{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:40:23Z","timestamp":1788234023477,"version":"build-2803163510"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H06219"],"award-info":[{"award-number":["15H06219"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17310027"],"award-info":[{"award-number":["17310027"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Harmful Algae"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.hal.2021.102013","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T23:10:48Z","timestamp":1616800248000},"page":"102013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Sublethal and antioxidant effects of six ichthyotoxic algae on early-life stages of the Japanese pearl oyster"],"prefix":"10.1016","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-4452","authenticated-orcid":false,"given":"Leila","family":"Basti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoji","family":"Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohito","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hal.2021.102013_bib0001","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0304-4165(94)00184-Y","article-title":"Properties of hemagglutinins newly separated from toxic phytoplankton","volume":"1243","author":"Ahmed","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.hal.2021.102013_bib0002","first-page":"1331","article-title":"Role of superoxidases (SODs) in controlling oxidative stress in plants","volume":"53","author":"Alscher","year":"2002","journal-title":"JBX"},{"key":"10.1016\/j.hal.2021.102013_bib0003","series-title":"Proceedings of the 15th International Conference on Harmful Algae","first-page":"3","article-title":"HABs in a changing world: a perspective on harmful algal blooms, their impacts, and research and management in a dynamic era of climactic and environmental change","author":"Anderson","year":"2012"},{"key":"10.1016\/j.hal.2021.102013_bib0004","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/BF02804901","article-title":"Harmful algal blooms and eutrophication: nutrient sources, composition, and consequences","volume":"25","author":"Anderson","year":"2002","journal-title":"Estuar. Coast."},{"key":"10.1016\/j.hal.2021.102013_bib0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2983\/035.037.0103","article-title":"Deleterious effects of harmful dinoflagellates and raphidophytes on egg viability and spermatozoa swimming velocity in the Japanese pearl oyster Pinctada fucata martensii","volume":"37","author":"Banno","year":"2018","journal-title":"J. Shellfish Res."},{"key":"10.1016\/j.hal.2021.102013_bib0006","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.pocean.2015.04.018","article-title":"Drivers and effects of Karenia mikimotoi blooms in the western English channel","volume":"137","author":"Barnes","year":"2015","journal-title":"Prog. Oceanogr."},{"key":"10.1016\/j.hal.2021.102013_bib0007","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2983\/035.030.0324","article-title":"Physiological, pathological, and defense alterations in Manila clams (short-neck clams), Ruditapes philippinarum, induced by Heterocapsa circularisquama","volume":"30","author":"Basti","year":"2011","journal-title":"J. Shellfish Res."},{"key":"10.1016\/j.hal.2021.102013_bib0008","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.aquatox.2015.03.012","article-title":"Prevalence and intensity of pathologies induced by the toxic dinoflagellate, Heterocapsa circularisquama, in the Mediterranean mussel, Mytilus galloprovincialis","volume":"163","author":"Basti","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.hal.2021.102013_bib0009","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2983\/035.030.0125","article-title":"Effects of the toxic dinoflagellate Heterocapsa circularisquama on larvae of the pearl oyster Pinctada fucata martensii (Dunker, 1873)","volume":"30","author":"Basti","year":"2011","journal-title":"J. Shellfish Res."},{"key":"10.1016\/j.hal.2021.102013_bib0010","series-title":"Harmful Algal Blooms: A Compendium Desk Reference","first-page":"135","article-title":"Harmful algal blooms and shellfish","author":"Basti","year":"2018"},{"key":"10.1016\/j.hal.2021.102013_bib0011","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.hal.2016.08.003","article-title":"Lethal effects of ichthyotoxic raphidophytes, Chattonella marina, C. antiqua, and Heterosigma akashiwo, on post-embryonic stages of the Japanese pearl oyster, Pinctada fucata martensii","volume":"59","author":"Basti","year":"2016","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0012","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.aquaculture.2009.02.029","article-title":"Effects of the toxic dinoflagellate Heterocapsa circularisquama on the valve movement behavior of the Manila clam Ruditapes philippinarum","volume":"291","author":"Basti","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.hal.2021.102013_bib0013","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00227-012-2079-2","article-title":"Sensitivity of gametes, fertilization, and embryo development of the Japanese pearl oyster, Pinctada fucata martensii, to the harmful dinoflagellate, Heterocapsa circularisquama","volume":"160","author":"Basti","year":"2013","journal-title":"Mar. Biol."