{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:05:31Z","timestamp":1786989931912,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","content-domain":{"domain":["em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gyn\u00e9cologie Obst\u00e9trique & Fertilit\u00e9"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.gyobfe.2014.04.005","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T18:30:18Z","timestamp":1400524218000},"page":"422-428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["D\u00e9ficits en 21-hydroxylase\u00a0et infertilit\u00e9 f\u00e9minine\u00a0: de la physiopathologie \u00e0 la prise en charge th\u00e9rapeutique"],"prefix":"10.1016","volume":"42","author":[{"given":"G.","family":"Robin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Decanter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Baffet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Catteau-Jonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Dewailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.gyobfe.2014.04.005_bib0005","first-page":"245","article-title":"Congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"21","author":"White","year":"2000","journal-title":"Endocr Rev"},{"issue":"3","key":"10.1016\/j.gyobfe.2014.04.005_bib0010","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-2002-35388","article-title":"Nonclassic 21-hydroxylase deficiency","volume":"20","author":"Dewailly","year":"2002","journal-title":"Semin Reprod Med"},{"issue":"3","key":"10.1016\/j.gyobfe.2014.04.005_bib0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0003-4266(05)81754-8","article-title":"21-hydroxylase deficiency: an exemplary model of the contribution of molecular biology in the understanding and management of the disease","volume":"66","author":"Forest","year":"2005","journal-title":"Ann Endocrinol (Paris)"},{"issue":"3","key":"10.1016\/j.gyobfe.2014.04.005_bib0020","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jpag.2010.10.001","article-title":"Congenital adrenal hyperplasia","volume":"24","author":"Witchel","year":"2011","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"6","key":"10.1016\/j.gyobfe.2014.04.005_bib0025","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/humupd\/dmh047","article-title":"Recent advances in the diagnosis and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"10","author":"Forest","year":"2004","journal-title":"Hum Reprod Update"},{"issue":"6","key":"10.1016\/j.gyobfe.2014.04.005_bib0030","first-page":"456","article-title":"D\u00e9ficit en 21-hydroxylase\u00a0: nouvelles d\u00e9marches d\u00e9duites des \u00e9tudes mol\u00e9culaires","volume":"64","author":"Morel","year":"2003","journal-title":"Ann Endocrinol (Paris)"},{"issue":"5","key":"10.1016\/j.gyobfe.2014.04.005_bib0035","first-page":"281","article-title":"Conseil g\u00e9n\u00e9tique et conduite \u00e0 tenir avant, pendant et apr\u00e8s la grossesse en cas de bloc surr\u00e9nalien en 21-hydroxylase","volume":"6","author":"Tardy","year":"2004","journal-title":"Med Ther Endocrinol Reprod"},{"issue":"3","key":"10.1016\/j.gyobfe.2014.04.005_bib0040","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1210\/jcem-51-3-647","article-title":"The attenuated form of congenital adrenal hyperplasia as an allelic form of 21-hydroxylase deficiency","volume":"51","author":"Migeon","year":"1980","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.gyobfe.2014.04.005_bib0045","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1515\/JPEM.2006.19.5.677","article-title":"Fertility in patients with congenital adrenal hyperplasia","volume":"19","author":"Claahsen-van der Grinten","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.gyobfe.2014.04.005_bib0050","first-page":"933","article-title":"Subnormal androgen and elevated progesterone levels in women treated for congenital virilizing 21-hydroxylase deficiency","volume":"76","author":"Helleday","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.gyobfe.2014.04.005_bib0055","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ando.2009.12.009","article-title":"Detection and management of late-onset 21-hydroxylase deficiency in women with hyperandrogenism","volume":"71","author":"Young","year":"2010","journal-title":"Ann Endocrinol (Paris)"},{"issue":"3","key":"10.1016\/j.gyobfe.2014.04.005_bib0060","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2265.1995.tb02034.x","article-title":"Menstrual disturbance and hypersecretion of progesterone in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"43","author":"Holmes-Walker","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"10.1016\/j.gyobfe.2014.04.005_bib0065","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ando.2007.06.019","article-title":"Hormonal treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"68","author":"Bachelot","year":"2007","journal-title":"Ann Endocrinol (Paris)"},{"issue":"2","key":"10.1016\/j.gyobfe.2014.04.005_bib0070","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1210\/jc.2006-1311","article-title":"Testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia: evaluation of pituitary-gonadal function before and after successful testis-sparing surgery in eight patients","volume":"92","author":"Claahsen-van der