{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:45:16Z","timestamp":1786787116095,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010571","name":"Bundesministerium f\u00fcr Bildung und Forschung Dienststelle Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ZX1903A"],"award-info":[{"award-number":["01ZX1903A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.hbpd.2024.06.001","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T07:01:57Z","timestamp":1717484517000},"page":"628-637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of triggers of senescence and senolysis in murine pancreatic cancer cells"],"prefix":"10.1016","volume":"23","author":[{"given":"Denis","family":"Revskij","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Woitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"K\u00f6lle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Umst\u00e4tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Zechner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiz M","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Fuellen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jaster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2024.06.001_bib0001","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular senescence: defining a path forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0002","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.645593","article-title":"Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype","volume":"9","author":"Kumari","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0004","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s13046-022-02555-3","article-title":"Cellular senescence in cancer: clinical detection and prognostic implications","volume":"41","author":"Domen","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0005","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.trecan.2016.10.001","article-title":"SASP: tumor suppressor or promoter?","volume":"2","author":"Rao","year":"2016","journal-title":"Yes! Trends Cancer"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0006","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41568-022-00450-9","article-title":"Exploiting senescence for the treatment of cancer","volume":"22","author":"Wang","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0007","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/febs.16350","article-title":"Targeting cellular senescence with senotherapeutics: senolytics and senomorphics","volume":"290","author":"Zhang","year":"2023","journal-title":"FEBS J"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0008","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acel.12445","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors","volume":"15","author":"Zhu","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0009","doi-asserted-by":"crossref","first-page":"955","DOI":"10.18632\/aging.101202","article-title":"New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463","volume":"9","author":"Zhu","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0010","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3390\/ijms23010254","article-title":"Pancreatic cancer and cellular senescence: tumor microenvironment under the spotlight","volume":"23","author":"Cortesi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0011","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1016\/j.cell.2021.07.028","article-title":"Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer","volume":"184","author":"Ruscetti","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0012","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s43556-023-00116-4","article-title":"Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy","volume":"4","author":"Jaber","year":"2023","journal-title":"Mol Biomed"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0013","first-page":"717","article-title":"Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL\/6 mice","volume":"44","author":"Corbett","year":"1984","journal-title":"Cancer Res"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0014","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4161\/cbt.8.5.7740","article-title":"Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide","volume":"8","author":"Sato","year":"2009","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0015","doi-asserted-by":"crossref","first-page":"e3291","DOI":"10.1002\/jgm.3291","article-title":"The lncRNA MEG3\/miR-16-5p\/VGLL4 regulatory axis is involved in etoposide-induced senescence of tumor cells","volume":"23","author":"Tao","year":"2021","journal-title":"J Gene Med"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0016","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.3390\/cells10061466","article-title":"Etoposide triggers cellular senescence by inducing multiple centrosomes and primary cilia in adrenocortical tumor cells","volume":"10","author":"Teng","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0017","first-page":"883","article-title":"Cellular senescence in ionizing radiation (Review)","volume":"42","author":"Chen","year":"2019","journal-title":"Oncol Rep"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0018","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.3390\/ijms23084168","article-title":"Cellular senescence: molecular targets, biomarkers, and senolytic drugs","volume":"23","author":"Kudlova","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0019","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3390\/biom9080341","article-title":"The TGF-\u03b21\/p53\/PAI-1 signaling axis in vascular senescence: role of caveolin-1","volume":"9","author":"Samarakoon","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/cdd.2017.187","article-title":"Relevance of the p53-MDM2 axis to aging","volume":"25","author":"Wu","year":"2018","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0021","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.3390\/cells11121966","article-title":"The senescence markers p16INK4A, p14ARF\/p19ARF, and p21 in organ development and homeostasis","volume":"11","author":"Wagner","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0022","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-1-4939-2522-3_10","article-title":"Measuring autophagy in stressed cells","volume":"1292","author":"Sharifi","year":"2015","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0023","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/gut.51.4.579","article-title":"Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells","volume":"51","author":"Jaster","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0024","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cellsig.2009.09.019","article-title":"Mathematical modelling of interferon-gamma signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activity","volume":"22","author":"Rateitschak","year":"2010","journal-title":"Cell Signal"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0025","doi-asserted-by":"crossref","first-page":"56395","DOI":"10.18632\/oncotarget.10892","article-title":"Intratumoral heterogeneity of the therapeutical response to gemcitabine and metformin","volume":"7","author":"Zechner","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0026","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.hbpd.2022.12.003","article-title":"Uncoupling protein 2 deficiency of non-cancerous tissues inhibits the progression of pancreatic cancer in mice","volume":"22","author":"Revskij","year":"2023","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0027","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00109-010-0623-4","article-title":"Role of hypoxia-inducible transcription factor 1alpha for progression and chemosensitivity of murine hepatocellular carcinoma","volume":"88","author":"Daskalow","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0028","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41388-018-0436-4","article-title":"Mouse ER+\/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents","volume":"38","author":"Stratikopoulos","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0029","first-page":"613","article-title":"Loss of histone H2AX increases sensitivity of immortalized mouse fibroblasts to the topoisomerase II inhibitor etoposide","volume":"33","author":"Don\u00e0","year":"2008","journal-title":"Int J Oncol"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255585","article-title":"Anti-HER2 monoclonal antibodies intensify the susceptibility of human gastric cancer cells to etoposide by promoting apoptosis, but not autophagy","volume":"16","author":"Gornowicz","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0031","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s13577-012-0043-6","article-title":"Effects of etoposide on the proliferation of hexaploid H1 (ES) cells","volume":"25","author":"Fujikawa-Yamamoto","year":"2012","journal-title":"Hum Cell"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0032","first-page":"vdab148","article-title":"Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax","volume":"3","author":"Yamamoto","year":"2021","journal-title":"Neurooncol Adv"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0033","doi-asserted-by":"crossref","first-page":"e368","DOI":"10.1038\/bcj.2015.88","article-title":"Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199)","volume":"5","author":"Phillips","year":"2015","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0034","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.247379","article-title":"Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy","volume":"133","author":"Townley","year":"2020","journal-title":"J Cell Sci"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0035","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.biocel.2004.05.009","article-title":"LC3 conjugation system in mammalian autophagy","volume":"36","author":"Tanida","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0036","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1161\/ATVBAHA.117.309451","article-title":"Plasminogen activator inhibitor-1 is a marker and a mediator of senescence","volume":"37","author":"Vaughan","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0037","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1158\/0008-5472.CAN-07-5836","article-title":"ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor","volume":"68","author":"Tse","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0038","doi-asserted-by":"crossref","first-page":"808","DOI":"10.4161\/auto.23922","article-title":"Autophagy and senescence: a partnership in search of definition","volume":"9","author":"Gewirtz","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0039","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/ijmm.2016.2620","article-title":"FGFR inhibitors: effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)","volume":"38","author":"Katoh","year":"2016","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0040","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.3390\/cancers12102976","article-title":"FGFR4 inhibitor BLU9931 attenuates pancreatic cancer cell proliferation and invasion while inducing senescence: evidence for senolytic therapy potential in pancreatic cancer","volume":"12","author":"Sasaki","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.hbpd.2024.06.001_bib0041","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.220171","article-title":"From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs","volume":"12","author":"L'H\u00f4te","year":"2022","journal-title":"Open Biol"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387224000754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387224000754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T14:53:08Z","timestamp":1733496788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387224000754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S1499387224000754"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2024.06.001","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of triggers of senescence and senolysis in murine pancreatic cancer cells","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2024.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}