{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:07:17Z","timestamp":1786990037613,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2407402"],"award-info":[{"award-number":["2022YFC2407402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["S2016-098-02"],"award-info":[{"award-number":["S2016-098-02"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","award":["2023QNRC001"],"award-info":[{"award-number":["2023QNRC001"]}],"id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020437","name":"Beijing Association for Science and Technology","doi-asserted-by":"publisher","award":["BYESS2024001"],"award-info":[{"award-number":["BYESS2024001"]}],"id":[{"id":"10.13039\/501100020437","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.hbpd.2025.04.008","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:42:51Z","timestamp":1746186171000},"page":"543-549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["New-onset diabetes worsens prognosis of patients with pancreatic ductal adenocarcinoma after R0 resection: A multicenter study"],"prefix":"10.1016","volume":"24","author":[{"given":"Peng-Jiong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Peng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Xing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2025.04.008_bib0001","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0002","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0003","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/jama.2019.6190","article-title":"Screening for pancreatic cancer: updated evidence report and systematic review for the US Preventive Services Task Force","volume":"322","author":"Henrikson","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0004","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/SLA.0000000000004093","article-title":"Detection, treatment, and survival of pancreatic cancer recurrence in the Netherlands: a nationwide analysis","volume":"275","author":"Daamen","year":"2022","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0005","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1245\/s10434-018-6558-7","article-title":"Implications of the pattern of disease recurrence on survival following pancreatectomy for pancreatic ductal adenocarcinoma","volume":"25","author":"Groot","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0006","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.surg.2020.06.042","article-title":"Recurrence patterns and postrecurrence survival after curative intent resection for pancreatic ductal adenocarcinoma","volume":"169","author":"Kolbeinsson","year":"2021","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0007","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s13046-018-0963-4","article-title":"Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting","volume":"37","author":"Pothuraju","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0008","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMp2029646","article-title":"Solving population-wide obesity - progress and future prospects","volume":"383","author":"Kumanyika","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0009","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/jama.2019.10232","article-title":"Screening for pancreatic cancer: US Preventive Services Task Force reaffirmation recommendation statement","volume":"322","author":"Owens","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0010","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1053\/j.gastro.2019.01.039","article-title":"Phases of metabolic and soft tissue changes in months preceding a diagnosis of pancreatic ductal adenocarcinoma","volume":"156","author":"Sah","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0011","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/jnci\/djy090","article-title":"Pancreatic cancer following incident diabetes in African Americans and Latinos: the multiethnic cohort","volume":"111","author":"Setiawan","year":"2019","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0012","first-page":"319","article-title":"Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity\/BMI through causal inference and mediation analyses","volume":"70","author":"Molina-Montes","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0013","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2337\/diaclin.34.1.3","article-title":"Standards of medical care in diabetes-2016 abridged for primary care providers","volume":"34","author":"Association","year":"2016","journal-title":"Clin Diabetes"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0014","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/MPA.0000000000001099","article-title":"Adverse oncologic impact of new-onset diabetes mellitus on recurrence in resected pancreatic ductal adenocarcinoma: a comparison with long-standing and non-diabetes mellitus patients","volume":"47","author":"Lee","year":"2018","journal-title":"Pancreas"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0015","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1245\/s10434-009-0789-6","article-title":"Preoperative diabetes mellitus and long-term survival after resection of pancreatic adenocarcinoma","volume":"17","author":"Chu","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0016","first-page":"12","article-title":"Clinical guidelines for prevention and treatment of type 2 diabetes mellitus in the elderly in China (2022 edition)","volume":"61","year":"2022","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0017","doi-asserted-by":"crossref","first-page":"485","DOI":"10.5833\/jjgs.2017.0181","article-title":"Predicting postoperative pancreatic fistula after distal pancreatectomy by measuring the CT value ratio of future pancreas remnant to spleen (P\/S Ratio) in preoperative unenhanced CT images","volume":"52","author":"Mori","year":"2019","journal-title":"Jpn J Gastroenterol Surg"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0018","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.surg.2016.11.014","article-title":"The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after","volume":"161","author":"Bassi","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0019","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.surg.2007.05.005","article-title":"Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS)","volume":"142","author":"Wente","year":"2007","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0020","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.surg.2011.12.028","article-title":"Bile leakage after hepatobiliary and pancreatic surgery: is the ISGLS definition too simple?","volume":"151","author":"Sonbare","year":"2012","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0021","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1245\/s10434-017-6025-x","article-title":"of the AJCC cancer staging manual: pancreas and hepatobiliary cancers","volume":"25","author":"Chun","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0022","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0140-6736(16)00141-0","article-title":"Pancreatic cancer","volume":"388","author":"Kamisawa","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0023","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1097\/SLA.0000000000002234","article-title":"Patterns, timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma","volume":"267","author":"Groot","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0024","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jso.24133","article-title":"Prognostic relevance of preoperative diabetes mellitus and the degree of hyperglycemia on the outcomes of resected pancreatic ductal