{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:21:51Z","timestamp":1761006111995,"version":"build-2065373602"},"reference-count":129,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.healun.2003.07.007","type":"journal-article","created":{"date-parts":[[2004,5,12]],"date-time":"2004-05-12T06:26:10Z","timestamp":1084343170000},"page":"515-526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Potential applications and prospects for cardiac xenotransplantation"],"prefix":"10.1016","volume":"23","author":[{"given":"Kiyoshi","family":"Ogata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L","family":"Platt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2002","series-title":"Morbidity and mortality: 2002 chart book on cardiovascular, lung, and blood diseases","key":"10.1016\/j.healun.2003.07.007_BIB1"},{"key":"10.1016\/j.healun.2003.07.007_BIB2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1046\/j.1440-1681.1999.03186.x","article-title":"Current status of xenotransplantation","volume":"26","author":"Platt","year":"1999","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.healun.2003.07.007_BIB3","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S1053-2498(00)00224-2","article-title":"Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation","volume":"19","author":"Cooper","year":"2000","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2003.07.007_BIB4","series-title":"Xenotransplantation","first-page":"29","article-title":"Coming to terms with reality","author":"Evans","year":"2001"},{"key":"10.1016\/j.healun.2003.07.007_BIB5","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1046\/j.1440-1681.1999.03182.x","article-title":"Xenotransplantation","volume":"26","author":"Mueller","year":"1999","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.healun.2003.07.007_BIB6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0140-6736(93)92553-6","article-title":"Baboon-to-human liver transplantation","volume":"341","author":"Starzl","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.healun.2003.07.007_BIB7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1749-6632.1998.tb09112.x","article-title":"The future promises of xenotransplantation","volume":"862","author":"Platt","year":"1998","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.healun.2003.07.007_BIB8","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1072-7515(98)00054-4","article-title":"Genetic therapies for xenotransplantation","volume":"186","author":"Lin","year":"1998","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.healun.2003.07.007_BIB9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/35100578","article-title":"Xenotransplantation and other means of organ replacement","volume":"1","author":"Cascalho","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB10","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa012175","article-title":"Long-term use of a left ventricular assist device for end-stage heart failure","volume":"345","author":"Rose","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB11","first-page":"e9005","article-title":"Totally contained AbioCor artificial heart implanted July 3, 2001","volume":"104","author":"SoRelle","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2003.07.007_BIB12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00005082-200301000-00004","article-title":"The AbioCor totally implantable replacement heart","volume":"18","author":"Holmes","year":"2003","journal-title":"J Cardiovasc Nurs"},{"issue":"Suppl","key":"10.1016\/j.healun.2003.07.007_BIB13","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/S0003-4975(00)02628-X","article-title":"Mechanical circulatory support for patients with acute-fulminant myocarditis","volume":"71","author":"Acker","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.healun.2003.07.007_BIB14","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJM199805143382004","article-title":"Treatment of the Crigler\u2013Najjar syndrome type I with hepatocyte transplantation","volume":"338","author":"Fox","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB15","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1126\/science.287.5456.1258","article-title":"Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes","volume":"287","author":"Kobayashi","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.healun.2003.07.007_BIB16","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00007890-200109150-00012","article-title":"Transplantation of hepatocytes in nonhuman primates","volume":"72","author":"Vons","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1525-1594.2001.025003187.x","article-title":"Development of regenerative cardiomyocytes from mesenchymal stem cells for cardiovascular tissue engineering","volume":"25","author":"Fukuda","year":"2001","journal-title":"Artif Org"},{"key":"10.1016\/j.healun.2003.07.007_BIB18","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.healun.2003.07.007_BIB19","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1126\/science.288.5471.1660","article-title":"Generalized potential of adult neural stem cells","volume":"288","author":"Clarke","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.healun.2003.07.007_BIB20","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nm0898-929","article-title":"Regenerating functional myocardium","volume":"4","author":"Taylor","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0140-6736(00)03617-5","article-title":"Myoblast transplantation for heart failure","volume":"357","author":"Menasche","year":"2001","journal-title":"Lancet"},{"issue":"suppl2","key":"10.1016\/j.healun.2003.07.007_BIB22","first-page":"S21","article-title":"Myocardial