{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:48:06Z","timestamp":1761630486000,"version":"build-2065373602"},"reference-count":50,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.healun.2008.04.010","type":"journal-article","created":{"date-parts":[[2008,6,7]],"date-time":"2008-06-07T05:13:27Z","timestamp":1212815607000},"page":"760-766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Follow-up Study on the Utility of von Willebrand Factor Levels in the Diagnosis of Cardiac Allograft Vasculopathy"],"prefix":"10.1016","volume":"27","author":[{"given":"Luis","family":"Mart\u00ednez-Dolz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Almenar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldemiro","family":"Reganon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virtudes","family":"Vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Chamorro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicenta","family":"Mart\u00ednez-Sales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Moro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Ag\u00fcero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"S\u00e1nchez-L\u00e1zaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2008.04.010_bib1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.healun.2007.06.004","article-title":"Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult heart transplant report\u20142007","volume":"26","author":"Taylor","year":"2007","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib2","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/j.1600-6143.2006.01314.x","article-title":"Contemporary concepts in prevention and treatment of cardiac allograft vasculopathy","volume":"6","author":"Mehra","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib3","first-page":"632","article-title":"Presence of severe intimal thickening by intravascular ultrasonography predicts cardiac events in cardiac allograft vasculopathy","volume":"14","author":"Mehra","year":"1995","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib4","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1161\/01.CIR.92.12.3445","article-title":"Prognostic importance of intimal thickness as measured by intracoronary ultrasound after cardiac transplantation","volume":"92","author":"Rickenbacher","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2008.04.010_bib5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00001573-199903000-00011","article-title":"Impact of intravascular ultrasound in understanding transplant coronary artery disease","volume":"14","author":"Kapadia","year":"1999","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib6","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1161\/01.CIR.95.3.600","article-title":"Effects of cardiac allograft vasculopathy on myocardial blood flow, vasodilatory capacity, and coronary vasomotion","volume":"95","author":"Kofoed","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2008.04.010_bib7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.CIR.76.4.827","article-title":"Development of coronary artery disease in cardiac transplant patients receiving immunosuppressive therapy with cyclosporine and prednisone","volume":"76","author":"Uretsky","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2008.04.010_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/1010-7940(90)90207-G","article-title":"Risk factors for development of accelerated coronary artery disease in cardiac transplant recipients","volume":"4","author":"Radovancevic","year":"1990","journal-title":"Eur J Cardiothorac Surg"},{"issue":"suppl","key":"10.1016\/j.healun.2008.04.010_bib9","first-page":"S104","article-title":"Graft atherosclerosis: effects of cellular rejection and human lymphocyte antigen","volume":"11","author":"Zerbe","year":"1992","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib10","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1053\/euhj.1999.1524","article-title":"Graft coronary artery disease is strongly related to the aetiology of heart failure and cellular rejections","volume":"20","author":"Lindelow","year":"1999","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2008.04.010_bib11","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.healun.2005.11.449","article-title":"Allograft vasculopathy: the cumulative effect of acute rejection on development of cardiac allograft vasculopathy","volume":"25","author":"Stoica","year":"2006","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.healun.2005.09.003","article-title":"Acute antibody-mediated rejection of cardiac transplants","volume":"25","author":"Reed","year":"2006","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib13","first-page":"24","article-title":"Vascular (humoral) rejection in cardiac allograft biopsies: relation to circulating anti-HLA antibodies","volume":"11","author":"Cherry","year":"1992","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00007890-199902150-00008","article-title":"The clinical significance of antibodies to human vascular endothelial cells after cardiac transplantation","volume":"67","author":"Fredrich","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2008.04.010_bib15","first-page":"233","article-title":"Degree of HLA mismatch as a predictor of death from allograft arteriopathy after heart transplant","volume":"25","author":"Cocanougher","year":"1993","journal-title":"Transplant Proc"},{"key":"10.1016\/j.healun.2008.04.010_bib16","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/0002-9149(94)90856-7","article-title":"Cardiac allograft vasculopathy assessed by intravascular ultrasonography and nonimmunologic risk