{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:00:01Z","timestamp":1790870401781,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.healun.2009.06.026","type":"journal-article","created":{"date-parts":[[2009,9,27]],"date-time":"2009-09-27T04:19:26Z","timestamp":1254025166000},"page":"1180-1184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Activated Protein C in Ischemia-Reperfusion Injury After Experimental Lung Transplantation"],"prefix":"10.1016","volume":"28","author":[{"given":"Shin","family":"Hirayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Cypel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Anraku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia C.","family":"Liaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Waddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaf","family":"Keshavjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2009.06.026_bib1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.healun.2008.07.018","article-title":"Registry of the International Society for Heart and Lung Transplantation: twenty-fifth official adult lung and heart\/lung transplantation report\u20142008","volume":"27","author":"Christie","year":"2008","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.06.026_bib2","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.healun.2007.01.031","article-title":"Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: analysis of the Extracorporeal Life Support Organization (ELSO) registry","volume":"26","author":"Fischer","year":"2007","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.06.026_bib3","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.healun.2005.03.011","article-title":"Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part VI: treatment","volume":"24","author":"Shargall","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2009.06.026_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00007890-199001000-00023","article-title":"The influence of preservation injury on rejection in the hepatic transplant recipient","volume":"49","author":"Howard","year":"1990","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2009.06.026_bib5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/00007890-199003000-00032","article-title":"Effect of recovery from ischemic injury on class I and class II MHC antigen expression","volume":"49","author":"Shackleton","year":"1990","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2009.06.026_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1164\/rccm.200608-1079OC","article-title":"Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome","volume":"175","author":"Daud","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.healun.2009.06.026_bib7","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1182\/blood-2006-09-003004","article-title":"The cytoprotective protein C pathway","volume":"109","author":"Mosnier","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.healun.2009.06.026_bib8","doi-asserted-by":"crossref","first-page":"S213","DOI":"10.1097\/01.CCM.0000057846.21303.AB","article-title":"Coagulation, fibrinolysis, and fibrin deposition in acute lung injury","volume":"31","author":"Idell","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.healun.2009.06.026_bib9","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1172\/JCI112902","article-title":"Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon","volume":"79","author":"Taylor","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/j.healun.2009.06.026_bib10","first-page":"L197","article-title":"Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production","volume":"272","author":"Murakami","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.healun.2009.06.026_bib11","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM200103083441001","article-title":"Efficacy and safety of recombinant human activated protein C for severe sepsis","volume":"344","author":"Bernard","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2009.06.026_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1164\/rccm.200606-827OC","article-title":"Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunction","volume":"175","author":"Christie","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.healun.2009.06.026_bib13","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1056\/NEJMoa050935","article-title":"Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death","volume":"353","author":"Abraham","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2009.06.026_bib14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2119\/2006-00036.Hirayama","article-title":"Prevention of neutrophil migration ameliorates rat lung allograft rejection","volume":"12","author":"Hirayama","year":"2006","journal-title":"Mol Med"},{"key":"10.1016\/j.healun.2009.06.026_bib15","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.athoracsur.2004.01.043","article-title":"Independent ventilation of the graft and native lungs in vivo after rat lung transplantation","volume":"79","author":"de Perrot","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.healun.2009.06.026_bib16","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1182\/blood-2004-03-1203","article-title":"Patients with severe sepsis vary markedly in their ability to generate activated protein C","volume":"104","author":"Liaw","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.healun.2009.06.026_bib17","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.4049\/jimmunol.171.10.4995","article-title":"Recipient T cells mediate reperfusion injury after lung transplantation in the rat","volume":"171","author":"de Perrot","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.healun.2009.06.026_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/01.shk.0000071060.78689.f1","article-title":"Effect of dose of hypertonic saline on its potential to prevent lung tissue damage in a mouse model of hemorrhagic shock","volume":"20","author":"Murao","year":"2003","journal-title":"Shock"},{"key":"10.1016\/j.healun.2009.06.026_bib19","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1164\/rccm.200207-670SO","article-title":"Ischemia-reperfusion-induced lung injury","volume":"167","author":"de Perrot","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.healun.2009.06.026_bib20","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1164\/rccm.200206-515OC","article-title":"Activated protein C inhibits the expression of platelet-derived growth factor in the lung","volume":"167","author":"Shimizu","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.healun.2009.06.026_bib21","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1164\/ajrccm.163.7.9911068","article-title":"Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse","volume":"163","author":"Yasui","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.healun.2009.06.026_bib22","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1182\/blood-2003-06-1980","article-title":"Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice","volume":"103","author":"Yuda","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.healun.2009.06.026_bib23","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/sj.bjp.0706915","article-title":"Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment","volume":"149","author":"Slofstra","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.healun.2009.06.026_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.vph.2006.06.016","article-title":"Inhaled activated protein C attenuates lung injury induced by aerosolized endotoxin in mice","volume":"45","author":"Kotanidou","year":"2006","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.healun.2009.06.026_bib25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.maturitas.2003.10.015","article-title":"Crosstalk between inflammation and thrombosis","volume":"47","author":"Esmon","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.healun.2009.06.026_bib26","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1097\/01.CCM.0000181729.46010.83","article-title":"Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment","volume":"33","author":"Vincent","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.healun.2009.06.026_bib27","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1161\/01.ATV.0000168421.13467.82","article-title":"Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition","volume":"25","author":"Dahlback","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.healun.2009.06.026_bib28","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1182\/blood-2004-06-2140","article-title":"Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis","volume":"104","author":"Nick","year":"2004","journal-title":"Blood"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249809005312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249809005312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:21:08Z","timestamp":1760948468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249809005312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S1053249809005312"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2009.06.026","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activated Protein C in Ischemia-Reperfusion Injury After Experimental Lung Transplantation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2009.06.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}