},{"key":"10.1016\/j.hal.2021.102013_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hal.2014.12.004","article-title":"Differential inimical effects of Alexandrium spp. and Karenia spp. on cleavage, hatching, and two larval stages of Japanese pearl oyster Pinctada fucata martensii","volume":"43","author":"Basti","year":"2015","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0015","series-title":"Marine and Freshwater Harmful Algae. Proceedings of the 16th International Conference on Harmful Algae","first-page":"94","article-title":"Harmful algal blooms affect early-life stages of Japanese pearl oyster, Pinctada fucata martensii","author":"Basti","year":"2015"},{"key":"10.1016\/j.hal.2021.102013_bib0016","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.aquatox.2016.04.011","article-title":"Neuroenzymatic activity and physiological energetics in Manila clam, Ruditapes philippinarum, during short-term sublethal exposure to harmful alga, Heterocaspa circularisquama","volume":"176","author":"Basti","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.hal.2021.102013_bib0017","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s12562-010-0252-4","article-title":"Mortalities of the short-neck clam Ruditapes philippinarum induced by the toxic dinoflagellate Heterocapsa circularisquama","volume":"76","author":"Basti","year":"2010","journal-title":"Fish. Sci."},{"key":"10.1016\/j.hal.2021.102013_bib0018","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1002\/etc.5620201115","article-title":"A comparison of biomarker responses in the earthworm Aporrectodea caliginosa to the organophosphorous insecticides diazinon and chlorpyrifos","volume":"20","author":"Booth","year":"2001","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.hal.2021.102013_bib0019","series-title":"Harmful and Toxic Algal Blooms","article-title":"Comparative physiological and behavioral responses to PSP toxins in two bivalve molluscs, the softshell clam, Mya arenaria, and surfclam, Spisula solidissima","author":"Bricelj","year":"1996"},{"key":"10.1016\/j.hal.2021.102013_bib0020","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.envpol.2018.09.110","article-title":"Plastic-associated harmful microalgae assemblages in marine environment","volume":"244","author":"Casabianca","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.hal.2021.102013_bib0021","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1529-8817.1969.tb02605.x","article-title":"Bonnemaisonia hamifera Hariot in nature and in culture","volume":"5","author":"Chen","year":"1969","journal-title":"J. Phycol."},{"key":"10.1016\/j.hal.2021.102013_bib0022","first-page":"31","article-title":"Haemolytic activity and reactive oxygen species production of four harmful algal bloom species","volume":"53","author":"Cho","year":"2017","journal-title":"European J. Phycol."},{"key":"10.1016\/j.hal.2021.102013_bib0023","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.hal.2009.11.003","article-title":"Regional economic impacts of razor clam beach closures due to harmful algal blooms (HABs) on the Pacific coast of Washington. 2010","volume":"9","author":"Dauson","year":"2010","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0024","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.hal.2008.07.007","article-title":"A large and prolonged bloom of Karenia mikimotoi in Scottish waters in 2006","volume":"8","author":"Davidson","year":"2009","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib118","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.fsi.2015.09.003","article-title":"Common European harmful algal blooms affect the viability and innate immune responses of Mytilus edulis larvae","volume":"47","author":"De Rijcke","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.hal.2021.102013_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133549","article-title":"Progress in understanding algal bloom-mediated fish kills: the role of superoxide radicals, phycotoxins and fatty acids","volume":"10","author":"Dorantes-Aranda","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.hal.2021.102013_bib0026","series-title":"Ecology of Harmful Algae. Ecological Studies (Analysis and Synthesis), Vol 189","article-title":"The Ecology of Harmful Flagellates within Prymnesiophyceae and Raphidophyceae","author":"Edvardsen","year":"2006"},{"key":"10.1016\/j.hal.2021.102013_bib116","series-title":"Toxic Marine Phytoplankton","first-page":"132","article-title":"Effects of Gyrodinium cf. aureolum on Pecten maximus (post larvae, juveniles and adults).","author":"Erard-LeDenn","year":"1990"},{"key":"10.1016\/j.hal.2021.102013_bib0027","series-title":"The State of World Fisheries and Aquaculture 2020","year":"2020"},{"key":"10.1016\/j.hal.2021.102013_bib110","first-page":"1","article-title":"Harmful Blooms in the Seto Inland Sea","author":"Fisheries Agency","year":"2018","journal-title":"Fisheries Agency Report"},{"key":"10.1016\/j.hal.2021.102013_bib0028","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.toxicon.2015.05.007","article-title":"Chemical analysis of Karenia papilionacea","volume":"101","author":"Fowler","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.hal.2021.102013_bib0029","series-title":"Harmful Algal Blooms in the PICES Region of the North Pacific","first-page":"7","article-title":"Red tides and other harmful algal blooms in Japan","author":"Furuyo","year":"2002"},{"key":"10.1016\/j.hal.2021.102013_bib102","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0742-8413(88)90182-X","article-title":"Physiological effects of Protogonyaulax tamarensis on caridac activity in bivalve molluscs","volume":"91","author":"Gainay","year":"1988","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.hal.2021.102013_bib0033","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2018.00454","article-title":"Mass mortality of cultivated Northern Bluefin Tuna Thynnus thynnus orientalis associated with Chattonella species in Baja California","author":"Garc\u00eda-Mendoza","year":"2018","journal-title":"Mexico. Front. Mar. Sci."},{"key":"10.1016\/j.hal.2021.102013_bib0034","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1098\/rstb.2007.2079","article-title":"Motility and autotoxicity in Karenia mikimotoi (Dinophyceae)","volume":"362","author":"Gentien","year":"2007","journal-title":"Philos. Trans. R. Soc. B"},{"key":"10.1016\/j.hal.2021.102013_bib122","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1111\/gcb.12662","article-title":"Vulnerability of coastal ecosystems to changes in harmful algal bloom distribution in response to climate change: projections based on model analysis","volume":"20","author":"Glibert","year":"2014","journal-title":"Glob. Change Biol."},{"key":"10.1016\/j.hal.2021.102013_bib0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.hal.2007.12.006","article-title":"Characterization, dynamics, and ecological impacts of harmful Cochlodinium polykrikoides blooms on eastern Long Island, NY, USA","volume":"7","author":"Gobler","year":"2008","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0036","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4490\/ALGAE.2006.21.4.445","article-title":"The Dinoflagellate Genera Brachidinium, Asterodinium, Microceratium and Karenia in the Open SE Pacific Ocean","volume":"21","author":"G\u00f3mez","year":"2006","journal-title":"Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0037","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.hal.2016.05.003","article-title":"Harmful algal blooms and public health","volume":"57","author":"Grattan","year":"2016","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0038","doi-asserted-by":"crossref","DOI":"10.1098\/rspb.2019.0340","article-title":"Ocean warming along temperate western boundaries of the Northern Hemisphere promotes an expansion of Cochlodinium polykrikoides blooms","author":"Griffith","year":"2019","journal-title":"Proc. R. Soc. B"},{"key":"10.1016\/j.hal.2021.102013_bib0039","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1002\/ece3.5100","article-title":"The harmful algae, Chochlodinium polykrikoides and Aureococcus anaphagefferebs, elicit stronger transcriptomic and mortality response in larval bivalves (Argopecten irradians) than climate change stressors","volume":"9","author":"Griffith","year":"2019","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.hal.2021.102013_bib0041","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s12237-018-0445-0","article-title":"Differential mortality of North Atlantic bivalve molluscs during harmful algal blooms caused by the dinoflagellate, Cochlodinium (a.k.a Margalefidinium) polykrikoides","volume":"42","author":"Griffith","year":"2019","journal-title":"Estuaries Coast"},{"key":"10.1016\/j.hal.2021.102013_bib0044","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2216\/i0031-8884-32-2-79.1","article-title":"A review of harmful algal blooms and their apparent global increase","volume":"32","author":"Hallegraeff","year":"1993","journal-title":"Phycologia"},{"key":"10.1016\/j.hal.2021.102013_bib0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1529-8817.2010.00815.x","article-title":"Ocean climate change, phytoplankton community responses, and harmful algal blooms: a formidable predictive challenge","volume":"46","author":"Hallegraeff","year":"2010","journal-title":"J. Phycol."