factors","volume":"74","author":"Escobar","year":"1994","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib17","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0735-1097(01)01337-7","article-title":"Impact of lipid abnormalities in development and progression of transplant coronary disease: a serial intravascular ultrasound study","volume":"38","author":"Kapadia","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib18","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1161\/01.ATV.20.3.698","article-title":"Oxidized low density lipoprotein is a prognostic marker of transplant-associated coronary artery disease","volume":"20","author":"Holvoet","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.healun.2008.04.010_bib19","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1097\/01.TP.0000090163.48433.48","article-title":"Cytomegalovirus infection status predicts progression of heart-transplant vasculopathy","volume":"76","author":"Fateh-Moghadam","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2008.04.010_bib20","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/01.TP.0000119722.37337.DC","article-title":"Comparison of combined prophylaxis of cytomegalovirus hyperimmune globulin plus ganciclovir versus cytomegalovirus hyperimmune globulin alone in high-risk heart transplant recipients","volume":"77","author":"Bonaros","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2008.04.010_bib21","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.jacc.2003.08.063","article-title":"Glucose intolerance, as reflected by hemoglobin A1c level, is associated with the incidence and severity of transplant coronary artery disease","volume":"43","author":"Kato","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib22","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0735-1097(96)00521-9","article-title":"Relation of donor age and preexisting coronary artery disease on angiography and intracoronary ultrasound to later development of accelerated allograft coronary artery disease","volume":"29","author":"Gao","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib23","first-page":"1024","article-title":"Noninvasive detection of transplant coronary artery disease by dobutamine stress echocardiography","volume":"13","author":"Akosah","year":"1994","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib24","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0735-1097(98)00169-7","article-title":"Dobutamine stress echocardiography early after heart transplantation predicts development of allograft coronary artery disease and outcome","volume":"31","author":"Akosah","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib25","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/01.CIR.100.5.509","article-title":"Diagnostic and prognostic value of serial dobutamine stress echocardiography for noninvasive assessment of cardiac allograft vasculopathy: a comparison with coronary angiography and intravascular ultrasound","volume":"100","author":"Spes","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2008.04.010_bib26","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1053-2498(00)00167-4","article-title":"Myocardial perfusion scintigraphy as a screening method for significant coronary artery stenosis in cardiac transplant recipients","volume":"19","author":"Carlsen","year":"2000","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib27","first-page":"2049","article-title":"Noninvasive diagnosis of cardiac transplant arteriopathy with dipyridamole thallium scintigraphy","volume":"34","author":"Tse","year":"1993","journal-title":"J Nucl Med"},{"key":"10.1016\/j.healun.2008.04.010_bib28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S1053-2498(00)00068-1","article-title":"Accuracy of dobutamine tetrofosmin myocardial perfusion imaging for the noninvasive diagnosis of transplant coronary artery stenosis","volume":"19","author":"Elhendy","year":"2000","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib29","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0002-9149(02)02247-6","article-title":"Prediction of mortality in heart transplant recipients by stress technetium-99m tetrofosmin myocardial perfusion imaging","volume":"89","author":"Elhendy","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib30","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0002-9149(97)00207-5","article-title":"Determinants of transplant-related coronary calcium detected by ultrafast computed tomography scanning","volume":"79","author":"Barbir","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1053-2498(98)00037-0","article-title":"Relationship between coronary function by positron emission tomography and temporal changes in morphology by intravascular ultrasound (IVUS) in transplant recipients","volume":"18","author":"Allen-Auerbach","year":"1999","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1053-2498(03)00150-5","article-title":"Changes in coronary endothelial function predict progression of allograft vasculopathy after heart transplantation","volume":"23","author":"Hollenberg","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib33","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1111\/j.1600-6143.2004.00485.x","article-title":"Surrogate markers for late cardiac allograft survival","volume":"4","author":"Mehra","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1053-2498(03)00097-4","article-title":"Mycophenolate mofetil for secondary prevention of cardiac allograft vasculopathy: influence on inflammation and progression of intimal hyperplasia","volume":"23","author":"Pethig","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib35","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/jama.284.4.457","article-title":"Cardiac-specific