{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:54:04Z","timestamp":1777974844730,"version":"3.51.4"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.hbpd.2024.09.003","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T21:47:55Z","timestamp":1725745675000},"page":"92-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fibrotic liver extracellular matrix induces cancerous phenotype in biomimetic micro-tissues of hepatocellular carcinoma model"],"prefix":"10.1016","volume":"24","author":[{"given":"Kosar","family":"Nouri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Piryaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homeyra","family":"Seydi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Zarkesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Ghoytasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahare","family":"Shokouhian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustapha","family":"Najimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massoud","family":"Vosough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2024.09.003_bib0001","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0002","unstructured":"Global cancer observatory: cancer tomorrow (version 1.1). lyon, france: international agency for research on cancer [Accessed 2024 August 2]. Available from: https:\/\/gco.iarc.fr\/tomorrow\/en\/dataviz\/isotype."},{"key":"10.1016\/j.hbpd.2024.09.003_bib0003","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-pathol-052016-100322","article-title":"The role of cancer-associated fibroblasts and fibrosis in liver cancer","volume":"12","author":"Affo","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0004","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.3390\/ijms20071723","article-title":"The role of fibrosis and liver-associated fibroblasts in the pathogenesis of hepatocellular carcinoma","volume":"20","author":"Baglieri","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0005","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1535370219898141","article-title":"Mechanisms of liver fibrosis and its role in liver cancer","volume":"245","author":"Dhar","year":"2020","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0006","doi-asserted-by":"crossref","first-page":"729","DOI":"10.21037\/atm-20-4354","article-title":"Non-alcoholic fatty liver disease (NAFLD)\/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention","volume":"9","author":"Tacke","year":"2021","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0007","doi-asserted-by":"crossref","first-page":"G807","DOI":"10.1152\/ajpgi.00447.2014","article-title":"Novel insights into the function and dynamics of extracellular matrix in liver fibrosis","volume":"308","author":"Karsdal","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0008","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/apt.15773","article-title":"Review article: the signalling and functional role of the extracellular matrix in the development of liver fibrosis","volume":"52","author":"Villesen","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0009","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/adt.2012.474","article-title":"Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure","volume":"11","author":"Karsdal","year":"2013","journal-title":"Assay Drug Dev Technol"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0010","article-title":"The extracellular matrix in hepatocellular carcinoma: mechanisms and therapeutic vulnerability","volume":"4","author":"Roy","year":"2023","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0011","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.biomaterials.2016.11.034","article-title":"Recapitulating the human tumor microenvironment: colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth","volume":"116","author":"Romero-L\u00f3pez","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0012","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41598-020-80019-4","article-title":"Generation of proliferating human adult hepatocytes using optimized 3D culture conditions","volume":"11","author":"Rose","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0013","first-page":"310","article-title":"Construction and application of liver cancer models in vitro","volume":"3","author":"Shao","year":"2022","journal-title":"Eng Regenerat"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0014","doi-asserted-by":"crossref","first-page":"9827","DOI":"10.1038\/s41598-017-09391-y","article-title":"A novel three-dimensional culture system maintaining the physiological extracellular matrix of fibrotic model livers accelerates progression of hepatocellular carcinoma cells","volume":"7","author":"Miyauchi","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0015","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s42242-021-00137-4","article-title":"Biofabrication of size-controlled liver microtissues incorporated with ECM-derived microparticles to prolong hepatocyte function","volume":"4","author":"Heydari","year":"2021","journal-title":"Bio-des Manuf"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0016","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3390\/cells10061274","article-title":"Tissue-specific microparticles improve organoid microenvironment for efficient maturation of pluripotent stem-cell-derived hepatocytes","volume":"10","author":"Zahmatkesh","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0017","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1172\/JCI107470","article-title":"Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria","volume":"52","author":"Jaffe","year":"1973","journal-title":"J Clin Invest"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0018","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1158\/0008-5472.CAN-17-3009","article-title":"Twist1 regulates vimentin through Cul2 circular RNA to