{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:06:10Z","timestamp":1790856370215,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007292","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.hbpd.2020.01.003","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T22:50:05Z","timestamp":1580338205000},"page":"109-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Human microbiome is a diagnostic biomarker in hepatocellular carcinoma"],"prefix":"10.1016","volume":"19","author":[{"given":"Ben-Chen","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Min","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Ying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-Jiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Gang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2020.01.003_bib0001","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0002","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/S0140-6736(18)32335-3","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0003","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1136\/gutjnl-2017-315084","article-title":"Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma","volume":"68","author":"Ren","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0004","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000315223","article-title":"Epidemiology of hepatocellular carcinoma","volume":"78","author":"Sherman","year":"2010","journal-title":"Oncology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0005","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","article-title":"A global view of hepatocellular carcinoma: trends, risk, prevention and management","volume":"16","author":"Yang","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0006","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1001\/jamaoncol.2016.3147","article-title":"MRI with liver-specific contrast for surveillance of patients with cirrhosis at high risk of hepatocellular carcinoma","volume":"3","author":"Kim","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0007","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1053\/j.gastro.2018.11.020","article-title":"Accuracy of the liver imaging reporting and data system in computed tomography and magnetic resonance image analysis of hepatocellular carcinoma or overall malignancy-a systematic review","volume":"156","author":"van der Pol","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0008","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1053\/j.gastro.2018.01.064","article-title":"Surveillance imaging and alpha fetoprotein for early detection of hepatocellular carcinoma in patients with cirrhosis: a meta-analysis","volume":"154","author":"Tzartzeva","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0009","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1053\/j.gastro.2009.04.005","article-title":"Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma","volume":"137","author":"Marrero","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0010","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S1470-2045(15)00048-0","article-title":"A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study","volume":"16","author":"Lin","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0011","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/ng.804","article-title":"High-resolution characterization of a hepatocellular carcinoma genome","volume":"43","author":"Totoki","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0012","doi-asserted-by":"crossref","first-page":"33142","DOI":"10.1038\/srep33142","article-title":"Deep sequencing reveals microbiota dysbiosis of tongue coat in patients with liver carcinoma","volume":"6","author":"Lu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0013","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0014","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"B\u00e4ckhed","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0015","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0016","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature11209","article-title":"A framework for human microbiome research","volume":"486","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0017","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1126\/science.315.5820.1781a","article-title":"Metagenomics. Massive microbial sequence project proposed","volume":"315","author":"Pennisi","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0018","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cell.2006.02.017","article-title":"Ecological and evolutionary forces shaping microbial diversity in the human intestine","volume":"124","author":"Ley","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0019","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.hbpd.2018.11.002","article-title":"Gut microbial dysbiosis associates hepatocellular carcinoma via the gut-liver axis","volume":"18","author":"Jiang","year":"2019","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0021","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/gutjnl-2015-309800","article-title":"Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer","volume":"66","author":"Yu","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0022","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0023","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature13568","article-title":"Alterations of the human gut microbiome in liver cirrhosis","volume":"513","author":"Qin","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0024","doi-asserted-by":"crossref","first-page":"95176","DOI":"10.18632\/oncotarget.18820","article-title":"Gut microbial profile analysis by MiSeq sequencing of pancreatic carcinoma patients in China","volume":"8","author":"Ren","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0025","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jchf.2015.10.009","article-title":"Pathogenic gut flora in patients with chronic heart failure","volume":"4","author":"Pasini","year":"2016","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0026","doi-asserted-by":"crossref","first-page":"12722","DOI":"10.1038\/s41598-017-11644-9","article-title":"Can intestinal microbiota be associated with non-intestinal cancers?","volume":"7","author":"Jacqueline","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0027","first-page":"170","article-title":"Salivary markers of systemic disease: noninvasive diagnosis of disease and monitoring of general health","volume":"68","author":"Lawrence","year":"2002","journal-title":"J Can Dent Assoc"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0028","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.3389\/fmicb.2018.01136","article-title":"Dysbiosis and ecotypes of the salivary microbiome associated with inflammatory bowel diseases and the assistance in diagnosis of diseases using oral bacterial profiles","volume":"9","author":"Xun","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0029","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1038\/s41598-017-06361-2","article-title":"The salivary microbiome as an indicator of