{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:02:31Z","timestamp":1776380551266,"version":"3.51.2"},"reference-count":13,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.healun.2005.04.008","type":"journal-article","created":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T08:25:53Z","timestamp":1123575953000},"page":"1965-1968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Need for a Tailored Immunosuppression in Older Heart Transplant Recipients"],"prefix":"10.1016","volume":"24","author":[{"given":"Ingo","family":"Kaczmarek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Sadoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schmoeckel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Daebritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Veberfuhr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Meiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Reichart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2005.04.008_bib1","first-page":"573","article-title":"Heart transplantation as a treatment option for end-stage heart disease in patients older than 65 years of age","volume":"12","author":"Heroux","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2005.04.008_bib2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1399-0012.1996.tb00732.x","article-title":"Heart transplantation for patients over age 60","volume":"10","author":"Everett","year":"1996","journal-title":"Clin Transplant"},{"key":"10.1016\/j.healun.2005.04.008_bib3","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/S0003-4975(02)03933-4","article-title":"Seventeen-year experience with 1,083 heart transplants at a single institution","volume":"74","author":"Marelli","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.healun.2005.04.008_bib4","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S1053-2498(99)00024-8","article-title":"An analysis of the effect of age on survival after heart transplantation","volume":"18","author":"Borkon","year":"1999","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2005.04.008_bib5","first-page":"929","article-title":"Heart transplantation in patients over 54 years of age with triple-drug immunosuppression","volume":"11","author":"Fabbri","year":"1992","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2005.04.008_bib6","first-page":"549","article-title":"Pretransplantation risk factors for death after heart transplantation: a multiinstitutional study. The Transplant Cardiologists Research Database Group","volume":"12","author":"Bourge","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2005.04.008_bib7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-5223(96)70452-X","article-title":"Long-term results of cardiac transplantation in patients older than 60 years. UTAH Cardiac Transplant Program","volume":"111","author":"Bull","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2005.04.008_bib8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1053-2498(01)00323-0","article-title":"The registry of the International Society for Heart and Lung Transplantation","volume":"20","author":"Hosenpud","year":"2001","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2005.04.008_bib9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0002-9343(87)90746-7","article-title":"Age-associated decline in cardiac allograft rejection","volume":"83","author":"Renlund","year":"1987","journal-title":"Am J Med"},{"key":"10.1016\/j.healun.2005.04.008_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1053-2498(98)00002-3","article-title":"Combination therapy with tacrolimus and mycophenolate mofetil following cardiac transplantation","volume":"18","author":"Meiser","year":"1999","journal-title":"J Heart Lung Transplant"},{"issue":"suppl 1","key":"10.1016\/j.healun.2005.04.008_bib11","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s001470050487","article-title":"Quantification of immunosuppression by flow cytometric measurement of intracellular cytokine synthesis","volume":"11","author":"Van den Berg","year":"1998","journal-title":"Transplant Int"},{"key":"10.1016\/j.healun.2005.04.008_bib12","first-page":"7","article-title":"One size fits all","volume":"8","author":"Baran","year":"2003","journal-title":"Ann Transplant"},{"issue":"suppl 5","key":"10.1016\/j.healun.2005.04.008_bib13","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1016\/j.healun.2004.03.010","article-title":"Optimizing the immunosuppressive regimen in heart transplantation","volume":"23","author":"Eisen","year":"2004","journal-title":"J Heart Lung Transplant"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249805002111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249805002111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:12:34Z","timestamp":1760947954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249805002111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S1053249805002111"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2005.04.008","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Need for a Tailored Immunosuppression in Older Heart Transplant Recipients","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2005.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}