{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:25:49Z","timestamp":1790025949607,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatobiliary &amp; Pancreatic Diseases International"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.hbpd.2018.01.015","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T13:42:50Z","timestamp":1517578970000},"page":"59-63","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy of octreotide in the prevention of complications after pancreaticoduodenectomy in patients with soft pancreas and non-dilated pancreatic duct: A prospective randomized trial"],"prefix":"10.1016","volume":"17","author":[{"given":"Ayman","family":"El Nakeeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"ElGawalby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"A. Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Shehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosam","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El Refea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Moneer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abd El Rafee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2018.01.015_bib0001","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/SLA.0b013e318185a990","article-title":"Left-sided pancreatectomy: A multicenter comparison of laparoscopic and open approaches","volume":"248","author":"Kooby","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0002","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jamcollsurg.2008.05.003","article-title":"Management and outcomes of postpancreatectomy fistula, leak, and abscess: Results of 908 patients resected at a single institution between 2000 and 2005","volume":"207","author":"Vin","year":"2008","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0003","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1477-2574.2011.00305.x","article-title":"History of pancreaticoduodenectomy: Early misconceptions, initial milestones and the pioneers","volume":"13","author":"Are","year":"2011","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0004","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1477-2574.2012.00486.x","article-title":"Toward defining grade C pancreatic fistula following pancreaticoduodenectomy: Incidence, risk factors, management and outcome","volume":"14","author":"Denbo","year":"2012","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0005","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/000313481107700310","article-title":"Risk factors of pancreatic fistula after pancreaticoduodenectomy: A collective review","volume":"77","author":"Ramacciato","year":"2011","journal-title":"Am Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0006","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1477-2574.2012.00608.x","article-title":"Prospective randomized trial of the effect of octreotide on pancreatic juice output after pancreaticoduodenectomy in relation to histological diagnosis, duct size and leakage","volume":"15","author":"Fern\u00e1ndez-Cruz","year":"2013","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0007","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJMc1407470","article-title":"Pasireotide for postoperative pancreatic fistula","volume":"371","author":"Allen","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0008","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00268-013-1998-5","article-title":"Pancreatic anastomotic leakage after pancreaticoduodenectomy. Risk factors, clinical predictors, and management (single center experience)","volume":"37","author":"El Nakeeb","year":"2013","journal-title":"World J Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0009","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/bjs.8654","article-title":"Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy","volume":"99","author":"Motoi","year":"2012","journal-title":"Br J Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0010","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S1470-2045(13)70126-8","article-title":"Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy for pancreatic or periampullary tumours: A multicentre randomised trial","volume":"14","author":"Topal","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0011","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1001\/archsurg.2009.193","article-title":"Measures to prevent pancreatic fistula after pancreatoduodenectomy: A comprehensive review","volume":"144","author":"Lai","year":"2009","journal-title":"Arch Surg"},{"issue":"3 Suppl","key":"10.1016\/j.hbpd.2018.01.015_bib0012","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1136\/gut.35.3_Suppl.S1","article-title":"Somatostatin and somatostatin analogues: Pharmacokinetics and pharmacodynamic effects","volume":"35","author":"Harris","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0013","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00268-003-6693-5","article-title":"Role of somatostatin in the prevention of pancreatic stump-related morbidity following elective pancreaticoduodenectomy in high-risk patients and elimination of surgeon-related factors: Prospective, randomized, controlled trial","volume":"27","author":"Shan","year":"2003","journal-title":"World J Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0014","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1046\/j.0007-1323.2001.01906.x","article-title":"Randomized controlled multicentre trial of somatostatin infusion after pancreaticoduodenectomy","volume":"88","author":"Gouillat","year":"2001","journal-title":"Br J Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0015","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/archsurg.139.3.288","article-title":"Octreotide in the prevention of intra-abdominal complications following elective pancreatic resection: A prospective, multicenter randomized controlled trial","volume":"139","author":"Suc","year":"2004","journal-title":"Arch Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0016","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S1072-7515(03)00104-2","article-title":"The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: A prospective, multicenter, double-blinded, randomized, placebo-controlled trial","volume":"196","author":"Sarr","year":"2003","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0017","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00000658-200009000-00014","article-title":"Does prophylactic octreotide decrease the rates of pancreatic fistula and other complications after pancreaticoduodenectomy? Results of a prospective randomized placebo-controlled trial","volume":"232","author":"Yeo","year":"2000","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0018","article-title":"Value