{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:46:05Z","timestamp":1784799965509,"version":"3.55.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307219\/2022-4"],"award-info":[{"award-number":["307219\/2022-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["E-26\/204.614\/2021"],"award-info":[{"award-number":["E-26\/204.614\/2021"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["E-26\/202.370\/2024"],"award-info":[{"award-number":["E-26\/202.370\/2024"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26\/200.551\/2023 - 281293"],"award-info":[{"award-number":["E-26\/200.551\/2023 - 281293"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Harmful Algae"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.hal.2025.103040","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T16:54:13Z","timestamp":1765299253000},"page":"103040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Environmentally relevant concentrations of the antibiotic azithromycin enhance the toxicity of the cyanobacterium Microcystis aeruginosa on the water flea Daphnia similis"],"prefix":"10.1016","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-7967","authenticated-orcid":false,"given":"Michael Ribas","family":"Celano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Vianna","family":"De Pinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Maria Feliciano de Oliveira e","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-6974","authenticated-orcid":false,"given":"Mauro Cesar Palmeira","family":"Vilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hal.2025.103040_bib0001","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4236\/jep.2013.46A002","article-title":"Effects of an anatoxin-a (s)-producing strain of anabaena spiroides (Cyanobacteria) on the survivorship and somatic growth of two daphnia similis clones","volume":"4","author":"Abreu","year":"2013","journal-title":"J. Env. Prot. (Irvine. Calif)"},{"key":"10.1016\/j.hal.2025.103040_bib0002","article-title":"Venda de medicamentos controlados e antimicrobianos \u2013 medicamentos industrializados","year":"2021","journal-title":"Dados. Abertos. \u2013. Gov. Fed."},{"issue":"3","key":"10.1016\/j.hal.2025.103040_bib0003","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/tox.20123","article-title":"Characterization of proteases in guts of daphnia magna and their inhibition by microcystis aeruginosa PCC 7806","volume":"20","author":"Agrawal","year":"2005","journal-title":"Environ. Toxicol.:. Int. J."},{"key":"10.1016\/j.hal.2025.103040_bib0004","first-page":"21","article-title":"Ecotoxicological studies of cephalosporin antibiotics on Daphnia magna","volume":"25","author":"Ahmad","year":"2018","journal-title":"Toxicol. Int"},{"key":"10.1016\/j.hal.2025.103040_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135827","article-title":"Changes in the life history traits of daphnia magna are associated with the gut microbiota composition shaped by diet and antibiotics","volume":"705","author":"Akbar","year":"2020","journal-title":"Sci. Total. Environ."},{"issue":"7","key":"10.1016\/j.hal.2025.103040_bib0006","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3390\/toxins17070321","article-title":"Unraveling the toxicity of a non-microcystin-producing strain (CCIBt3106) of microcystis aeruginosa: ecotoxicological effects on aquatic invertebrates","volume":"17","author":"Almeida","year":"2025","journal-title":"Toxins. (Basel)"},{"issue":"2","key":"10.1016\/j.hal.2025.103040_bib0007","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.envint.2009.10.010","article-title":"Oxidative stress generation by microcystins in aquatic animals: why and how","volume":"36","author":"Amado","year":"2010","journal-title":"Env. Int"},{"issue":"37","key":"10.1016\/j.hal.2025.103040_bib0008","doi-asserted-by":"crossref","first-page":"49905","DOI":"10.1007\/s11356-024-34406-3","article-title":"Contrasting toxicity response to a mixture of azithromycin and ivermectin between a freshwater and a euryhaline rotifer","volume":"31","author":"Arreguin-Rebolledo","year":"2024","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.hal.2025.103040_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139781","article-title":"Presence of antibiotic resistance genes and its association with antibiotic occurrence in Dil\u00favio River in southern Brazil","volume":"738","author":"Arsand","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.hal.2025.103040_bib0010","unstructured":"Augusto, O. (2021). Venda de cloroquina subiu 47% em 2020; de azitromicina, 105%. Metr\u00f3poles. https:\/\/www.metropoles.com\/brasil\/venda-de-cloroquina-subiu-47-em-2020-de-azitromicina-105."