neovascularization by adult bone marrow-derived angioblasts","volume":"81","author":"Itescu","year":"2002","journal-title":"Ann Hematol"},{"key":"10.1016\/j.healun.2003.07.007_BIB23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/science.284.5413.489","article-title":"Functional arteries grown in vitro","volume":"284","author":"Niklason","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.healun.2003.07.007_BIB24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1089\/ten.1999.5.387","article-title":"The role of vascular smooth muscle cell integrins in the compaction and mechanical strengthening of a tissue-engineered blood vessel","volume":"5","author":"Ogle","year":"1999","journal-title":"Tissue Eng"},{"issue":"suppl","key":"10.1016\/j.healun.2003.07.007_BIB25","doi-asserted-by":"crossref","first-page":"S513","DOI":"10.1016\/S0003-4975(21)01185-1","article-title":"Tissue engineering heart valves","volume":"60","author":"Shin-oka","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.healun.2003.07.007_BIB26","doi-asserted-by":"crossref","first-page":"III-56","DOI":"10.1161\/circ.102.suppl_3.III-56","article-title":"Bioengineered cardiac grafts","volume":"102","author":"Leor","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2003.07.007_BIB27","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0022-5223(00)70193-0","article-title":"Construction of a bioengineered cardiac graft","volume":"119","author":"Li","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2003.07.007_BIB28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0022-5223(00)70218-2","article-title":"Autologous porcine heart cell transplantation improved heart function after a myocardial infarction","volume":"119","author":"Li","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2003.07.007_BIB29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1126\/science.118.3054.52","article-title":"Inductive epithelio-mesenchymal interaction in cultured organ rudiments of the mouse","volume":"118","author":"Grobstein","year":"1953","journal-title":"Science"},{"key":"10.1016\/j.healun.2003.07.007_BIB30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.91.1.1","article-title":"Formation of basement membranes in the embryonic kidney","volume":"91","author":"Ekblom","year":"1981","journal-title":"J Cell Biol"},{"key":"10.1016\/j.healun.2003.07.007_BIB31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1523-1755.1998.00971.x","article-title":"Transplantation of developing metanephroi into adult rats","volume":"54","author":"Rogers","year":"1998","journal-title":"Kidney Int"},{"key":"10.1016\/j.healun.2003.07.007_BIB32","first-page":"R1865","article-title":"Transplantation of rat metanephroi into mice","volume":"280","author":"Rogers","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1016\/j.healun.2003.07.007_BIB33","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1074-7613(01)00124-8","article-title":"The immunological barrier to xenotransplantation","volume":"14","author":"Cascalho","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.healun.2003.07.007_BIB34","first-page":"575","article-title":"De reins au pli du coude par soutures arterielles et veineuses","volume":"107","author":"Jaboulay","year":"1906","journal-title":"Lyon Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00000658-191408000-00006","article-title":"Tissue and organ transplantation","volume":"60","author":"Ullman","year":"1914","journal-title":"Ann Surg"},{"key":"10.1016\/j.healun.2003.07.007_BIB36","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/eji.1830260630","article-title":"Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population","volume":"26","author":"Dorling","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB37","series-title":"Transplantation immunobiology","first-page":"577","article-title":"Immune aspects of xenotransplantation","author":"Nagayasu","year":"2000"},{"issue":"supplII","key":"10.1016\/j.healun.2003.07.007_BIB38","first-page":"S152","article-title":"A perspective on xenotransplantation","volume":"2","author":"Nagayasu","year":"1999","journal-title":"Graft"},{"key":"10.1016\/j.healun.2003.07.007_BIB39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1084\/jem.172.1.291","article-title":"The immunological basis of islet allograft primary non-function","volume":"172","author":"Kaufman","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB40","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1097\/00007890-199403270-00024","article-title":"The importance of nonimmune factors in reconstitution by discordant xenogeneic hematopoietic cells","volume":"57","author":"Gritsch","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB41","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00007890-200107270-00026","article-title":"Expression of complement regulatory proteins on islets of Langerhans","volume":"72","author":"Bennet","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/1074-7613(94)90009-4","article-title":"Porcine aortic endothelial cells activate human T cells","volume":"1","author":"Murray","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/j.healun.2003.07.007_BIB43","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.4049\/jimmunol.155.11.5249","article-title":"Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition","volume":"155","author":"Yamada","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB44","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0167-5699(90)90174-8","article-title":"Transplantation of discordant xenografts","volume":"11","author":"Platt","year":"1990","journal-title":"Immunol