{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:06:46Z","timestamp":1791040006666,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.healun.2009.05.021","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T04:54:36Z","timestamp":1251348876000},"page":"912-918","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long-term Immunosuppression With Anti-CD25 Monoclonal Antibodies in Heart Transplant Patients With Chronic Kidney Disease"],"prefix":"10.1016","volume":"28","author":[{"given":"Marcelo","family":"Cantarovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Giannetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Routy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Cecere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Barkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2009.05.021_bib1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMoa021744","article-title":"Chronic renal failure after transplantation of a nonrenal organ","volume":"349","author":"Ojo","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2009.05.021_bib2","first-page":"708","article-title":"Influence on survival after heart transplantation of contraindications seen in transplant recipients","volume":"11","author":"Anguita","year":"1992","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1600-6143.2006.01640.x","article-title":"The outcome of heart transplant recipients following the development of end stage renal disease: analysis of the Canadian Organ Replacement Register","volume":"7","author":"Alam","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1053-2498(03)00147-5","article-title":"Analysis of survivors more than 10 years after heart transplantation in the cyclosporine era: Stanford experience","volume":"23","author":"Shiba","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib5","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/00007890-199703150-00009","article-title":"Cyclosporine-associated end-stage nephropathy after cardiac transplantation: incidence and progression","volume":"65","author":"Goldstein","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2009.05.021_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000168677","article-title":"Time course of the decline in renal function in cyclosporine-treated heart transplant recipients","volume":"14","author":"Zietse","year":"1994","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.healun.2009.05.021_bib7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/00007890-199010000-00012","article-title":"Cyclosporine nephrotoxicity in cardiac allograft patients\u2014a seven-year follow-up","volume":"50","author":"Greenberg","year":"1990","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2009.05.021_bib8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1681\/ASN.V115951","article-title":"Predictors and evolution of renal function during 9 years following heart transplantation","volume":"11","author":"Lindelow","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.healun.2009.05.021_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000045534","article-title":"Risk factors for chronic renal dysfunction in cardiac allograft recipients","volume":"84","author":"Esposito","year":"2000","journal-title":"Nephron"},{"key":"10.1016\/j.healun.2009.05.021_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0012.2004.00105.x","article-title":"End-stage renal failure and cardiac mortality after heart transplantation","volume":"18","author":"Senechal","year":"2004","journal-title":"Clin Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S1053-2498(01)00411-9","article-title":"The incidence of end-stage renal failure in 17 years of heart transplantation: a single center experience","volume":"21","author":"Satchithananda","year":"2002","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0272-6386(87)80156-7","article-title":"Early and late forms of cyclosporine nephrotoxicity: studies in cardiac transplant recipients","volume":"9","author":"Greenberg","year":"1987","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.healun.2009.05.021_bib13","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1093\/ndt\/13.9.2322","article-title":"Renal insufficiency after heart transplantation: a case\u2013control study","volume":"13","author":"van Gelder","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib14","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1097\/00007890-200004270-00012","article-title":"Improvement of impaired renal function in heart transplant recipients treated with mycophenolate mofetil and low-dose cyclosporine","volume":"69","author":"Aleksic","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2009.05.021_bib15","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0041-1345(03)00360-9","article-title":"Renal function and safety of heart transplant recipients switched to mycophenolate mofetil and low-dose cyclosporine","volume":"35","author":"Baryalei","year":"2003","journal-title":"Transplant Proc"},{"key":"10.1016\/j.healun.2009.05.021_bib16","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1016\/j.transproceed.2004.09.035","article-title":"Chronic cyclosporine-induced nephrotoxiciy in heart transplant patients: long-term benefits of treatment with mycophenolate mofetil and low-dose cyclosporine","volume":"36","author":"Sanchez","year":"2004","journal-title":"Transplant Proc"},{"key":"10.1016\/j.healun.2009.05.021_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1055\/s-2004-820880","article-title":"First experience with rapamycin-based immunosuppression to improve kidney function after heart transplantation","volume":"52","author":"Tr\u00f6sch","year":"2004","journal-title":"Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2009.05.021_bib18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1399-0012.2006.00632.x","article-title":"Calcineurin inhibitor substitution with sirolimus versus reduced-dose calcineurin inhibitor plus sirolimus is associated with improved renal dysfunction in heart transplant patients","volume":"21","author":"Potter","year":"2007","journal-title":"Clin Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0041-1345(00)00817-4","article-title":"Introduction of mycophenolate mofetil and cyclosporine withdrawal in heart transplant patients with progressive deteriorating renal function","volume":"32","author":"Dureau","year":"2000","journal-title":"Transplant Proc"},{"key":"10.1016\/j.healun.2009.05.021_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ejcts.2003.11.030","article-title":"Renal recovery after conversion to a calcineurin inhibitor-free immunosuppression in late cardiac transplant recipients","volume":"25","author":"Groetzner","year":"2004","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.healun.2009.05.021_bib21","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1016\/j.transproceed.2004.10.062","article-title":"Initial experience with sirolimus and mycophenolate mofetil for renal rescue from cyclosporine nephrotoxicity after heart transplantation","volume":"36","author":"Lyster","year":"2004","journal-title":"Transplant Proc"},{"key":"10.1016\/j.healun.2009.05.021_bib22","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.transproceed.2005.02.090","article-title":"Preservation