Grinten","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.gyobfe.2014.04.005_bib0075","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s00330-004-2329-x","article-title":"Prevalence of ovarian adrenal rest tumours and polycystic ovaries in females with congenital adrenal hyperplasia: results of ultrasonography and MR imaging","volume":"14","author":"Stikkelbroeck","year":"2004","journal-title":"Eur Radiol"},{"issue":"3","key":"10.1016\/j.gyobfe.2014.04.005_bib0080","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1210\/jc.2009-1383","article-title":"Fertility in women with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"95","author":"Bidet","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.gyobfe.2014.04.005_bib0085","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1210\/jc.2006-0062","article-title":"Reproductive outcome of women with 21-hydroxylase-deficient nonclassic adrenal hyperplasia","volume":"91","author":"Moran","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.gyobfe.2014.04.005_bib0090","first-page":"635","article-title":"Fertility in women with late-onset adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"74","author":"Feldman","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.gyobfe.2014.04.005_bib0095","first-page":"810","article-title":"Clinical review 56: nonclassic adrenal hyperplasia: current concepts","volume":"78","author":"Azziz","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.gyobfe.2014.04.005_bib0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1365-2265.1994.tb01818.x","article-title":"Ovarian stromal hypertrophy in hyperandrogenic women","volume":"41","author":"Dewailly","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"9588","key":"10.1016\/j.gyobfe.2014.04.005_bib0105","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.gyobfe.2014.04.005_bib0110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003\u00a0consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.gyobfe.2014.04.005_bib0115","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The androgen excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report","volume":"91","author":"Azziz","year":"2009","journal-title":"Fertil Steril"},{"issue":"9","key":"10.1016\/j.gyobfe.2014.04.005_bib0120","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1210\/jc.2009-2631","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society Clinical Practice Guideline","volume":"95","author":"Speiser","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.gyobfe.2014.04.005_bib0125","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2265.2005.02410.x","article-title":"Congenital adrenal hyperplasia in adults: a review of medical, surgical and psychological issues","volume":"64","author":"Ogilvie","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"10.1016\/j.gyobfe.2014.04.005_bib0130","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0022-3476(84)80310-8","article-title":"Prenatal treatment of congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency","volume":"105","author":"David","year":"1984","journal-title":"J Pediatr"},{"issue":"1-2","key":"10.1016\/j.gyobfe.2014.04.005_bib0135","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.mce.2008.11.027","article-title":"Prenatal diagnosis and treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"300","author":"Nimkarn","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"7","key":"10.1016\/j.gyobfe.2014.04.005_bib0140","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S1043-2760(98)00068-X","article-title":"Prenatal treatment of congenital adrenal hyperplasia: a promising experimental therapy of unproven safety","volume":"9","author":"Miller","year":"1998","journal-title":"Trends Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.gyobfe.2014.04.005_bib0145","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0022-5347(05)68624-7","article-title":"Dexamethasone treatment of congenital adrenal hyperplasia in utero: an experimental therapy of unproven safety","volume":"162","author":"Miller","year":"1999","journal-title":"J Urol"},{"issue":"4","key":"10.1016\/j.gyobfe.2014.04.005_bib0150","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1053\/siny.2001.0071","article-title":"Prenatal dexamethasone treatment of fetuses at risk for congenital adrenal hyperplasia: benefits and concerns","volume":"6","author":"Ritzen","year":"2001","journal-title":"Semin Neonatol"}],"container-title":["Gyn\u00e9cologie Obst\u00e9trique & Fertilit\u00e9"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297958914001210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297958914001210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T23:20:25Z","timestamp":1538608825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297958914001210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S1297958914001210"],"URL":"https:\/\/doi.org\/10.1016\/j.gyobfe.2014.04.005","relation":{},"ISSN":["1297-9589"],"issn-type":[{"value":"1297-9589","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"D\u00e9ficits en 21-hydroxylase\u00a0et infertilit\u00e9 f\u00e9minine\u00a0: de la physiopathologie \u00e0 la prise en charge th\u00e9rapeutique","name":"articletitle","label":"Article Title"},{"value":"Gyn\u00e9cologie Obst\u00e9trique & Fertilit\u00e9","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gyobfe.2014.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}