Today"},{"key":"10.1016\/j.healun.2003.07.007_BIB45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00007890-198807000-00001","article-title":"Xenogeneic transplantation","volume":"46","author":"Auchincloss","year":"1988","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev.immunol.16.1.433","article-title":"Xenogeneic transplantation","volume":"16","author":"Auchincloss","year":"1998","journal-title":"Annu Rev Immunol"},{"year":"1995","series-title":"Hyperacute xenograft rejection. Medical intelligence unit","author":"Platt","key":"10.1016\/j.healun.2003.07.007_BIB47"},{"key":"10.1016\/j.healun.2003.07.007_BIB48","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1097\/00007890-199604150-00019","article-title":"Prolonged survival of discordant porcine islet xenografts","volume":"61","author":"Marchetti","year":"1996","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB49","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nm0197-48","article-title":"Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation","volume":"3","author":"Gunsalus","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB50","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1053\/gast.2003.50065","article-title":"Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation","volume":"124","author":"Nagata","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.healun.2003.07.007_BIB51","first-page":"238","article-title":"Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon","volume":"7","author":"Cooper","year":"1988","journal-title":"J Heart Transplant"},{"key":"10.1016\/j.healun.2003.07.007_BIB52","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/00007890-199108000-00006","article-title":"Immunopathology of hyperacute xenograft rejection in a swine-to-primate model","volume":"52","author":"Platt","year":"1991","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB53","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1097\/00007890-199806270-00006","article-title":"Orthotopic heart transplantation in a transgenic pig-to-primate model","volume":"65","author":"Schmoeckel","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB54","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00007890-199901150-00004","article-title":"Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption","volume":"67","author":"Kozlowski","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB55","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1540-8191.2001.tb00534.x","article-title":"The pig as a source of cardiac xenografts","volume":"16","author":"Appel","year":"2001","journal-title":"J Card Surg"},{"key":"10.1016\/j.healun.2003.07.007_BIB56","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S1053-2498(01)00402-8","article-title":"Histopathology of cardiac xenograft rejection in the pig-to-baboon model","volume":"21","author":"Goddard","year":"2002","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2003.07.007_BIB57","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1073\/pnas.84.5.1369","article-title":"Evolutionary relationship between the natural anti-Gal antibody and the Gal\u03b11-3Gal epitope in primates","volume":"84","author":"Galili","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.healun.2003.07.007_BIB58","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1097\/00007890-199806270-00008","article-title":"Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors","volume":"65","author":"Zaidi","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB59","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0065-2776(08)60697-5","article-title":"The regulators of complement activation (RCA) gene cluster","volume":"45","author":"Hourcade","year":"1989","journal-title":"Adv Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB60","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0167-5699(91)90005-E","article-title":"The control of homologous lysis","volume":"12","author":"Lachmann","year":"1991","journal-title":"Immunol Today"},{"key":"10.1016\/j.healun.2003.07.007_BIB61","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.4049\/jimmunol.152.8.4095","article-title":"Complement-inhibiting activities of human CD59 and analogues from rat, sheep, and pig are not homologously restricted","volume":"152","author":"Van den Berg","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB62","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/00007890-199604270-00021","article-title":"Characterization of transgenic pigs expressing functionally active human CD59 on cardiac endothelium","volume":"61","author":"Diamond","year":"1996","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB63","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1084\/jem.181.1.21","article-title":"Transient perturbation of endothelial integrity induced by natural antibodies and complement","volume":"181","author":"Saadi","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB64","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nm0595-423","article-title":"Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury","volume":"1","author":"McCurry","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB65","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nbt0302-251","article-title":"Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs","volume":"20","author":"Dai","year":"2002","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.healun.2003.07.007_BIB66","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/01.TP.0000053615.98201.77","article-title":"Pig cells that lack the gene for alpha1\u20133 galactosyltransferase express low levels of the gal antigen","volume":"75","author":"Sharma","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB67","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nbt0302-231","article-title":"Knocking