{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:52:13Z","timestamp":1791197533756,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gyn\u00e9cologie Obst\u00e9trique & Fertilit\u00e9"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.gyobfe.2015.10.007","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T20:57:08Z","timestamp":1447534628000},"page":"786-790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Papaverine as a replacement for pentoxifylline to select thawed testicular or epididymal spermatozoa before ICSI"],"prefix":"10.1016","volume":"43","author":[{"given":"P.","family":"Terriou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cortvrindt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Avon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Charles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Salzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lazdunski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Giorgetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gyobfe.2015.10.007_bib0150","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1439-0272.1980.tb00617.x","article-title":"Pentoxifillyne (BL 191) by oral administration in the treatment of asth\u00e9nospermia","volume":"12","author":"Aparicio","year":"1980","journal-title":"Andrologia"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0155","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/oxfordjournals.humrep.a137837","article-title":"Effect of pentoxifylline on sperm movement characteristics in normozoospermic and asthenozoospermic specimens","volume":"7","author":"Tesarik","year":"1992","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0160","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0015-0282(16)60030-4","article-title":"Preliminary results using Pentoxyfillyne in a pronuclear stage tubal transfer (PROST) program for severe male factor infertility","volume":"50","author":"Yovich","year":"1988","journal-title":"Fertil Steril"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0165","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/humrep\/13.4.911","article-title":"Correlation between intracellular cAMP content, kinematic parameters and hyperactivation of human spermatozoa after incubation with pentoxifylline","volume":"13","author":"Calogero","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1439-0272.1999.00241.x","article-title":"Pentoxifylline stimulates various sperm motion parameters and cervical mucus penetrability in patients with astenozoospermia","volume":"31","author":"Nassar","year":"1999","journal-title":"Andrologia"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0175","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/oxfordjournals.humrep.a019363","article-title":"Effectiveness of pentoxifylline in semen preparation for intauterine insemination","volume":"6","author":"Negri","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0180","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0015-0282(16)53470-0","article-title":"Influence of Pentoxifillyne in severe male factor infertility","volume":"53","author":"Yovich","year":"1990","journal-title":"Fertil Steril"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0185","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0015-0282(16)56052-X","article-title":"Sperm treatment with pentoxifylline improves the fertilizing ability in patients with acrosome reaction insufficiency","volume":"60","author":"Tesarik","year":"1993","journal-title":"Fertil Steril"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0190","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1023\/A:1009435732258","article-title":"Pentoxifylline initiates motility in spontaneously immotile epididymal and testicular spermatozoa and allows normal fertilization, pregnancy and birth after intracytoplasmic sperm injection","volume":"17","author":"Terriou","year":"2000","journal-title":"J Ass Reprod Genet"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0195","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/oxfordjournals.humrep.a019384","article-title":"Pregnancies achieved with testicular and ejaculated spermatozoa in combination with intracytoplasmic sperm injection in men with totally or initially immotile spermatozoa in the ejaculate","volume":"11","author":"Kahraman","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0200","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1093\/oxfordjournals.humrep.a019073","article-title":"Fertilizing ability of immotile spermatozoa after intracytoplasmic sperm injection","volume":"10","author":"Nijs","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0205","series-title":"R\u00e9\u00e9valuation du service m\u00e9dical rendu par la pentoxifylline","author":"Haute Autorit\u00e9 de Sant\u00e9","year":"2011"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0210","series-title":"Liste des proc\u00e9d\u00e9s biologiques r\u00e9guli\u00e8rement utilis\u00e9s en AMP et des techniques visant \u00e0 am\u00e9liorer les proc\u00e9d\u00e9s biologiques autoris\u00e9s","author":"Agence de BioM\u00e9decine","year":"2013"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0215","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF02766832","article-title":"Effect of pentoxifylline on immotile testicular spermatozoa","volume":"15","author":"Tasdemir","year":"1998","journal-title":"J Ass Reprod Genet"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0220","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0015-0282(00)00559-8","article-title":"In