{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:52:29Z","timestamp":1761493949988,"version":"build-2065373602"},"reference-count":52,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary &amp; Pancreatic Diseases International"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.hbpd.2021.05.002","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T13:31:30Z","timestamp":1622122290000},"page":"323-329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Symptomatic Val122del mutated hereditary transthyretin amyloidosis: Need for early diagnosis and prioritization for heart and liver transplantation"],"prefix":"10.1016","volume":"20","author":[{"given":"Adriano-Valerio","family":"Schettini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Llado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie K","family":"Heimbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Gonzalez","family":"Costello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Tran\u00e4ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Van Caenegem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C","family":"Daly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Van den Bergh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Casasnovas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Fabregat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J","family":"Poterucha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Foguenne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo G\u00f6ran","family":"Ericzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lerut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2021.05.002_bib0001","series-title":"Amyloid and amyloidosis","first-page":"88","article-title":"Forty years of experience with type I amyloid neuropathy: review of 483 cases","author":"Coutinho","year":"1980"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0002","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/TP.0000000000001021","article-title":"Wilczek HE; FAPWTR\u02bcs investigators. Survival after transplantation in patients with mutations other than Val30Met: Extracts from the FAP World Transplant Registry","volume":"100","author":"Suhr","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0003","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/lt.24058","article-title":"Liver transplantation in transthyretin amyloidosis: issues and challenges","volume":"21","author":"Carvalho","year":"2015","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0004","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy","volume":"379","author":"Maurer","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJMoa1716793","article-title":"Inotersen treatment for patients with hereditary transthyretin amyloidosis","volume":"379","author":"Benson","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0006","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/lt.21996","article-title":"Liver transplantation and combined liver-heart transplantation in patients with familial amyloid polyneuropathy: a single-center experience","volume":"16","author":"Barreiros","year":"2010","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0007","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1097\/WCO.0000000000000289","article-title":"First European consensus for diagnosis, management, and treatment of transthyretin familial amyloid polyneuropathy","volume":"29","author":"Adams","year":"2016","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0008","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","article-title":"Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis","volume":"379","author":"Adams","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0009","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.healun.2017.11.015","article-title":"Improved outcomes after heart transplantation for cardiac amyloidosis in the modern era","volume":"37","author":"Kristen","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0010","unstructured":"The Familial Amyloidotic Polyneuorpathy World Transplant Registry. Results from the familial world transplant registry. Available from: http:\/\/www.fapwtr.org\/ram_fap.htm."},{"key":"10.1016\/j.hbpd.2021.05.002_bib0011","unstructured":"The familial amyloidotic polyneuorpathy world transplant registry the domino liver transplant registry. Results from the domino liver transplant registry. Available from: http:\/\/www.fapwtr.org\/ram_domino.htm."},{"key":"10.1016\/j.hbpd.2021.05.002_bib0012","doi-asserted-by":"crossref","first-page":"E2403","DOI":"10.1002\/humu.22619","article-title":"Online registry for mutations in hereditary amyloidosis including nomenclature recommendations","volume":"35","author":"Rowczenio","year":"2014","journal-title":"Hum Mutat"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0013","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/TP.0b013e3181ac60db","article-title":"Combined heart and liver transplantation: a single-center experience","volume":"88","author":"Raichlin","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0014","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/13506129.2012.674580","article-title":"Late-onset familial amyloid polyneuropathy in Japan","volume":"19","author":"Koike","year":"2012","journal-title":"Amyloid"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0015","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/lt.21817","article-title":"Liver transplantation for familial amyloidotic polyneuropathy: impact on Swedish patients' survival","volume":"15","author":"Okamoto","year":"2009","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0016","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/path.2411","article-title":"Amyloid fibril composition is related to the phenotype of hereditary transthyretin V30M amyloidosis","volume":"216","author":"Ihse","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0017","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/TP.0b013e31824b3749","article-title":"Amyloid