{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:51:17Z","timestamp":1791586277523,"version":"4.3.4"},"reference-count":79,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.hbpd.2026.07.002","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:58:35Z","timestamp":1783353515000},"page":"490-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Per- and polyfluoroalkyl substances exposure and risk of liver cancer: A comprehensive review of epidemiological and mechanistic evidence"],"prefix":"10.1016","volume":"25","author":[{"given":"Jia-Mian","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang-Biao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Sen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Ping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2026.07.002_bib0001","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/humupd\/dmaa018","article-title":"Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary","volume":"26","author":"Ding","year":"2020","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0002","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.envpol.2023.122910","article-title":"Environment relevant exposure of perfluorooctanoic acid accelerates the growth of hepatocellular carcinoma cells through mammalian target of rapamycin (mTOR) signal pathway","volume":"341","author":"Hong","year":"2024","journal-title":"Env Pollut"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0003","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jenvman.2022.115291","article-title":"PFAS use in electronic products and exposure risks during handling and processing of e-waste: a review","volume":"316","author":"Tansel","year":"2022","journal-title":"J Env Manage"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0004","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41370-018-0094-1","article-title":"A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects","volume":"29","author":"Sunderland","year":"2019","journal-title":"J Expo Sci Env Epidemiol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0005","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1021\/acs.estlett.6b00260","article-title":"Detection of poly- and perfluoroalkyl substances (PFASs) in U.S. drinking water linked to industrial sites, military fire training areas, and wastewater treatment plants","volume":"3","author":"Hu","year":"2016","journal-title":"Env Sci Technol Lett"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0006","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.chemosphere.2020.127340","article-title":"What are the effects of PFAS exposure at environmentally relevant concentrations?","volume":"258","author":"Sinclair","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0007","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integr Env Assess Manag"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0008","doi-asserted-by":"crossref","first-page":"115410","DOI":"10.1016\/j.trac.2019.02.011","article-title":"Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment","volume":"121","author":"Nakayama","year":"2019","journal-title":"Trends Anal Chem"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0009","series-title":"Guidance on pfas exposure, testing, and clinical follow-up","year":"2022"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0010","doi-asserted-by":"crossref","first-page":"e449","DOI":"10.1016\/S2542-5196(23)00088-8","article-title":"Folate concentrations and serum perfluoroalkyl and polyfluoroalkyl substance concentrations in adolescents and adults in the USA (National Health and Nutrition Examination Study 2003-16): an observational study","volume":"7","author":"Zhang","year":"2023","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2022.114040","article-title":"Serum concentration trends and apparent half-lives of per- and polyfluoroalkyl substances (PFAS) in Australian firefighters","volume":"246","author":"Nilsson","year":"2022","journal-title":"Int J Hyg Env Health"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0012","doi-asserted-by":"crossref","first-page":"7930","DOI":"10.1007\/s11356-013-1777-8","article-title":"Perfluorinated alkylated substances in vegetables collected in four European countries; occurrence and human exposure estimations","volume":"20","author":"Herzke","year":"2013","journal-title":"Env Sci Pollut Res Int"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0013","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0014","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hep.29466","article-title":"Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease","volume":"67","author":"Estes","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0015","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2023.02.034","article-title":"The exposome and liver disease - how environmental factors affect liver health","volume":"79","author":"Barouki","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0016","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.canlet.2009.02.057","article-title":"The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy","volume":"286","author":"Gouas","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0017","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.3390\/ijms21165761","article-title":"Potential mechanisms of bisphenol A (BPA) contributing to human disease","volume":"21","author":"Cimmino","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0018","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0019","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.envpol.2023.122610","article-title":"Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on toxicologically relevant gene expression profiles in a liver-on-a-chip model","volume":"337","author":"Solan","year":"2023","journal-title":"Env Pollut"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0020","doi-asserted-by":"crossref","first-page":"22027","DOI":"10.1021\/acs.est.4c08669","article-title":"PFOS and its commercial alternative, 6:2 Cl-PFESA, induce multidrug resistance in pancreatic cancer","volume":"58","author":"Hong","year":"2024","journal-title":"Env Sci Technol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134790","article-title":"6:2 Cl-PFESA, a proposed safe alternative for PFOS, diminishes the gemcitabine effectiveness in the treatment of pancreatic cancer","volume":"474","author":"Hong","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0022","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.3390\/cancers14122919","article-title":"Toward a mechanistic understanding of poly- and perfluoroalkylated substances and cancer","volume":"14","author":"Boyd","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0023","unstructured":"OCEBM Levels of Evidence Working Group. \u201cThe oxford levels of evidence 2\u201d. Oxford Centre for Evidence-Based Medicine, 2020. Available from: https:\/\/www.cebm.ox.ac.uk\/resources\/levels-of-evidence\/ocebm-levels-of-evidence."