},{"key":"10.1016\/j.hal.2025.103040_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103932","article-title":"Ecotoxicological effects of human and veterinary antibiotics on water flea (Daphnia magna)","volume":"94","author":"Bawa-Allah","year":"2022","journal-title":"Env.,. Toxicol,. Pharmacol"},{"issue":"4","key":"10.1016\/j.hal.2025.103040_bib0012","first-page":"390","article-title":"HPLC-MS\/MS method for quantification of pharmaceuticals in subtropical rivers and water treatment plants in Brazil","volume":"4","author":"B\u00f6ger","year":"2020","journal-title":"J. Environ. Sci. Public. Health"},{"key":"10.1016\/j.hal.2025.103040_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123448","article-title":"Occurrence of antibiotics and antibiotic-resistant bacteria in subtropical urban rivers in Brazil","volume":"402","author":"B\u00f6ger","year":"2021","journal-title":"J. Hazard,. Mater"},{"key":"10.1016\/j.hal.2025.103040_bib0014","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.scitotenv.2017.05.199","article-title":"Daphnia swimming behaviour as a biomarker in toxicity assessment: a review","volume":"601","author":"Bownik","year":"2017","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.hal.2025.103040_bib0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10750-010-0130-1","article-title":"Combined and single effects of pesticide carbaryl and toxic microcystis aeruginosa on the life history of Daphnia pulicaria","volume":"643","author":"Cerbin","year":"2010","journal-title":"Hydrobiologia"},{"issue":"2","key":"10.1016\/j.hal.2025.103040_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11270-025-08662-z","article-title":"Azithromycin at environmentally relevant concentrations increases the growth and microcystin content in the cyanobacterium microcystis aeruginosa","volume":"237","author":"Celano","year":"2026","journal-title":"Water. Air. Soil. Pollut."},{"key":"10.1016\/j.hal.2025.103040_bib0017","doi-asserted-by":"crossref","first-page":"11295","DOI":"10.1007\/s11356-017-9809-4","article-title":"MOSAIC: a web interface for statistical analyses in ecotoxicology","volume":"25","author":"Charles","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.hal.2025.103040_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148352","article-title":"Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in Wuhan","volume":"792","author":"Chen","year":"2021","journal-title":"Sci. Total. Environ."},{"issue":"4","key":"10.1016\/j.hal.2025.103040_bib0019","first-page":"10","article-title":"Eutrophication: causes, consequences, and controls in aquatic ecosystems","volume":"4","author":"Chislock","year":"2013","journal-title":"Nat. Educ. Knowl."},{"key":"10.1016\/j.hal.2025.103040_bib0020","doi-asserted-by":"crossref","unstructured":"Chorus, I., & Welker, M. (2021). Toxic cyanobacteria in water: a guide to their public health consequences, monitoring, and management (p. 858). Taylor & Francis.","DOI":"10.1201\/9781003081449"},{"key":"10.1016\/j.hal.2025.103040_bib0021","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.scitotenv.2019.01.406","article-title":"Antibiotic pollution in surface fresh waters: occurrence and effects","volume":"664","author":"Danner","year":"2019","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.hal.2025.103040_bib0022","first-page":"1","article-title":"Introduction to cyanobacteria and cyanotoxins","author":"De la Cruz","year":"2020","journal-title":"Water. Treat. Purif. Cyanobacteria. Cyanotoxins"},{"issue":"17","key":"10.1016\/j.hal.2025.103040_bib0023","doi-asserted-by":"crossref","first-page":"49487","DOI":"10.1007\/s11356-023-25512-9","article-title":"Presence and toxicity of drugs used to treat SARS-CoV-2 in Llobregat River, Catalonia, Spain","volume":"30","author":"Dom\u00ednguez-Garc\u00eda","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"18","key":"10.1016\/j.hal.2025.103040_bib0024","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1111\/gcb.16838","article-title":"Climate change amplifies the risk of potentially toxigenic cyanobacteria","volume":"29","author":"Erratt","year":"2023","journal-title":"Glob. Chang. Biol"},{"issue":"1","key":"10.1016\/j.hal.2025.103040_bib0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0014-4827(89)90039-6","article-title":"Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxin","volume":"185","author":"Eriksson","year":"1989","journal-title":"Exp. Cell. Res"},{"key":"10.1016\/j.hal.2025.103040_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.hal.2025.102839","article-title":"Environmental-level antibiotics disrupt microcystis stoichiometry: an overlooked risk in the context of cyanobacterial harmful algal blooms","author":"Feng","year":"2025","journal-title":"Harmful. Algae"},{"issue":"12","key":"10.1016\/j.hal.2025.103040_bib0028","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.3390\/md9122729","article-title":"Cyanotoxins: bioaccumulation and effects on aquatic animals","volume":"9","author":"Ferr\u00e3o-Filho","year":"2011","journal-title":"Mar. Drug."