carcinogenesis in patients with oropharyngeal squamous cell carcinoma: a pilot study","volume":"7","author":"Wolf","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0030","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s13238-018-0596-6","article-title":"Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade","volume":"10","author":"Cui","year":"2019","journal-title":"Protein Cell"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0031","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/gutjnl-2011-300784","article-title":"Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer","volume":"61","author":"Farrell","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0032","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.3748\/wjg.v22.i12.3305","article-title":"Latest developments in precancerous lesions of hepatocellular carcinoma","volume":"22","author":"Niu","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0033","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bpg.2013.03.015","article-title":"Advanced precancerous lesions in the liver","volume":"27","author":"Di Tommaso","year":"2013","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0034","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nrgastro.2017.72","article-title":"The gut microbiome and liver cancer: mechanisms and clinical translation","volume":"14","author":"Yu","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0035","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.26494","article-title":"Microbiota-liver axis in hepatic disease","volume":"59","author":"Chassaing","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0036","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/S0140-6736(18)31865-8","article-title":"Chronic hepatitis B virus infection","volume":"392","author":"Seto","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0037","doi-asserted-by":"crossref","first-page":"17006","DOI":"10.1038\/nrdp.2017.6","article-title":"Hepatitis C virus infection","volume":"3","author":"Manns","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0038","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.3389\/fmicb.2017.02222","article-title":"Gut microbial dysbiosis is associated with altered hepatic functions and serum metabolites in chronic hepatitis B patients","volume":"8","author":"Wang","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0039","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00248-010-9801-8","article-title":"Intestinal microbiota was assessed in cirrhotic patients with hepatitis B virus infection. intestinal microbiota of HBV cirrhotic patients","volume":"61","author":"Lu","year":"2011","journal-title":"Microb Ecol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0040","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/cid\/ciy205","article-title":"Gut dysbiosis associated with hepatitis C virus infection","volume":"67","author":"Inoue","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0041","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13099-016-0124-2","article-title":"Gut microbiome alterations in patients with stage 4 hepatitis C","volume":"8","author":"Aly","year":"2016","journal-title":"Gut Pathog"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0042","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/apt.15004","article-title":"Influence of hepatitis C virus eradication with direct-acting antivirals on the gut microbiota in patients with cirrhosis","volume":"48","author":"Ponziani","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0043","doi-asserted-by":"crossref","first-page":"59","DOI":"10.17116\/terarkh2015871259-65","article-title":"Specific features of the enteric microbiota composition in patients with alcoholic liver cirrhosis","volume":"87","author":"Shalikiani","year":"2015","journal-title":"Ter Arkh"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0044","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s40168-017-0359-2","article-title":"Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease","volume":"5","author":"Dubinkina","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0045","doi-asserted-by":"crossref","first-page":"G966","DOI":"10.1152\/ajpgi.00380.2011","article-title":"Colonic microbiome is altered in alcoholism","volume":"302","author":"Mutlu","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0046","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1002\/hep.29623","article-title":"The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis","volume":"67","author":"Puri","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0047","doi-asserted-by":"crossref","first-page":"16639","DOI":"10.3748\/wjg.v20.i44.16639","article-title":"Gut microbiota in alcoholic liver disease: pathogenetic role and therapeutic perspectives","volume":"20","author":"Malaguarnera","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0048","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/hep.24018","article-title":"Enteric dysbiosis associated with a mouse model of alcoholic liver disease","volume":"53","author":"Yan","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0049","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hep.26321","article-title":"Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice","volume":"58","author":"Hartmann","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2014.10.042","article-title":"Gut-liver axis in alcoholic liver disease","volume":"148","author":"Szabo","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0051","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2016.01.003","article-title":"Intestinal REG3 lectins protect against alcoholic steatohepatitis by reducing mucosa-associated microbiota and preventing bacterial translocation","volume":"19","author":"Wang","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0052","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/MCG.0b013e3182872f29","article-title":"Epidemiology of hepatocellular carcinoma: consider the population","volume":"47","author":"Mittal","year":"2013","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0053","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1499-3872(17)60019-5","article-title":"Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease","volume":"16","author":"Shen","year":"2017","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0054","doi-asserted-by":"crossref","first-page":"32002","DOI":"10.1038\/srep32002","article-title":"Altered fecal microbiota correlates with liver biochemistry in nonobese patients with non-alcoholic fatty liver disease","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0055","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.numecd.2017.10.014","article-title":"Gut microbiome composition in lean patients with NASH is associated with liver damage independent of caloric intake: a prospective pilot study","volume":"28","author":"Duarte","year":"2018","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsec\/fiu002","article-title":"Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease","volume":"91","author":"Michail","year":"2015","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0057","doi-asserted-by":"crossref","first-page":"81","DOI":"10.5114\/aoms.2016.62150","article-title":"Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as