out xenograft rejection","volume":"20","author":"Platt","year":"2002","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.healun.2003.07.007_BIB68","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nbt0403-359","article-title":"Xeno","volume":"21","author":"Miyata","year":"2003","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.healun.2003.07.007_BIB69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00007890-199307000-00001","article-title":"The immunopathology of cardiac xenograft rejection in the guinea pig-to-rat model","volume":"56","author":"Leventhal","year":"1993","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB70","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1172\/JCI118297","article-title":"Immunoglobulin prevents complement mediated hyperacute rejection in swine-to-primate xenotransplantation","volume":"96","author":"Magee","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.healun.2003.07.007_BIB71","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/01.RES.0000046236.20251.FA","article-title":"Apoptosis and cellular activation in the pathogenesis of acute vascular rejection","volume":"91","author":"Holzknecht","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2003.07.007_BIB72","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0167-5699(96)10028-1","article-title":"Transplantation of discordant xenografts","volume":"17","author":"Parker","year":"1996","journal-title":"Immunol Today"},{"issue":"suppl","key":"10.1016\/j.healun.2003.07.007_BIB73","first-page":"11","article-title":"New directions for organ transplantation","volume":"392","author":"Platt","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.healun.2003.07.007_BIB74","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/00007890-199411270-00001","article-title":"Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection","volume":"58","author":"Blakely","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB75","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1172\/JCI2134","article-title":"The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants","volume":"101","author":"Lin","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.healun.2003.07.007_BIB76","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/00007890-200002270-00003","article-title":"Expression of tissue factor mRNA in cardiac xenografts","volume":"69","author":"Nagayasu","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB77","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0167-5699(96)10024-4","article-title":"Delayed xenograft rejection","volume":"17","author":"Bach","year":"1996","journal-title":"Immunol Today"},{"key":"10.1016\/j.healun.2003.07.007_BIB78","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1399-3089.1995.tb00101.x","article-title":"Tolerance across discordant xenogeneic barriers","volume":"2","author":"Sachs","year":"1995","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB79","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1097\/00007890-199904150-00007","article-title":"Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors","volume":"67","author":"Sablinski","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB80","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1097\/00007890-199812150-00006","article-title":"Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts","volume":"66","author":"Ierino","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB81","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/80242","article-title":"Production of cloned pigs from in vitro systems","volume":"18","author":"Betthauser","year":"2000","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.healun.2003.07.007_BIB82","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1126\/science.289.5482.1188","article-title":"Pig cloning by microinjection of fetal fibroblast nuclei","volume":"289","author":"Onishi","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.healun.2003.07.007_BIB83","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35024082","article-title":"Cloned piglets produced by nuclear transfer from adult somatic cells","volume":"407","author":"Polejaeva","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.healun.2003.07.007_BIB84","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/89313","article-title":"Deletion of the a(1,3) galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep","volume":"19","author":"Denning","year":"2001","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.healun.2003.07.007_BIB85","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1068228","article-title":"Production of \u03b1-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning","volume":"295","author":"Lai","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.healun.2003.07.007_BIB86","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1126\/science.1078942","article-title":"Production of alpha 1,3-galactosyltransferase-deficient pigs","volume":"299","author":"Phelps","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.healun.2003.07.007_BIB87","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1097\/00007890-200012270-00002","article-title":"The role of anti-Gal\u03b11-3Gal antibodies in acute vascular rejection and accommodation of xenografts","volume":"70","author":"Lin","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB88","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-0897.1996.tb00010.x","article-title":"Lymphocyte subsets and mitogen stimulation of blood lymphocytes in normal pregnancy","volume":"35","author":"Matthiesen","year":"1996","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB89","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0198-8859(97)00229-2","article-title":"Humoral