},{"key":"10.1016\/j.hal.2021.102013_bib108","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0025-326X(91)90441-T","article-title":"Transport of toxic dinoflagellate cysts via ships\u2019 ballast water","volume":"22","author":"Hallegraeff","year":"1991","journal-title":"Mar. Poll. Bull."},{"key":"10.1016\/j.hal.2021.102013_bib0046","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2216\/i0031-8884-40-3-246.1","article-title":"Harmful dinoflagellate resting cysts in ships' ballast tank sediments: potential for introduction into English and Welsh waters","volume":"40","author":"Hamer","year":"2001","journal-title":"Phycologia"},{"key":"10.1016\/j.hal.2021.102013_bib111","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.0022-3646.2004.02-149.x","article-title":"Comparative morphology and molecular phylogenetic analysis of three new species of the genus Karenia (dinophyceae) from New Zealand","volume":"40","author":"Haywood","year":"2004","journal-title":"J. Phycol."},{"key":"10.1016\/j.hal.2021.102013_bib0047","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.hal.2012.04.006","article-title":"Effects of the toxic dinoflagellare Alexandrium catenella on histopathological and escape responses of the Northern scallop Argopecten purpuratus","volume":"18","author":"H\u00e9garet","year":"2012","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0049","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10565-011-9186-6","article-title":"In vitro interactions between several species of harmful algae and hemocytes of bivalve molluscs","volume":"27","author":"H\u00e9garet","year":"2011","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.hal.2021.102013_bib0050","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3354\/meps07375","article-title":"Potential transport of harmful algae via relocation of bivalve molluscs","volume":"361","author":"H\u00e9garet","year":"2008","journal-title":"Mar. Ecol. Progr. Ser."},{"key":"10.1016\/j.hal.2021.102013_bib105","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.marenvres.2009.12.008","article-title":"Combined effects of a parasite, QPX, and the harmful-alga, Prorocentrum minimum on northern quahogs, Mercenaria mercenaria","volume":"69","author":"H\u00e9garet","year":"2010","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.hal.2021.102013_bib104","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.hal.2003.12.004","article-title":"Time-dependent changes in hemocytes of eastern oysters, Crassostrea virginica, and northern bay scallops, Argopecten irradians irradians, exposed to a cultured strain of Prorocentrum minimum","volume":"4","author":"H\u00e9garet","year":"2005","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib103","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.hal.2003.12.005","article-title":"Effects of natural and field-simulated blooms of the dinoflagellate Prorocentrum minimum upon hemocytes of eastern oysters, Crassostrea virginica, from two different populations","volume":"2","author":"H\u00e9garet","year":"2005","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0052","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/BF02804908","article-title":"The economic effects of harmful algal blooms in the United States: estimates, assessment issues, and information needs","volume":"25","author":"Hoagland","year":"2002","journal-title":"Estuaries"},{"key":"10.1016\/j.hal.2021.102013_bib0053","series-title":"Ecology of Harmful Algae","first-page":"391","article-title":"The economic effects of harmful algal blooms","author":"Hoagland","year":"2006"},{"key":"10.1016\/j.hal.2021.102013_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.hal.2020.101904","article-title":"Is a delay a disaster? Economic impacts of the delay of the California dunganess crab fishery due to harmful algal bloom","volume":"98","author":"Holland","year":"2020","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0056","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3800\/pbr.1.71","article-title":"Eutrophication and occurrences of harmful algal blooms in the Seto Inland Sea, Japan","volume":"1","author":"Imai","year":"2006","journal-title":"Plankton Benthos Res."