health players?","volume":"14","author":"Nobili","year":"2018","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0058","doi-asserted-by":"crossref","first-page":"16464","DOI":"10.3748\/wjg.v20.i44.16464","article-title":"Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development","volume":"20","author":"Jiang","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0059","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.livres.2017.11.005","article-title":"Gut microbiota, fatty liver disease, and hepatocellular carcinoma","volume":"2","author":"Chu","year":"2018","journal-title":"Liver Res"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0060","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/febs.14209","article-title":"Nonalcoholic fatty liver disease promotes hepatocellular carcinoma through direct and indirect effects on hepatocytes","volume":"285","author":"Ma","year":"2018","journal-title":"FEBS J"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0061","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cgh.2018.08.065","article-title":"Emerging role of the gut microbiome in nonalcoholic fatty liver disease: from composition to function","volume":"17","author":"Sharpton","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0062","article-title":"Gut Microbiota as a driver of inflammation in nonalcoholic fatty liver disease","volume":"2018","author":"Bibb\u00f2","year":"2018","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0063","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3945\/an.116.013151","article-title":"Nonalcoholic fatty liver disease, the gut microbiome, and diet","volume":"8","author":"Mokhtari","year":"2017","journal-title":"Adv Nutr"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0064","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/hep.22848","article-title":"Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease","volume":"49","author":"Miele","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0065","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jhep.2013.12.019","article-title":"Altered profile of human gut microbiome is associated with cirrhosis and its complications","volume":"60","author":"Bajaj","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0066","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00284-012-0105-8","article-title":"Comparison of the gut microbe profiles and numbers between patients with liver cirrhosis and healthy individuals","volume":"65","author":"Liu","year":"2012","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0067","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/hep.24423","article-title":"Characterization of fecal microbial communities in patients with liver cirrhosis","volume":"54","author":"Chen","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0068","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cmet.2017.04.001","article-title":"Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease","volume":"25","author":"Loomba","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0069","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/hep.30036","article-title":"Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease","volume":"69","author":"Ponziani","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0070","doi-asserted-by":"crossref","first-page":"17098","DOI":"10.1038\/srep17098","article-title":"Decreased diversity of the oral microbiota of patients with hepatitis B virus-induced chronic liver disease: a pilot project","volume":"5","author":"Ling","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0071","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/hep.27819","article-title":"Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy","volume":"62","author":"Bajaj","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0072","doi-asserted-by":"crossref","first-page":"E115","DOI":"10.3390\/biomedicines6040115","article-title":"Oral dysbiosis in pancreatic cancer and liver cirrhosis: a review of the literature","volume":"6","author":"Mohammed","year":"2018","journal-title":"Biomedicines"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0073","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.3748\/wjg.v24.i30.3448","article-title":"Altered oral microbiota in chronic hepatitis B patients with different tongue coatings","volume":"24","author":"Zhao","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0074","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198757","article-title":"Dysbiosis of oral microbiota and its association with salivary immunological biomarkers in autoimmune liver disease","volume":"13","author":"Abe","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0075","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12879-015-0977-x","article-title":"Alterations of Bacteroides sp., Neisseria sp., Actinomyces sp., and Streptococcus sp. populations in the oropharyngeal microbiome are associated with liver cirrhosis and pneumonia","volume":"15","author":"Lu","year":"2015","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0076","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1002\/hep.28829","article-title":"Changes in blood microbiota profiles associated with liver fibrosis in obese patients: a pilot analysis","volume":"64","author":"Lelouvier","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0077","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3389\/fcimb.2018.00420","article-title":"Ascitic bacterial composition is associated with clinical outcomes in cirrhotic patients with culture-negative and non-neutrocytic ascites","volume":"8","author":"Chen","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0078","doi-asserted-by":"crossref","first-page":"e74884","DOI":"10.1371\/journal.pone.0074884","article-title":"Ascitic microbiota composition is correlated with clinical severity in cirrhosis with portal hypertension","volume":"8","author":"Rogers","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2020.01.003_bib0079","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1038\/s41591-018-0164-x","article-title":"Regional variation limits applications of healthy gut microbiome reference ranges and disease models","volume":"24","author":"He","year":"2018","journal-title":"Nat Med"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387220300096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387220300096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:40:37Z","timestamp":1761493237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387220300096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1499387220300096"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2020.01.003","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human microbiome is a diagnostic biomarker in hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2020.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}