of preoperative biliary drainage on postoperative outcome after pancreaticoduodenectomy: A case-control study","author":"El Nakeeb","year":"2016","journal-title":"Asian J Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0019","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1499-3872(16)60105-4","article-title":"Outcomes of pancreaticoduodenectomy in elderly patients","volume":"15","author":"El Nakeeb","year":"2016","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0020","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/hpb.12210","article-title":"Isolated Roux loop pancreaticojejunostomy versus pancreaticogastrostomy after pancreaticoduodenectomy: a prospective randomized study","volume":"16","author":"El Nakeeb","year":"2014","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0021","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0022","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.surg.2005.05.001","article-title":"Postoperative pancreatic fistula: An international study group (ISGPF) definition","volume":"138","author":"Bassi","year":"2005","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0023","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.surg.2010.12.002","article-title":"Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery","volume":"149","author":"Koch","year":"2011","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0024","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.surg.2007.05.005","article-title":"Delayed gastric emptying (DGE) after pancreatic surgery: A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS)","volume":"142","author":"Wente","year":"2007","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0025","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.surg.2013.07.001","article-title":"Clinical evaluation of somatostatin use in pancreatic resections: clinical efficacy or limited benefit?","volume":"154","author":"Anderson","year":"2013","journal-title":"Surgery"},{"issue":"Suppl","key":"10.1016\/j.hbpd.2018.01.015_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000201179","article-title":"Inhibition of exocrine pancreatic secretion by somatostatin and its analogues","volume":"55","author":"Heintges","year":"1994","journal-title":"Digestion"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0027","first-page":"427","article-title":"Prevention of postoperative pancreatic complications following duodenopancreatectomy using somatostatin","volume":"50","author":"Klempa","year":"1979","journal-title":"Chirurg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0028","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/00006676-198603000-00008","article-title":"Effect of a new somatostatin analogue on pancreatic function in healthy volunteers","volume":"1","author":"K\u00f6hler","year":"1986","journal-title":"Pancreas"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0029","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/0024-3205(82)90087-X","article-title":"SMS 201-995: A very potent and selective octapeptide analogue of somatostatin with prolonged action","volume":"31","author":"Bauer","year":"1982","journal-title":"Life Sci"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0030","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000381032","article-title":"Systematic review and meta-analysis of somatostatin analogues in the prevention of postoperative complication after pancreaticoduodenectomy","volume":"32","author":"Jin","year":"2015","journal-title":"Dig Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0031","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/00000658-199711000-00008","article-title":"Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease","volume":"226","author":"Lowy","year":"1997","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0032","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.ejso.2008.01.014","article-title":"Prophylactic octreotide and delayed gastric emptying after pancreaticoduodenectomy: results of a prospective randomized double-blinded placebo-controlled trial","volume":"34","author":"Kollmar","year":"2008","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0033","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1007\/s11605-015-2925-x","article-title":"Octreotide does not prevent pancreatic fistula following pancreatoduodenectomy in patients with soft pancreas and non-dilated duct: A prospective randomized controlled trial","volume":"19","author":"Kurumboor","year":"2015","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0034","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/hpb.12314","article-title":"Prophylactic octreotide for pancreatoduodenectomy: More harm than good?","volume":"16","author":"McMillan","year":"2014","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0002-9610(92)90264-R","article-title":"Role of octreotide in the prevention of postoperative complications following pancreatic resection","volume":"163","author":"B\u00fcchler","year":"1992","journal-title":"Am J Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0036","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/bjs.1800810237","article-title":"Efficacy of octreotide in the prevention of complications of elective pancreatic surgery. Italian Study Group","volume":"81","author":"Pederzoli","year":"1994","journal-title":"Br J Surg"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0037","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0039-6060(05)80225-9","article-title":"Efficacy of octreotide in the prevention of pancreatic fistula after elective pancreatic resections: A prospective, controlled, randomized clinical trial","volume":"117","author":"Montorsi","year":"1995","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2018.01.015_bib0038","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/bjs.1800820938","article-title":"Randomized controlled multicentre study of the prevention of complications by octreotide in patients undergoing surgery for chronic pancreatitis","volume":"82","author":"Friess","year":"1995","journal-title":"Br J Surg"}],"container-title":["Hepatobiliary &amp; Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387218300225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387218300225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T20:52:38Z","timestamp":1660423958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387218300225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S1499387218300225"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2018.01.015","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}