{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:10:26Z","timestamp":1793934626839,"version":"4.8.0"},"reference-count":155,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["58\/30\/2020\/PHA\/BMS dtd 9.11.2021"],"award-info":[{"award-number":["58\/30\/2020\/PHA\/BMS dtd 9.11.2021"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.hbpd.2022.10.003","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T01:17:36Z","timestamp":1666228656000},"page":"333-345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Wnt\/beta\u2010catenin signaling and its modulators in nonalcoholic fatty liver diseases"],"prefix":"10.1016","volume":"22","author":[{"given":"Karthik","family":"Shree Harini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devaraj","family":"Ezhilarasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2022.10.003_bib0001","doi-asserted-by":"crossref","first-page":"s77","DOI":"10.7861\/clinmedicine.15-6-s77","article-title":"An overview of the genetics, mechanisms and management of NAFLD and ALD","volume":"15","author":"Rowell","year":"2015","journal-title":"Clin Med (Lond)"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0002","doi-asserted-by":"crossref","first-page":"d3897","DOI":"10.1136\/bmj.d3897","article-title":"How big a problem is non-alcoholic fatty liver disease?","volume":"343","author":"Anstee","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0003","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0006","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cld.2017.08.003","article-title":"The natural history of nonalcoholic fatty liver disease-an evolving view","volume":"22","author":"Lindenmeyer","year":"2018","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0007","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0008","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jhep.2009.03.019","article-title":"Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis","volume":"51","author":"Argo","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0009","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/MOG.0000000000000176","article-title":"Aging and liver disease","volume":"31","author":"Kim","year":"2015","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0010","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0011","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s00439-013-1294-3","article-title":"Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan","volume":"132","author":"Kitamoto","year":"2013","journal-title":"Hum Genet"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0012","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cld.2009.07.005","article-title":"Epidemiology and natural history of non-alcoholic steatohepatitis","volume":"13","author":"Argo","year":"2009","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0013","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1136\/gut.2008.161885","article-title":"Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men","volume":"58","author":"Chang","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0014","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MAJ.0b013e3181812879","article-title":"Effect of body weight and lifestyle changes on long-term course of nonalcoholic fatty liver disease in Koreans","volume":"337","author":"Kim","year":"2009","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0015","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.3748\/wjg.v16.i34.4243","article-title":"Obstructive sleep apnea syndrome and fatty liver: association or causal link?","volume":"16","author":"Ahmed","year":"2010","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0016","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1136\/gutjnl-2012-303816","article-title":"Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice","volume":"62","author":"Le Roy","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0017","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dmm.001180","article-title":"A comprehensive definition for metabolic syndrome","volume":"2","author":"Huang","year":"2009","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0018","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0019","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.metabol.2016.06.009","article-title":"Non-alcoholic fatty liver disease with and without metabolic syndrome: different long-term outcomes","volume":"66","author":"K\u00e4r\u00e4j\u00e4m\u00e4ki","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0020","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1471-2458-10-237","article-title":"Non-alcoholic and alcoholic fatty liver disease - two diseases of affluence associated with the metabolic syndrome and type 2 diabetes: the FIN-D2D survey","volume":"10","author":"Kotronen","year":"2010","journal-title":"BMC Public Health"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0021","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.3748\/wjg.v20.i26.8393","article-title":"Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease","volume":"20","author":"Toshikuni","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0022","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrgastro.2013.41","article-title":"Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis","volume":"10","author":"Anstee","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0023","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.freeradbiomed.2009.07.016","article-title":"SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats","volume":"47","author":"Aragno","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0024","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jpeds.2012.08.043","article-title":"Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010","volume":"162","author":"Welsh","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0025","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.3748\/wjg.v24.i27.2974","article-title":"Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From \"two hit theory\" to \"multiple hit model\"","volume":"24","author":"Fang","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0026","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \"hits\"?