{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:12:34Z","timestamp":1784794354245,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2017ZX10203201"],"award-info":[{"award-number":["2017ZX10203201"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2308802"],"award-info":[{"award-number":["2023YFC2308802"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary &amp; Pancreatic Diseases International"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.hbpd.2026.02.001","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:13:07Z","timestamp":1770999187000},"page":"170-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of multimodal artificial liver support for acute-on-chronic liver failure: A single-center cohort study"],"prefix":"10.1016","volume":"25","author":[{"given":"Jing-Yi","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Rui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Fen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2026.02.001_bib0001","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrgastro.2015.219","article-title":"Acute-on-chronic liver failure: terminology, mechanisms and management","volume":"13","author":"Sarin","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0002","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12072-019-09946-3","article-title":"Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL): an update","volume":"13","author":"Sarin","year":"2019","journal-title":"Hepatol Int"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0003","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1056\/NEJMra1914900","article-title":"Acute-on-chronic liver failure","volume":"382","author":"Arroyo","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0004","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/jgh.13799","article-title":"Systemic inflammatory response syndrome in acute-on-chronic liver failure: relevance of 'golden window': a prospective study","volume":"32","author":"Choudhury","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0005","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/j.jhep.2014.11.045","article-title":"Acute-on-chronic liver failure: a new syndrome that will re-classify cirrhosis","volume":"62","author":"Arroyo","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0006","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.jhep.2017.06.009","article-title":"Liver transplantation in the most severely ill cirrhotic patients: a multicenter study in acute-on-chronic liver failure grade 3","volume":"67","author":"Artru","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0007","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1053\/j.gastro.2018.12.007","article-title":"Factors associated with survival of patients with severe acute-on-chronic liver failure before and after liver transplantation","volume":"156","author":"Sundaram","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0008","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/lt.23678","article-title":"Acute-on-chronic liver failure: excellent outcomes after liver transplantation but high mortality on the wait list","volume":"19","author":"Finkenstedt","year":"2013","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0009","first-page":"187","article-title":"Artificial liver support in acute and acute-on-chronic liver failure","volume":"25","author":"Larsen","year":"2019","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jhep.2015.08.018","article-title":"High-volume plasma exchange in patients with acute liver failure: an open randomised controlled trial","volume":"64","author":"Larsen","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0011","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/bjh.12629","article-title":"The mechanisms of action of plasma exchange","volume":"164","author":"Reeves","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0012","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1499-3872(16)60084-X","article-title":"Plasma exchange-centered artificial liver support system in hepatitis B virus-related acute-on-chronic liver failure: a nationwide prospective multicenter study in China","volume":"15","author":"Chen","year":"2016","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0013","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s12072-023-10573-2","article-title":"Mixed mode of artificial liver support in patients with acute-on-chronic liver failure: a retrospective cohort study","volume":"17","author":"Wang","year":"2023","journal-title":"Hepatol Int"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0014","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jhep.2015.03.018","article-title":"Efficacy of coupled low-volume plasma exchange with plasma filtration adsorption in treating pigs with acute liver failure: a randomised study","volume":"63","author":"Zhou","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0015","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/jhep.2001.22172","article-title":"A model to predict survival in patients with end-stage liver disease","volume":"33","author":"Kamath","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.1075383","article-title":"Association between fatigue and cytokine profiles in patients with ischemic stroke","volume":"13","author":"Kirchberger","year":"2023","journal-title":"Front Neurol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0017","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/hepr.13497","article-title":"Artificial liver treatment improves survival in patients with hepatitis B virus-related acute-on-chronic liver failure: a case-control matched analysis","volume":"50","author":"Yang","year":"2020","journal-title":"Hepatol Res"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0018","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1744-9987.2006.00358.x","article-title":"Artificial liver support system in China: a review over the last 30 years","volume":"10","author":"Li","year":"2006","journal-title":"Ther Apher Dial"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0019","article-title":"A multi-subgroup predictive model based on clinical parameters and laboratory biomarkers to predict in-hospital outcomes of plasma exchange-centered artificial liver treatment in patients with hepatitis B virus-related acute-on-chronic liver failure","volume":"13","author":"Liu","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0020","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1136\/gutjnl-2017-314641","article-title":"Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure","volume":"67","author":"Wu","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0021","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s12072-020-10053-x","article-title":"Plasma perfusion combined with plasma exchange in chronic hepatitis B-related acute-on-chronic liver failure patients","volume":"14","author":"Yang","year":"2020","journal-title":"Hepatol Int"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0022","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s00134-019-05886-6","article-title":"The persistent potential of extracorporeal therapies in liver failure","volume":"46","author":"Fuhrmann","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0023","doi-asserted-by":"crossref","DOI":"10.1177\/1756284819879565","article-title":"Meta-analysis of individual patient data of albumin dialysis in acute-on-chronic liver failure: focus on treatment