promote EMT in hepatocellular carcinoma","volume":"78","author":"Meng","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0019","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3892\/etm.2021.9740","article-title":"Integrin \u03b17 knockdown suppresses cell proliferation, migration, invasion and EMT in hepatocellular carcinoma","volume":"21","author":"Wu","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.779748","article-title":"Ribosomal protein L23 drives the metastasis of hepatocellular carcinoma via upregulating MMP9","volume":"11","author":"Yang","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0021","first-page":"1198","article-title":"The effect of nanomicelle curcumin, sorafenib, and combination of the two on the cyclin D1 gene expression of the hepatocellular carcinoma cell line (HUH7)","volume":"22","author":"Hosseini","year":"2019","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0022","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/cas.15686","article-title":"HNF4\u03b1 is possibly the missing link between epithelial-mesenchymal transition and Warburg effect during hepatocarcinogenesis","volume":"114","author":"Shokouhian","year":"2023","journal-title":"Cancer Sci"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0023","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/s41467-021-21828-7","article-title":"RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-\u03b22","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0024","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.3390\/biomedicines10112686","article-title":"The role of CYP3A in health and disease","volume":"10","author":"Klyushova","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0025","article-title":"UCHL3 promotes hepatocellular carcinoma cell migration by de-ubiquitinating and stabilizing Vimentin","volume":"13","author":"Ma","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0026","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.3748\/wjg.v24.i39.4436","article-title":"Carcinogenesis on the background of liver fibrosis: implications for the management of hepatocellular cancer","volume":"24","author":"O'Rourke","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0027","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s40425-019-0749-z","article-title":"Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response","volume":"7","author":"Keenan","year":"2019","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0028","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41419-021-03443-y","article-title":"Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis","volume":"12","author":"Wu","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0029","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12935-022-02662-3","article-title":"Three-dimensional (3D) cell culture: a valuable step in advancing treatments for human hepatocellular carcinoma","volume":"22","author":"Khafaga","year":"2022","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102264","article-title":"Protocol for generation of multicellular spheroids through reduced gravity","volume":"4","author":"Zinn","year":"2023","journal-title":"STAR Protoc"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0031","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.3390\/ijms24076248","article-title":"Three-dimensional cell co-culture liver models and their applications in pharmaceutical research","volume":"24","author":"Ma","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.730008","article-title":"Human three-dimensional hepatic models: cell type variety and corresponding applications","volume":"9","author":"Xu","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0033","doi-asserted-by":"crossref","first-page":"8436","DOI":"10.1016\/j.biomaterials.2011.07.056","article-title":"Changes of chondrocyte expression profiles in human MSC aggregates in the presence of PEG microspheres and TGF-\u03b23","volume":"32","author":"Ravindran","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0034","doi-asserted-by":"crossref","first-page":"356","DOI":"10.5483\/BMBRep.2021.54.7.059","article-title":"Biomaterials-assisted spheroid engineering for regenerative therapy","volume":"54","author":"Lee","year":"2021","journal-title":"BMB Rep"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0035","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202000608","article-title":"Engineering multi-cellular spheroids for tissue engineering and regenerative medicine","volume":"9","author":"Kim","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0036","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ab145d","article-title":"Self-organization of hepatocyte morphogenesis depending on the size of collagen microbeads relative to hepatocytes","volume":"11","author":"Ajoudanian","year":"2019","journal-title":"Biofabrication"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0037","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2121-6-8","article-title":"Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells","volume":"6","author":"Rahman","year":"2005","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0038","doi-asserted-by":"crossref","first-page":"27398","DOI":"10.1038\/srep27398","article-title":"The alterations in the extracellular matrix composition guide the repair of damaged liver tissue","volume":"6","author":"Klaas","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0039","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.3390\/ijms20112792","article-title":"Fibronectin promotes cell growth and migration in human renal cell carcinoma Cells","volume":"20","author":"Ou","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0040","doi-asserted-by":"crossref","first-page":"17177","DOI":"10.1073\/pnas.2002898117","article-title":"A negative reciprocal regulatory axis between cyclin D1 and HNF4\u03b1 