},{"key":"10.1016\/j.hal.2025.103040_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135751","article-title":"Saxitoxin-producing Raphidiopsis raciborskii (cyanobacteria) inhibits swimming and physiological parameters in Daphnia similis","volume":"706","author":"Ferr\u00e3o-Filho","year":"2020","journal-title":"Sci. Total. Environ."},{"issue":"10","key":"10.1016\/j.hal.2025.103040_bib0029","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1002\/etc.3819","article-title":"Single and combined effects of microcystin-and saxitoxin-producing cyanobacteria on the fitness and antioxidant defenses of cladocerans","volume":"36","author":"Ferr\u00e3o-Filho","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.hal.2025.103040_bib0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.toxicon.2014.05.015","article-title":"Microcystin accumulation in cladocerans: first evidence of MC uptake from aqueous extracts of a natural bloom sample","volume":"87","author":"Ferr\u00e3o-Filho","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.hal.2025.103040_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.cotox.2025.100542","article-title":"More toxic than thought!","author":"Fotler","year":"2025","journal-title":"Curr. Opin. Toxicol."},{"issue":"4","key":"10.1016\/j.hal.2025.103040_bib0032","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1139\/er-2022-0121","article-title":"Towards a quantitative definition of cyanobacteria blooms","volume":"31","author":"Frau","year":"2023","journal-title":"Environ. Rev."},{"issue":"5","key":"10.1016\/j.hal.2025.103040_bib0033","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/jox15050145","article-title":"Effects of azithromycin on the functioning of the food web in Freshwater plankton","volume":"15","author":"Galir","year":"2025","journal-title":"J. Xenobiotics"},{"key":"10.1016\/j.hal.2025.103040_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121105","article-title":"Stimulation of microcystis aeruginosa by subtoxic concentrations of contaminants: a meta-analysis","author":"Geng","year":"2025","journal-title":"Env.,. Res"},{"issue":"3","key":"10.1016\/j.hal.2025.103040_bib0035","doi-asserted-by":"crossref","first-page":"666","DOI":"10.4319\/lo.2004.49.3.0666","article-title":"Effects of microcystis aeruginosa and purified microcystin-LR on the feeding behavior of Daphnia pulicaria","volume":"49","author":"Ghadouani","year":"2004","journal-title":"Limnol,. Ocean."},{"key":"10.1016\/j.hal.2025.103040_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fenvs.2021.801599","article-title":"Emerging contaminants in streams of Doce river watershed","volume":"9","author":"Gomes","year":"2022","journal-title":"Front. Environ. Sci."},{"issue":"2","key":"10.1016\/j.hal.2025.103040_bib0037","first-page":"796","article-title":"Isolation and culture of toxic strains of Anabaena flos-aquae (Lyngb.) de Br\u00e9b: with plate 7, 1 figure and 3 tables in the text","volume":"15","author":"Gorham","year":"1964","journal-title":"Int. Ver. Theor. Angew. Limnol.:. Verh."},{"issue":"8","key":"10.1016\/j.hal.2025.103040_bib0038","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.3390\/molecules27082577","article-title":"Mixed contaminants: occurrence, interactions, toxicity, detection, and remediation","volume":"27","author":"Mukherjee","year":"2022","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.hal.2025.103040_bib0039","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s10311-021-01356-y","article-title":"COVID-19 drugs in aquatic systems: a review","volume":"20","author":"Gwenzi","year":"2022","journal-title":"Env. Chem. Lett"},{"key":"10.1016\/j.hal.2025.103040_bib0040","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s10934-017-0538-3","article-title":"The synergistic cooperation between MCM-41 and azithromycin: a pH-responsive system for drug adsorption and release","volume":"25","author":"Hamzehloo","year":"2018","journal-title":"J. Porous. Mater."