{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:06:50Z","timestamp":1782281210250,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872738"],"award-info":[{"award-number":["31872738"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673241"],"award-info":[{"award-number":["81673241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873915"],"award-info":[{"award-number":["81873915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","award":["S20200318-052"],"award-info":[{"award-number":["S20200318-052"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","award":["TDYX2021010"],"award-info":[{"award-number":["TDYX2021010"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.hbpd.2022.11.004","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T18:48:45Z","timestamp":1668192525000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oncogenic Wnt3a is a promising sensitive biomarker for monitoring hepatocarcinogenesis"],"prefix":"10.1016","volume":"22","author":[{"given":"Min","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Li","family":"Sai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng-Fu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2022.11.004_bib0001","doi-asserted-by":"crossref","first-page":"2","DOI":"10.21037\/cco-20-162","article-title":"Epidemiology, mutational landscape and staging of hepatocellular carcinoma","volume":"10","author":"Fenton","year":"2021","journal-title":"Chin Clin Oncol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0002","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3390\/jcm10020353","article-title":"Stratification of hepatocellular carcinoma risk following HCV eradication or HBV control","volume":"10","author":"Nahon","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0003","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.jhep.2021.08.012","article-title":"Epidemiology and risk-stratification of NAFLD-associated HCC","volume":"75","author":"Ioannou","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0004","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jhep.2020.11.026","article-title":"Systemic treatment of HCC in special populations","volume":"74","author":"Rimassa","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0005","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.hbpd.2022.09.002","article-title":"Immunotherapy for hepatobiliary malignancies: Progress and prospective","volume":"21","author":"Qin","year":"2022","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0006","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.hbpd.2022.08.003","article-title":"Strategies for improving the efficacy of immunotherapy in hepatocellular carcinoma","volume":"21","author":"Zhu","year":"2022","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0007","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.3390\/cells10113091","article-title":"Treatment for viral hepatitis as secondary prevention for hepatocellular carcinoma","volume":"10","author":"Alqahtani","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0008","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41575-018-0075-9","article-title":"Wnt-\u03b2-catenin signalling in liver development, health and disease","volume":"16","author":"Perugorria","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0009","first-page":"713","article-title":"Multi\u2011layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT\/\u03b2\u2011catenin signaling activation (Review)","volume":"42","author":"Katoh","year":"2018","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110851","article-title":"WNT\/\u03b2-catenin signaling in the development of liver cancers","volume":"132","author":"He","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0011","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.7150\/jca.31599","article-title":"Oncogenic Wnt3a: a candidate specific marker and novel molecular target for hepatocellular carcinoma","volume":"10","author":"Zheng","year":"2019","journal-title":"J Cancer"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0012","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.hbpd.2018.03.005","article-title":"Expression of hepatic Wnt5a and its clinicopathological features in patients with hepatocellular carcinoma","volume":"17","author":"Wang","year":"2018","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0013","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2147\/JHC.S336858","article-title":"Wnt\/\u03b2-catenin signaling as a driver of hepatocellular carcinoma progression: an emphasis on molecular pathways","volume":"8","author":"Deldar Abad Paskeh","year":"2021","journal-title":"J Hepatocell Carcinoma"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0014","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.12998\/wjcc.v9.i19.4890","article-title":"Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update","volume":"9","author":"Elpek","year":"2021","journal-title":"World J Clin Cases"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/bs.acr.2020.10.002","article-title":"Signaling pathways in hepatocellular carcinoma","volume":"149","author":"Garcia-Lezana","year":"2021","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0016","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3892\/mmr.2021.11957","article-title":"lncRNA DQ786243 promotes hepatocellular carcinoma cell invasion and proliferation by regulating the miR\u201115p\u20115p\/Wnt3A axis","volume":"23","author":"Lin","year":"2021","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0017","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3892\/ijo.2017.4112","article-title":"Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis","volume":"51","author":"Lu","year":"2017","journal-title":"Int J Oncol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0018","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.3748\/wjg.v22.i14.3829","article-title":"Oncogenic Wnt3a expression as an estimable prognostic marker for hepatocellular carcinoma","volume":"22","author":"Pan","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0019","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4251\/wjgo.v12.i1.66","article-title":"Abnormal CD44 activation of hepatocytes with nonalcoholic fatty accumulation in rat hepatocarcinogenesis","volume":"12","author":"Fang","year":"2020","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0020","doi-asserted-by":"crossref","first-page":"16915","DOI":"10.1038\/s41598-021-96071-7","article-title":"Implications of zonal architecture on differential gene expression profiling and altered pathway expressions in mandibular condylar cartilage","volume":"11","author":"Basudan","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0021","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jceh.2019.01.004","article-title":"Hepatocellular