{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:02:11Z","timestamp":1792738931630,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.healun.2014.01.004","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T23:46:00Z","timestamp":1390088760000},"page":"470-477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Association between cell-derived microparticles and adverse events in patients with nonpulsatile left ventricular assist devices"],"prefix":"10.1016","volume":"33","author":[{"given":"Angelo","family":"Nascimbene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joggy K.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L.","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhashree","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Vinod","family":"Vijayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Civitello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nawrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vei-Vei","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari R.","family":"Mallidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reynolds M.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Fei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.H.","family":"Frazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2014.01.004_bib1","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jtcvs.2007.12.077","article-title":"Low thromboembolic risk for patients with the Heartmate II left ventricular assist device","volume":"136","author":"John","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2014.01.004_bib2","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.jacc.2009.02.048","article-title":"Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II)","volume":"53","author":"Klovaite","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2014.01.004_bib3","doi-asserted-by":"crossref","first-page":"e45207","DOI":"10.1371\/journal.pone.0045207","article-title":"Structural basis of type 2A von Willebrand disease investigated by molecular dynamics simulations and experiments","volume":"7","author":"Interlandi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.healun.2014.01.004_bib4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1540-8191.2010.01025.x","article-title":"Increased incidence of gastrointestinal bleeding following implantation of the HeartMate II LVAD","volume":"25","author":"Stern","year":"2010","journal-title":"J Card Surg"},{"key":"10.1016\/j.healun.2014.01.004_bib5","doi-asserted-by":"crossref","unstructured":"Letsou GV, Shah N, Gregoric ID, Myers TJ, Delgado R, Frazier OH. Gastrointestinal bleeding from arteriovenous malformations in patients supported by the Jarvik 2000 axial-flow left ventricular assist device. J Heart Lung Transplant 2005;24:105\u2013109.","DOI":"10.1016\/j.healun.2003.10.018"},{"key":"10.1016\/j.healun.2014.01.004_bib6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jtcvs.2008.07.032","article-title":"Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices","volume":"137","author":"Crow","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2014.01.004_bib7","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.healun.2011.03.008","article-title":"Arteriovenous malformation and gastrointestinal bleeding in patients with the HeartMate II left ventricular assist device","volume":"30","author":"Demirozu","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2014.01.004_bib8","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/STROKEAHA.111.639682","article-title":"Asymmetric pattern of cerebrovascular lesions in patients after left ventricular assist device implantation","volume":"43","author":"Kato","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.healun.2014.01.004_bib9","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1056\/NEJMoa0909938","article-title":"Advanced heart failure treated with continuous-flow left ventricular assist device","volume":"361","author":"Slaughter","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2014.01.004_bib10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jtcvs.2007.02.044","article-title":"Cerebrovascular accidents in patients with a ventricular assist device","volume":"134","author":"Tsukui","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2014.01.004_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0021-9150(01)00433-6","article-title":"High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells","volume":"158","author":"Nomura","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.healun.2014.01.004_bib12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jbiomech.2012.11.033","article-title":"Device thrombogenicity emulation: a novel methodology for optimizing the thromboresistance of cardiovascular devices","volume":"46","author":"Bluestein","year":"2013","journal-title":"J Biomech"},{"key":"10.1016\/j.healun.2014.01.004_bib13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF02648048","article-title":"Fluid mechanics of arterial stenosis: relationship to the development of mural thrombus","volume":"25","author":"Bluestein","year":"1997","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.healun.2014.01.004_bib14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1525-1594.2001.025005341.x","article-title":"Assessment of hemolysis related quantities in a microaxial blood pump by computational fluid dynamics","volume":"25","author":"Apel","year":"2001","journal-title":"Artif Organs"},{"key":"10.1016\/j.healun.2014.01.004_bib15","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1160\/TH07-05-0334","article-title":"Increased levels of circulating microparticles in patients with severe aortic valve stenosis","volume":"99","author":"Diehl","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.healun.2014.01.004_bib16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1160\/TH06-06-0313","article-title":"Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets","volume":"97","author":"Sinauridze","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.healun.2014.01.004_bib17","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1161\/01.CIR.99.3.348","article-title":"Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity","volume":"99","author":"Mallat","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2014.01.004_bib18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1183\/09031936.00087212","article-title":"Cellular microparticles in the pathogenesis of pulmonary hypertension","volume":"42","author":"Amabile","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2014.01.004_bib19","doi-asserted-by":"crossref","first-page":"e001842","DOI":"10.1161\/JAHA.112.001842","article-title":"Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence","volume":"1","author":"Burger","year":"2012","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.healun.2014.01.004_bib20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/156720212801619018","article-title":"Platelet microparticles induce angiogenesis and neurogenesis after cerebral ischemia","volume":"9","author":"Hayon","year":"2012","journal-title":"Curr Neurovasc Res"},{"key":"10.1016\/j.healun.2014.01.004_bib21","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/cc6133","article-title":"Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction","volume":"11","author":"Gambim","year":"2007","journal-title":"Crit Care"},{"key":"10.1016\/j.healun.2014.01.004_bib22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.thromres.2008.04.001","article-title":"Circulating platelet-derived microparticles and endothelium-derived microparticles may be a potential cause of microthrombosis in patients with osteonecrosis of the femoral head","volume":"123","author":"Kang","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.healun.2014.01.004_bib23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.thromres.2009.09.019","article-title":"Increased microparticle tissue factor activity in cancer patients with venous thromboembolism","volume":"125","author":"Manly","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.healun.2014.01.004_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1510\/icvts.2010.232603","article-title":"Enhanced microparticles in ventricular assist device patients predict platelet, leukocyte and endothelial cell activation","volume":"11","author":"Diehl","year":"2010","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.healun.2014.01.004_bib25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/eurjhf\/hfq006","article-title":"Patient selection for left ventricular assist devices","volume":"12","author":"Lund","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.healun.2014.01.004_bib26","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jvs.2010.08.029","article-title":"Variability and persistence of aspirin response in lower extremity peripheral arterial disease patients","volume":"53","author":"Saunders","year":"2011","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.healun.2014.01.004_bib27","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jacc.2008.05.031","article-title":"Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease","volume":"52","author":"Guthikonda","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2014.01.004_bib28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/09537100802054107","article-title":"Flow cytometric measurement of microparticles: pitfalls and protocol modifications","volume":"19","author":"Shah","year":"2008","journal-title":"Platelets"},{"key":"10.1016\/j.healun.2014.01.004_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/09537100902780643","article-title":"Differences in responses of platelets to fluid shear stress in patients with peripheral artery disease (PAD) and coronary artery disease (CAD)","volume":"20","author":"Nambi","year":"2009","journal-title":"Platelets"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249814000175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249814000175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:27:23Z","timestamp":1760948843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249814000175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1053249814000175"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2014.01.004","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between cell-derived microparticles and adverse events in patients with nonpulsatile left ventricular assist devices","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2014.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}