{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:15:36Z","timestamp":1767896136090,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.hbpd.2025.12.019","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T23:51:50Z","timestamp":1767397910000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronological change in subcutaneous adipose tissue radiodensity as a predictor of surgical outcome in patients with perihilar cholangiocarcinoma undergoing major hepatectomy"],"prefix":"10.1016","author":[{"given":"Ryo","family":"Sugiura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Kuwatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Noji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumichi","family":"Kawakubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitsugu","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimitaka","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2025.12.019_bib0001","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00534-009-0208-1","article-title":"Outcome of surgical treatment of hilar cholangiocarcinoma: a special reference to postoperative morbidity and mortality","volume":"17","author":"Hirano","year":"2010","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0002","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.surg.2019.01.010","article-title":"Morbidity and mortality after major liver resection in patients with perihilar cholangiocarcinoma: a systematic review and meta-analysis","volume":"165","author":"Franken","year":"2019","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0003","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4291\/wjgp.v5.i3.344","article-title":"Perihilar cholangiocarcinoma: current therapy","volume":"5","author":"Zhang","year":"2014","journal-title":"World J Gastrointest Pathophysiol"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0004","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jhbp.314","article-title":"Biliary tract cancer registry in Japan from 2008 to 2013","volume":"23","author":"Ishihara","year":"2016","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0005","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejca.2015.12.030","article-title":"Prognostic value of sarcopenia in adults with solid tumours: a meta-analysis and systematic review","volume":"57","author":"Shachar","year":"2016","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0006","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.atherosclerosis.2018.09.001","article-title":"Associations of cardiovascular fat radiodensity and vascular calcification in midlife women: the SWAN cardiovascular fat ancillary study","volume":"279","author":"Hanley","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0007","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/oby.22695","article-title":"Associations of thigh and abdominal adipose tissue radiodensity with glucose and insulin in nondiabetic African-ancestry men","volume":"28","author":"Tilves","year":"2020","journal-title":"Obes (Silver Spring)"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0008","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1467-789X.2009.00623.x","article-title":"Subcutaneous and visceral adipose tissue: structural and functional differences","volume":"11","author":"Ibrahim","year":"2010","journal-title":"Obes Rev"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0009","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/ajcn\/nqab285","article-title":"Abdominal adipose tissue radiodensity is associated with survival after colorectal cancer","volume":"114","author":"Feliciano","year":"2021","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0010","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1016\/j.clnu.2022.09.016","article-title":"Cespedes Feliciano EM. Adipose tissue radiodensity and mortality among patients with nonmetastatic breast cancer","volume":"41","author":"Cheng","year":"2022","journal-title":"Clin Nutr"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0011","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/jhbp.12105","article-title":"Subcutaneous adipose tissue radiodensity as a predictor of poor prognosis in advanced biliary tract cancer","volume":"32","author":"Sugiura","year":"2025","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0012","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.3390\/ijms25073939","article-title":"Prognostic impact of visceral adipose tissue imaging parameters in patients with cholangiocarcinoma after surgical resection","volume":"25","author":"Lee","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0013","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000521510","article-title":"Endoscopic nasobiliary drainage comparable with endoscopic biliary stenting as a preoperative drainage method for malignant hilar biliary obstruction: a multicenter retrospective study","volume":"103","author":"Sugiura","year":"2022","journal-title":"Digestion"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0014","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2214\/AJR.20.23280","article-title":"Significance of acquisition parameters for adipose tissue segmentation on CT images","volume":"217","author":"Troschel","year":"2021","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0015","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/lt.23970","article-title":"Impact of quality as well as quantity of skeletal muscle on outcomes after liver transplantation","volume":"20","author":"Hamaguchi","year":"2014","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0016","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/jhbp.12006","article-title":"Preoperative risk factors for skeletal muscle mass loss in patients with biliary tract cancer","volume":"31","author":"Sugiura","year":"2024","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0017","article-title":"Higher subcutaneous adipose tissue radiodensity is associated with increased mortality in patients with cirrhosis","volume":"4","author":"Ebadi","year":"2022","journal-title":"JHEP Rep"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0018","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/liv.14755","article-title":"High subcutaneous adipose tissue density correlates negatively with survival in patients with hepatocellular carcinoma","volume":"41","author":"von Hessen","year":"2021","journal-title":"Liver Int"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0019","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/hepr.13499","article-title":"Analysis of the optimal psoas muscle mass index cut-off values, as measured by computed tomography, for the diagnosis of loss of skeletal muscle mass in Japanese people","volume":"50","author":"Ohara","year":"2020","journal-title":"Hepatol Res"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0020","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1007\/s11605-020-04891-1","article-title":"Transhepatic direct approach to the \u201climit of the division of the hepatic ducts\u201d leads to a high R0 resection rate in perihilar cholangiocarcinoma","volume":"25","author":"Noji","year":"2021","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0021","series-title":"AJCC Cancer staging manual, 8th ed","author":"Amin","year":"2017"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0022","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s00534-009-0127-1","article-title":"Impact of residual in situ carcinoma on postoperative survival in 125 patients with extrahepatic bile duct carcinoma","volume":"17","author":"Nakanishi","year":"2010","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0023","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s00595-015-1236-x","article-title":"Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria","volume":"46","author":"Katayama","year":"2016","journal-title":"Surg Today"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0024","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transpl."},{"key":"10.1016\/j.hbpd.2025.12.019_bib0025","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.surg.2015.10.027","article-title":"A new prognostic scoring system using factors available preoperatively to predict survival after operative resection of perihilar cholangiocarcinoma","volume":"159","author":"Saito","year":"2016","journal-title":"Surgery"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0026","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.3390\/nu11112553","article-title":"Adipose tissue quality in aging: how structural and functional aspects of adipose tissue impact skeletal muscle quality","volume":"11","author":"De Carvalho","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0027","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/jcp.26811","article-title":"Adipose tissue dysfunction in cancer cachexia","volume":"234","author":"Daas","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0028","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/jgh.16035","article-title":"Home-based intensive nutrition therapy improves frailty and sarcopenia in patients with decompensated cirrhosis: a randomized clinical trial","volume":"38","author":"Meena","year":"2023","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0029","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0140-6736(22)02038-4","article-title":"Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial","volume":"401","author":"Nakachi","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0030","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/hpb.12394","article-title":"Preoperative computed tomography assessment of skeletal muscle mass is valuable in predicting outcomes following hepatectomy for perihilar cholangiocarcinoma","volume":"17","author":"Coelen","year":"2015","journal-title":"HPB"},{"key":"10.1016\/j.hbpd.2025.12.019_bib0031","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/jhbp.1220","article-title":"Impact of preoperative muscle mass and quality on surgical outcomes in patients undergoing major hepatectomy for perihilar cholangiocarcinoma","volume":"30","author":"Asai","year":"2023","journal-title":"J Hepatobiliary Pancreat Sci"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387225002565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387225002565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:56:50Z","timestamp":1767877010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387225002565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"alternative-id":["S1499387225002565"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2025.12.019","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronological change in subcutaneous adipose tissue radiodensity as a predictor of surgical outcome in patients with perihilar cholangiocarcinoma undergoing major hepatectomy","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2025.12.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}