fibril composition as a predictor of development of cardiomyopathy after liver transplantation for hereditary transthyretin amyloidosis","volume":"93","author":"Gustafsson","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0018","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/joim.12585","article-title":"One mutation, two distinct disease variants: unravelling the impact of transthyretin amyloid fibril composition","volume":"281","author":"Suhr","year":"2017","journal-title":"J Intern Med"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0019","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1001\/jama.2013.283815","article-title":"Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial","volume":"310","author":"Berk","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40120-016-0040-x","article-title":"Mechanism of action and clinical application of tafamidis in hereditary transthyretin amyloidosis","volume":"5","author":"Coelho","year":"2016","journal-title":"Neurol Ther"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0021","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126526","article-title":"Predictive model of response to tafamidis in hereditary ATTR polyneuropathy","volume":"4","author":"Monteiro","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0022","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/joim.12506","article-title":"Current and future treatment of amyloid diseases","volume":"280","author":"Ankarcrona","year":"2016","journal-title":"J Intern Med"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0023","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/CIRCULATIONAHA.118.035831","article-title":"Effects of patisiran, an RNA interference therapeutic, on cardiac parameters in patients with hereditary transthyretin-mediated amyloidosis","volume":"139","author":"Solomon","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0024","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10557-019-06919-4","article-title":"Phase 3 multicenter study of revusiran in patients with hereditary transthyretin-mediated (hATTR) amyloidosis with cardiomyopathy (ENDEAVOUR)","volume":"34","author":"Judge","year":"2020","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0025","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1161\/CIRCULATIONAHA.119.039645","article-title":"Letter by Gonz\u00e1lez-Costello et\u00a0al regarding article, \"Effects of patisiran, an RNA interference therapeutic, on cardiac parameters in patients with hereditary transthyretin-mediated amyloidosis: analysis of the APOLLO study\"","volume":"140","author":"Gonz\u00e1lez-Costello","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0026","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/0140-6736(93)93127-M","article-title":"Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis","volume":"341","author":"Holmgren","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0027","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/13506129.2015.1123149","article-title":"Long-term outcome of patients with hereditary transthyretin V30M amyloidosis with polyneuropathy after liver transplantation","volume":"23","author":"Okumura","year":"2016","journal-title":"Amyloid"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0028","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1097\/TP.0000000000000574","article-title":"Liver transplantation for hereditary transthyretin amyloidosis: after 20 years still the best therapeutic alternative?","volume":"99","author":"Ericzon","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0029","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/ctr.12053","article-title":"Long-term outcome in patients treated with combined heart and liver transplantation for familial amyloidotic cardiomyopathy","volume":"27","author":"Nelson","year":"2013","journal-title":"Clin Transplant"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0030","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/ctr.12633","article-title":"Outcome in patients treated with isolated liver transplantation for familial transthyretin amyloidosis to prevent cardiomyopathy","volume":"29","author":"Nelson","year":"2015","journal-title":"Clin Transplant"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0031","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.healun.2008.04.004","article-title":"Current state of combined heart-liver transplantation in the United States","volume":"27","author":"Te","year":"2008","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0032","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1016\/j.transproceed.2011.04.010","article-title":"Implantation of the liver during reperfusion of the heart in combined heart-liver transplantation: own experience and review of the literature","volume":"43","author":"Rauchfuss","year":"2011","journal-title":"Transplant Proc"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0033","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1432-2277.2012.01551.x","article-title":"A review of the United States experience with combined heart-liver transplantation","volume":"25","author":"Cannon","year":"2012","journal-title":"Transpl Int"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0034","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.athoracsur.2012.09.010","article-title":"Combined heart and liver transplantation: the Cleveland clinic experience","volume":"95","author":"Nagpal","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0035","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.athoracsur.2014.04.100","article-title":"Combined heart and liver transplantation can be safely performed with excellent short- and long-term results","volume":"98","author":"Atluri","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0036","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/tri.12549","article-title":"Combined heart-liver transplantation: a single-center