011","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0180","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/humrep\/der058","article-title":"Comparison of a 24-day and a 21-day pill regimen for the novel combined oral contraceptive, nomegestrol acetate and 17{beta}-estradiol (NOMAC\/E2): a double-blind, randomized study","volume":"26","author":"Christin-Maitre","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0185","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1160\/TH10-05-0327","article-title":"Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate\/17\u03b2-estradiol, compared with those of levonorgestrel\/ethinyl estradiol. A double-blind, randomised study","volume":"105","author":"Gaussem","year":"2011","journal-title":"Thromb Haemos"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0190","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3109\/13625187.2010.504313","article-title":"Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17beta-oestradiol on ovarian function in comparison to a monophasic combined oral contraceptive containing drospirenone and ethinylestradiol","volume":"15","author":"Duijkers","year":"2010","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0195","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0010-7824(95)00271-5","article-title":"A comparative study of the effects of the hemostatic system of two monophasic gestodene oral contraceptives containing 20\u00a0micrograms and 30\u00a0micrograms ethinylestradiol","volume":"53","author":"Winkler","year":"1996","journal-title":"Contraception"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0200","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.contraception.2005.09.015","article-title":"A prospective study on the effects on hemostasis of two oral contraceptives containing drospirenone in combination with either30\u00a0or 20\u00a0microgethinyl estradiol and a reference containing desogestrel and 30\u00a0microgethinyl estradiol","volume":"73","author":"Kluft","year":"2006","journal-title":"Contraception"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0205","first-page":"15S","article-title":"Metabolic effects of a new four-phasic oral contraceptive containing estradiol valerate and dienogest","volume":"111","author":"Parke","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0210","doi-asserted-by":"crossref","DOI":"10.2165\/11590220-000000000-00000","article-title":"Metabolic and haemostatic effects of estradiol valerate\/dienogest, a novel oral contraceptive. A randomized, open-label, single-centre study","author":"Junge","year":"2011","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0215","article-title":"Effects of an oral contraceptive containing nomegestrol acetate and 17beta-estradiol on carbohydrate metabolism. The Hague, the Netherlands","author":"\u00c5gren","year":"2010","journal-title":"Eur Soc Contracept Reprod Health"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0220","first-page":"i77","article-title":"Oral Comparative effects of a four-phasic regimen of estradiol valerate\/dienogest versus ethinylestradiol\/levonorgestrel on haemostatic parameters","volume":"23","author":"Parke","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0225","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1517\/14656561003724713","article-title":"Evaluation of a new estradiol oral contraceptive: estradiol valerate and dienogest","volume":"11","author":"Jensen","year":"2010","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0230","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2165\/11591200-000000000-00000","article-title":"Hemostatic Effects of a novel estradiol-based oral contraceptive. An open-label, Randomized, crossover study of estradiol valerate\/dienogest versus ethinylestradiol\/levonorgestrel","volume":"11","author":"Klipping","year":"2011","journal-title":"Drugs R D"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0235","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1210\/jc.2007-0026","article-title":"Effects of oral and trans-vaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, cross-over study","volume":"2","author":"Sitruk-Ware","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0240","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/MOH.0b013e32833c07bc","article-title":"Risk of venous thrombosis with oral versus transdermal estrogen therapy among postmenopausal women","volume":"17","author":"Oli\u00e9","year":"2010","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.gyobfe.2011.10.009_bib0245","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejogrb.2010.04.002","article-title":"Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study","volume":"151","author":"Strowitzki","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["Gyn\u00e9cologie Obst\u00e9trique & Fertilit\u00e9"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297958911004036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297958911004036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T19:13:40Z","timestamp":1742325220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297958911004036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S1297958911004036"],"URL":"https:\/\/doi.org\/10.1016\/j.gyobfe.2011.10.009","relation":{},"ISSN":["1297-9589"],"issn-type":[{"value":"1297-9589","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}