adenocarcinoma","volume":"113","author":"Lee","year":"2016","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5190314","article-title":"Hyperglycemia promotes the epithelial-mesenchymal transition of pancreatic cancer via hydrogen peroxide","volume":"2016","author":"Li","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0026","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.3390\/cancers13205224","article-title":"Role of pancreatic stellate cell-derived exosomes in pancreatic cancer-related diabetes: a novel hypothesis","volume":"13","author":"Perera","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0027","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1186\/s12935-021-02378-w","article-title":"Metabolic syndrome related gene signature predicts the prognosis of patients with pancreatic ductal carcinoma. A novel link between metabolic dysregulation and pancreatic ductal carcinoma","volume":"21","author":"Cai","year":"2021","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0028","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1053\/j.gastro.2018.04.025","article-title":"Fasting blood glucose levels provide estimate of duration and progression of pancreatic cancer before diagnosis","volume":"155","author":"Sharma","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0029","doi-asserted-by":"crossref","first-page":"7706","DOI":"10.1111\/jcmm.15413","article-title":"The impact of obesity and diabetes mellitus on pancreatic cancer: molecular mechanisms and clinical perspectives","volume":"24","author":"Quoc Lam","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0030","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1245\/s10434-013-3415-6","article-title":"Impact of preoperative diabetes on long-term survival after curative resection of pancreatic adenocarcinoma: a systematic review and meta-analysis","volume":"21","author":"Walter","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.109860","article-title":"Pancreatic fat infiltration, \u03b2-cell function and insulin resistance: a study of the young patients with obesity","volume":"187","author":"Wen","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0032","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pan.2019.10.007","article-title":"Diabetes mellitus is associated with unfavorable pathologic features, increased postoperative mortality, and worse long-term survival in resected pancreatic cancer","volume":"20","author":"Hank","year":"2020","journal-title":"Pancreatology"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0033","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.hpb.2020.07.001","article-title":"Impact of enhanced recovery after surgery protocol on pancreaticoduodenectomy: a meta-analysis of non-randomized and randomized controlled trials","volume":"22","author":"Wang","year":"2020","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0034","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.3748\/wjg.v18.i29.3787","article-title":"Tight glycemic control using an artificial endocrine pancreas may play an important role in preventing infection after pancreatic resection","volume":"18","author":"Hanazaki","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0035","doi-asserted-by":"crossref","first-page":"7532","DOI":"10.3390\/jcm12247532","article-title":"Incidence of diabetes mellitus and its impact on outcomes in patients undergoing surgical pancreatectomy for non-malignant and malignant pancreatobiliary diseases-a retrospective analysis","volume":"12","author":"Schranz","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0036","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1200\/JCO.2014.57.5688","article-title":"Survival among patients with pancreatic cancer and long-standing or recent-onset diabetes mellitus","volume":"33","author":"Yuan","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0037","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/cncr.27731","article-title":"Type 2 diabetes mellitus and survival in pancreatic adenocarcinoma: a retrospective cohort study","volume":"119","author":"Hwang","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0038","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1053\/j.gastro.2018.05.023","article-title":"Model to determine risk of pancreatic cancer in patients with new-onset diabetes","volume":"155","author":"Sharma","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0039","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/j.gastro.2016.11.046","article-title":"A clinical prediction model to assess risk for pancreatic cancer among patients with new-onset diabetes","volume":"152","author":"Boursi","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0040","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1158\/0008-5472.CAN-17-0015","article-title":"Posttranscriptional upregulation of IDH1 by HuR establishes a powerful survival phenotype in pancreatic cancer cells","volume":"77","author":"Zarei","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0041","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.2337\/db16-1477","article-title":"Diabetes, pancreatogenic diabetes, and pancreatic cancer","volume":"66","author":"Andersen","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188844","article-title":"Obesity, diabetes mellitus, and pancreatic carcinogenesis: correlations, prevention, and diagnostic implications","volume":"1878","author":"Ruze","year":"2023","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0043","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.3748\/wjg.v27.i30.4939","article-title":"Diabetes and pancreatic cancer: exploring the two-way traffic","volume":"27","author":"Roy","year":"2021","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0044","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s13402-019-00428-0","article-title":"Leptin-induced signaling pathways in cancer cell migration and invasion","volume":"42","author":"Ghasemi","year":"2019","journal-title":"Cell Oncol (Dordr)"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0045","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1158\/2159-8290.CD-15-1177","article-title":"Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy","volume":"6","author":"Incio","year":"2016","journal-title":"Cancer Discov"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0046","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.hpb.2021.04.004","article-title":"Recurrence after surgical resection of pancreatic cancer: the importance of postoperative complications beyond tumor biology","volume":"23","author":"Crippa","year":"2021","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.hbpd.2025.04.008_bib0047","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.ejso.2018.03.024","article-title":"Severe postoperative complications decrease overall and disease free survival in pancreatic ductal adenocarcinoma after pancreaticoduodenectomy","volume":"44","author":"Lubrano","year":"2018","journal-title":"Eur J Surg Oncol"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387225000888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387225000888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:51:08Z","timestamp":1758703868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387225000888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1499387225000888"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2025.04.008","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New-onset diabetes worsens prognosis of patients with pancreatic ductal adenocarcinoma after R0 resection: A multicenter study","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2025.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}