modulates cell cycle progression and metabolism in the liver","volume":"117","author":"Wu","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0041","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.ajpath.2021.05.019","article-title":"Nondegradable collagen increases liver fibrosis but not hepatocellular carcinoma in mice","volume":"191","author":"Baglieri","year":"2021","journal-title":"Am J Pathol"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0042","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/hep.30405","article-title":"Hepatocyte nuclear factor 4 alpha activation is essential for termination of liver regeneration in mice","volume":"70","author":"Huck","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0043","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/hep.22510","article-title":"Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene","volume":"48","author":"Yin","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0044","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s12276-020-00551-1","article-title":"Hepatocyte nuclear factor 4\u03b1 and cancer-related cell signaling pathways: a promising insight into cancer treatment","volume":"53","author":"Lv","year":"2021","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0045","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1172\/JCI73137","article-title":"Resetting the transcription factor network reverses terminal chronic hepatic failure","volume":"125","author":"Nishikawa","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0046","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/gut.2008.174904","article-title":"Hepatocyte nuclear factor 4alpha attenuates hepatic fibrosis in rats","volume":"59","author":"Yue","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0047","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.3390\/cells9102185","article-title":"Control of cell identity by the nuclear receptor HNF4 in organ pathophysiology","volume":"9","author":"Dubois","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0048","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.jhep.2021.08.011","article-title":"Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model","volume":"75","author":"Yang","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0049","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3390\/cancers11101407","article-title":"Hepatic stress response in HCV infection promotes STAT3-mediated inhibition of HNF4A-miR-122 feedback loop in liver fibrosis and cancer progression","volume":"11","author":"Aydin","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0050","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1053\/j.gastro.2020.12.015","article-title":"Hepatic stellate cells in hepatocellular carcinoma promote tumor growth via growth differentiation factor 15 production","volume":"160","author":"Myojin","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0051","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.celrep.2016.04.019","article-title":"Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met\/FRA1\/HEY1 signaling","volume":"15","author":"Lau","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0052","doi-asserted-by":"crossref","first-page":"36750","DOI":"10.1038\/srep36750","article-title":"Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids","volume":"6","author":"Song","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0053","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.omtn.2019.10.044","article-title":"Liver activation of hepatocellular nuclear factor-4\u03b1 by small activating RNA rescues dyslipidemia and improves metabolic profile","volume":"19","author":"Huang","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0054","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3390\/cancers14020444","article-title":"Clinical significance of the duality of Wnt\/\u03b2-catenin signaling in human hepatocellular carcinoma","volume":"14","author":"Aoki","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.reth.2021.03.002","article-title":"Liver cancer stem cells: recent progress in basic and clinical research","volume":"17","author":"Yamashita","year":"2021","journal-title":"Regen Ther"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0056","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2147\/JHC.S275008","article-title":"Cross-linked multimeric pro-peptides of type III collagen (PC3X) in hepatocellular carcinoma - a biomarker that provides additional prognostic value in AFP positive patients","volume":"7","author":"Jensen","year":"2020","journal-title":"J Hepatocell Carcinoma"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0057","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3390\/cancers11060786","article-title":"Collagen 1A1 (COL1A1) is a reliable biomarker and putative therapeutic target for hepatocellular carcinogenesis and metastasis","volume":"11","author":"Ma","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.hbpd.2024.09.003_bib0058","article-title":"Cellular origins of regenerating liver and hepatocellular carcinoma","volume":"4","author":"Holczbauer","year":"2021","journal-title":"JHEP Rep"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387224001152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387224001152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T22:57:41Z","timestamp":1740610661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387224001152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1499387224001152"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2024.09.003","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibrotic liver extracellular matrix induces cancerous phenotype in biomimetic micro-tissues of hepatocellular carcinoma model","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2024.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}