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0027","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0028","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.2174\/138161210791208875","article-title":"Insulin resistance in nonalcoholic fatty liver disease","volume":"16","author":"Bugianesi","year":"2010","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0029","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/hep.20283","article-title":"Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway","volume":"40","author":"Feldstein","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0030","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrm2391","article-title":"Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes","volume":"9","author":"Guilherme","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0031","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1055\/s-0028-1091981","article-title":"Mechanisms of disease progression in nonalcoholic fatty liver disease","volume":"28","author":"Jou","year":"2008","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0032","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0002-9440(10)63489-X","article-title":"Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease","volume":"163","author":"Roskams","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0033","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jhep.2010.04.008","article-title":"A position statement on NAFLD\/NASH based on the EASL 2009 special conference","volume":"53","author":"Ratziu","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0034","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI34275","article-title":"Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice","volume":"118","author":"Postic","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12916-017-0806-8","article-title":"Non-alcoholic fatty liver disease","volume":"15","author":"Neuschwander-Tetri","year":"2017","journal-title":"BMC Med"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0036","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1111\/j.1572-0241.2004.30159.x","article-title":"Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis","volume":"99","author":"Chalasani","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0037","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jhep.2005.03.004","article-title":"NASH: a mitochondrial disease","volume":"42","author":"Pessayre","year":"2005","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2005.10.004","article-title":"Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it","volume":"6","author":"Begriche","year":"2006","journal-title":"Mitochondrion"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0039","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/S0016-5085(96)70028-8","article-title":"Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation","volume":"111","author":"Weltman","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0040","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0041","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm1166","article-title":"Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB","volume":"11","author":"Cai","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0042","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/gut.2005.071118","article-title":"Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice","volume":"55","author":"Tomita","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0043","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.jhep.2006.02.011","article-title":"Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2","volume":"44","author":"Haukeland","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0044","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02924","article-title":"NF-kappaB functions as a tumour promoter in inflammation-associated cancer","volume":"431","author":"Pikarsky","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0045","doi-asserted-by":"crossref","first-page":"G1248","DOI":"10.1152\/ajpgi.90223.2008","article-title":"Inflammasome-mediated regulation of hepatic stellate cells","volume":"296","author":"Watanabe","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0046","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-immunol-030409-101311","article-title":"The sterile inflammatory response","volume":"28","author":"Rock","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0047","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/hep.23337","article-title":"Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity","volume":"51","author":"Stienstra","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0048","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/j.gastro.2010.03.052","article-title":"Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice","volume":"139","author":"Miura","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0049","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets","volume":"22","author":"Zhang","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0050","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jcp.30582","article-title":"Hepatic stellate cells in the injured liver: perspectives beyond hepatic fibrosis","volume":"237","author":"Ezhilarasan","year":"2022","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0051","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-2005-858989","article-title":"TGF-beta\/Smad signaling in the injured liver","volume":"44","author":"Breitkopf","year":"2006","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0052","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1177\/1535370220949148","article-title":"Endothelin-1 in portal hypertension: the intricate role of hepatic stellate cells","volume":"245","author":"Ezhilarasan","year":"2020","journal-title":"Exp Biol Med"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0053","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nrgastro.2010.168","article-title":"Functional role of chemokines in liver disease models","volume":"7","author":"Sahin","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0054","doi-asserted-by":"crossref","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","author":"Ramachandran","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0055","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0056","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0057","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/CCO.0000000000000042","article-title":"Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer","volume":"26","author":"Lade","year":"2014","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0058","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/pgmj.74.870.193","article-title":"Liver cirrhosis","volume":"74","author":"Williams","year":"1998","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0059","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/cs0920103","article-title":"Pathogenesis of liver fibrosis","volume":"92","author":"Alcolado","year":"1997","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0060","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1053\/j.gastro.2015.02.056","article-title":"\u03b2-catenin