responses in pig-to-baboon cardiac transplantation","volume":"58","author":"McCurry","year":"1997","journal-title":"Hum Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB90","first-page":"4553","article-title":"ABO-incompatible renal transplantation","volume":"19","author":"Chopek","year":"1987","journal-title":"Transplant Proc"},{"key":"10.1016\/j.healun.2003.07.007_BIB91","first-page":"783","article-title":"ABO incompatible renal transplantation","volume":"21","author":"Bannett","year":"1989","journal-title":"Transplant Proc"},{"key":"10.1016\/j.healun.2003.07.007_BIB92","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4049\/jimmunol.160.1.369","article-title":"Accommodation and T-independent B cell tolerance in rats with long term surviving hamster heart xenografts","volume":"160","author":"Lin","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0966-3274(96)80027-X","article-title":"Cellular mechanisms of adaptation of grafts to antibody","volume":"4","author":"Andres","year":"1996","journal-title":"Transplant Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB94","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.4049\/jimmunol.164.7.3764","article-title":"Resistance against the membrane attack complex of complement induced in porcine endothelial cells with a Gal alpha(1\u20133)Gal binding lectin","volume":"164","author":"Dalmasso","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB95","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/00007890-200103150-00004","article-title":"Nitric oxide-mediated expression of Bcl-2 and Bcl-xl and protection from TNF\u03b1-mediated apoptosis in porcine endothelial cells after exposure to low concentrations of xenoreactive natural antibody","volume":"71","author":"Delikouras","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB96","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nm0297-196","article-title":"Accommodation of vascularized xenografts","volume":"3","author":"Bach","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB97","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/2063","article-title":"Expression of heme oxygenase-1 can determine cardiac xenograft survival","volume":"4","author":"Soares","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB98","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.4049\/jimmunol.166.6.4185","article-title":"Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants","volume":"166","author":"Sato","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB99","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/hh1301.092679","article-title":"Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice","volume":"89","author":"Imai","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2003.07.007_BIB100","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/00007890-200103150-00002","article-title":"Accommodation and the reversibility of biological systems","volume":"71","author":"Holzknecht","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB101","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1034\/j.1600-6143.2001.010106.x","article-title":"T-cell-mediated rejection of vascularized xenografts in the absence of induced anti-donor antibody response","volume":"1","author":"Sebille","year":"2001","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2003.07.007_BIB102","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/3982","article-title":"Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes","volume":"4","author":"Hancock","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB103","doi-asserted-by":"crossref","unstructured":"Sablinski T, Latinne D, Gianello P, et al. Xenotransplantation of pig kidneys to nonhuman primates: I. Development of the model. Xenotransplantation 1995;2:264\u201370","DOI":"10.1111\/j.1399-3089.1995.tb00107.x"},{"key":"10.1016\/j.healun.2003.07.007_BIB104","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0022-5223(98)70438-6","article-title":"Total respiratory support from swine lungs in primate recipients","volume":"115","author":"Daggett","year":"1998","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2003.07.007_BIB105","doi-asserted-by":"crossref","first-page":"12100","DOI":"10.1073\/pnas.94.22.12100","article-title":"Restoration of \u03b2-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer","volume":"94","author":"Akhter","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.healun.2003.07.007_BIB106","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1097\/00007890-200011150-00010","article-title":"Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates","volume":"70","author":"Buhler","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB107","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1053\/jlts.2002.35172","article-title":"Detection of albumin synthesis in transplanted porcine hepatocytes in mice","volume":"8","author":"Nishitai","year":"2002","journal-title":"Liver Transplant"},{"key":"10.1016\/j.healun.2003.07.007_BIB108","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0952-7915(00)00128-X","article-title":"Xenotransplantation","volume":"12","author":"Takeuchi","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.14.1.1-14.2001","article-title":"Infectious disease issues in xenotransplantation","volume":"14","author":"Boneva","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.healun.2003.07.007_BIB110","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0952-7915(98)80220-3","article-title":"Zoonosis in