{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T21:12:29Z","timestamp":1778015549182,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870433"],"award-info":[{"award-number":["81870433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary &amp; Pancreatic Diseases International"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.hbpd.2020.12.002","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T17:29:40Z","timestamp":1607534980000},"page":"61-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Biliary microbiota and mucin 4 impact the calcification of cholesterol gallstones"],"prefix":"10.1016","volume":"20","author":[{"given":"Feng-Ling","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Tan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Fang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Hua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen-Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2020.12.002_bib0001","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/MOG.0000000000000425","article-title":"Gallstone disease, towards a better understanding and clinical practice","volume":"34","author":"Housset","year":"2018","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0002","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.suc.2018.12.006","article-title":"Gallstone disease: cholecystitis, Mirizzi syndrome, Bouveret syndrome, gallstone ileus","volume":"99","author":"Alemi","year":"2019","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0003","doi-asserted-by":"crossref","first-page":"14942","DOI":"10.3748\/wjg.v20.i40.14942","article-title":"Prevalence of and risk factors for gallstones in Uighur and Han Chinese","volume":"20","author":"Zhu","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0004","doi-asserted-by":"crossref","first-page":"29937","DOI":"10.1038\/srep29937","article-title":"The association between gallstones and metabolic syndrome in urban Han Chinese: a longitudinal cohort study","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0005","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1053\/j.gastro.2009.02.038","article-title":"Burden of digestive diseases in the United States part III: liver, biliary tract, and pancreas","volume":"136","author":"Everhart","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0006","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/1457496916650998","article-title":"Gallstone disease and the risk of cardiovascular disease: a systematic review and meta-Analysis of observational studies","volume":"106","author":"Upala","year":"2017","journal-title":"Scand J Surg"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0007","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10654-017-0263-x","article-title":"Screen-detected gallstone disease and cardiovascular disease","volume":"32","author":"Shabanzadeh","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0008","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/MOG.0000000000000423","article-title":"An update on the pathogenesis of cholesterol gallstone disease","volume":"34","author":"Di Ciaula","year":"2018","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0009","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1148\/radiographics.20.3.g00ma16751","article-title":"Gallbladder stones: imaging and intervention","volume":"20","author":"Bortoff","year":"2000","journal-title":"Radiographics"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0010","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/SGA.0000000000000235","article-title":"Risk factors for cholelithiasis","volume":"39","author":"Pak","year":"2016","journal-title":"Gastroenterol Nurs"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0011","doi-asserted-by":"crossref","first-page":"16024","DOI":"10.1038\/nrdp.2016.24","article-title":"Gallstones","volume":"2","author":"Lammert","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0012","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gtc.2010.02.010","article-title":"Pathogenesis of gallstones","volume":"39","author":"Venneman","year":"2010","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0013","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/eci.12734","article-title":"Impaired intestinal cholecystokinin secretion, a fascinating but overlooked link between coeliac disease and cholesterol gallstone disease","volume":"47","author":"Wang","year":"2017","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0014","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1111\/jgh.14113","article-title":"The characteristics of small intestinal bacterial overgrowth in patients with gallstone diseases","volume":"33","author":"Kim","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0015","first-page":"795","article-title":"Surgical and nonsurgical management of gallstones","volume":"89","author":"Abraham","year":"2014","journal-title":"Am Fam Phys"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0016","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4292\/wjgpt.v3.i2.7","article-title":"Therapy of gallstone disease: what it was, what it is, what it will be","volume":"3","author":"Portincasa","year":"2012","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0017","doi-asserted-by":"crossref","first-page":"851","DOI":"10.5009\/gnl15600","article-title":"MUC expression in gallbladder epithelial tissues in cholesterol-associated gallbladder disease","volume":"10","author":"Yoo","year":"2016","journal-title":"Gut Liver"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0018","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7314\/APJCP.2016.17.2.467","article-title":"Gallstone etiopathogenesis, lith and mucin genes and new treatment approaches","volume":"17","author":"Goral","year":"2016","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0019","doi-asserted-by":"crossref","first-page":"e70657","DOI":"10.1371\/journal.pone.0070657","article-title":"An analysis of the role of the indigenous microbiota in cholesterol gallstone pathogenesis","volume":"8","author":"Fremont-Rahl","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0020","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/0016-5085(91)90095-3","article-title":"Significance of computed tomography for shock-wave therapy of radiolucent gallbladder stones","volume":"101","author":"Ell","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0021","article-title":"Differential staining of bacteria: gram stain","author":"Moyes","year":"2009","journal-title":"Curr Protoc Microbiol"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0022","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.3748\/wjg.15.2367","article-title":"Mucin gene expression in bile of patients with and without gallstone disease, collected by endoscopic retrograde cholangiography","volume":"15","author":"Vilkin","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0023","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/labinvest.2014.140","article-title":"Cholesterol gallstone disease: focusing on the role of gallbladder","volume":"95","author":"Chen","year":"2015","journal-title":"Lab Invest"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0024","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s40168-019-0712-8","article-title":"The human gallbladder microbiome is related to the physiological state and the biliary metabolic profile","volume":"7","author":"Molinero","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0025","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/1477-7819-10-224","article-title":"Prognostic significance of muc4 expression in gallbladder carcinoma","volume":"10","author":"Lee","year":"2012","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0026","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1194\/jlr.M300468-JLR200","article-title":"Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation","volume":"45","author":"Wang","year":"2004","journal-title":"J Lipid Res"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0027","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1023\/A:1005573213100","article-title":"Altered mucin core peptide expression in acute and chronic cholecystitis","volume":"45","author":"Ho","year":"2000","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0028","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.proghi.2007.02.001","article-title":"Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: physiological distribution and pathological significance","volume":"42","author":"Sasaki","year":"2007","journal-title":"Prog Histochem Cytochem"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0029","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1053\/j.gastro.2007.07.005","article-title":"T-cell function is critical for murine cholesterol gallstone formation","volume":"133","author":"Maurer","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.21037\/atm.2018.07.16","article-title":"Current and future roles of mucins in cholangiocarcinoma-recent evidences for a possible interplay with bile acids","volume":"6","author":"Danese","year":"2018","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0031","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1186\/1471-2164-14-669","article-title":"Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study","volume":"14","author":"Wu","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0032","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/13651820310025192","article-title":"The frequency of live bacteria in gallstones","volume":"6","author":"Hazrah","year":"2004","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.hbpd.2020.12.002_bib0033","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1080\/17474124.2018.1533812","article-title":"Role of the biliary microbiome in gallstone disease","volume":"12","author":"Wang","year":"2018","journal-title":"Expert Rev Gastroenterol Hepatol"}],"container-title":["Hepatobiliary &amp; Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S149938722030240X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S149938722030240X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:41:23Z","timestamp":1761493283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S149938722030240X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S149938722030240X"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2020.12.002","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biliary microbiota and mucin 4 impact the calcification of cholesterol gallstones","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2020.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}