troponin I levels and risk of coronary artery disease and graft failure following heart transplantation","volume":"284","author":"Labarrere","year":"2000","journal-title":"JAMA"},{"issue":"suppl","key":"10.1016\/j.healun.2008.04.010_bib36","first-page":"III-233","article-title":"Systemic inflammatory response in cardiac allograft vasculopathy: high-sensitive C-reactive protein is associated with progressive luminal obstruction","volume":"102","author":"Pethig","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2008.04.010_bib37","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/S0140-6736(02)11473-5","article-title":"C-reactive protein, arterial endothelial activation, and development of transplant coronary artery disease: a prospective study","volume":"360","author":"Labarrere","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.healun.2008.04.010_bib38","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.healun.2007.05.008","article-title":"Systemic inflammation and metabolic syndrome in cardiac allograft vasculopathy","volume":"26","author":"Raichlin","year":"2007","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib39","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1161\/01.CIR.102.17.2100","article-title":"Elevated levels of plasma C-reactive protein are associated with decreased graft survival in cardiac transplant recipients","volume":"102","author":"Eisenberg","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2008.04.010_bib40","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.amjcard.2004.04.060","article-title":"Usefulness of an elevated B-type natriuretic peptide to predict allograft failure, cardiac allograft vasculopathy, and survival after heart transplantation","volume":"94","author":"Mehra","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib41","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/0735-1097(95)00357-6","article-title":"Predictive model to assess risk for cardiac allograft vasculopathy: an intravascular ultrasound study","volume":"26","author":"Mehra","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib42","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jacc.2005.02.035","article-title":"Multicenter intravascular ultrasound validation study among heart transplant recipients: outcomes after five years","volume":"45","author":"Kobashigawa","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2008.04.010_bib43","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.jacc.2004.12.076","article-title":"Intravascular ultrasound evidence of angiographically silent progression in coronary atherosclerosis predicts long-term morbidity and mortality after cardiac transplantation","volume":"45","author":"Tuzcu","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"suppl","key":"10.1016\/j.healun.2008.04.010_bib44","first-page":"S124","article-title":"Transplant coronary disease: nonimmunologic risk factors","volume":"11","author":"Johnson","year":"1992","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2008.04.010_bib45","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1056\/NEJM199509073331003","article-title":"Effect of pravastatin on outcomes after cardiac transplantation","volume":"333","author":"Kobashigawa","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2008.04.010_bib46","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1161\/01.CIR.103.17.2144","article-title":"Metabolic abnormalities characteristic of dysmetabolic syndrome predict the development of transplant coronary artery disease: a prospective study","volume":"103","author":"Valantine","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2008.04.010_bib47","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/00007890-199707270-00007","article-title":"Factors contributing to the development of chronic rejection in heterotopic rat heart transplantation","volume":"64","author":"Schmid","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2008.04.010_bib48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1161\/01.CIR.92.1.31","article-title":"Fibrinogen after coronary angioplasty as a risk factor for restenosis","volume":"92","author":"Montalescot","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2008.04.010_bib49","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/01.RES.51.5.587","article-title":"Arteriosclerosis in normal and von Willebrand pigs: long-term prospective study and aortic transplantation study","volume":"51","author":"Fuster","year":"1982","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2008.04.010_bib50","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0735-1097(00)00756-7","article-title":"Plasma atherogenic markers in congestive heart failure and posttransplant (heart) patients","volume":"36","author":"Cooke","year":"2000","journal-title":"J Am Coll Cardiol"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249808003471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249808003471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:16:27Z","timestamp":1760948187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249808003471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S1053249808003471"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2008.04.010","relation":{},"ISSN":["1053-2498"],"issn-type":[{"type":"print","value":"1053-2498"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Follow-up Study on the Utility of von Willebrand Factor Levels in the Diagnosis of Cardiac Allograft Vasculopathy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2008.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}