},{"key":"10.1016\/j.hal.2025.103040_bib0041","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.toxrep.2014.10.017","article-title":"Effects of a cyanobacterial bloom sample containing microcystin-LR on the ecophysiology of Daphnia similis","volume":"1","author":"Herrera","year":"2014","journal-title":"Toxicol. Rep"},{"issue":"10","key":"10.1016\/j.hal.2025.103040_bib0042","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1080\/03067319.2014.914184","article-title":"Simultaneous determination of eight antibiotics from distinct classes in surface and wastewater samples by solid-phase extraction and high-performance liquid chromatography-electrospray ionization mass spectrometry","volume":"94","author":"Jank","year":"2014","journal-title":"Int. J. Env. Anal. Chem"},{"key":"10.1016\/j.hal.2025.103040_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114193","article-title":"Antibiotic contaminants reduced the treatment efficiency of UV-C on Microcystis aeruginosa through hormesis","volume":"261","author":"Jiang","year":"2020","journal-title":"Environ. Pollut."},{"issue":"49","key":"10.1016\/j.hal.2025.103040_bib0044","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2411919121","article-title":"Global trends in antibiotic consumption during 2016\u20132023 and future projections through 2030","volume":"121","author":"Klein","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.hal.2025.103040_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126351","article-title":"Occurrence and toxicity of antibiotics in the aquatic environment: a review","volume":"251","author":"Kovalakova","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.hal.2025.103040_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145740","article-title":"Predicted occurrence, ecotoxicological risk, and environmentally acquired resistance of antiviral drugs associated with COVID-19 in environmental waters","volume":"776","author":"Kuroda","year":"2021","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.hal.2025.103040_bib0047","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.envpol.2017.11.011","article-title":"Physiological effects caused by microcystin-producing and non-microcystin producing microcystis aeruginosa on Medaka fish: a proteomic and metabolomic study on liver","volume":"234","author":"Le Manach","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.hal.2025.103040_bib0048","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10201-014-0433-4","article-title":"Combined effects of four Microcystis aeruginosa strains and Scenedesmus obliquus concentrations on population dynamics and resting egg formation of two Daphnia species","volume":"15","author":"Li","year":"2014","journal-title":"Limnology"},{"key":"10.1016\/j.hal.2025.103040_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110573","article-title":"Effects of azithromycin on feeding behavior and nutrition accumulation of Daphnia magna under the different exposure pathways","volume":"197","author":"Li","year":"2020","journal-title":"Ecotoxicol,. Env.,. Saf"},{"issue":"11","key":"10.1016\/j.hal.2025.103040_bib0050","doi-asserted-by":"crossref","DOI":"10.1002\/clen.202200298","article-title":"Interactions between typical antibiotics and microcystis aeruginosa in aquatic environment","volume":"51","author":"Li","year":"2023","journal-title":"CLEAN\u2013Soil. Air. Water"},{"issue":"4","key":"10.1016\/j.hal.2025.103040_bib0051","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.ecoenv.2011.01.022","article-title":"Toxic effects of erythromycin, ciprofloxacin, and sulfamethoxazole on photosynthetic apparatus in Selenastrum capricornutum","volume":"74","author":"Liu","year":"2011","journal-title":"Ecotoxicol,. Env.,. Saf"},{"key":"10.1016\/j.hal.2025.103040_bib0052","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.watres.2016.01.060","article-title":"Growth, microcystin-production, and proteomic responses of Microcystis aeruginosa under long-term exposure to amoxicillin","volume":"93","author":"Liu","year":"2016","journal-title":"Water. Res"},{"key":"10.1016\/j.hal.2025.103040_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106192","article-title":"Intergenerational and biological effects of roxithromycin and polystyrene microplastics to Daphnia magna","volume":"248","author":"Liu","year":"2022","journal-title":"Aquat. Toxicol."