{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:41:07Z","timestamp":1789929667762,"version":"4.0.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.healun.2009.04.028","type":"journal-article","created":{"date-parts":[[2009,7,25]],"date-time":"2009-07-25T11:25:07Z","timestamp":1248521107000},"page":"785-790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["High Incidence of Thromboembolic Events in Left Ventricular Assist Device Patients Treated With Recombinant Activated Factor VII"],"prefix":"10.1016","volume":"28","author":[{"given":"Brian A.","family":"Bruckner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"DiBardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Adeboygeun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Valdes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Eze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denton A.","family":"Cooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor D.","family":"Gregoric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar H.","family":"Frazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2009.04.028_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1477-9560-2-9","article-title":"Recombinant activated factor VII (rFVIIa) as salvage treatment for intractable hemorrhage","volume":"2","author":"Aggarwal","year":"2004","journal-title":"Thromb J"},{"key":"10.1016\/j.healun.2009.04.028_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.TA.0000171453.37949.B7","article-title":"Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials","volume":"59","author":"Boffard","year":"2005","journal-title":"J Trauma"},{"key":"10.1016\/j.healun.2009.04.028_bib3","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.athoracsur.2006.05.076","article-title":"Effective management of refractory postcardiotomy bleeding with the use of recombinant activated factor VII","volume":"82","author":"Filsoufi","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.healun.2009.04.028_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0140-6736(03)12268-4","article-title":"Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial","volume":"361","author":"Friederich","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.healun.2009.04.028_bib5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJMoa042991","article-title":"Recombinant activated factor VII for acute intracerebral hemorrhage","volume":"352","author":"Mayer","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2009.04.028_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/01.mbc.0000233370.49099.c0","article-title":"Efficacy of recombinant activated factor VII in unselected patients with uncontrolled haemorrhage: a single centre experience","volume":"17","author":"Payne","year":"2006","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.healun.2009.04.028_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.athoracsur.2005.02.044","article-title":"Recombinant factor VIIa in the treatment of postoperative hemorrhage after cardiac surgery","volume":"80","author":"Raivio","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.healun.2009.04.028_bib8","doi-asserted-by":"crossref","first-page":"R178","DOI":"10.1186\/cc5133","article-title":"Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials","volume":"10","author":"Rizoli","year":"2006","journal-title":"Crit Care"},{"key":"10.1016\/j.healun.2009.04.028_bib9","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1056\/NEJM200505193522017","article-title":"Recombinant activated factor VII for acute intracerebral hemorrhage","volume":"352","author":"Sheth","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2009.04.028_bib10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jama.295.3.293","article-title":"Thromboembolic adverse events after use of recombinant human coagulation factor VIIa","volume":"295","author":"O'Connell","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.healun.2009.04.028_bib11","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1177\/0310057X0603400520","article-title":"Thrombogenic side-effects of recombinant factor VIIa after use in coronary artery bypass surgery","volume":"34","author":"White","year":"2006","journal-title":"Anaesth Intensive Care"},{"issue":"suppl","key":"10.1016\/j.healun.2009.04.028_bib12","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1053\/j.seminhematol.2005.11.006","article-title":"High-dose recombinant factor VIIa therapy in hemophilia patients with inhibitors","volume":"43","author":"Kenet","year":"2006","journal-title":"Semin Hematol"},{"key":"10.1016\/j.healun.2009.04.028_bib13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.healun.2003.12.001","article-title":"Use of recombinant factor VII to control bleeding in a patient supported by right ventricular assist device after heart transplantation","volume":"24","author":"Kogan","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.04.028_bib14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1213\/ane.0b013e31815edb52","article-title":"Acute left atrial thrombus after recombinant factor VIIa administration during left ventricular assist device implantation in a patient with heparin-induced thrombocytopenia","volume":"106","author":"Apostolidou","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.healun.2009.04.028_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1749-8090-2-32","article-title":"Use of activated recombinant factor VII for severe coagulopathy post ventricular assist device or orthotopic heart transplant","volume":"2","author":"Gandhi","year":"2007","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.healun.2009.04.028_bib16","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1111\/j.1538-7836.2006.02088.x","article-title":"Recombinant factor VIIa reverses the inhibitory effect of aspirin or aspirin plus clopidogrel on in vitro thrombin generation","volume":"4","author":"Altman","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.healun.2009.04.028_bib17","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1213\/01.ane.0000209023.96418.e5","article-title":"Small-dose recombinant activated factor VII (NovoSeven) in cardiac surgery","volume":"102","author":"Romagnoli","year":"2006","journal-title":"Anesth Analg"},{"key":"10.1016\/j.healun.2009.04.028_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1537-2995.2005.04216.x","article-title":"Recombinant factor VIIa for intractable blood loss after cardiac surgery: a propensity score-matched case-control analysis","volume":"45","author":"Karkouti","year":"2005","journal-title":"Transfusion (Paris)"},{"key":"10.1016\/j.healun.2009.04.028_bib19","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/j.1537-2995.2005.00548.x","article-title":"A multicenter assessment of recombinant factor VIIa off-label usage: clinical experiences and associated outcomes","volume":"45","author":"MacLaren","year":"2005","journal-title":"Transfusion (Paris)"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249809003106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249809003106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:20:20Z","timestamp":1760948420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249809003106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S1053249809003106"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2009.04.028","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High Incidence of Thromboembolic Events in Left Ventricular Assist Device Patients Treated With Recombinant Activated Factor VII","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2009.04.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}