{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:11:25Z","timestamp":1778818285073,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0804300\/2020YFA0804301"],"award-info":[{"award-number":["2020YFA0804300\/2020YFA0804301"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82188102"],"award-info":[{"award-number":["82188102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473461"],"award-info":[{"award-number":["82473461"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.hbpd.2025.12.009","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:31:38Z","timestamp":1765499498000},"page":"152-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor micronecrosis is a marker of poor prognosis of hepatocellular carcinoma after liver resection"],"prefix":"10.1016","volume":"25","author":[{"given":"Yang-Yang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Bin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Bo","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2025.12.009_bib0001","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0002","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1097\/SLA.0000000000001556","article-title":"A review and update of treatment options and controversies in the management of hepatocellular carcinoma","volume":"263","author":"Dhir","year":"2016","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0003","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2147\/JHC.S339707","article-title":"Albumin-bilirubin (ALBI) and monocyte to lymphocyte ratio (MLR)-based nomogram model to predict tumor recurrence of AFP-negative hepatocellular carcinoma","volume":"8","author":"Mao","year":"2021","journal-title":"J Hepatocell Carcinoma"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0004","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/SLA.0000000000000710","article-title":"Recurrence of hepatocellular cancer after resection: patterns, treatments, and prognosis","volume":"261","author":"Tabrizian","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0005","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jamcollsurg.2003.07.003","article-title":"Predictors and patterns of recurrence after resection of hepatocellular carcinoma","volume":"197","author":"Cha","year":"2003","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0006","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1007\/s00268-012-1723-9","article-title":"Long-term outcomes following aggressive management of recurrent hepatocellular carcinoma after upfront liver resection","volume":"36","author":"Tranchart","year":"2012","journal-title":"World J Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0007","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.surg.2011.12.015","article-title":"Survival in patients with recurrent hepatocellular carcinoma after primary hepatectomy: comparative effectiveness of treatment modalities","volume":"151","author":"Ho","year":"2012","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0008","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1136\/gutjnl-2019-318912","article-title":"Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas","volume":"68","author":"Zhang","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0009","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41392-021-00838-3","article-title":"Whole-genome sequencing reveals the evolutionary trajectory of HBV-related hepatocellular carcinoma early recurrence","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0010","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","article-title":"Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma","volume":"184","author":"Sun","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0011","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2217\/epi.15.23","article-title":"DNA methylation consistency implicates the primary tumor cell origin of recurrent hepatocellular carcinoma","volume":"7","author":"Zhang","year":"2015","journal-title":"Epigenomics"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0012","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ebiom.2018.12.058","article-title":"Comprehensive molecular and immunological characterization of hepatocellular carcinoma","volume":"40","author":"Shimada","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2022.106852","article-title":"Histological tumor micronecrosis in resected specimens after R0 hepatectomy for hepatocellular carcinomas is a factor in determining adjuvant TACE: a retrospective propensity score-matched study","volume":"105","author":"Wang","year":"2022","journal-title":"Int J Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0014","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1245\/s10434-020-09390-w","article-title":"Tumor necrosis impacts prognosis of patients undergoing curative-intent hepatocellular carcinoma","volume":"28","author":"Wei","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0015","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1309\/AJCPLBK9L9KDYQZP","article-title":"Histologic tumor necrosis is an independent prognostic indicator for clear cell and papillary renal cell carcinoma","volume":"137","author":"Pichler","year":"2012","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0016","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0169-5002(02)00172-1","article-title":"Tumour necrosis is an independent prognostic marker in non-small cell lung cancer: correlation with biological variables","volume":"37","author":"Swinson","year":"2002","journal-title":"Lung Cancer"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0017","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1186\/s12885-018-4773-z","article-title":"Tumor necrosis as a prognostic variable for the clinical outcome in patients with renal cell carcinoma: a systematic review and meta-analysis","volume":"18","author":"Zhang","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0018","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/bjc.2016.128","article-title":"Clinical impact and network of determinants of tumour necrosis in colorectal cancer","volume":"114","author":"V\u00e4yrynen","year":"2016","journal-title":"Br J Cancer"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0019","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1245\/s10434-022-11462-y","article-title":"Tumor necrosis impacts prognosis of patients undergoing resection for T1 intrahepatic cholangiocarcinoma","volume":"29","author":"Tsilimigras","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0020","doi-asserted-by":"crossref","first-page":"e1541","DOI":"10.1634\/theoncologist.2019-0944","article-title":"Early and late recurrence of hepatitis B virus-associated hepatocellular carcinoma","volume":"25","author":"Wang","year":"2020","journal-title":"Oncologist"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0021","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/SLA.0000000000002360","article-title":"Prediction of hepatocellular carcinoma recurrence beyond Milan criteria after resection: validation of a clinical risk score in an international cohort","volume":"266","author":"Zheng","year":"2017","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0022","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jhep.2021.11.018","article-title":"BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update","volume":"76","author":"Reig","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0023","article-title":"ALBI