},{"issue":"1","key":"10.1016\/j.hal.2025.103040_bib0054","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10750-020-04370-3","article-title":"Grazing resistance in phytoplankton","volume":"848","author":"L\u00fcrling","year":"2021","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.hal.2025.103040_bib0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1023\/A:1024436508387","article-title":"FO-spectra of chlorophyll fluorescence for the determination of zooplankton grazing","volume":"491","author":"L\u00fcrling","year":"2003","journal-title":"Hydrobiologia"},{"issue":"2","key":"10.1016\/j.hal.2025.103040_bib0056","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/fwb.14203","article-title":"Cyanobacterial effects on an aquatic keystone grazer are reshaped by the presence of the herbicide atrazine","volume":"69","author":"Lyu","year":"2023","journal-title":"Freshw,. Biol"},{"issue":"1","key":"10.1016\/j.hal.2025.103040_bib0057","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/aje.12170","article-title":"Incidence of microcystin-producing cyanobacteria in Lake Tana, the largest waterbody in Ethiopia","volume":"53","author":"Mankiewicz-Boczek","year":"2015","journal-title":"Afr. J. Ecol"},{"key":"10.1016\/j.hal.2025.103040_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164309","article-title":"COVID-19 pharmaceuticals in aquatic matrices: the threatening effects over cyanobacteria and microalgae","volume":"892","author":"Marques","year":"2023","journal-title":"Sci. Total. Environ."},{"issue":"2","key":"10.1016\/j.hal.2025.103040_bib0059","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4319\/lo.2008.53.2.0456","article-title":"Nutritional constraints at the cyanobacteria\u2014daphnia magna interface: the role of sterols","volume":"53","author":"Martin-Creuzburg","year":"2008","journal-title":"Limnol,. Ocean."},{"key":"10.1016\/j.hal.2025.103040_bib0060","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.scitotenv.2017.07.272","article-title":"Occurrence and fate of most prescribed antibiotics in different water environments of Tehran, Iran","volume":"619","author":"Mirzaei","year":"2018","journal-title":"Sci. Total. Environ."},{"issue":"4","key":"10.1016\/j.hal.2025.103040_bib0061","first-page":"801","article-title":"Development and validation of liquid chromatography-tandem mass spectrometry methods for determination of beta-lactams, macrolides, fluoroquinolones, sulfonamides and tetracyclines in surface and drinking water from Rio de Janeiro, Brazil","volume":"29","author":"Monteiro","year":"2018","journal-title":"J. Braz. Chem. Soc"},{"key":"10.1016\/j.hal.2025.103040_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152691","article-title":"Pharmaceutical compounds used in the COVID-19 pandemic: a review of their presence in water and treatment techniques for their elimination","volume":"814","author":"Morales-Paredes","year":"2022","journal-title":"Sci. Total. Environ."},{"issue":"6","key":"10.1016\/j.hal.2025.103040_bib0063","first-page":"1587","article-title":"Effects of harmful blooms of large-sized and colonial cyanobacteria on aquatic food webs","volume":"12","author":"Moustaka-Gouni","year":"2020","journal-title":"Water. (Basel)"},{"key":"10.1016\/j.hal.2025.103040_bib0064","series-title":"Life history responses to changes in food quality within daphnia populations (doctoral dissertation","author":"Navarro","year":"2020"},{"key":"10.1016\/j.hal.2025.103040_bib0065","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.chemosphere.2017.11.037","article-title":"Ecological risk assessment of microcystin-LR in the upstream section of the Haihe River based on a species sensitivity distribution model","volume":"193","author":"Niu","year":"2018","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.hal.2025.103040_bib0066","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/10643389.2024.2406575","article-title":"Antibiotic and microplastic co-exposure: effects on Daphnia magna and implications for ecological risk assessment","volume":"55","author":"Pei","year":"2024","journal-title":"Crit. Rev. Env. Sci. Technol"},{"key":"10.1016\/j.hal.2025.103040_bib0067","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.coph.2018.07.008","article-title":"Recent advances in combinatorial drug screening and synergy scoring","volume":"42","author":"Pemovska","year":"2018","journal-title":"Curr. Opin. Pharmacol"},{"key":"10.1016\/j.hal.2025.103040_bib0068","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s00210-020-01901-6","article-title":"A comprehensive review on drug repositioning against coronavirus disease 2019 (COVID19)","volume":"393","author":"Rameshrad","year":"2020","journal-title":"Naunyn. Schmiedeb. Arch,. Pharmacol"},{"issue":"7","key":"10.1016\/j.hal.2025.103040_bib0069","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/toxins17070343","article-title":"Chemical and morphological constitutive defensive traits of cyanobacteria have different effects on the grazing of a small tropical cladoceran","volume":"17","author":"Rangel","year":"2025","journal-title":"Toxins. (Basel)"},{"issue":"8","key":"10.1016\/j.hal.2025.103040_bib0070","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3390\/toxics11080693","article-title":"Saxitoxin-producing