{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:48:53Z","timestamp":1791607733497,"version":"4.3.4"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100016359","name":"Zhongnan Hospital of Wuhan University","doi-asserted-by":"publisher","award":["LCYF 202205"],"award-info":[{"award-number":["LCYF 202205"]}],"id":[{"id":"10.13039\/501100016359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370671"],"award-info":[{"award-number":["82370671"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hepatobiliary & Pancreatic Diseases International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.hbpd.2026.09.004","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:59:13Z","timestamp":1790006353000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute-on-chronic liver failure: Therapeutic challenges managed with bioartificial liver support"],"prefix":"10.1016","author":[{"given":"Hao-Yang","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Fa","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hbpd.2026.09.004_bib0001","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.jhep.2020.11.047","article-title":"Acute-on-chronic liver failure: a distinct clinical syndrome","volume":"75","author":"Moreau","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0002","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.jhep.2023.07.011","article-title":"Metabolic biomarkers significantly enhance the prediction of HBV-related ACLF occurrence and outcomes","volume":"79","author":"Zhang","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0003","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000516977","article-title":"Chronic abdominal pain: gastroenterologist approach","volume":"40","author":"Lukic","year":"2022","journal-title":"Dig Dis"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0004","article-title":"Case Report: dynamic monocyte reprogramming during ALSS therapy in type B HBV-ACLF revealed by single-cell transcriptomics","volume":"17","author":"Xie","year":"2026","journal-title":"Front Immunol"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0005","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41575-024-00967-4","article-title":"Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions","volume":"21","author":"Mak","year":"2024","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.70360","article-title":"Single-cell atlas of the peripheral immune response in patients with chronic hepatitis B","volume":"97","author":"Huang","year":"2025","journal-title":"J Med Virol"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1488527","article-title":"Dysfunction and regulatory interplay of T and B cells in chronic hepatitis B: immunotherapy and emerging antiviral strategies","volume":"14","author":"Yu","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0008","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.1111\/jcmm.15202","article-title":"Hepatitis B virus-induced hyperactivation of B cells in chronic hepatitis B patients via TLR4","volume":"24","author":"Li","year":"2020","journal-title":"J Cellular Molecular Med"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0009","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2022.38","article-title":"Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B","volume":"25","author":"Low","year":"2023","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0010","first-page":"139","article-title":"Comparison of extracorporeal cellular therapy (ELAD\u00ae) vs standard of care in a randomized controlled clinical trial in treating Chinese subjects with acute-on-chronic liver failure","volume":"10","author":"Duan","year":"2018","journal-title":"Hepat Med"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0011","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/lt.24986","article-title":"Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: a multinational, prospective, controlled, randomized trial","volume":"24","author":"Thompson","year":"2018","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0012","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/01.sla.0000124298.74199.e5","article-title":"Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure","volume":"239","author":"Demetriou","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0013","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/CCM.0000000000005824","article-title":"Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU: neurology, peri-transplant medicine, infectious disease, and gastroenterology considerations","volume":"51","author":"Nanchal","year":"2023","journal-title":"Crit Care Med"},{"key":"10.1016\/j.hbpd.2026.09.004_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.1071025","article-title":"Evaluation of liver function in patients with liver cirrhosis and chronic liver disease using functional liver imaging scores at different acquisition time points","volume":"13","author":"Tang","year":"2022","journal-title":"Front Genet"}],"container-title":["Hepatobiliary & Pancreatic Diseases International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387226001566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499387226001566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:54:21Z","timestamp":1791604461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499387226001566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":14,"alternative-id":["S1499387226001566"],"URL":"https:\/\/doi.org\/10.1016\/j.hbpd.2026.09.004","relation":{},"ISSN":["1499-3872"],"issn-type":[{"value":"1499-3872","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute-on-chronic liver failure: Therapeutic challenges managed with bioartificial liver support","name":"articletitle","label":"Article Title"},{"value":"Hepatobiliary & Pancreatic Diseases International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hbpd.2026.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}