},{"key":"10.1016\/j.hal.2021.102013_bib0057","series-title":"Harmful Algal Blooms","first-page":"461","article-title":"Mitigation by cysteine compounds of rheotoxicity, cytotoxicity and fish mortality caused by the dinoflagellates, Gymnodinium mikimotoi and G. cf. maguelonnese","author":"Jenkinson","year":"2001"},{"key":"10.1016\/j.hal.2021.102013_bib121","first-page":"77","article-title":"Effect of Chattonella marina [(Subrahmanyan)Hara et Chihara 1982] bloom on the coastal fishery resources along Kerala coast, India","volume":"38","author":"Jugnu","year":"2009","journal-title":"Indian J. Mar. Sci."},{"key":"10.1016\/j.hal.2021.102013_bib0058","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.hal.2007.04.002","article-title":"A new and simple screening method for the detection of cytotoxic substances produced by harmful red tide phytoplankton","volume":"6","author":"Katsuo","year":"2007","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0059","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1749-7345.1996.tb00607.x","article-title":"Neurotoxin production by a chloromonad Fibrocapsa japonica (Raphidophyceae)","volume":"27","author":"Khan","year":"1996","journal-title":"J. World Aquacult. Soc."},{"key":"10.1016\/j.hal.2021.102013_bib0060","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0304-4165(00)00161-6","article-title":"Mechanism of superoxide anion generation in the toxic red tide phytoplankton Chattonella marina: possible involvement of NAD(P)H oxidase","volume":"1524","author":"Kim","year":"2000","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.hal.2021.102013_bib0061","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/plankt\/fbm011","article-title":"Presence of the distinct systems responsible for superoxide anion and hydrogen peroxide generation in red tide phytoplankton Chattonella marina and Chattonella ovata","volume":"29","author":"Kim","year":"2007","journal-title":"J. Plankton Res."},{"key":"10.1016\/j.hal.2021.102013_bib0062","series-title":"Coastal Environmental and Ecosystem Issues of the East China Sea","first-page":"245","article-title":"Possible factors responsible for the fish-killing mechanisms of the red tide phytoplankton, Chattonella marina and Cochlodinium polykrikoides","author":"Kim","year":"2010"},{"key":"10.1016\/j.hal.2021.102013_bib0063","first-page":"185","article-title":"Recent harmful algal blooms and mitigation strategies in Korea","volume":"19","author":"Kim","year":"1997","journal-title":"Ocean Res."},{"key":"10.1016\/j.hal.2021.102013_bib0064","series-title":"Harmful Algal Blooms. A Scientific Summary for Policy Makers","author":"Kudela","year":"2015"},{"key":"10.1016\/j.hal.2021.102013_bib0065","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.hal.2011.10.015","article-title":"Harmful dinoflagellate blooms caused by Cochlodinium sp.: global expansion and ecological strategies facilitating bloom formation","volume":"14","author":"Kudela","year":"2012","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0066","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.cca.2005.07.009","article-title":"Isolation and characterization of light-dependent hemolytic cytotoxin from harmful red tide phytoplankton Chattonella marina","volume":"141","author":"Kuroda","year":"2005","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.hal.2021.102013_bib0067","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/20026491051695","article-title":"The effects of harmful algal blooms on aquatic organisms","volume":"10","author":"Landsberg","year":"2002","journal-title":"Rev. Fish. Sci."},{"key":"10.1016\/j.hal.2021.102013_bib0068","first-page":"211","article-title":"Effect of a continuous supply of the toxic dinoflagellate Alexandrium minutum Balim on the feeding behavior of the Pacific oyster (Crassostrea gigas Thunberg)","volume":"18","author":"Lassus","year":"1999","journal-title":"J. Shellfish Res."},{"key":"10.1016\/j.hal.2021.102013_bib0069","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/s41598-018-19461-4","article-title":"Hydroclimatic conditions trigger record harmful algal bloom in western Patagonia (summer 2016)","volume":"8","author":"Le\u00f3n-Mu\u00f1oz","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.hal.2021.102013_bib0070","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1023\/B:HYDR.0000020331.75003.18","article-title":"Harmful algal bloom causative collected from Hong Kong waters","volume":"512","author":"Lu","year":"2004","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.hal.2021.102013_bib0071","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00227-005-1596-7","article-title":"Superoxide production by marine microalgae","volume":"147","author":"Marshall","year":"2005","journal-title":"Mar. Biol."