Raphidiopsis raciborskii (Cyanobacteria) constrains Daphnia fitness and feeding rate despite high nutritious food availability","volume":"11","author":"Reis","year":"2023","journal-title":"Toxics"},{"issue":"2","key":"10.1016\/j.hal.2025.103040_bib0071","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/plankt\/7.2.279","article-title":"The relationship between cell carbon and cell volume in freshwater algal species used in zooplanktonic studies","volume":"7","author":"Rocha","year":"1985","journal-title":"J. Plankton. Res"},{"key":"10.1016\/j.hal.2025.103040_bib0072","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1023\/A:1024889925732","article-title":"Isolation, characterization, and quantitative analysis of microviridin J, a new Microcystis metabolite toxic to Daphnia","volume":"29","author":"Rohrlack","year":"2003","journal-title":"J. Chem,. Ecol"},{"key":"10.1016\/j.hal.2025.103040_bib0073","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4319\/lo.2005.50.2.0440","article-title":"Ingestion of microcystins by daphnia: intestinal uptake and toxic effects","volume":"50","author":"Rohrlack","year":"2005","journal-title":"Limnol. Ocean."},{"issue":"2","key":"10.1016\/j.hal.2025.103040_bib0074","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxlet.2009.02.003","volume":"187","author":"Sanderson","year":"2009","journal-title":"Toxicol,. Lett"},{"key":"10.1016\/j.hal.2025.103040_bib0075","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.toxicon.2021.03.009","article-title":"Cell free microcystis aeruginosa spent medium affects Daphnia magna survival and stress response","volume":"195","author":"Savic","year":"2021","journal-title":"Toxicon"},{"key":"10.1016\/j.hal.2025.103040_bib0076","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.watres.2014.11.015","article-title":"Temporal variations in microcystin-producing cells and microcystin concentrations in two freshwater ponds","volume":"69","author":"Singh","year":"2015","journal-title":"Water. Res"},{"issue":"8","key":"10.1016\/j.hal.2025.103040_bib0077","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1128\/aem.58.8.2495-2500.1992","article-title":"Isolation and characterization of a variety of microcystins from seven strains of the cyanobacterial genus Anabaena","volume":"58","author":"Sivonen","year":"1992","journal-title":"Appl. Env. Microbiol"},{"issue":"1","key":"10.1016\/j.hal.2025.103040_bib0078","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-ecolsys-110411-160251","article-title":"Beyond the plankton ecology group (peg) model: mechanisms driving plankton succession","volume":"43","author":"Sommer","year":"2012","journal-title":"Annu. Rev. Ecol. Evol. Syst"},{"issue":"8","key":"10.1016\/j.hal.2025.103040_bib0079","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1038\/ismej.2017.45","article-title":"Allelopathic interactions of linoleic acid and nitric oxide increase the competitive ability of microcystis aeruginosa","volume":"11","author":"Song","year":"2017","journal-title":"ISME. J"},{"key":"10.1016\/j.hal.2025.103040_bib0080","series-title":"The Evolution of Life Histories","author":"Stearns","year":"1998"},{"issue":"11","key":"10.1016\/j.hal.2025.103040_bib0081","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1093\/plankt\/fbg096","article-title":"Geometric models for calculating cell biovolume and surface area for phytoplankton","volume":"25","author":"Sun","year":"2003","journal-title":"J. Plankton. Res"},{"issue":"12","key":"10.1016\/j.hal.2025.103040_bib0082","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3390\/antibiotics9120918","article-title":"Global trends in antimicrobial use in food animals from 2017 to 2030","volume":"9","author":"Tiseo","year":"2020","journal-title":"Antibiotics"},{"issue":"11","key":"10.1016\/j.hal.2025.103040_bib0083","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/plankt\/15.11.1309","article-title":"Neckteeth formation in Daphnia pulex as an example of continuous phenotypic plasticity: morphological effects of Chaoborus kairomone concentration and their quantification","volume":"15","author":"Tollrian","year":"1993","journal-title":"J. Plankton. Res"},{"key":"10.1016\/j.hal.2025.103040_bib0084","article-title":"Rivers at risks: the interplay of \u201cCOVID kit\u201d medication misuse and urban waterway contaminants","volume":"370","author":"Trisotto","year":"2025","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.hal.2025.103040_bib0085","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1127\/0003-9136\/2006\/0167-0533","article-title":"Effects of differing concentrations of microcystin-producing microcystis aeruginosa on growth, reproduction, survivorship and offspring of Daphnia magna","volume":"167","author":"Trubetskova","year":"2006","journal-title":"Arch. Hydrobiol."