{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:54:35Z","timestamp":1789768475571,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3603100"],"award-info":[{"award-number":["2023YFC3603100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3603105"],"award-info":[{"award-number":["2023YFC3603105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022C03076-4"],"award-info":[{"award-number":["2022C03076-4"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary &amp; Pancreatic Diseases International"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.hbpd.2025.06.008","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T03:28:44Z","timestamp":1751426924000},"page":"527-534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Baicalin and its nanoliposome ameliorate diquat-induced liver injury by promoting PINK1\/Parkin-dependent mitophagy"],"prefix":"10.1016","volume":"24","author":[{"given":"Han-Ying","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Qiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2025.06.008_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101609","article-title":"Lethal diquat poisoning manifests as acute central nervous system injury and circulatory failure: a retrospective cohort study of 50 cases","volume":"52","author":"Zhou","year":"2022","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117188","article-title":"Diquat exacerbates oxidative stress and neuroinflammation by blocking the autophagic flux of microglia in the hippocampus","volume":"286","author":"Wang","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0003","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2374013","article-title":"Fractionated plasma separation and adsorption integrated with continuous veno-venous hemofiltration in patients with acute bipyridine herbicide poisoning","volume":"46","author":"Dong","year":"2024","journal-title":"Ren Fail"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0004","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.aninu.2023.09.001","article-title":"Plant-derived squalene supplementation improves growth performance and alleviates acute oxidative stress-induced growth retardation and intestinal damage in piglets","volume":"15","author":"Tian","year":"2023","journal-title":"Anim Nutr"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0005","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s00253-021-11111-6","article-title":"Pediococcus pentosaceus ZJUAF-4 relieves oxidative stress and restores the gut microbiota in diquat-induced intestinal injury","volume":"105","author":"Hao","year":"2021","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116661","article-title":"Baicalin protects against hepatocyte injury caused by aflatoxin B1 via the TP53-related ferroptosis pathway","volume":"281","author":"Zhang","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0007","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41401-024-01376-8","article-title":"Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages","volume":"46","author":"You","year":"2025","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0008","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1007\/s11418-024-01814-1","article-title":"Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content","volume":"78","author":"Oshima","year":"2024","journal-title":"J Nat Med"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106208","article-title":"Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice","volume":"80","author":"Liu","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0010","doi-asserted-by":"crossref","first-page":"41289","DOI":"10.1021\/acsomega.4c03356","article-title":"Preparation of baicalin liposomes using microfluidic technology and evaluation of their antitumor activity by a zebrafish model","volume":"9","author":"Gu","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0011","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1021\/acs.molpharmaceut.3c00903","article-title":"A multifunctional liposome for synergistic chemotherapy with ferroptosis activation of triple-negative breast cancer","volume":"21","author":"Chai","year":"2024","journal-title":"Mol Pharm"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114240","article-title":"Brain targeted borneol-baicalin liposome improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury via inhibiting HIF-1\u03b1\/VEGF\/eNOS\/NO signal pathway","volume":"160","author":"Long","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0013","first-page":"1134","article-title":"Active herbal ingredients and drug delivery design for tumor therapy: a review","volume":"22","author":"Han","year":"2024","journal-title":"Chin J Nat Med"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0014","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12989-024-00605-6","article-title":"Integrated hepatic transcriptomics and metabolomics identify Pck1 as a key factor in the broad dysregulation induced by vehicle pollutants","volume":"21","author":"Ramanathan","year":"2024","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0015","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ajpath.2024.10.022","article-title":"P46Shc inhibits mitochondrial ACAA2 thiolase, exacerbating mitochondrial injury and inflammation in aging livers","volume":"195","author":"Li","year":"2025","journal-title":"Am J Pathol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0016","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.hbpd.2021.04.010","article-title":"Mitochondria: a critical hub for hepatic stellate cells activation during chronic liver diseases","volume":"20","author":"Ezhilarasan","year":"2021","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0017","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/s41401-024-01424-3","article-title":"Nicotinamide mononucleotide protects septic hearts in mice via preventing cyclophilin F modification and lysosomal dysfunction","volume":"46","author":"Ni","year":"2025","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1491315","article-title":"JiangyaTongluo decoction ameliorates tubulointerstitial fibrosis via regulating the SIRT1\/PGC-1\u03b1\/mitophagy axis in hypertensive nephropathy","volume":"15","author":"Zhao","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0019","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.hbpd.2023.10.008","article-title":"Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N, 3-dimethylbenzamide: a case series","volume":"23","author":"Feng","year":"2024","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155296","article-title":"Baicalin ameliorates insulin resistance and regulates hepatic glucose metabolism via activating insulin signaling pathway in obese pre-diabetic