},{"key":"10.1016\/j.hbpd.2026.07.002_bib0024","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.yrtph.2019.05.008","article-title":"Interspecies differences in perfluoroalkyl substances (PFAS) toxicokinetics and application to health-based criteria","volume":"106","author":"Piizzurro","year":"2019","journal-title":"Regul Toxicol Pharmacol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0025","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jes.2023.05.026","article-title":"Distribution of per- and polyfluoroalkyl substances in blood, serum, and urine of patients with liver cancer and associations with liver function biomarkers","volume":"139","author":"Dai","year":"2024","journal-title":"J Env Sci (China)"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0026","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jhazmat.2024.133743","article-title":"Effect of liver cancer on the accumulation and hepatobiliary transport of per- and polyfluoroalkyl substances","volume":"468","author":"Liu","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0027","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.scitotenv.2024.176717","article-title":"Effects of per- and polyfluoroalkyl substances on the liver: human-relevant mechanisms of toxicity","volume":"954","author":"Maerten","year":"2024","journal-title":"Sci Total Env"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0028","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/toxics9030045","article-title":"Perfluoroalkyl acid binding with peroxisome proliferator-activated receptors \u03b1, \u03b3, and \u03b4, and fatty acid binding proteins by equilibrium dialysis with a comparison of methods","volume":"9","author":"Khazaee","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0029","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.scitotenv.2018.04.380","article-title":"A short review on human exposure to and tissue distribution of per- and polyfluoroalkyl substances (PFASs)","volume":"636","author":"Jian","year":"2018","journal-title":"Sci Total Env"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0030","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1021\/acs.est.8b05564","article-title":"Screening of potential PFOS alternatives to decrease liver bioaccumulation: experimental and computational approaches","volume":"53","author":"Cao","year":"2019","journal-title":"Env Sci Technol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0031","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/2190-4715-23-38","article-title":"Toxicology of perfluorinated compounds","volume":"23","author":"Stahl","year":"2011","journal-title":"Env Sci Eur"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0032","series-title":"Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS)","year":"2025"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0033","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jhazmat.2024.134642","article-title":"Use of Tox21 screening data to profile PFAS bioactivities on nuclear receptors, cellular stress pathways, and cytochrome p450 enzymes","volume":"473","author":"Ooka","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0034","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/etc.4890","article-title":"Per- and polyfluoroalkyl substance toxicity and human health review: current state of knowledge and strategies for informing future research","volume":"40","author":"Fenton","year":"2020","journal-title":"Env Toxicol Chem"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0035","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.envint.2021.106843","article-title":"Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury","volume":"157","author":"Roth","year":"2021","journal-title":"Env Int"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0036","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.envint.2024.108582","article-title":"Evidence of promoting effects of 6:2 Cl-PFESA on hepatocellular carcinoma proliferation in humans: an ideal alternative for PFOS in terms of environmental health?","volume":"186","author":"Hong","year":"2024","journal-title":"Env Int"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0037","first-page":"100","article-title":"Exposure to perfluoroalkyl substances and risk of hepatocellular carcinoma in a multiethnic cohort","volume":"4","author":"Goodrich","year":"2022","journal-title":"JHEP Rep"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0038","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/ajg.2009.707","article-title":"Investigation of the associations between low-dose serum perfluorinated chemicals and liver enzymes in US adults","volume":"105","author":"Lin","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0039","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.envres.2019.02.013","article-title":"Liver function biomarkers disorder is associated with exposure to perfluoroalkyl acids in adults: isomers of C8 health project in China","volume":"172","author":"Nian","year":"2019","journal-title":"Env Res"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0040","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.envint.2022.107179","article-title":"Per- and perfluoroalkyl substances alternatives, mixtures and liver function in adults: a community-based population study in China","volume":"163","author":"Liu","year":"2022","journal-title":"Env Int"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0041","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.envres.2023.116651","article-title":"Associations between per- and polyfluoroalkyl substances, liver function, and daily alcohol consumption in a sample of U.S. adults","volume":"235","author":"Ma","year":"2023","journal-title":"Env