xenotransplantation","volume":"10","author":"Patience","year":"1998","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB111","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/35024089","article-title":"Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice","volume":"407","author":"Van der Laan","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.healun.2003.07.007_BIB112","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1126\/science.285.5431.1236","article-title":"Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue","volume":"285","author":"Paradis","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.healun.2003.07.007_BIB113","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1034\/j.1399-3089.2003.01128.x","article-title":"Porcine cytomegalovirus in pigs being bred for xenograft organs","volume":"10","author":"Clark","year":"2003","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB114","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.0000031064.67525.28","article-title":"Recommendations of the National Heart, Lung, and Blood Institute Heart and Lung Xenotransplantation Working Group","volume":"106","author":"Platt","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2003.07.007_BIB115","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jama.1964.03060390034008","article-title":"Heart transplantation in man","volume":"188","author":"Hardy","year":"1964","journal-title":"JAMA"},{"key":"10.1016\/j.healun.2003.07.007_BIB116","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/0002-9149(68)90175-6","article-title":"Human heart transplantation","volume":"22","author":"Cooley","year":"1968","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.healun.2003.07.007_BIB117","unstructured":"Ross DN. In: Shapiro H, ed. Experience with human heart transplantation. Durban, South Africa: Butterworth; 1969:227"},{"key":"10.1016\/j.healun.2003.07.007_BIB118","first-page":"114","article-title":"The first heart transplants in the United Kingdom, 1968\u20131980\u2014the role of Guy's graduates. Part 2","volume":"109","author":"Cooper","year":"1995","journal-title":"Guy's Hosp Gazette"},{"key":"10.1016\/j.healun.2003.07.007_BIB119","first-page":"585","article-title":"Les transplantations cardiaques et les transplantations hepatiques","volume":"222","author":"Marion","year":"1969","journal-title":"Lyon Med"},{"key":"10.1016\/j.healun.2003.07.007_BIB120","first-page":"1035","article-title":"Heterotopic cardiac transplantation with a xenograft for assistance of the left heart in cardiogenic shock after cardiopulmonary bypass","volume":"52","author":"Barnard","year":"1977","journal-title":"S Afr Med J"},{"key":"10.1016\/j.healun.2003.07.007_BIB121","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1001\/jama.1985.03360230053022","article-title":"Baboon-to-human cardiac xenotransplantation in a neonate","volume":"254","author":"Bailey","year":"1985","journal-title":"JAMA"},{"key":"10.1016\/j.healun.2003.07.007_BIB122","first-page":"393","article-title":"The lack of hyperacute xenogeneic heart transplant rejection in a human","volume":"11","author":"Czaplicki","year":"1992","journal-title":"J Heart Lung Transplant"},{"year":"1991","series-title":"Xenotransplantation","author":"Cooper","key":"10.1016\/j.healun.2003.07.007_BIB123"},{"key":"10.1016\/j.healun.2003.07.007_BIB124","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0966-3274(97)80040-8","article-title":"The role of natural anti-Gal\u03b11-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants","volume":"5","author":"Lin","year":"1997","journal-title":"Transplant Immunol"},{"key":"10.1016\/j.healun.2003.07.007_BIB125","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/00007890-199304000-00033","article-title":"Prolongation of cardiac xenograft survival by depletion of complement","volume":"55","author":"Leventhal","year":"1993","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB126","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/00007890-199402150-00009","article-title":"The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts","volume":"57","author":"Pruitt","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB127","series-title":"Xenotransplantation","first-page":"665","article-title":"Effect of transgenic expression of human decay-accelerating factor on the inhibition of hyperacute rejection of pig organs","author":"Cozzi","year":"1997"},{"key":"10.1016\/j.healun.2003.07.007_BIB128","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00007890-200101150-00021","article-title":"A human CD46 transgenic pig model system for the study of discordant xenotransplantation","volume":"71","author":"Diamond","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2003.07.007_BIB129","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1126\/science.281.5384.1845","article-title":"Inhibition of xenoreactive natural antibody production by retroviral gene therapy","volume":"281","author":"Bracy","year":"1998","journal-title":"Science"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249803003401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249803003401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:09:04Z","timestamp":1760947744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249803003401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":129,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S1053249803003401"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2003.07.007","relation":{},"ISSN":["1053-2498"],"issn-type":[{"type":"print","value":"1053-2498"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential applications and prospects for cardiac xenotransplantation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2003.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}