intensity","volume":"12","author":"Ba\u00f1ares","year":"2019","journal-title":"Therap Adv Gastroenterol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0024","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/s41598-021-81019-8","article-title":"A prognostic score for patients with acute-on-chronic liver failure treated with plasma exchange-centered artificial liver support system","volume":"11","author":"Du","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0025","article-title":"Outcome of patients with different stages of acute-on-chronic liver failure treated with artificial liver support system","volume":"11","author":"Ma","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0026","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s12072-019-09992-x","article-title":"Complications constitute a major risk factor for mortality in hepatitis B virus-related acute-on-chronic liver failure patients: a multi-national study from the Asia-Pacific region","volume":"13","author":"Chen","year":"2019","journal-title":"Hepatol Int"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0027","article-title":"Systemic inflammatory regulators and risk of acute-on-chronic liver failure: a bidirectional mendelian-randomization study","volume":"11","author":"Wang","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0028","doi-asserted-by":"crossref","first-page":"R192","DOI":"10.1186\/cc9309","article-title":"Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit","volume":"14","author":"de Jager","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175332","article-title":"Neutrophil-lymphocyte ratio predicts short term mortality in patients with hepatitis B virus-related acute-on-chronic liver failure treated with an artificial liver support system","volume":"12","author":"Fan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0030","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/apt.15932","article-title":"Leucocyte ratios are biomarkers of mortality in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure","volume":"52","author":"Bernsmeier","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0031","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.3390\/cells9122632","article-title":"Leukocytes, systemic inflammation and immunopathology in acute-on-chronic liver failure","volume":"9","author":"Casulleras","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0032","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/liv.13504","article-title":"Characteristics of systemic inflammation in hepatitis B-precipitated ACLF: differentiate it from no-ACLF","volume":"38","author":"Wu","year":"2018","journal-title":"Liver Int"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0033","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/HEP.0000000000000907","article-title":"Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure","volume":"81","author":"Feio-Azevedo","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0034","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.ajt.2024.02.001","article-title":"Immunopathogenesis of acute on chronic liver failure","volume":"24","author":"Artru","year":"2024","journal-title":"Am J Transplant"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0035","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1136\/gutjnl-2017-314184","article-title":"CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure","volume":"67","author":"Bernsmeier","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0036","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/liv.14806","article-title":"Therapeutic plasma-exchange improves systemic inflammation and survival in acute-on-chronic liver failure: a propensity-score matched study from AARC","volume":"41","author":"Maiwall","year":"2021","journal-title":"Liver Int"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155828","article-title":"Interleukin-8: an evolving chemokine","volume":"153","author":"Matsushima","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0038","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2287708","article-title":"Interleukin-8 predicts short-term mortality in acute-on-chronic liver failure patients with hepatitis B-related-related cirrhosis background","volume":"55","author":"Liu","year":"2023","journal-title":"Ann Med"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0039","doi-asserted-by":"crossref","DOI":"10.1038\/srep38714","article-title":"Low expression of CXCR1\/2 on neutrophils predicts poor survival in patients with hepatitis B virus-related acute-on-chronic liver failure","volume":"6","author":"Xu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0040","article-title":"Serum cytokine and chemokine profiles and disease prognosis in hepatitis B virus-related acute-on-chronic liver failure","volume":"14","author":"Zhu","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0041","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41584-019-0238-2","article-title":"The immunobiology of MIF: function, genetics and prospects for precision medicine","volume":"15","author":"Kang","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108024","article-title":"Macrophage migration inhibitory factor (MIF): a multifaceted cytokine regulated by genetic and physiological strategies","volume":"233","author":"Sumaiya","year":"2022","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0043","article-title":"Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis","volume":"3","author":"Wirtz","year":"2020","journal-title":"JHEP Rep"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0044","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1210\/jcem.86.6.7570","article-title":"Macrophage migration inhibitory factor and hypothalamo-pituitary-adrenal function during critical illness","volume":"86","author":"Beishuizen","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0045","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1086\/514344","article-title":"Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe sepsis","volume":"44","author":"Emonts","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0046","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/72262","article-title":"Protection from septic shock by neutralization of macrophage migration inhibitory factor","volume":"6","author":"Calandra","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.hbpd.2026.02.001_bib0047","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.intimp.2011.04.017","article-title":"Characterization, epitope identification and mechanisms of the anti-septic capacity of monoclonal antibodies against macrophage migration inhibitory factor","volume":"11","author":"Zhang","year":"2011","journal-title":"Int Immunopharmacol"}],"container-title":["Hepatobiliary &amp; Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387226000135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387226000135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:42:46Z","timestamp":1778816566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387226000135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1499387226000135"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2026.02.001","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of multimodal artificial liver support for acute-on-chronic liver failure: A single-center cohort study","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2026.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}