grade: evidence for an improved model for liver functional estimation in patients with hepatocellular carcinoma","volume":"3","author":"Demirtas","year":"2021","journal-title":"JHEP Rep"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0024","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1053\/j.gastro.2009.06.003","article-title":"A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma","volume":"137","author":"Roayaie","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0025","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/cncr.21206","article-title":"Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness","volume":"104","author":"Sengupta","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0026","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/0003-4975(96)00540-1","article-title":"Blood vessel invasion is a major prognostic factor in resected non-small cell lung cancer","volume":"62","author":"Kessler","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0027","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/bjs.7755","article-title":"Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer","volume":"99","author":"Richards","year":"2012","journal-title":"Br J Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0028","doi-asserted-by":"crossref","first-page":"9279","DOI":"10.3748\/wjg.v22.i42.9279","article-title":"Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update","volume":"22","author":"Cong","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0029","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ctrv.2018.11.002","article-title":"Updated use of TACE for hepatocellular carcinoma treatment: how and when to use it based on clinical evidence","volume":"72","author":"Raoul","year":"2019","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00000658-200007000-00003","article-title":"Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma","volume":"232","author":"Tung-Ping Poon","year":"2000","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0031","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1415","article-title":"Inflammation and necrosis promote tumour growth","volume":"4","author":"Vakkila","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0032","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ijc.11303","article-title":"Hepatitis C virus NS5A as a potential viral bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma","volume":"107","author":"Chung","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0033","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(02)00360-4","article-title":"Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy","volume":"38","author":"Imamura","year":"2003","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0034","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s11605-019-04503-7","article-title":"Factors affecting local and intra hepatic distant recurrence after surgery for HCC: an alternative perspective on microvascular invasion and satellitosis-A western European multicentre study","volume":"25","author":"Famularo","year":"2021","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0035","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000006","article-title":"Identifying clonal origin of multifocal hepatocellular carcinoma and its clinical implications","volume":"10","author":"Xie","year":"2019","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0036","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1245\/s10434-007-9415-7","article-title":"Analysis of prognostic factors affecting survival after initial recurrence and treatment efficacy for recurrence in patients undergoing potentially curative hepatectomy for arcinomas","volume":"14","author":"Shimada","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0037","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1053\/j.gastro.2019.09.005","article-title":"Genomic and epigenomic features of primary and recurrent hepatocellular carcinomas","volume":"157","author":"Ding","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0038","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/hep.29681","article-title":"Hypoxia-inducible factor-1\u03b1\/interleukin-1\u03b2 signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment","volume":"67","author":"Zhang","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0039","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fonc.2018.00235","article-title":"Active role of the necrotic zone in desensitization of hypoxic macrophages and regulation of CSC-fate: a hypothesis","volume":"8","author":"Mehrabi","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0040","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-3-030-35727-6_6","article-title":"Necrosis in the tumor microenvironment and its role in cancer recurrence","volume":"1225","author":"Karsch-Bluman","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0041","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12916-015-0278-7","article-title":"New horizons in tumor microenvironment biology: challenges and opportunities","volume":"13","author":"Chen","year":"2015","journal-title":"BMC Med"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0042","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.cell.2007.04.019","article-title":"Hypoxia-inducible factors, stem cells, and cancer","volume":"129","author":"Keith","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0043","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/JS9.0000000000000805","article-title":"Effect of transarterial chemoembolization as postoperative adjuvant therapy for intermediate-stage hepatocellular carcinoma with microvascular invasion: a multicenter cohort study","volume":"110","author":"Xiang","year":"2024","journal-title":"Int J Surg"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0044","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1158\/1078-0432.CCR-17-2899","article-title":"Adjuvant transarterial chemoembolization for HBV-related hepatocellular carcinoma after resection: a randomized controlled study","volume":"24","author":"Wang","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.hbpd.2025.12.009_bib0045","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1097\/HEP.0000000000001233","article-title":"Adjuvant transarterial chemoembolization for hepatocellular carcinoma following curative resection: A randomized, open-label, phase 3 trial","volume":"82","author":"Ma","year":"2025","journal-title":"Hepatology"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387225002231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387225002231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:43:10Z","timestamp":1778816590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387225002231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1499387225002231"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2025.12.009","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor micronecrosis is a marker of poor prognosis of hepatocellular carcinoma after liver resection","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2025.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}