of renal function after heart transplantation: initial single-center experience with sirolimus","volume":"37","author":"De Meester","year":"2005","journal-title":"Transplant Proc"},{"key":"10.1016\/j.healun.2009.05.021_bib23","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.healun.2005.02.018","article-title":"Improvement of renal dysfunction by conversion from calcineurin inhibitors to sirolimus after heart transplantation","volume":"24","author":"Hunt","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib24","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.transproceed.2005.02.006","article-title":"Sirolimus improves renal function in cardiac transplantation","volume":"37","author":"Cabez\u00f3n","year":"2005","journal-title":"Transplant Proc"},{"key":"10.1016\/j.healun.2009.05.021_bib25","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/01.tp.0000177644.45192.a3","article-title":"Switch from calcineurin inhibitors to sirolimus-induced renal recovery in heart transplant recipients in the midterm follow-up","volume":"81","author":"Bestetti","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2009.05.021_bib26","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1111\/j.1600-6143.2006.01527.x","article-title":"Cyclosporine withdrawal improves renal function in heart transplant patients on reduced-dose cyclosporine therapy","volume":"6","author":"Gleissner","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib27","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0140-6736(97)09278-7","article-title":"Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients","volume":"350","author":"Nashan","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.healun.2009.05.021_bib28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJM199801153380304","article-title":"Interleukin-2 receptor blockade with daclizumab to prevent acute rejection in renal transplantation","volume":"338","author":"Vincenti","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2009.05.021_bib29","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJM200003023420902","article-title":"Prevention of rejection in cardiac transplantation by blockade of the interleukin-2 receptor with a monoclonal antibody","volume":"342","author":"Beniaminovitz","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2009.05.021_bib30","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1097\/00007890-200005150-00022","article-title":"The safety and efficacy of two-dose daclizumab (Zenapax) induction in liver transplant recipients","volume":"69","author":"Eckhoff","year":"2000","journal-title":"Transplantation"},{"issue":"suppl","key":"10.1016\/j.healun.2009.05.021_bib31","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1097\/00007890-200004271-00026","article-title":"Basiliximab (Simulect) reduces the rate and severity of acute rejection in adult liver transplant recipients","volume":"69","author":"Neuhaus","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2009.05.021_bib32","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.healun.2008.05.013","article-title":"Interleukin-2 receptor antagonists as induction therapy after heart transplantation: systematic review with meta-analysis of randomized trials","volume":"27","author":"Moller","year":"2008","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib33","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1097\/00007890-200204150-00030","article-title":"Anti-CD25 monoclonal antibody coverage allows for calcineurin inhibitor \u201choliday\u201d in solid organ transplant patients with acute renal dysfunction","volume":"73","author":"Cantarovich","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2009.05.021_bib34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1016\/j.healun.2009.05.021_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1034\/j.1600-6143.2003.30109.x","article-title":"Pharmacokinetic and pharmacodynamic studies of one or two doses of daclizumab in renal transplantation","volume":"3","author":"Vincenti","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib36","first-page":"587","article-title":"A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection","volume":"6","author":"Billingham","year":"1990","journal-title":"J Heart Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib37","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.healun.2005.03.019","article-title":"Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection","volume":"24","author":"Stewart","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib38","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1097\/00007890-199812270-00002","article-title":"Synergistic effects of mycophenolate mofetil and sirolimus in prevention of acute heart, pancreas and kidney allograft rejection and in reversal of ongoing heart allograft rejection in the rat","volume":"66","author":"Vu","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2009.05.021_bib39","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1111\/j.1600-6143.2004.00627.x","article-title":"De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years","volume":"4","author":"Flechner","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib40","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1111\/j.1600-6143.2005.01055.x","article-title":"A randomized controlled trial of late conversion from CNI-based to sirolimus-based immunosuppression following renal transplantation","volume":"5","author":"Watson","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib41","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/01.TP.0000074360.62032.39","article-title":"Long-term improvement in renal function with sirolimus after early cyclosporine withdrawal in renal transplant recipients: 2-year results of Rapamune Maintenance Regimen Study","volume":"76","author":"Oberbauer","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2009.05.021_bib42","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.healun.2008.04.005","article-title":"Prolonged basiliximab use as an alternative to calcineurin inhibition to allow renal recovery late after heart transplantation","volume":"27","author":"Anselm","year":"2008","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.05.021_bib43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0896-8411(03)00113-6","article-title":"Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration","volume":"21","author":"Nussenblatt","year":"2003","journal-title":"J Autoimmun"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249809003647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249809003647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:19:14Z","timestamp":1760948354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249809003647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S1053249809003647"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2009.05.021","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term Immunosuppression With Anti-CD25 Monoclonal Antibodies in Heart Transplant Patients With Chronic Kidney Disease","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2009.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}