},{"key":"10.1016\/j.hal.2025.103040_bib0086","series-title":"Globally harmonized system of classification and labeling of chemicals (firth revised edition)","author":"Nations","year":"2011"},{"key":"10.1016\/j.hal.2025.103040_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141053","article-title":"Environmental side effects of the injudicious use of antimicrobials in the era of COVID-19","volume":"745","author":"Usman","year":"2020","journal-title":"Sci. Total. Environ."},{"issue":"5","key":"10.1016\/j.hal.2025.103040_bib0088","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/etc.3260","article-title":"Use of acute and chronic ecotoxicity data in environmental risk assessment of pharmaceuticals","volume":"35","author":"Vestel","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.hal.2025.103040_bib0089","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s10886-021-01315-5","article-title":"Grazer-induced chemical defense in a microcystin-producing microcystis aeruginosa (Cyanobacteria) exposed to Daphnia gessneri infochemicals","volume":"47","author":"Vilar","year":"2021","journal-title":"J. Chem,. Ecol"},{"key":"10.1016\/j.hal.2025.103040_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.fooweb.2022.e00245","article-title":"Single and mixed diets of the toxic cyanobacteria microcystis aeruginosa and Raphidiopsis raciborskii differently affect Daphnia feeding behavior","volume":"32","author":"Vilar","year":"2022","journal-title":"Food. Webs"},{"issue":"2","key":"10.1016\/j.hal.2025.103040_bib0091","first-page":"342","article-title":"The geldanamycins are potent inhibitors of the hepatocyte growth factor\/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network","volume":"60","author":"Webb","year":"2000","journal-title":"Cancer. Res"},{"issue":"2","key":"10.1016\/j.hal.2025.103040_bib0092","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s43441-020-00216-1","article-title":"Update of EMA\u2019s guideline on the environmental risk assessment (ERA) of medicinal products for human use","volume":"55","author":"Wess","year":"2021","journal-title":"Ther. Innov. Regul. Sci"},{"key":"10.1016\/j.hal.2025.103040_bib0093","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152703","article-title":"Physiological, biochemical and transcriptional responses of cyanobacteria to environmentally relevant concentrations of a typical antibiotic\u2014roxithromycin","volume":"814","author":"Xin","year":"2022","journal-title":"Sci. Total. Environ."},{"issue":"3","key":"10.1016\/j.hal.2025.103040_bib0094","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.envpol.2006.05.038","article-title":"Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"145","author":"Xu","year":"2007","journal-title":"Environ. pollut."},{"key":"10.1016\/j.hal.2025.103040_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2025.118432","article-title":"Microcystins in transitional and marine ecosystems: source categories, distribution patterns, and ecological impacts","volume":"220","author":"Yousaf","year":"2025","journal-title":"Mar,. Pollut,. Bull"},{"key":"10.1016\/j.hal.2025.103040_bib0096","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecolind.2022.109028","article-title":"Impact of cyanobacterial bloom intensity on plankton ecosystem functioning measured by eukaryotic phytoplankton and zooplankton indicators","volume":"140","author":"Zhao","year":"2022","journal-title":"Ecol. Indic"}],"container-title":["Harmful Algae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568988325002410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568988325002410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:05:34Z","timestamp":1773907534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568988325002410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":96,"alternative-id":["S1568988325002410"],"URL":"https:\/\/doi.org\/10.1016\/j.hal.2025.103040","relation":{},"ISSN":["1568-9883"],"issn-type":[{"value":"1568-9883","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmentally relevant concentrations of the antibiotic azithromycin enhance the toxicity of the cyanobacterium Microcystis aeruginosa on the water flea Daphnia similis","name":"articletitle","label":"Article Title"},{"value":"Harmful Algae","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hal.2025.103040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103040"}}