signaling and roles in liver homeostasis, injury, and tumorigenesis","volume":"148","author":"Monga","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0061","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1093\/emboj\/16.13.3797","article-title":"Beta-catenin is a target for the ubiquitin-proteasome pathway","volume":"16","author":"Aberle","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0062","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/35035124","article-title":"An LDL-receptor-related protein mediates Wnt signalling in mice","volume":"407","author":"Pinson","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0063","first-page":"1428","article-title":"The Wnt\/Frizzled GPCR signaling pathway","volume":"75","author":"Katanaev","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0064","doi-asserted-by":"crossref","first-page":"12752","DOI":"10.1073\/pnas.1006437108","article-title":"Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia\/Goltz syndrome","volume":"108","author":"Barrott","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0065","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1093\/emboj\/18.15.4233","article-title":"Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1","volume":"18","author":"Li","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0066","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1053\/j.gastro.2003.12.047","article-title":"Beta-catenin is temporally regulated during normal liver development","volume":"126","author":"Micsenyi","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0067","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0002-9440(10)61215-1","article-title":"Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors","volume":"167","author":"Monga","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0068","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1053\/j.gastro.2006.08.042","article-title":"Conditional deletion of beta-catenin reveals its role in liver growth and regeneration","volume":"131","author":"Tan","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0069","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1053\/jhep.2001.23786","article-title":"Changes in WNT\/beta-catenin pathway during regulated growth in rat liver regeneration","volume":"33","author":"Monga","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.semcancer.2010.12.010","article-title":"Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad","volume":"21","author":"Nejak-Bowen","year":"2011","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0071","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/hep.26924","article-title":"T-cell factor 4 and \u03b2-catenin chromatin occupancies pattern zonal liver metabolism in mice","volume":"59","author":"Gougelet","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0072","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1038\/sj.onc.1206118","article-title":"New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism","volume":"21","author":"Cadoret","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0073","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/hep.21131","article-title":"Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice","volume":"43","author":"Sekine","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0074","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/hep.23801","article-title":"Liver-specific \u03b2-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis","volume":"52","author":"Yeh","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0075","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00418-008-0546-0","article-title":"Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells","volume":"131","author":"Son","year":"2009","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0076","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1479164117738442","article-title":"Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases","volume":"15","author":"Ackers","year":"2018","journal-title":"Diab Vasc Dis Res"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0077","first-page":"2201","article-title":"Role and mechanisms of action of microRNA-21 as regards the regulation of the WNT\/\u03b2-catenin signaling pathway in the pathogenesis of non-alcoholic fatty liver disease","volume":"44","author":"Wang","year":"2019","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0078","doi-asserted-by":"crossref","first-page":"77707","DOI":"10.18632\/oncotarget.12774","article-title":"SIRT1 suppresses adipogenesis by activating Wnt\/\u03b2-catenin signaling in vivo and in vitro","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0079","doi-asserted-by":"crossref","first-page":"7213","DOI":"10.1074\/jbc.M111.286724","article-title":"Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure","volume":"287","author":"Liu","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0080","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.3390\/nu7064453","article-title":"Low-density lipoprotein receptor-related protein 6 (LRP6) is a novel nutritional therapeutic target for hyperlipidemia, non-alcoholic fatty liver disease, and atherosclerosis","volume":"7","author":"Go","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0081","doi-asserted-by":"crossref","first-page":"E60","DOI":"10.1210\/jc.2012-3038","article-title":"Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes","volume":"98","author":"Register","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0082","doi-asserted-by":"crossref","first-page":"ra6","DOI":"10.1126\/scisignal.2001249","article-title":"Wnt signaling regulates hepatic metabolism","volume":"4","author":"Liu","year":"2011","journal-title":"Sci Signal"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0083","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s11892-009-0034-5","article-title":"The role of FOXO in the regulation of