Res"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0042","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.envres.2025.122139","article-title":"Short-chain per- and polyfluoroalkyl substances associate with elevated alanine aminotransferase: cross-sectional analysis results from the STRIVE cohort","volume":"283","author":"Seo","year":"2025","journal-title":"Env Res"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0043","first-page":"100","article-title":"Association of per- and polyfluoroalkyl substance exposure with fatty liver disease risk in US adults","volume":"5","author":"Zhang","year":"2023","journal-title":"JHEP Rep"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0044","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1021\/EHP.6c00400","article-title":"Circulating per- and polyfluoroalkyl substances and liver cancer risk: a nested case-control analysis of individual participant data from 12 prospective cohorts","volume":"134","author":"Watling","year":"2026","journal-title":"Env Health Perspect"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0045","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/hep.31483","article-title":"Prenatal exposure to perfluoroalkyl substances associated with increased susceptibility to liver injury in children","volume":"72","author":"Stratakis","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0046","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.chemosphere.2023.138208","article-title":"Exposure to serum perfluoroalkyl substances and biomarkers of liver function: the Korean national environmental health survey 2015-2017","volume":"322","author":"Kim","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134083","article-title":"Per-\/polyfluoroalkyl substance concentrations in human serum and their associations with liver cancer","volume":"296","author":"Cao","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0048","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.envres.2021.111775","article-title":"Occurrence and distribution of per- and polyfluoroalkyl substances (PFASs) in human livers with liver cancer","volume":"202","author":"Liu","year":"2021","journal-title":"Env Res"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0049","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jhazmat.2025.137613","article-title":"Celecoxib as a potential treatment for hepatocellular carcinoma in populations exposed to high PFAS levels","volume":"489","author":"Sun","year":"2025","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0050","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tox.2016.12.007","article-title":"Perfluoroalkyl acids-induced liver steatosis: effects on genes controlling lipid homeostasis","volume":"378","author":"Das","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0051","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1038\/srep04582","article-title":"PFOS induced lipid metabolism disturbances in BALB\/c mice through inhibition of low density lipoproteins excretion","volume":"4","author":"Wang","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0052","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/10408444.2021.1888073","article-title":"Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?","volume":"51","author":"Fragki","year":"2021","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0053","doi-asserted-by":"crossref","first-page":"18866","DOI":"10.1007\/s11356-019-05258-z","article-title":"Maternal exposure to perfluorooctanoic acid (PFOA) causes liver toxicity through PPAR-\u03b1 pathway and lowered histone acetylation in female offspring mice","volume":"26","author":"Li","year":"2019","journal-title":"Env Sci Pollut Res Int"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0054","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3390\/cimb47020098","article-title":"Dose-dependent PFESA-BP2 exposure increases risk of liver toxicity and hepatocellular carcinoma","volume":"47","author":"Kostecki","year":"2025","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0055","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1039\/D2AN00904H","article-title":"Investigating the cytotoxic redox mechanism of PFOS within Hep G2 by hyperspectral-assisted scanning electrochemical microscopy","volume":"147","author":"Goines","year":"2022","journal-title":"Analyst"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0056","doi-asserted-by":"crossref","DOI":"10.1289\/EHP10092","article-title":"Exposure to per- and polyfluoroalkyl substances and markers of liver injury: a systematic review and meta-analysis","volume":"130","author":"Costello","year":"2022","journal-title":"Env Health Perspect"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0057","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.envint.2023.108138","article-title":"PPAR\u03b1\/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: an integrated approach","volume":"178","author":"Yang","year":"2023","journal-title":"Env Int"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0058","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.taap.2022.116136","article-title":"In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays","volume":"449","author":"Evans","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0059","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.tox.2025.154167","article-title":"Per- and polyfluoroalkyl substances as potentiators of hepatotoxicity in an exposome framework: current challenges of environmental toxicology","volume":"515","author":"Choi","year":"2025","journal-title":"Toxicology"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0060","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.envpol.2017.09.019","article-title":"Association among total serum isomers of perfluorinated chemicals, glucose homeostasis, lipid profiles, serum protein and metabolic syndrome in adults: NHANES, 2013-2014","volume":"232","author":"Liu","year":"2018","journal-title":"Env Pollut"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0061","doi-asserted-by":"crossref","first-page":"12170","DOI":"10.1021\/es3027715","article-title":"Global liver proteome analysis using iTRAQ labeling quantitative proteomic technology to reveal biomarkers in mice exposed to perfluorooctane sulfonate (PFOS)","volume":"46","author":"Tan","year":"2012","journal-title":"Env