carcinoma: etiology and current and future drugs","volume":"9","author":"Jindal","year":"2019","journal-title":"J Clin Exp Hepatol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0022","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3390\/ijms22020479","article-title":"Risk factors and biomarkers for chronic hepatitis B associated hepatocellular carcinoma","volume":"22","author":"Pandyarajan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0023","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-020-00381-6","article-title":"Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention","volume":"18","author":"Huang","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0024","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.gendis.2020.01.014","article-title":"Advances in the early diagnosis of hepatocellular carcinoma","volume":"7","author":"Wang","year":"2020","journal-title":"Genes Dis"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0025","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/hep.31306","article-title":"Evolution of systemic therapy for hepatocellular carcinoma","volume":"73","author":"Finn","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0026","doi-asserted-by":"crossref","first-page":"5","DOI":"10.21037\/cco-20-130","article-title":"Surgical resection of early stage hepatocellular carcinoma: balancing tumor biology with the host liver","volume":"10","author":"Ju","year":"2021","journal-title":"Chin Clin Oncol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0027","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41568-020-00307-z","article-title":"Mutations and mechanisms of WNT pathway tumour suppressors in cancer","volume":"21","author":"Bugter","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0028","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.18632\/aging.102831","article-title":"SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt\/\u03b2-catenin signaling pathway","volume":"12","author":"Tian","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0029","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.109972","article-title":"LGR5\/R-Spo1\/Wnt3a axis promotes stemness and aggressive phenotype in hepatoblast-like hepatocellular carcinoma cell lines","volume":"82","author":"Akbari","year":"2021","journal-title":"Cell Signal"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0031","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.clinre.2018.09.012","article-title":"Interplay of Wnt \u03b2-catenin pathway and miRNAs in HBV pathogenesis leading to HCC","volume":"43","author":"Rana","year":"2019","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0032","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2147\/JHC.S156701","article-title":"Role of Wnt\/\u03b2-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance","volume":"5","author":"Khalaf","year":"2018","journal-title":"J Hepatocell Carcinoma"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0033","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/j.jhep.2016.02.021","article-title":"Mechanisms of HBV-induced hepatocellular carcinoma","volume":"64","author":"Levrero","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0034","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00535-016-1299-5","article-title":"Action and function of Wnt\/\u03b2-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma","volume":"52","author":"Wang","year":"2017","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0035","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3390\/cancers11070926","article-title":"Wnt\/\u03b2-catenin signaling in liver cancers","volume":"11","author":"Wang","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0036","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s10038-021-00928-8","article-title":"Genomic landscape of hepatocarcinogenesis","volume":"66","author":"Shibata","year":"2021","journal-title":"J Hum Genet"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0037","article-title":"Potential biomarkers for liver cancer diagnosis based on multi-omics strategy","volume":"12","author":"Chen","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0038","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jhep.2021.08.028","article-title":"Rational HCC screening approaches for patients with NAFLD","volume":"76","author":"Singal","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0039","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/hep.31175","article-title":"Biomarkers for Hepatobiliary Cancers","volume":"73 Suppl 1","author":"Nault","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0040","first-page":"241","article-title":"Specific molecular markers in hepatocellular carcinoma","volume":"6","author":"Yao","year":"2007","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0041","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4251\/wjgo.v13.i4.197","article-title":"Early diagnosis and therapeutic strategies for hepatocellular carcinoma: From bench to bedside","volume":"13","author":"Guan","year":"2021","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0042","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5582\/bst.2016.01176","article-title":"Advances in the study of oncofetal antigen glypican-3 expression in HBV-related hepatocellular carcinoma","volume":"10","author":"Yao","year":"2016","journal-title":"Biosci Trends"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0043","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ctrv.2017.11.002","article-title":"Targeting the Wnt\/beta-catenin pathway in cancer: Update on effectors and inhibitors","volume":"62","author":"Krishnamurthy","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.hbpd.2022.11.004_bib0044","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.3390\/cancers13153666","article-title":"Role of oncogenic pathways on the cancer immunosuppressive microenvironment and its clinical implications in hepatocellular carcinoma","volume":"13","author":"Nishida","year":"2021","journal-title":"Cancers (Basel)"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387222002508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387222002508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:02:26Z","timestamp":1778616146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387222002508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S1499387222002508"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2022.11.004","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oncogenic Wnt3a is a promising sensitive biomarker for monitoring hepatocarcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2022.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}