mice","volume":"124","author":"Miao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0021","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1007\/s00210-024-03704-5","article-title":"Baicalin plays a protective role by regulating ferroptosis in multiple diseases","volume":"398","author":"Guo","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116832","article-title":"Baicalin ameliorates heat stress-induced hepatic injury and intestinal microecology dysbiosis in late gestational mice","volume":"283","author":"Li","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0023","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12906-023-03903-2","article-title":"Protective effects of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3\/caspase-1\/IL-1\u03b2 signaling pathway","volume":"23","author":"Guan","year":"2023","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0024","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/iub.2810","article-title":"Exosomes derived from Baicalin-pretreated bone mesenchymal stem cells improve Th17\/treg imbalance after hepatic ischemia-reperfusion via FGF21 and the JAK2\/STAT3 pathway","volume":"76","author":"Zhang","year":"2024","journal-title":"IUBMB Life"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175270","article-title":"Baicalin improved hepatic injury of NASH by regulating NRF2\/HO-1\/NRLP3 pathway","volume":"934","author":"Shi","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0026","doi-asserted-by":"crossref","DOI":"10.1177\/20587384211073397","article-title":"Protective effect of baicalin against arsenic trioxide-induced acute hepatic injury in mice through JAK2\/STAT3 signaling pathway","volume":"36","author":"He","year":"2022","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0027","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/02652048.2024.2348462","article-title":"Improving physicochemical characteristics and cytotoxicity of baicalin esters by liposome encapsulation","volume":"41","author":"Wang","year":"2024","journal-title":"J Microencapsul"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0028","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1080\/10408398.2021.1987858","article-title":"Potential micro-\/nano-encapsulation systems for improving stability and bioavailability of anthocyanins: an updated review","volume":"63","author":"Rashwan","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0029","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3390\/biomedicines10040900","article-title":"Liver-targeted nanoparticles facilitate the bioavailability and anti-HBV efficacy of baicalin in vitro and in vivo","volume":"10","author":"Xu","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/pharmaceutics12020107","article-title":"Nanoparticle-mediated dual targeting: an approach for enhanced baicalin delivery to the liver","volume":"12","author":"Ahmed","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0031","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1080\/15548627.2024.2384348","article-title":"Preserving mitochondrial homeostasis protects against drug-induced liver injury via inducing OPTN (optineurin)-dependent mitophagy","volume":"20","author":"Wang","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134855","article-title":"Selenium restored mitophagic flux to alleviate cadmium-induced hepatotoxicity by inhibiting excessive GPER1-mediated mitophagy activation","volume":"475","author":"Zhang","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167259","article-title":"Cyanidin-3-O-glucoside alleviates ethanol-induced liver injury by promoting mitophagy in a Gao-binge mouse model of alcohol-associated liver disease","volume":"1870","author":"He","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.177100","article-title":"Taxifolin attenuates hepatic ischemia-reperfusion injury by enhancing PINK1\/Parkin-mediated mitophagy","volume":"985","author":"Zhang","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156056","article-title":"Dioscin improves fatty liver hemorrhagic syndrome by promoting ER\u03b1-AMPK mediated mitophagy in laying hens","volume":"135","author":"Xing","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135979","article-title":"HSP90-regulated mitophagy can alleviate heat stress damage by inhibiting pyroptosis in the hepatocytes of Wenchang chickens","volume":"280","author":"Shi","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156053","article-title":"Shaoyao-Gancao Decoction, a famous Chinese medicine formula, protects against APAP-induced liver injury by promoting autophagy\/mitophagy","volume":"135","author":"Wu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0038","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S1499-3872(15)60348-4","article-title":"Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress","volume":"14","author":"Rocha-Santos","year":"2015","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0039","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00424-24","article-title":"The impact of HBx protein on mitochondrial dynamics and associated signaling pathways strongly depends on the hepatitis B virus genotype","volume":"98","author":"Schollmeier","year":"2024","journal-title":"J Virol"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116574","article-title":"Lactobacillus salivarius ameliorates AFB1-induced hepatotoxicity via PINK1\/parkin-mediated mitophagy in geese","volume":"280","author":"Qiu","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117066","article-title":"The role of Drp1\u2013Pink1\u2013Parkin\u2013mediated mitophagy in perfluorobutane sulfonate\u2013induced hepatocyte damage","volume":"285","author":"Feng","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.hbpd.2025.06.008_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116137","article-title":"Mitophagy protects against silver nanoparticle-induced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome","volume":"273","author":"Li","year":"2024","journal-title":"Ecotoxicol Environ Saf"}],"container-title":["Hepatobiliary &amp; Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387225001043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387225001043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T20:36:53Z","timestamp":1762547813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387225001043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1499387225001043"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2025.06.008","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalin and its nanoliposome ameliorate diquat-induced liver injury by promoting PINK1\/Parkin-dependent mitophagy","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2025.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}