situ use of pentoxifylline to assess sperm vitality in trancytoplasmic sperm injection for treatment of patients with total lack of sperm movement","volume":"74","author":"Hurtado de Mendoza","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0225","first-page":"14","article-title":"Interest of pentoxifylline in icsi with frozen-thawed testicular spermatozoa from patients with non-obstructive azoospermia","volume":"12","author":"Griveau","year":"2006","journal-title":"RBMOnline"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0230","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1530\/jrf.0.0700219","article-title":"Development of an assay to assess the functional integrity of the human sperm membrane and its relationship to other semen characteristics","volume":"70","author":"Jeyendran","year":"1984","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0235","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/S0015-0282(16)58271-5","article-title":"The hypo-osmotic swelling test for selection of viable sperm for intracytoplasmic sperm injection in men with complete asthenozoospermia","volume":"5","author":"Casper","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0240","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/humupd\/3.3.195","article-title":"Comparison of different hypo-osmotic swelling solutions to select viable immotile spermatozoa for potential use in intracytoplasmic sperm injection","volume":"3","author":"Verheyen","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0245","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.fertnstert.2010.10.007","article-title":"Selection of viable spermatozoa from testicular biopsies: a comparative study between pentoxifylline and hypoosmotic swelling test","volume":"95","author":"Mangoli","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0250","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0015-0282(98)00434-8","article-title":"Enhancement or initiation of testicular sperm motility by in vitro culture of testicular tissue","volume":"71","author":"Angelopoulos","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0255","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1093\/oxfordjournals.humrep.a019141","article-title":"Changes in motility patterns during in vitro culture of fresh and frozen\/thawed testicular and epididymal spermatozoa: implications for planning treatment by intra-cytoplasmic sperm injection","volume":"11","author":"Edirisinghe","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0260","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/humrep\/12.8.1667","article-title":"Outcome of in-vitro culture of fresh and frozen-thawed human testicular spermatozoa","volume":"12","author":"Liu","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0265","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.fertnstert.2011.08.041","article-title":"Pharmacological stimulation of sperm motility in frozen and thawed testicular sperm using the dimethylxanthine theophylline","volume":"96","author":"Ebner","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0270","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/tera.1420320209","article-title":"Developmental and cytogenetic effects of caffeine on mouse blastocysts, alone or in combination with benzo(a)pyrene","volume":"32","author":"Spindle","year":"1985","journal-title":"Teratology"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0275","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF01203756","article-title":"The effect of caffeine on the ability of spermatozoa to fertilize mature human oocytes","volume":"9","author":"Imoedemhe","year":"1992","journal-title":"J Ass Reprod Genet"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0280","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/oxfordjournals.humrep.a138356","article-title":"The effect of pentoxifylline on mouse in-vitro fertilization and early embryonic development","volume":"9","author":"Tournaye","year":"1994","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0285","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/oxfordjournals.humrep.a138545","article-title":"Effect of pentoxifylline on mouse embryos","volume":"9","author":"Yovich","year":"1994","journal-title":"Hum Reprod"},{"key":"10.1016\/j.gyobfe.2015.10.007_bib0290","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1093\/humrep\/deu196","article-title":"Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity","volume":"10","author":"Tardif","year":"2014","journal-title":"Hum Reprod"}],"container-title":["Gyn\u00e9cologie Obst\u00e9trique & Fertilit\u00e9"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S129795891500301X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S129795891500301X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T18:22:57Z","timestamp":1537208577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S129795891500301X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S129795891500301X"],"URL":"https:\/\/doi.org\/10.1016\/j.gyobfe.2015.10.007","relation":{},"ISSN":["1297-9589"],"issn-type":[{"value":"1297-9589","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Papaverine as a replacement for pentoxifylline to select thawed testicular or epididymal spermatozoa before ICSI","name":"articletitle","label":"Article Title"},{"value":"Gyn\u00e9cologie Obst\u00e9trique & Fertilit\u00e9","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gyobfe.2015.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}