metabolism","volume":"9","author":"Gross","year":"2009","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0084","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng1732","article-title":"Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes","volume":"38","author":"Grant","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0085","doi-asserted-by":"crossref","first-page":"11402","DOI":"10.1073\/pnas.1205015109","article-title":"Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism","volume":"109","author":"Li","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0086","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1096\/fj.15-271171","article-title":"Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a","volume":"29","author":"Wang","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0087","doi-asserted-by":"crossref","first-page":"744","DOI":"10.2353\/ajpath.2010.090667","article-title":"Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis","volume":"176","author":"Behari","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0088","doi-asserted-by":"crossref","first-page":"32345","DOI":"10.1074\/jbc.M313478200","article-title":"Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease","volume":"279","author":"Samuel","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0089","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1126\/science.1188280","article-title":"Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity","volume":"329","author":"Ouchi","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/jaut.2001.0522","article-title":"Genomic analysis of differentially expressed genes in liver and biliary epithelial cells of patients with primary biliary cirrhosis","volume":"17","author":"Tanaka","year":"2001","journal-title":"J Autoimmun"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0091","doi-asserted-by":"crossref","first-page":"G39","DOI":"10.1152\/ajpgi.00263.2007","article-title":"Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis","volume":"294","author":"Cheng","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0092","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1016\/j.febslet.2007.05.050","article-title":"Wnt signaling enhances the activation and survival of human hepatic stellate cells","volume":"581","author":"Myung","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0093","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3748\/wjg.v18.i15.1745","article-title":"Wnt5a participates in hepatic stellate cell activation observed by gene expression profile and functional assays","volume":"18","author":"Xiong","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0094","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.3892\/mmr.2014.2099","article-title":"Zhu L. \u03b2-catenin is overexpressed in hepatic fibrosis and blockage of Wnt\/\u03b2-catenin signaling inhibits hepatic stellate cell activation","volume":"9","author":"Ge","year":"2014","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0095","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5009\/gnl.2014.8.3.282","article-title":"Mest attenuates CCl4-induced liver fibrosis in rats by inhibiting the Wnt\/\u03b2-catenin signaling pathway","volume":"8","author":"Li","year":"2014","journal-title":"Gut Liver"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0096","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.289.5481.950","article-title":"Inhibition of adipogenesis by Wnt signaling","volume":"289","author":"Ross","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0097","doi-asserted-by":"crossref","first-page":"11392","DOI":"10.1074\/jbc.M310284200","article-title":"Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells","volume":"279","author":"Hazra","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0098","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1074\/jbc.M410078200","article-title":"Adipogenic transcriptional regulation of hepatic stellate cells","volume":"280","author":"She","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0099","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jhep.2006.03.016","article-title":"Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation","volume":"45","author":"Jiang","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11010-012-1498-1","article-title":"Wnt\/\u03b2-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production","volume":"374","author":"Zhang","year":"2013","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0101","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4910601","article-title":"Heme oxygenase-1 suppresses Wnt signaling pathway in nonalcoholic steatohepatitis-related liver fibrosis","volume":"2020","author":"Du","year":"2020","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0102","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/hep.21473","article-title":"Wnt'er in liver: expression of Wnt and frizzled genes in mouse","volume":"45","author":"Zeng","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0103","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/hep.22084","article-title":"Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway","volume":"47","author":"Klein","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0104","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.791861","article-title":"Sirt1 promotes the restoration of hepatic progenitor cell (HPC)-mediated liver fatty injury in NAFLD through activating the Wnt\/\u03b2-catenin signal pathway","volume":"8","author":"Li","year":"2021","journal-title":"Front Nutr"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157246","article-title":"Macrophage activation in pediatric nonalcoholic fatty liver disease (NAFLD) correlates with hepatic progenitor cell response via Wnt3a pathway","volume":"11","author":"Carpino","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0106","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nrd2154","article-title":"Mining the Wnt pathway for cancer therapeutics","volume":"5","author":"Barker","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0107","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.apsb.2017.10.003","article-title":"Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6\/Wnt pathway","volume":"8","author":"Xiao","year":"2018","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0108","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s13277-012-0331-5","article-title":"Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma","volume":"33","author":"Kaur","year":"2012","journal-title":"Tumour Biol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0109","doi-asserted-by":"crossref","first-page":"743","DOI":"10.4161\/epi.5.8.13104","article-title":"SOX17 antagonizes WNT\/\u03b2-catenin signaling pathway in hepatocellular carcinoma","volume":"5","author":"Jia","year":"2010","journal-title":"Epigenetics"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0110","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1158\/0008-5472.CAN-10-3342","article-title":"EZH2-mediated concordant repression of Wnt antagonists promotes \u03b2-catenin-dependent hepatocarcinogenesis","volume":"71","author":"Cheng","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0111","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1158\/0008-5472.CAN-14-3786","article-title":"Histone