{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:13:17Z","timestamp":1788469997656,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51872279"],"award-info":[{"award-number":["51872279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52072005"],"award-info":[{"award-number":["52072005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["Quick-PJ 2020-16-30"],"award-info":[{"award-number":["Quick-PJ 2020-16-30"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.hbpd.2023.09.004","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T21:30:30Z","timestamp":1695677430000},"page":"195-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["TuBG1 promotes hepatocellular carcinoma via ATR\/P53-apoptosis and cycling pathways"],"prefix":"10.1016","volume":"23","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Qi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Ya","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Xin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Ming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2023.09.004_bib0001","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0002","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.hbpd.2022.11.010","article-title":"Sirolimus improves the prognosis of liver recipients with hepatocellular carcinoma: a single-center experience","volume":"22","author":"Liu","year":"2023","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0003","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3390\/biomedicines9101345","article-title":"HCC and molecular targeting therapies: back to the future","volume":"9","author":"Rinaldi","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0004","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.hbpd.2022.10.006","article-title":"Conversion therapy in liver transplantation for hepatocellular carcinoma: what's new in the era of molecular and immune therapy?","volume":"22","author":"Jiang","year":"2023","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0005","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/jcb.10033","article-title":"Regulation of tubulin synthesis and cell cycle progression in mammalian cells by gamma-tubulin-mediated microtubule nucleation","volume":"84","author":"Zhou","year":"2002","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0006","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/jcp.22077","article-title":"Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines","volume":"223","author":"Caracciolo","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0007","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4161\/cbt.9.1.10451","article-title":"Delocalization of gamma-tubulin due to increased solubility in human breast cancer cell lines","volume":"9","author":"Cho","year":"2010","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0008","first-page":"1183","article-title":"Overexpression of \u03b3-tubulin in non-small cell lung cancer","volume":"27","author":"Maounis","year":"2012","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0009","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1479-5876-11-77","article-title":"Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma","volume":"11","author":"Dementyeva","year":"2013","journal-title":"J Transl Med"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0010","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1349-7006.2008.01075.x","article-title":"Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast","volume":"100","author":"Niu","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0011","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/01.jnen.0000229235.20995.6e","article-title":"Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines","volume":"65","author":"Katsetos","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0012","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ng.2613","article-title":"Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly","volume":"45","author":"Poirier","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0013","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1038\/s41467-019-10081-8","article-title":"TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis","volume":"10","author":"Ivanova","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0014","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12032-023-01966-2","article-title":"Upregulation of TUBG1 expression promotes hepatocellular carcinoma development","volume":"40","author":"Wang","year":"2023","journal-title":"Med Oncol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0015","doi-asserted-by":"crossref","first-page":"e14415","DOI":"10.7717\/peerj.14415","article-title":"Upregulated TUBG1 expression is correlated with poor prognosis in hepatocellular carcinoma","volume":"10","author":"Zhang","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0016","doi-asserted-by":"crossref","first-page":"9227","DOI":"10.1038\/s41598-018-27521-y","article-title":"Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets","volume":"8","author":"Nagy","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0017","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells","volume":"77","author":"Li","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0018","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1093\/bioinformatics\/btz210","article-title":"TISIDB: an integrated repository portal for tumor-immune system interactions","volume":"35","author":"Ru","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0019","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1200\/JCO.2007.12.9791","article-title":"How to build and interpret a nomogram for cancer prognosis","volume":"26","author":"Iasonos","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0020","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3390\/ijms18020405","article-title":"Tumor microenvironment, a paradigm in hepatocellular carcinoma progression and therapy","volume":"18","author":"Tahmasebi Birgani","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0021","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s40425-019-0749-z","article-title":"Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response","volume":"7","author":"Keenan","year":"2019","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0022","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1634\/theoncologist.2019-IO-S1-s01","article-title":"Immune checkpoint inhibitors in hepatocellular carcinoma: opportunities and challenges","volume":"24","author":"Liu","year":"2019","journal-title":"Oncologist"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0023","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1096\/fj.11-187484","article-title":"Nuclear localization of \u03b3-tubulin affects E2F transcriptional activity and S-phase progression","volume":"25","author":"H\u00f6\u00f6g","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0024","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/jcb.21195","article-title":"Centrosomal localization of DNA damage checkpoint proteins","volume":"101","author":"Zhang","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0025","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/excr.2000.4800","article-title":"p53 localizes to the centrosomes and spindles of mitotic cells in the embryonic chick epiblast, human cell lines, and a human primary culture: An immunofluorescence study","volume":"256","author":"Morris","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0026","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.fct.2009.12.028","article-title":"Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells","volume":"48","author":"Choi","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0027","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1128\/MCB.22.6.1834-1843.2002","article-title":"Hypoxia links ATR and p53 through replication arrest","volume":"22","author":"Hammond","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0028","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.3390\/ijms18112393","article-title":"Dynamic