{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:02:31Z","timestamp":1791201751866,"version":"4.2.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.hbpd.2026.09.001","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:35:31Z","timestamp":1789666531000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Raman spectral signature uncovers predictive biomarkers for primary graft dysfunction in liver transplant: A proof-of-concept study"],"prefix":"10.1016","author":[{"given":"Edouard","family":"Wasielewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Castel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eblle","family":"Guillout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Sebillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Pecot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Desille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Turlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Allaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Fassari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Coulouarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Robin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Sulpice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2026.09.001_bib0001","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/hep.1840200410","article-title":"Selecting the donor liver: risk factors for poor function after orthotopic liver transplantation","volume":"20","author":"Strasberg","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0002","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1053\/jlts.2003.50105","article-title":"The utility of marginal donors in liver transplantation","volume":"9","author":"Busuttil","year":"2003","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0003","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1600-6143.2007.01758.x","article-title":"Waitlist mortality decreases with increased use of extended criteria donor liver grafts at adult liver transplant centers","volume":"7","author":"Barshes","year":"2007","journal-title":"Am J Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0004","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.cgh.2023.04.005","article-title":"Liver transplantation 2023: status report, current and future challenges","volume":"21","author":"Terrault","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0005","unstructured":"Rapport m\u00e9dical et scientifique du pr\u00e9l\u00e8vement et de la greffe en france. Available from: https:\/\/rams.agence-biomedecine.fr\/2024\/organes-tissus\/greffe-hepatique."},{"key":"10.1016\/j.hbpd.2026.09.001_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.trre.2021.100639","article-title":"Extended criteria grafts and emerging therapeutics strategy in liver transplantation. The unstable balance between damage and repair","volume":"35","author":"Ghinolfi","year":"2021","journal-title":"Transpl Rev"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0007","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/lt.21359","article-title":"Critical use of extended criteria donor liver grafts in adult-to-adult whole liver transplantation: a single-center experience","volume":"14","author":"Gruttadauria","year":"2008","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0008","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/01.sla.0000164077.77912.98","article-title":"Analysis of long-term outcomes of 3200 liver transplantations over two decades: a single-center experience","volume":"241","author":"Busuttil","year":"2005","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0009","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.addr.2015.02.006","article-title":"Raman microscopy for cellular investigations\u2014from single cell imaging to drug carrier uptake visualization","volume":"89","author":"Kann","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0010","doi-asserted-by":"crossref","first-page":"10846","DOI":"10.1111\/jcmm.16902","article-title":"Integration of Raman spectra with transcriptome data in glioblastoma multiforme defines tumour subtypes and predicts patient outcome","volume":"25","author":"Le Reste","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0011","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/lt.22091","article-title":"Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors","volume":"16","author":"Olthoff","year":"2010","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0012","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1001\/jamasurg.2017.5040","article-title":"Evaluation of early allograft function using the liver graft assessment following transplantation risk score model","volume":"153","author":"Agopian","year":"2018","journal-title":"JAMA Surg"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.nxnano.2023.100022","article-title":"Triple-bond Raman probes: expanding molecular imaging in the cell-silent region","volume":"3-4","author":"Wang","year":"2023","journal-title":"Next Nanotechnol"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0014","doi-asserted-by":"crossref","first-page":"19651","DOI":"10.1021\/jacs.2c05359","article-title":"Raman spectroscopy for chemical biology research","volume":"144","author":"Dodo","year":"2022","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0015","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/05704920701551530","article-title":"Raman spectroscopy of biological tissues","volume":"42","author":"Movasaghi","year":"2007","journal-title":"Appl Spectrosc Rev"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0016","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1600-6143.2006.01242.x","article-title":"Characteristics associated with liver graft failure: the concept of a donor risk index","volume":"6","author":"Feng","year":"2006","journal-title":"Am J Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0017","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/01.sla.0000219669.84192.b3","article-title":"Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplants","volume":"243","author":"Cameron","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0018","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1600-6143.2008.02491.x","article-title":"D-MELD, a simple predictor of post liver transplant mortality for optimization of donor\/recipient matching","volume":"9","author":"Halldorson","year":"2009","journal-title":"Am J Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0019","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1097\/SLA.0b013e318272dea2","article-title":"The use of fatty liver grafts in modern allocation systems: risk assessment by the balance