},{"key":"10.1016\/j.hal.2021.102013_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.hal.2020.101912","article-title":"An approach to evaluating the economic impacts of harmful algal blooms: the effects of blooms Dinophysis spp. on the productivity of Scottish shellfish farms","volume":"99","author":"Martino","year":"2020","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0073","series-title":"Harmful Algal Blooms 2000. Proceedings of the Ninth International Conference on Harmful Algal Blooms","first-page":"411","article-title":"Effects of harmful algae on the early planktonic larvae of the oyster, Crassostrea gigas","author":"Matsuyama","year":"2001"},{"key":"10.1016\/j.hal.2021.102013_bib106","first-page":"283","article-title":"Harmful effects of dinoflagellate Heterocapsa circularisquama on shellfish aquaculture in Japan","volume":"33","author":"Matsuyama","year":"1999","journal-title":"JARQ"},{"key":"10.1016\/j.hal.2021.102013_bib0074","first-page":"13","article-title":"Physiological and ecological studies on harmful dinoflagellate Heterocapsa circularisquama. II. Clarification on toxicity of H. circularisquama and its mechanisms causing shellfish kills","volume":"9","author":"Matsuyama","year":"2003","journal-title":"Bull. Fish. Res. Agen."},{"key":"10.1016\/j.hal.2021.102013_bib107","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.hal.2011.10.019","article-title":"Impacts of the harmful dinoflagellate Heterocapsa circularisquama bloom on shellfish aquaculture in Japan and some experimental studies on invertebrates","volume":"14","author":"Matsuyama","year":"2012","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0075","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3354\/meps146073","article-title":"Toxic effects of the dinoflagellate Heterocapsa circularisquama on clearance rate of the Blue mussel Mytilus galloprovincialis","volume":"146","author":"Matsuyama","year":"1997","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.hal.2021.102013_bib0076","first-page":"91","article-title":"Characteristics of a red tide due to the harmful dinoflagellate Karenia mikimotoi occurred in Usuki Bay, Oita Prefecture, in 2003","volume":"68","author":"Miyamura","year":"2005","journal-title":"Bull. Fish. Res. Agen."},{"key":"10.1016\/j.hal.2021.102013_bib114","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.hal.2014.10.006","article-title":"Genetic diversity of the harmful family Kareniaceae (Gymnodiniales, Dinophyceae) in France, with the description of Karlodinium gentienii sp. nov.: A new potentially toxic dinoflagellate","volume":"40","author":"N\u00e9zan","year":"2014","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0077","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.aquatox.2016.08.019","article-title":"Intracellular haemolytic agents of Heterocapsa circularisquama exhibit toxic effects on H. circularisquama cells themselves and suppress both cell-mediated haemolytic activity and toxicity to rotifers (Brachionus plicatilis)","volume":"179","author":"Nishiguchi","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.hal.2021.102013_bib0078","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s002270050331","article-title":"Lectininduced enhancement of superoxide anion production by a red tide phytoplankton","volume":"131","author":"Oda","year":"1998","journal-title":"Mar. Biol."},{"key":"10.1016\/j.hal.2021.102013_bib0079","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1271\/bbb.61.1658","article-title":"Generation of reactive oxygen species by raphidophycean phytoplankton","volume":"61","author":"Oda","year":"1997","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.hal.2021.102013_bib0080","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1046\/j.1529-8817.2001.037004509.x","article-title":"Hemolytic activity of Heterocapsa circularisquama (Dinophyceae) and its possible involvement in shellfish toxicity","volume":"137","author":"Oda","year":"2001","journal-title":"J. Phycol."},{"key":"10.1016\/j.hal.2021.102013_bib0081","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/B:HYDR.0000020329.06666.8c","article-title":"Some observations on harmful algal bloom (HAB) events along the coast of Guangdong, southern China in 1998","volume":"512","author":"Qi","year":"2004","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.hal.2021.102013_bib100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.hal.2018.09.002","article-title":"Economic and sociocultural impacts of fisheries closures in two fishing-dependent communities following the massive 2015 U.S. West Coast harmful algal bloom","volume":"80","author":"Ritzman","year":"2018","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0082","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.toxicon.2015.03.002","article-title":"Susceptibility