deacetylase HDAC8 promotes insulin resistance and \u03b2-catenin activation in NAFLD-associated hepatocellular carcinoma","volume":"75","author":"Tian","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0112","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1172\/JCI63539","article-title":"Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver","volume":"122","author":"Hsu","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0113","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2014-308969","article-title":"Antitumour activity of an inhibitor of miR-34a in liver cancer with \u03b2-catenin-mutations","volume":"65","author":"Gougelet","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0114","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cellsig.2017.06.001","article-title":"Sirt1 suppresses Wnt\/\u03b2Catenin signaling in liver cancer cells by targeting \u03b2Catenin in a PKA\u03b1-dependent manner","volume":"37","author":"Wu","year":"2017","journal-title":"Cell Signal"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0115","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/pro.3122","article-title":"Modulating the wnt signaling pathway with small molecules","volume":"26","author":"Tran","year":"2017","journal-title":"Protein Sci"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0116","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120919","article-title":"Derricin and derricidin inhibit Wnt\/\u03b2-catenin signaling and suppress colon cancer cell growth in vitro","volume":"10","author":"Fonseca","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0117","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/ncomms1680","article-title":"An intrinsically labile \u03b1-helix abutting the BCL9-binding site of \u03b2-catenin is required for its inhibition by carnosic acid","volume":"3","author":"de la Roche","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0118","doi-asserted-by":"crossref","first-page":"11717","DOI":"10.1073\/pnas.1120068109","article-title":"Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors","volume":"109","author":"Gurney","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0119","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cellsig.2013.09.016","article-title":"Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a\/\u03b2-catenin signaling","volume":"26","author":"Xavier","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0120","doi-asserted-by":"crossref","first-page":"e81710","DOI":"10.1371\/journal.pone.0081710","article-title":"Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition","volume":"8","author":"Boschert","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0121","doi-asserted-by":"crossref","first-page":"15495","DOI":"10.1021\/bi0512602","article-title":"Identification of a specific inhibitor of the dishevelled PDZ domain","volume":"44","author":"Shan","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0122","doi-asserted-by":"crossref","first-page":"16256","DOI":"10.1074\/jbc.M109.009647","article-title":"Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled","volume":"284","author":"Grandy","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0123","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1747-0285.2011.01295.x","article-title":"Synthesis of potent dishevelled PDZ domain inhibitors guided by virtual screening and NMR studies","volume":"79","author":"Shan","year":"2012","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0124","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/cpr.12161","article-title":"Silencing dishevelled-1 sensitizes paclitaxel-resistant human ovarian cancer cells via AKT\/GSK-3\u03b2\/\u03b2-catenin signalling","volume":"48","author":"Zhang","year":"2015","journal-title":"Cell Prolif"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0125","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1158\/1535-7163.MCT-13-0048","article-title":"Sulindac selectively inhibits colon tumor cell growth by activating the cGMP\/PKG pathway to suppress Wnt\/\u03b2-catenin signaling","volume":"12","author":"Li","year":"2013","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0126","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.3727\/096504017X14992942781895","article-title":"Pharmacologic inhibition of \u03b2-catenin with pyrvinium inhibits murine and human models of Wilms tumor","volume":"25","author":"Polosukhina","year":"2017","journal-title":"Oncol Res"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0127","doi-asserted-by":"crossref","first-page":"e15521","DOI":"10.1371\/journal.pone.0015521","article-title":"Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling","volume":"5","author":"Saraswati","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0128","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113942","article-title":"Pyrvinium pamoate attenuates non-alcoholic steatohepatitis: insight on hedgehog\/Gli and Wnt\/\u03b2-catenin signaling crosstalk","volume":"177","author":"El-Derany","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0129","doi-asserted-by":"crossref","first-page":"e83819","DOI":"10.1371\/journal.pone.0083819","article-title":"Celecoxib ameliorates non-alcoholic steatohepatitis in type 2 diabetic rats via suppression of the non-canonical Wnt signaling pathway expression","volume":"9","author":"Tian","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0130","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1002\/jcp.22593","article-title":"CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver","volume":"226","author":"Cohen","year":"2011","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0131","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1634\/theoncologist.2012-0211","article-title":"CF102 for the treatment of hepatocellular carcinoma: a phase I\/II, open-label, dose-escalation study","volume":"18","author":"Stemmer","year":"2013","journal-title":"Oncologist"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0132","first-page":"2256","article-title":"The A3 adenosine receptor agonist, namodenoson, ameliorates non-alcoholic steatohepatitis in mice","volume":"44","author":"Fishman","year":"2019","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0133","doi-asserted-by":"crossref","first-page":"768","DOI":"10.7150\/ijbs.14718","article-title":"Inhibition of wnt\/\u03b2-catenin signaling in hepatocellular carcinoma by an antipsychotic drug pimozide","volume":"12","author":"Fako","year":"2016","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0134","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/CMR.12.1.40","article-title":"Current and emerging azole antifungal