of risk (BAR) score","volume":"256","author":"Dutkowski","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.12659\/AOT.883452","article-title":"The Donor-Risk-index, ECD-score and d-MELD-score all fail to predict short-term outcome after liver transplantation with acceptable sensitivity and specificity","volume":"17","author":"Klempnauer","year":"2012","journal-title":"Ann Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0021","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000000896","article-title":"Predictive capacity of risk models in liver transplantation","volume":"5","author":"de Boer","year":"2019","journal-title":"Transpl Direct"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0022","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/tri.13861","article-title":"Prognostic role of the donor risk index, the eurotransplant donor risk index, and the balance of risk score on graft loss after liver transplantation","volume":"34","author":"Lozanovski","year":"2021","journal-title":"Transpl Int"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0023","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.3748\/wjg.v22.i26.5936","article-title":"Predictive factors of short term outcome after liver transplantation: a review","volume":"22","author":"Bolondi","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0024","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/lt.23547","article-title":"Declining liver utilization for transplantation in the United States and the impact of donation after cardiac death","volume":"19","author":"Orman","year":"2013","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0025","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.3390\/cells12222645","article-title":"Assessment of primary human liver cancer cells by artificial intelligence-assisted Raman spectroscopy","volume":"12","author":"Esposito","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0026","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0304-3940(92)90331-Z","article-title":"Near-infrared FT-Raman spectra of the rat brain tissues","volume":"141","author":"Mizuno","year":"1992","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.22.9.095006","article-title":"Discrimination of human and nonhuman blood using Raman spectroscopy with self-reference algorithm","volume":"22","author":"Bian","year":"2017","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0028","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.bios.2017.08.041","article-title":"Novel ratiometric surface-enhanced raman spectroscopy aptasensor for sensitive and reproducible sensing of Hg2","volume":"99","author":"Wu","year":"2018","journal-title":"Biosens Bioelectron"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0029","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1499-3872(14)60023-0","article-title":"Primary graft dysfunction after liver transplantation","volume":"13","author":"Chen","year":"2014","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0030","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1002\/lt.23746","article-title":"Early allograft dysfunction: causes, recognition, and management","volume":"19","author":"Deschenes","year":"2013","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0031","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5604\/16652681.1184212","article-title":"Early allograft dysfunction after liver transplantation: an intermediate outcome measure for targeted improvements","volume":"15","author":"Lee","year":"2016","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0032","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/lt.20992","article-title":"Liver retransplantation for primary nonfunction: analysis of a 20-year single-center experience","volume":"13","author":"Uemura","year":"2007","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0033","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1159\/000522052","article-title":"Primary nonfunction and early allograft dysfunction after liver transplantation","volume":"40","author":"Masior","year":"2022","journal-title":"Dig Dis"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0034","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.3390\/jcm13133762","article-title":"Advancements in predictive tools for primary graft dysfunction in liver transplantation: a comprehensive review","volume":"13","author":"Gierej","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0035","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jhep.2014.04.023","article-title":"Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction","volume":"61","author":"Cortes","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0036","doi-asserted-by":"crossref","DOI":"10.1038\/srep17737","article-title":"Lipidomics comparing DCD and DBD liver allografts uncovers lysophospholipids elevated in recipients undergoing early allograft dysfunction","volume":"5","author":"Xu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0037","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jcmgh.2023.03.003","article-title":"Mechanistic insight and clinical implications of ischemia\/reperfusion injury post liver transplantation","volume":"15","author":"Liu","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0038","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/lt.25955","article-title":"Hypothermic oxygenated perfusion improves extended criteria donor liver graft function and reduces duration of hospitalization without extra cost: the PERPHO study","volume":"27","author":"Rayar","year":"2021","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2026.09.001_bib0039","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/LVT.0000000000000560","article-title":"Transforming the logistics of liver transplantation with normothermic machine perfusion: clinical impact versus cost","volume":"31","author":"Gao","year":"2025","journal-title":"Liver Transpl"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387226001530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387226001530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:34:29Z","timestamp":1791200069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387226001530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":39,"alternative-id":["S1499387226001530"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2026.09.001","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Raman spectral signature uncovers predictive biomarkers for primary graft dysfunction in liver transplant: A proof-of-concept study","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2026.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}