experience","volume":"28","author":"Careddu","year":"2015","journal-title":"Transpl Int"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0037","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1016\/j.transproceed.2015.07.038","article-title":"Combined heart and liver transplantation: the Cedars-Sinai experience","volume":"47","author":"Reich","year":"2015","journal-title":"Transplant Proc"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0038","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/TP.0000000000000231","article-title":"The perioperative management of patients undergoing combined heart-liver transplantation","volume":"99","author":"Barbara","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0039","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1111\/ajt.13870","article-title":"Liver allograft provides immunoprotection for the cardiac allograft in combined heart-liver transplantation","volume":"16","author":"Wong","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0040","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/MOT.0000000000000509","article-title":"Conquering combined thoracic organ and liver transplantation: indications and outcomes for heart-liver and lung-liver transplantation","volume":"23","author":"Yi","year":"2018","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0041","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1097\/TP.0000000000001978","article-title":"Contemporary outcomes of combined heart-liver transplant in patients with congenital heart disease","volume":"102","author":"3rd","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0042","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/01.tp.0000243731.29657.87","article-title":"A pooled analysis of posttransplant survival following combined heart-liver transplantation","volume":"83","author":"Barshes","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0043","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.healun.2018.07.022","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-fifth adult heart transplantation report-2018; focus theme: multiorgan transplantation","volume":"37","author":"Khush","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0044","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/ajt.12595","article-title":"Combined heart-liver transplantation in the MELD era: do waitlisted patients require exception status?","volume":"14","author":"Schaffer","year":"2014","journal-title":"Am J Transplant"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0045","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/13506129.2012.674073","article-title":"Arrhythmia\u2013a pitfall in tests of cardiac autonomic function after liver transplantation for familial amyloidotic polyneuropathy: a long-term follow-up of Swedish patients","volume":"19","author":"H\u00f6rnsten","year":"2012","journal-title":"Amyloid"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0046","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1097\/TP.0b013e318277226d","article-title":"Combined heart and liver transplantation: protection of the cardiac graft from antibody rejection by initial liver implantation","volume":"95","author":"Daly","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0047","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1097\/01.tp.0000241104.58576.e6","article-title":"Comparison of renal allograft outcomes in combined liver-kidney transplantation versus subsequent kidney transplantation in liver transplant recipients: Analysis of UNOS Database","volume":"82","author":"Simpson","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0048","first-page":"415","article-title":"Combined cardiac surgery and liver transplantation: three decades of worldwide results","volume":"20","author":"Giakoustidis","year":"2011","journal-title":"J Gastrointestin Liv Dis"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0049","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.medcli.2013.10.022","article-title":"Sequential heart and liver transplantation for familial amyloid polyneuropathy","volume":"142","author":"Llad\u00f3","year":"2014","journal-title":"Med Clin"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0050","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0041-1345(96)00206-0","article-title":"Sequential liver transplantation","volume":"29","author":"Furtado","year":"1997","journal-title":"Transplant Proc"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0051","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1600-6143.2011.03477.x","article-title":"Operative risks of domino liver transplantation for the familial amyloid polyneuropathy liver donor and recipient: a double analysis","volume":"11","author":"Tincani","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1016\/j.hbpd.2021.05.002_bib0052","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/modpathol.2015.40","article-title":"The liver in heart failure: a biopsy and explant series of the histopathologic and laboratory findings with a particular focus on pre-cardiac transplant evaluation","volume":"28","author":"Louie","year":"2015","journal-title":"Mod Pathol"}],"container-title":["Hepatobiliary &amp; Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387221000849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387221000849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:42:06Z","timestamp":1761493326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387221000849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1499387221000849"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2021.05.002","relation":{},"ISSN":["1499-3872"],"issn-type":[{"type":"print","value":"1499-3872"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Symptomatic Val122del mutated hereditary transthyretin amyloidosis: Need for early diagnosis and prioritization for heart and liver transplantation","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2021.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}