agents","volume":"12","author":"Sheehan","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110661","article-title":"Itraconazole exerts anti-liver cancer potential through the Wnt, PI3K\/AKT\/mTOR, and ROS pathways","volume":"131","author":"Wang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0136","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0137","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/nm.3699","article-title":"Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice","volume":"20","author":"Tao","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0138","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155250","article-title":"The role of WNT\/\u03b2-catenin signaling pathway and glutamine metabolism in the pathogenesis of CCl4-induced liver fibrosis: repositioning of niclosamide and concerns about lithium","volume":"136","author":"El-Ashmawy","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0139","article-title":"Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs","volume":"15","author":"Zhang","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0140","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/S0959-8049(16)32668-5","article-title":"Initial results from a phase 1a\/b study of OMP-131R10, a first-in-class anti-RSPO3 antibody, in advanced solid tumors and previously treated metastatic colorectal cancer (CRC)","volume":"69","author":"Bendell","year":"2016","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0141","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1038\/onc.2015.280","article-title":"Wnt addiction of genetically defined cancers reversed by PORCN inhibition","volume":"35","author":"Madan","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0142","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1158\/0008-5472.CAN-14-2041","article-title":"Wnt\/\u03b2-catenin small-molecule inhibitor CWP232228 preferentially inhibits the growth of breast cancer stem-like cells","volume":"75","author":"Jang","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0143","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1158\/0008-5472.CAN-15-1519","article-title":"A small-molecule antagonist of the \u03b2-catenin\/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis","volume":"76","author":"Fang","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0144","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.bbadis.2017.12.001","article-title":"Inhibition of canonical WNT signaling pathway by \u03b2-catenin\/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12","volume":"1864","author":"Akcora","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0145","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbrc.2005.03.007","article-title":"Wnt5b partially inhibits canonical Wnt\/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes","volume":"330","author":"Kanazawa","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0146","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0024-3205(00)00605-6","article-title":"Morin hydrate: a potential antioxidant in minimizing the free-radicals-mediated damage to cardiovascular cells by anti-tumor drugs","volume":"67","author":"Kok","year":"2000","journal-title":"Life Sci"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0147","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cbi.2007.09.003","article-title":"Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin","volume":"171","author":"Sivaramakrishnan","year":"2008","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0148","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.lfs.2003.07.017","article-title":"Morin sulfates\/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock","volume":"74","author":"Fang","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0149","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.taap.2014.03.008","article-title":"Morin ameliorates chemically induced liver fibrosis in vivo and inhibits stellate cell proliferation in vitro by suppressing Wnt\/\u03b2-catenin signaling","volume":"277","author":"MadanKumar","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.canlet.2009.06.009","article-title":"Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice","volume":"287","author":"Wu","year":"2010","journal-title":"Cancer Lett"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0151","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13046-018-0678-6","article-title":"The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt\/\u03b2-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells","volume":"37","author":"Zhang","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0152","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.3892\/mmr.2016.5148","article-title":"Herbal medicine Gan-fu-kang downregulates Wnt\/Ca2+ signaling to attenuate liver fibrogenesis in vitro and in vivo","volume":"13","author":"Jia","year":"2016","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0153","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jphs.2018.01.003","article-title":"Oligo-peptide I-C-F-6 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing NF-\u03baB signaling and Wnt\/\u03b2-catenin signaling","volume":"136","author":"Sun","year":"2018","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0154","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s11596-019-2123-2","article-title":"Diwu Yanggan modulates the Wnt\/\u03b2-catenin pathway and inhibits liver carcinogenesis signaling in 2-AAF\/PH model rats","volume":"39","author":"Zhao","year":"2019","journal-title":"Curr Med Sci"},{"key":"10.1016\/j.hbpd.2022.10.003_bib0155","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.biopha.2018.11.149","article-title":"Dendrobium candidum extract inhibits proliferation and induces apoptosis of liver cancer cells by inactivating Wnt\/\u03b2-catenin signaling pathway","volume":"110","author":"Guo","year":"2019","journal-title":"Biomed Pharmacother"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387222002399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387222002399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:42:43Z","timestamp":1778816563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387222002399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":155,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S1499387222002399"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2022.10.003","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wnt\/beta\u2010catenin signaling and its modulators in nonalcoholic fatty liver diseases","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2022.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}