reorganization of the cytoskeleton during apoptosis: the two coffins hypothesis","volume":"18","author":"Povea-Cabello","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0029","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1142\/S0192415X1850009X","article-title":"Protective effect of safflower seed on cisplatin-induced renal damage in mice via oxidative stress and apoptosis-mediated pathways","volume":"46","author":"Park","year":"2018","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0030","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1470-2045(16)30631-3","article-title":"Tumour-infiltrating lymphocytes in advanced HER2-positive breast cancer treated with pertuzumab or placebo in addition to trastuzumab and docetaxel: a retrospective analysis of the CLEOPATRA study","volume":"18","author":"Luen","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0031","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1093\/annonc\/mdz395","article-title":"Prognostic value of tumor-infiltrating lymphocytes in patients with early-stage triple-negative breast cancers (TNBC) who did not receive adjuvant chemotherapy","volume":"30","author":"Park","year":"2019","journal-title":"Ann Oncol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0032","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nature13954","article-title":"PD-1 blockade induces responses by inhibiting adaptive immune resistance","volume":"515","author":"Tumeh","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0033","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijsu.2020.10.004","article-title":"Expression and prognostic roles of PABPC1 in hepatocellular carcinoma","volume":"84","author":"YuFeng","year":"2020","journal-title":"Int J Surg"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0034","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/jcmm.16181","article-title":"Development and validation of a CTNNB1-associated metabolic prognostic model for hepatocellular carcinoma","volume":"25","author":"Huo","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0035","doi-asserted-by":"crossref","first-page":"76S","DOI":"10.1177\/0963689719893950","article-title":"Screening hub genes as prognostic biomarkers of hepatocellular carcinoma by bioinformatics analysis","volume":"28","author":"Zhou","year":"2019","journal-title":"Cell Transplant"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0036","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12967-020-02255-6","article-title":"Development and validation of a novel immune-related prognostic model in hepatocellular carcinoma","volume":"18","author":"Wang","year":"2020","journal-title":"J Transl Med"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0037","doi-asserted-by":"crossref","first-page":"12107","DOI":"10.1111\/jcmm.15852","article-title":"EPDR1 correlates with immune cell infiltration in hepatocellular carcinoma and can be used as a prognostic biomarker","volume":"24","author":"Chen","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0038","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3389\/fimmu.2019.01078","article-title":"Cell adhesion molecules and their roles and regulation in the immune and tumor microenvironment","volume":"10","author":"Harjunp\u00e4\u00e4","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0039","first-page":"1158","article-title":"Characterization of hepatocellular carcinoma cell lines based on cell adhesion molecules","volume":"29","author":"Jung","year":"2012","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0040","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jhep.2015.04.018","article-title":"Curcumin effectively inhibits oncogenic NF-\u03baB signaling and restrains stemness features in liver cancer","volume":"63","author":"Marquardt","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0041","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/annonc\/mdn054","article-title":"A clinical study assessing the tolerability and biological effects of infliximab, a TNF-alpha inhibitor, in patients with advanced cancer","volume":"19","author":"Brown","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0042","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.cell.2017.08.004","article-title":"NF-\u03baB c-Rel is crucial for the regulatory T cell immune checkpoint in cancer","volume":"170","author":"Grinberg-Bleyer","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0043","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.1158\/0008-5472.CAN-12-4174","article-title":"OX40 is a potent immune-stimulating target in late-stage cancer patients","volume":"73","author":"Curti","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0044","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00262-020-02501-2","article-title":"Development and characterization of a novel anti-OX40 antibody for potent immune activation","volume":"69","author":"Kuang","year":"2020","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0045","article-title":"KPNA2-associated immune analyses highlight the dysregulation and prognostic effects of GRB2, NRAS, and their RNA-binding proteins in hepatocellular carcinoma","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Genet"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0046","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3390\/cancers13051055","article-title":"Silencing CDCA8 suppresses hepatocellular carcinoma growth and stemness via restoration of ATF3 tumor suppressor and inactivation of AKT\/\u03b2-catenin signaling","volume":"13","author":"Jeon","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0047","first-page":"2222","article-title":"Tumor\u2011suppressive microRNA\u2011223 targets WDR62 directly in bladder cancer","volume":"54","author":"Sugita","year":"2019","journal-title":"Int J Oncol"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0048","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/mc.22647","article-title":"WDR62 overexpression is associated with a poor prognosis in patients with lung adenocarcinoma","volume":"56","author":"Shinmura","year":"2017","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0049","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1757-2215-6-55","article-title":"Overexpression of WDR62 is associated with centrosome amplification in human ovarian cancer","volume":"6","author":"Zhang","year":"2013","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0050","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9940274","article-title":"Systematic analysis of the oncogenic role of WDR62 in human tumors","volume":"2021","author":"Bu","year":"2021","journal-title":"Dis Markers"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0051","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/ijc.23968","article-title":"TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance","volume":"124","author":"Wong","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.hbpd.2023.09.004_bib0052","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4612158","article-title":"CCNB2, TOP2A, and ASPM reflect the prognosis of hepatocellular carcinoma, as determined by weighted gene coexpression network analysis","volume":"2020","author":"Zeng","year":"2020","journal-title":"Biomed Res Int"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387223001741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387223001741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:44:28Z","timestamp":1761493468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387223001741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1499387223001741"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2023.09.004","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TuBG1 promotes hepatocellular carcinoma via ATR\/P53-apoptosis and cycling pathways","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2023.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}