Sci Technol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138112","article-title":"Integrative transcriptomics analysis reveals convergent toxicological effects of perfluorooctanoic acid and perfluorooctane sulfonate on human liver: evidence from multiple models","volume":"492","author":"Yang","year":"2025","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0063","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/toxsci\/kfad004","article-title":"Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans","volume":"192","author":"Heintz","year":"2023","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0064","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/jat.4818","article-title":"Systematic exploration of potential toxicity targets and molecular mechanisms of emerging short-chain PFAS substitutes: PFBA- and PFBS-induced hepatocellular carcinoma based on toxicity network analysis, machine learning, and biomimetic calculations","volume":"45","author":"Zhang","year":"2025","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0065","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s00204-024-03685-7","article-title":"Involvement of per- and polyfluoroalkyl compounds in tumor development","volume":"98","author":"Pesonen","year":"2024","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0066","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1186\/s12967-025-06517-z","article-title":"Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach","volume":"23","author":"Hong","year":"2025","journal-title":"J Transl Med"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0067","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/tox.23680","article-title":"Per- and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells","volume":"38","author":"Qi","year":"2023","journal-title":"Env Toxicol"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0068","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tox.2022.153259","article-title":"GenX induces fibroinflammatory gene expression in primary human hepatocytes","volume":"477","author":"Robarts","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0069","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.1097\/JS9.0000000000002632","article-title":"Integrative in silico analysis of per- and polyfluorinated alkyl substances (PFAS)-associated molecular alterations in human cancers: a multi-cancer framework for predicting toxicogenomic disruption","volume":"111","author":"Hong","year":"2025","journal-title":"Int J Surg"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0070","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tiv.2020.104797","article-title":"Epigenetic toxicity of PFOA and GenX in HepG2 cells and their role in lipid metabolism","volume":"65","author":"Wen","year":"2020","journal-title":"Toxicol Vitro"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0071","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1289\/ehp.11728","article-title":"Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems","volume":"117","author":"Upham","year":"2009","journal-title":"Env Health Perspect"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0072","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tox.2021.152997","article-title":"Transcriptional effects of binary combinations of PFAS in FaO cells","volume":"464","author":"Bjork","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0073","first-page":"293","article-title":"Current status and perspectives in environmental oncology","volume":"10","author":"Liu","year":"2024","journal-title":"Chronic Dis Transl Med"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0074","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s43856-025-01168-z","article-title":"Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents","volume":"5","author":"Baumert","year":"2025","journal-title":"Commun Med (Lond)"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0075","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.envint.2024.108556","article-title":"Comparative hepatotoxicity of novel lithium bis(trifluoromethanesulfonyl)imide (LiTFSI, ie. HQ-115) and legacy perfluorooctanoic acid (PFOA) in male mice: insights into epigenetic mechanisms and pathway-specific responses","volume":"185","author":"Sands","year":"2024","journal-title":"Env Int"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0076","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ecoenv.2024.117268","article-title":"Exposure to perfluorodecanoic acid impairs follicular development via inducing granulosa cell necroptosis","volume":"287","author":"Liu","year":"2024","journal-title":"Ecotoxicol Env Saf"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0077","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1038\/s41467-024-50450-6","article-title":"Necroptosis enhances \u2018don\u2019t eat me\u2019 signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis","volume":"15","author":"Liao","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0078","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00423-025-03651-6","article-title":"Systematic review on the use of artificial intelligence to identify anatomical structures during laparoscopic cholecystectomy: a tool towards the future","volume":"410","author":"Corallino","year":"2025","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.hbpd.2026.07.002_bib0079","unstructured":"United States Environmental Protection Agency. Drinking water regulations, 2026. Available from: https:\/\/www.epa.gov\/dwreginfo\/drinking-water-regulations."}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387226001128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387226001128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:58:02Z","timestamp":1791547082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387226001128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":79,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1499387226001128"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2026.07.002","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Per- and polyfluoroalkyl substances exposure and risk of liver cancer: A comprehensive review of epidemiological and mechanistic evidence","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2026.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}