{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:59:51Z","timestamp":1790099991600,"version":"4.0.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472245"],"award-info":[{"award-number":["31472245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772807"],"award-info":[{"award-number":["31772807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.hbpd.2018.12.001","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:26:52Z","timestamp":1544056012000},"page":"48-61","source":"Crossref","is-referenced-by-count":11,"title":["Hydrogen-rich saline protects against hepatic injury induced by ischemia-reperfusion and laparoscopic hepatectomy in swine"],"prefix":"10.1016","volume":"18","author":[{"given":"Yan-Song","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hui","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2018.12.001_bib0001","first-page":"956","article-title":"Laparoscopic excision of benign liver lesions","volume":"78","author":"Reich","year":"1991","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0002","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1001\/archsurg.2010.248","article-title":"Comparative benefits of laparoscopic vs open hepatic resection: a critical appraisal","volume":"146","author":"Nguyen","year":"2011","journal-title":"Arch Surg"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0003","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s005340200026","article-title":"Prospective assessment of the safety and benefit of laparoscopic liver resections","volume":"9","author":"Farges","year":"2002","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0004","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1007\/s11605-009-0993-5","article-title":"Laparoscopic versus open liver resection: a matched-pair case control study","volume":"13","author":"Ito","year":"2009","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0005","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/SLA.0b013e3181d50299","article-title":"Inchinkoto, an herbal medicine, exerts beneficial effects in the rat liver under stress with hepatic ischemia-reperfusion and subsequent hepatectomy","volume":"251","author":"Kawai","year":"2010","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0006","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrgastro.2012.225","article-title":"Ischaemia-reperfusion injury in liver transplantation\u2013from bench to bedside","volume":"10","author":"Zhai","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0007","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jss.2012.02.014","article-title":"Adipose tissue-derived mesenchymal stem cell transplantation promotes hepatic regeneration after hepatic ischemia-reperfusion and subsequent hepatectomy in rats","volume":"178","author":"Seki","year":"2012","journal-title":"J Surg Res"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0008","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1124\/jpet.108.147835","article-title":"Are angiotensin II receptor antagonists useful strategies in steatotic and nonsteatotic livers in conditions of partial hepatectomy under ischemia-reperfusion?","volume":"329","author":"Ramalho","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0009","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/hep.510300215","article-title":"Ischemia impairs liver regeneration after major tissue loss in rodents: protective effects of interleukin-6","volume":"30","author":"Selzner","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0010","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0011","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbrc.2008.05.165","article-title":"Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury","volume":"373","author":"Hayashida","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0012","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/TP.0000000000001052","article-title":"Hydrogen-rich saline attenuates acute kidney injury after liver transplantation via activating p53-mediated autophagy","volume":"100","author":"Du","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0013","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13618-015-0035-1","article-title":"Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles","volume":"5","author":"Ichihara","year":"2015","journal-title":"Med Gas Res"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0014","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/hep.25782","article-title":"Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice","volume":"56","author":"Kawai","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0015","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.3748\/wjg.v21.i14.4195","article-title":"Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice","volume":"21","author":"Zhang","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0016","first-page":"5197","article-title":"Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine","volume":"18","author":"Xiang","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0017","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.bbrc.2007.07.088","article-title":"Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia\/reperfusion through reducing oxidative stress","volume":"361","author":"Fukuda","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0018","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4142\/jvs.2014.15.3.417","article-title":"Laparoscopic left hepatectomy in swine: a safe and feasible technique","volume":"15","author":"Zhang","year":"2014","journal-title":"J Vet Sci"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0019","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.lfs.2017.12.022","article-title":"Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress","volume":"194","author":"Li","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0020","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.rvsc.2018.07.005","article-title":"Effect of hydrogen-rich saline on apoptosis induced by hepatic ischemia reperfusion upon laparoscopic hepatectomy in miniature pigs","volume":"119","author":"Zhang","year":"2018","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0021","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/00007890-199306000-00011","article-title":"Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine","volume":"55","author":"Suzuki","year":"1993","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0022","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1365-2559.2012.04193.x","article-title":"Quantifying hepatic steatosis - more than meets the eye","volume":"60","author":"Levene","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0023","doi-asserted-by":"crossref","first-page":"e5182","DOI":"10.1097\/MD.0000000000005182","article-title":"Surgical outcomes following laparoscopic major hepatectomy for various liver diseases","volume":"95","author":"Kang","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0024","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/bjs.1800810504","article-title":"Ischaemia-reperfusion injury","volume":"81","author":"Grace","year":"1994","journal-title":"Br J Surg"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0025","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.3892\/mmr.2015.4426","article-title":"Protection against ischemia\/reperfusion-induced renal injury by co-treatment with erythropoietin and sodium