of gametes and embryos of the eastern oyster, Crassostrea virginica, to Karenia brevis and its toxins","volume":"99","author":"Rolton","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.hal.2021.102013_bib0083","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.aquatox.2014.06.023","article-title":"Effects of the red tide dinoflagellate, Karenia brevis, on early development of the eastern oyster Crassostrea virginica and northern quahog Mercenaria mercenaria","volume":"155","author":"Rolton","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.hal.2021.102013_bib0085","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1016\/j.tetlet.2005.03.115","article-title":"Gymnocin-B with the largest contiguous polyether rings from the red tide dinoflagellate Karenia (formerly Gymnodinium) mikimotoi","volume":"46","author":"Satake","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.hal.2021.102013_bib0086","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1749-7345.1990.tb00529.x","article-title":"A review of the effects of algal blooms on shellfish and aquaculture","volume":"21","author":"Shumway","year":"1990","journal-title":"J. World Aquac. Soc."},{"key":"10.1016\/j.hal.2021.102013_bib101","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0166-445X(87)90024-5","article-title":"The effects of the toxic dinoflagellate Protogonyaulax tamarensis on the feeding and behaviour of bivalve molluscs","volume":"10","author":"Shumway","year":"1987","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.hal.2021.102013_bib0088","first-page":"8","article-title":"Shellfish aquaculture\u2013in praise of sustainable economies and environments","volume":"34","author":"Shumway","year":"2003","journal-title":"J. World Aquac. Soc."},{"key":"10.1016\/j.hal.2021.102013_bib0089","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.rse.2012.11.003","article-title":"Detection of harmful algal blooms of Karenia mikimotoi using MODIS measurements: a case study of the Seto-Inland Sea","volume":"15","author":"Siswanto","year":"2013","journal-title":"Japan. Remote Sens. Environ."},{"key":"10.1016\/j.hal.2021.102013_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.hal.2019.101624","article-title":"Estimating the economic costs of algal blooms in the Canadian Lake Erie Basin","volume":"87","author":"Smith","year":"2019","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib112","first-page":"269","article-title":"Identification of Kareniaceae (Dinophycae) in the Gulf of Mexico","volume":"133","author":"Steidinger","year":"2008","journal-title":"Nova Hedwigia Beiheft"},{"key":"10.1016\/j.hal.2021.102013_bib117","doi-asserted-by":"crossref","first-page":"322","DOI":"10.2307\/1351923","article-title":"Recruitment failure of the Bay scallop, Argopecten irradians concentricus, during the first red tide, Ptychodiscus brevis, outbreak recorded in North Carolina","volume":"13","author":"Summerson","year":"1991","journal-title":"Estuaries"},{"key":"10.1016\/j.hal.2021.102013_bib0091","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.hal.2008.10.001","article-title":"Characterization of the toxicity of Cochlodinium polykrikoides isolates from Northeast US estuaries to finfish and shellfsih","volume":"8","author":"Tang","year":"2009","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib120","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00227-011-1800-x","article-title":"Lethal effects of Northwest Atlantic Ocean isolates of the dinoflagellate, Scrippsiella trochoidea, on Eastern oyster (Crassostrea virginica) and Northern quahog (Mercenaria mercenaria) larvae","volume":"159","author":"Tang","year":"2012","journal-title":"Mar. Biol."},{"key":"10.1016\/j.hal.2021.102013_bib0092","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.4319\/lo.2001.46.6.1400","article-title":"Toxic effects of Heterosigma akashiwo do not appear to be mediated by hydrogen peroxide","volume":"46","author":"Twiner","year":"2001","journal-title":"Limnol. Oceanogr."