selenite","volume":"12","author":"Liu","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0026","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.3748\/wjg.v23.i27.4920","article-title":"Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice","volume":"23","author":"Lin","year":"2017","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0027","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1189\/jlb.1204697","article-title":"Myeloperoxidase: friend and foe","volume":"77","author":"Klebanoff","year":"2005","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0028","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12967-015-0548-3","article-title":"Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation","volume":"13","author":"Guo","year":"2015","journal-title":"J Transl Med"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0029","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2119\/2007-00134.Vardanian","article-title":"Molecular mediators of liver ischemia and reperfusion injury: a brief review","volume":"14","author":"Vardanian","year":"2008","journal-title":"Mol Med"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0030","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.3748\/wjg.v18.i45.6605","article-title":"Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice","volume":"18","author":"Huang","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0031","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3892\/br.2014.381","article-title":"Minocycline protects against hepatic ischemia\/reperfusion injury in a rat model","volume":"3","author":"Li","year":"2015","journal-title":"Biomed Rep"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0032","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1320365","article-title":"Hydrogen-rich saline attenuates cardiac and hepatic injury in doxorubicin rat model by inhibiting inflammation and apoptosis","volume":"2016","author":"Gao","year":"2016","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0033","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.3748\/wjg.v21.i14.4195","article-title":"Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice","volume":"21","author":"Zhang","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0034","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cca.2006.12.002","article-title":"Pathogenic implications for autoantibodies against C-reactive protein and other acute phase proteins","volume":"378","author":"Sjowall","year":"2007","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0035","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.surg.2014.09.009","article-title":"Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation: a systematic review","volume":"157","author":"Watt","year":"2015","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0036","doi-asserted-by":"crossref","first-page":"e6121","DOI":"10.1097\/MD.0000000000006121","article-title":"Impact of hypertonic saline on postoperative complications for patients undergoing upper gastrointestinal surgery","volume":"96","author":"Hong","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0037","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0038","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jhep.2009.10.037","article-title":"Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice","volume":"52","author":"McNeilly","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0039","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/bfgp\/elt028","article-title":"The IL-10\/STAT3-mediated anti-inflammatory response: recent developments and future challenges","volume":"12","author":"Hutchins","year":"2013","journal-title":"Brief Funct Genom"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/685043","article-title":"Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-\u03baB pathway","volume":"2015","author":"Shi","year":"2015","journal-title":"Med Inflamm"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0041","article-title":"Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats","volume":"10","author":"Guo","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0042","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/01.TP.0000161627.84481.5E","article-title":"Dual role of vascular endothelial growth factor in hepatic ischemia-reperfusion injury","volume":"79","author":"Tsurui","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0043","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.canlet.2012.08.018","article-title":"Angiopoietins in angiogenesis","volume":"328","author":"Fagiani","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0044","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1167\/iovs.10-6167","article-title":"Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model","volume":"52","author":"Kubota","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0045","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/861435","article-title":"Angiogenin reduces immune inflammation via inhibition of TANK-binding kinase 1 expression in human corneal fibroblast cells","volume":"2014","author":"Lee","year":"2014","journal-title":"Med Inflamm"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0046","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0014-4827(83)90458-5","article-title":"Endothelial cells are a site of uptake and degradation of hyaluronic acid in the liver","volume":"144","author":"Eriksson","year":"1983","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0047","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.3748\/wjg.v21.i14.4195","article-title":"Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice","volume":"21","author":"Zhang","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0048","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/hep.25918","article-title":"Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice","volume":"56","author":"Borude","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0049","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/hep.1840170618","article-title":"Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells","volume":"17","author":"Johnson","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0050","first-page":"397","article-title":"Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes","volume":"10","author":"Albrecht","year":"1999","journal-title":"Cell Growth Differ"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0051","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1002\/hep.23449","article-title":"Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver","volume":"51","author":"Thenappan","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0052","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jss.2015.01.034","article-title":"Lactulose accelerates liver regeneration in rats by inducing hydrogen","volume":"195","author":"Yu","year":"2015","journal-title":"J Surg Res"},{"key":"10.1016\/j.hbpd.2018.12.001_bib0053","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.4317\/medoral.18573","article-title":"Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors","volume":"18","author":"Bologna-Molina","year":"2013","journal-title":"Med Oral Patol Oral Cir Bucal"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387218302674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387218302674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T06:38:26Z","timestamp":1565246306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387218302674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S1499387218302674"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2018.12.001","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}