},{"key":"10.1016\/j.hal.2021.102013_bib0093","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.hal.2003.10.003","article-title":"Extracellular organics from specific cultures of Heterosigma akashiwo (Raphidophyceae) irreversibly alter respiratory activity in mammalian cells","volume":"3","author":"Twiner","year":"2004","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0094","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0308-597X(01)00032-X","article-title":"Exotic harmful algae in marine ecosystems: an integrated biological-economic-legal analysis of impacts and policies","author":"Van der Bergh","year":"2002","journal-title":"Mar. Policy"},{"issue":"5325","key":"10.1016\/j.hal.2021.102013_bib0095","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1126\/science.277.5325.494","article-title":"Human domination of Earth's ecosystems","volume":"277","author":"Vitousek","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.hal.2021.102013_bib119","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.aquaculture.2005.11.057","article-title":"Impacts of HAB species Heterosigma akashiwo on early development of the scallop Argopecten irradians Lamarck","volume":"255","author":"Wang","year":"2006","journal-title":"Aquaculture"},{"key":"10.1016\/j.hal.2021.102013_bib0096","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.hal.2015.07.009","article-title":"Harmful algal blooms and climate change: learning from the past and present to forecast the future","volume":"49","author":"Wells","year":"2015","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0097","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2307\/1542308","article-title":"Experimental and histological studies of four life-history stages of the Eastern oyster, Crassostrea virginica, exposed to a cultured strain of the dinoflagellate Prorocentrum minimum","volume":"188","author":"Wikfors","year":"1995","journal-title":"Biol. Bull."},{"key":"10.1016\/j.hal.2021.102013_bib115","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.hal.2016.04.007","article-title":"Occurrence of Karenia papilionacea (Dinophyceae) and its novel sister phylotype in Japanese coastal waters","volume":"57","author":"Yamaguchi","year":"2016","journal-title":"Harmful Algae"},{"key":"10.1016\/j.hal.2021.102013_bib0098","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S1389-1723(04)70193-0","article-title":"Production of superoxide anion and hydrogen peroxide by the red tide dinoflagellate Karenia mikimotoi","volume":"97","author":"Yamasaki","year":"2004","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.hal.2021.102013_bib113","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1017\/S0025315405011690","article-title":"Characterization of a Karenia papilionacea-like dinoflagellate from the South China","volume":"85","author":"Yeung","year":"2005","journal-title":"J. Biol. Ass. U.K."},{"key":"10.1016\/j.hal.2021.102013_fur2e","first-page":"269","article-title":"Identification of Kareninaceae (Dinophyceae) in the Gulf of Mexico","volume":"133","author":"Stedinger","year":"2008","journal-title":"Nova Hedwegia"},{"key":"10.1016\/j.hal.2021.102013_fur2g","first-page":"269","article-title":"Identification of Kareninaceae (Dinophyceae) in the Gulf of Mexico","volume":"133","author":"Stedinger","year":"2008","journal-title":"Nova Hedwegia"},{"key":"10.1016\/j.hal.2021.102013_fur2i","first-page":"269","article-title":"Identification of Kareninaceae (Dinophyceae) in the Gulf of Mexico","volume":"133","author":"Stedinger","year":"2008","journal-title":"Nova Hedwegia"},{"key":"10.1016\/j.hal.2021.102013_fur1e","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1017\/S0025315405011690","article-title":"Characterization of a Karenia papilionacea-like dinoflagellate from the South China","volume":"85","author":"Yeung","year":"2005","journal-title":"J. Mar. Biol. Ass. U.K."},{"key":"10.1016\/j.hal.2021.102013_fur1f","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1017\/S0025315405011690","article-title":"Characterization of a Karenia papilionacea-like dinoflagellate from the South China","volume":"85","author":"Yeung","year":"2005","journal-title":"J. Mar. Biol. Ass. U.K."},{"key":"10.1016\/j.hal.2021.102013_fur1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1017\/S0025315405011690","article-title":"Characterization of a Karenia papilionacea-like dinoflagellate from the South China","volume":"85","author":"Yeung","year":"2005","journal-title":"J. Mar. Biol. Ass. U.K."}],"container-title":["Harmful Algae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568988321000408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568988321000408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:08:16Z","timestamp":1761599296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568988321000408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":115,"alternative-id":["S1568988321000408"],"URL":"https:\/\/doi.org\/10.1016\/j.hal.2021.102013","relation":{},"ISSN":["1568-9883"],"issn-type":[{"value":"1568-9883","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sublethal and antioxidant effects of six ichthyotoxic algae on early-life stages of the Japanese pearl oyster","name":"articletitle","label":"Article Title"},{"value":"Harmful Algae","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hal.2021.102013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102013"}}